Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_004295                                                              20     390
NP_055325                                                              18    1135
NP_149015                                                              18    1135
XP_006715989                                                           18    1135
NP_004542                                                              18    1482
XP_005245103                                                           17    3301
XP_005245102                                                           17    3301
NP_002013                                                              17    3301
NP_000050                                                              17    4312
NP_006222                                                              17    4312
NP_001188478                                                           16    5631
NP_001188476                                                           16    5631
NP_004687                                                              16    5631
NP_001188477                                                           16    5631
NP_001188475                                                           16    5631
XP_005271375                                                           16    5631
XP_006711096                                                           16    5631
XP_005271374                                                           16    5631
XP_006710110                                                           16    5631
NP_000283                                                              16    7355
NP_689585                                                              16    7355
NP_570721                                                              16    7355
NP_001273737                                                           16    7355
NP_660317                                                              16    7355
NP_001182315                                                           16    7355
NP_001182316                                                           16    7355
XP_006724561                                                           16    7355
XP_005274607                                                           16    7355
XP_005274605                                                           16    7355
XP_006724560                                                           16    7355
XP_006724559                                                           16    7355
XP_005257146                                                           16    7355
XP_006714592                                                           16    7355
NP_055935                                                              15    9605
NP_001155018                                                           15    9605
NP_002141                                                              15    9605
NP_001165464                                                           15    9605
NP_001103132                                                           15    9605
NP_060529                                                              15    9605
NP_001239079                                                           15    9605
NP_114130                                                              15    9605
NP_001239077                                                           15    9605
NP_060845                                                              15    9605
XP_005274734                                                           15    9605
XP_005267891                                                           15    9605
XP_005267210                                                           15    9605
XP_006714819                                                           15    9605
NP_055040                                                              15    9605
>NP_004295
          Length = 1620

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   GSYIAQLLP 9
           G YIAQLLP
Sbjct: 359 GRYIAQLLP 367
>NP_055325
          Length = 4935

 Score = 18.5 bits (36), Expect =  1135
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1    GSYIAQLLP 9
            G+YIA++LP
Sbjct: 4531 GAYIAKILP 4539
>NP_149015
          Length = 5142

 Score = 18.5 bits (36), Expect =  1135
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1    GSYIAQLLP 9
            G+YIA++LP
Sbjct: 4531 GAYIAKILP 4539
>XP_006715989
          Length = 5148

 Score = 18.5 bits (36), Expect =  1135
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1    GSYIAQLLP 9
            G+YIA++LP
Sbjct: 4531 GAYIAKILP 4539
>NP_004542
          Length = 264

 Score = 18.1 bits (35), Expect =  1482
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  GSYIAQLLP 9
          G Y+A++LP
Sbjct: 62 GEYVAEILP 70
>XP_005245103
          Length = 495

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   SYIAQLLP 9
           S+IAQ+LP
Sbjct: 178 SFIAQVLP 185
>XP_005245102
          Length = 508

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   SYIAQLLP 9
           S+IAQ+LP
Sbjct: 191 SFIAQVLP 198
>NP_002013
          Length = 558

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   SYIAQLLP 9
           S+IAQ+LP
Sbjct: 241 SFIAQVLP 248
>NP_000050
          Length = 3418

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    GSYIAQLLP 9
            G Y AQ++P
Sbjct: 3201 GPYTAQIIP 3209
>NP_006222
          Length = 2286

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   GSYIAQLLP 9
           G Y+A +LP
Sbjct: 935 GPYLAMILP 943
>NP_001188478
          Length = 319

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   GSYIAQLLP 9
           G Y+A +LP
Sbjct: 236 GGYLALILP 244
>NP_001188476
          Length = 425

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   GSYIAQLLP 9
           G Y+A +LP
Sbjct: 342 GGYLALILP 350
>NP_004687
          Length = 487

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   GSYIAQLLP 9
           G Y+A +LP
Sbjct: 404 GGYLALILP 412
>NP_001188477
          Length = 382

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   GSYIAQLLP 9
           G Y+A +LP
Sbjct: 294 GGYLALILP 302
>NP_001188475
          Length = 439

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   GSYIAQLLP 9
           G Y+A +LP
Sbjct: 356 GGYLALILP 364
>XP_005271375
          Length = 257

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   GSYIAQLLP 9
           G Y+A +LP
Sbjct: 174 GGYLALILP 182
>XP_006711096
          Length = 377

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   GSYIAQLLP 9
           G Y+A +LP
Sbjct: 294 GGYLALILP 302
>XP_005271374
          Length = 487

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   GSYIAQLLP 9
           G Y+A +LP
Sbjct: 404 GGYLALILP 412
>XP_006710110
          Length = 299

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   SYIAQLLP 9
           SY+ Q+LP
Sbjct: 113 SYLCQVLP 120

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   SYIAQLLP 9
           SY+ Q+LP
Sbjct: 146 SYLCQVLP 153

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   SYIAQLLP 9
           SY+ Q+LP
Sbjct: 196 SYLCQVLP 203
>NP_000283
          Length = 1235

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    SYIAQLLP 9
            SY+ +LLP
Sbjct: 1221 SYLQELLP 1228
>NP_689585
          Length = 1437

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1    GSYIAQL 7
            GSY AQL
Sbjct: 1076 GSYTAQL 1082
>NP_570721
          Length = 445

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   SYIAQLLP 9
           ++IA+LLP
Sbjct: 333 NFIAELLP 340
>NP_001273737
          Length = 462

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   SYIAQLLP 9
           ++IA+LLP
Sbjct: 333 NFIAELLP 340
>NP_660317
          Length = 258

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   GSYIAQLLP 9
           GS++A  LP
Sbjct: 130 GSHVAAFLP 138
>NP_001182315
          Length = 258

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   GSYIAQLLP 9
           GS++A  LP
Sbjct: 130 GSHVAAFLP 138
>NP_001182316
          Length = 258

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   GSYIAQLLP 9
           GS++A  LP
Sbjct: 130 GSHVAAFLP 138
>XP_006724561
          Length = 1061

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    SYIAQLLP 9
            SY+ +LLP
Sbjct: 1047 SYLQELLP 1054
>XP_005274607
          Length = 1207

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    SYIAQLLP 9
            SY+ +LLP
Sbjct: 1193 SYLQELLP 1200
>XP_005274605
          Length = 1217

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    SYIAQLLP 9
            SY+ +LLP
Sbjct: 1203 SYLQELLP 1210
>XP_006724560
          Length = 1225

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    SYIAQLLP 9
            SY+ +LLP
Sbjct: 1211 SYLQELLP 1218
>XP_006724559
          Length = 1243

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    SYIAQLLP 9
            SY+ +LLP
Sbjct: 1229 SYLQELLP 1236
>XP_005257146
          Length = 258

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   GSYIAQLLP 9
           GS++A  LP
Sbjct: 130 GSHVAAFLP 138
>XP_006714592
          Length = 445

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   SYIAQLLP 9
           ++IA+LLP
Sbjct: 333 NFIAELLP 340
>NP_055935
          Length = 4169

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    GSYIAQLLP 9
            GS+  Q+LP
Sbjct: 1437 GSFYQQVLP 1445
>NP_001155018
          Length = 1015

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   GSYIAQLLP 9
           G Y+  LLP
Sbjct: 911 GQYVEVLLP 919
>NP_002141
          Length = 393

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   SYIAQLLP 9
           +YI Q LP
Sbjct: 151 NYIGQFLP 158
>NP_001165464
          Length = 354

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   SYIAQLLP 9
           +YI Q LP
Sbjct: 112 NYIGQFLP 119
>NP_001103132
          Length = 4284

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   GSYIAQLLP 9
           G+Y+  L+P
Sbjct: 386 GTYLVMLVP 394
>NP_060529
          Length = 1075

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    GSYIAQLLP 9
            G YI  LLP
Sbjct: 1002 GLYIQTLLP 1010
>NP_001239079
          Length = 232

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1  GSYIAQLLP 9
          G Y+A ++P
Sbjct: 17 GCYVAGIIP 25
>NP_114130
          Length = 560

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   YIAQLLP 9
           Y+A LLP
Sbjct: 404 YLADLLP 410
>NP_001239077
          Length = 284

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1  GSYIAQLLP 9
          G Y+A ++P
Sbjct: 17 GCYVAGIIP 25
>NP_060845
          Length = 307

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1  GSYIAQLLP 9
          G Y+A ++P
Sbjct: 17 GCYVAGIIP 25
>XP_005274734
          Length = 397

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  IAQLLP 9
          IAQLLP
Sbjct: 64 IAQLLP 69
>XP_005267891
          Length = 241

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1  GSYIAQLLP 9
          G Y+A ++P
Sbjct: 17 GCYVAGIIP 25
>XP_005267210
          Length = 464

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   YIAQLLP 9
           Y+A LLP
Sbjct: 308 YLADLLP 314
>XP_006714819
          Length = 450

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   YIAQLLP 9
           YI Q+LP
Sbjct: 245 YITQVLP 251
>NP_055040
          Length = 589

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   IAQLLP 9
           IAQLLP
Sbjct: 231 IAQLLP 236
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.320    0.143    0.415 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 456,280
Number of extensions: 855
Number of successful extensions: 50
Number of sequences better than 10000.0: 48
Number of HSP's gapped: 50
Number of HSP's successfully gapped: 50
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.7 bits)
S2: 28 (15.4 bits)

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