Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_004351                                                              20     299
NP_001784                                                              18    1935
NP_002940                                                              17    2528
NP_003176                                                              17    3301
NP_001406                                                              16    5631
NP_004414                                                              16    7355
NP_004412                                                              16    7355
NP_002327                                                              16    7355
NP_005449                                                              16    7355
NP_001271175                                                           16    7355
NP_056371                                                              16    7355
NP_001271176                                                           16    7355
NP_001271174                                                           16    7355
NP_004413                                                              16    7355
XP_006721532                                                           16    7355
XP_005256559                                                           16    7355
XP_005267576                                                           16    7355
XP_006720175                                                           16    7355
XP_006720174                                                           16    7355
XP_005267573                                                           16    7355
XP_006720173                                                           16    7355
XP_006720172                                                           16    7355
XP_005267571                                                           16    7355
XP_006719141                                                           16    7355
XP_005247229                                                           16    7355
XP_005244790                                                           16    7355
XP_005244789                                                           16    7355
XP_005244788                                                           16    7355
NP_075561                                                              15    9605
NP_006334                                                              15    9605
NP_001838                                                              15    9605
NP_001191675                                                           15    9605
NP_001191674                                                           15    9605
NP_001191673                                                           15    9605
NP_004053                                                              15    9605
NP_001274688                                                           15    9605
NP_378667                                                              15    9605
NP_001274687                                                           15    9605
NP_001274689                                                           15    9605
NP_001182719                                                           15    9605
XP_005261644                                                           15    9605
XP_006724681                                                           15    9605
XP_006724680                                                           15    9605
XP_005255827                                                           15    9605
XP_005255826                                                           15    9605
XP_005255825                                                           15    9605
XP_005248410                                                           15    9605
XP_006714553                                                           15    9605
XP_005248407                                                           15    9605
XP_005248406                                                           15    9605
XP_005248404                                                           15    9605
XP_005248403                                                           15    9605
XP_006714552                                                           15    9605
XP_005248402                                                           15    9605
XP_005263625                                                           15    9605
XP_005263622                                                           15    9605
>NP_004351
          Length = 882

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   GSVMKGALP 9
           GSVM+GALP
Sbjct: 269 GSVMEGALP 277
>NP_001784
          Length = 829

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   GSVMKGALP 9
           GSV++G LP
Sbjct: 222 GSVLEGVLP 230
>NP_002940
          Length = 198

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   GSVMKGALP 9
           G VM GA+P
Sbjct: 101 GGVMSGAVP 109
>NP_003176
          Length = 1085

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   GSVMKGALP 9
           G  M+GALP
Sbjct: 376 GPTMQGALP 384
>NP_001406
          Length = 472

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   GSVMKGAL 8
           GS++KG L
Sbjct: 281 GSILKGVL 288
>NP_004414
          Length = 716

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   GSVMKG 6
           GS+MKG
Sbjct: 279 GSIMKG 284
>NP_004412
          Length = 670

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   GSVMKG 6
           GS+MKG
Sbjct: 281 GSIMKG 286
>NP_002327
          Length = 1613

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   SVMKGALP 9
           +V+KG+LP
Sbjct: 218 AVVKGSLP 225
>NP_005449
          Length = 941

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  GSVMKGALP 9
          GS+ +G LP
Sbjct: 71 GSIGRGVLP 79
>NP_001271175
          Length = 1782

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   GSVMKGALP 9
           GSV++ A+P
Sbjct: 549 GSVLEDAIP 557
>NP_056371
          Length = 1804

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   GSVMKGALP 9
           GSV++ A+P
Sbjct: 549 GSVLEDAIP 557
>NP_001271176
          Length = 1803

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   GSVMKGALP 9
           GSV++ A+P
Sbjct: 549 GSVLEDAIP 557
>NP_001271174
          Length = 1783

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   GSVMKGALP 9
           GSV++ A+P
Sbjct: 549 GSVLEDAIP 557
>NP_004413
          Length = 736

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   GSVMKG 6
           GS+MKG
Sbjct: 297 GSIMKG 302
>XP_006721532
          Length = 523

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   GSVMKG 6
           GS+MKG
Sbjct: 297 GSIMKG 302
>XP_005256559
          Length = 732

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   GSVMKG 6
           GS+MKG
Sbjct: 293 GSIMKG 298
>XP_005267576
          Length = 1782

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   GSVMKGALP 9
           GSV++ A+P
Sbjct: 549 GSVLEDAIP 557
>XP_006720175
          Length = 1783

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   GSVMKGALP 9
           GSV++ A+P
Sbjct: 549 GSVLEDAIP 557
>XP_006720174
          Length = 1803

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   GSVMKGALP 9
           GSV++ A+P
Sbjct: 549 GSVLEDAIP 557
>XP_005267573
          Length = 1804

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   GSVMKGALP 9
           GSV++ A+P
Sbjct: 549 GSVLEDAIP 557
>XP_006720173
          Length = 1804

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   GSVMKGALP 9
           GSV++ A+P
Sbjct: 549 GSVLEDAIP 557
>XP_006720172
          Length = 1804

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   GSVMKGALP 9
           GSV++ A+P
Sbjct: 549 GSVLEDAIP 557
>XP_005267571
          Length = 1804

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   GSVMKGALP 9
           GSV++ A+P
Sbjct: 549 GSVLEDAIP 557
>XP_006719141
          Length = 1613

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   SVMKGALP 9
           +V+KG+LP
Sbjct: 218 AVVKGSLP 225
>XP_005247229
          Length = 718

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   GSVMKG 6
           GS+MKG
Sbjct: 279 GSIMKG 284
>XP_005244790
          Length = 549

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   GSVMKG 6
           GS+MKG
Sbjct: 281 GSIMKG 286
>XP_005244789
          Length = 574

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   GSVMKG 6
           GS+MKG
Sbjct: 281 GSIMKG 286
>XP_005244788
          Length = 695

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   GSVMKG 6
           GS+MKG
Sbjct: 281 GSIMKG 286
>NP_075561
          Length = 3197

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    MKGALP 9
            MKG+LP
Sbjct: 1227 MKGSLP 1232
>NP_006334
          Length = 999

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   GSVMKGAL 8
           GSVM+G L
Sbjct: 599 GSVMEGNL 606
>NP_001838
          Length = 1691

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   GSVMKGALP 9
           GS++K  LP
Sbjct: 855 GSIVKKGLP 863
>NP_001191675
          Length = 732

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   GSVMKGALP 9
           GSV  G LP
Sbjct: 301 GSVTLGVLP 309
>NP_001191674
          Length = 790

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   GSVMKGALP 9
           GSV  G LP
Sbjct: 398 GSVTLGVLP 406
>NP_001191673
          Length = 807

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   GSVMKGALP 9
           GSV  G LP
Sbjct: 398 GSVTLGVLP 406
>NP_004053
          Length = 829

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   GSVMKGALP 9
           GSV  G LP
Sbjct: 398 GSVTLGVLP 406
>NP_001274688
          Length = 1666

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   GSVMKGALP 9
           GS++K  LP
Sbjct: 854 GSIVKKGLP 862
>NP_378667
          Length = 1690

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   GSVMKGALP 9
           GS++K  LP
Sbjct: 854 GSIVKKGLP 862
>NP_001274687
          Length = 1707

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   GSVMKGALP 9
           GS++K  LP
Sbjct: 871 GSIVKKGLP 879
>NP_001274689
          Length = 1633

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   GSVMKGALP 9
           GS++K  LP
Sbjct: 854 GSIVKKGLP 862
>NP_001182719
          Length = 588

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   GSVMKGAL 8
           GSV KG+L
Sbjct: 434 GSVNKGSL 441
>XP_005261644
          Length = 289

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  VMKGALP 9
          ++KGALP
Sbjct: 35 LIKGALP 41
>XP_006724681
          Length = 1249

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   GSVMKGALP 9
           GS++K  LP
Sbjct: 855 GSIVKKGLP 863
>XP_006724680
          Length = 1708

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   GSVMKGALP 9
           GS++K  LP
Sbjct: 872 GSIVKKGLP 880
>XP_005255827
          Length = 651

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   GSVMKGALP 9
           GSV  G LP
Sbjct: 220 GSVTLGVLP 228
>XP_005255826
          Length = 766

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   GSVMKGALP 9
           GSV  G LP
Sbjct: 398 GSVTLGVLP 406
>XP_005255825
          Length = 829

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   GSVMKGALP 9
           GSV  G LP
Sbjct: 398 GSVTLGVLP 406
>XP_005248410
          Length = 2132

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   MKGALP 9
           MKG+LP
Sbjct: 108 MKGSLP 113
>XP_006714553
          Length = 2792

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    MKGALP 9
            MKG+LP
Sbjct: 1227 MKGSLP 1232
>XP_005248407
          Length = 3208

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    MKGALP 9
            MKG+LP
Sbjct: 1184 MKGSLP 1189
>XP_005248406
          Length = 3214

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    MKGALP 9
            MKG+LP
Sbjct: 1227 MKGSLP 1232
>XP_005248404
          Length = 3250

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    MKGALP 9
            MKG+LP
Sbjct: 1227 MKGSLP 1232
>XP_005248403
          Length = 3250

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    MKGALP 9
            MKG+LP
Sbjct: 1227 MKGSLP 1232
>XP_006714552
          Length = 3251

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    MKGALP 9
            MKG+LP
Sbjct: 1227 MKGSLP 1232
>XP_005248402
          Length = 3251

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    MKGALP 9
            MKG+LP
Sbjct: 1227 MKGSLP 1232
>XP_005263625
          Length = 733

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   GSVMKGAL 8
           GSVM+G L
Sbjct: 599 GSVMEGNL 606
>XP_005263622
          Length = 832

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   GSVMKGAL 8
           GSVM+G L
Sbjct: 599 GSVMEGNL 606
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.312    0.134    0.384 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 469,583
Number of extensions: 1085
Number of successful extensions: 56
Number of sequences better than 10000.0: 56
Number of HSP's gapped: 56
Number of HSP's successfully gapped: 56
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.5 bits)
S2: 28 (15.4 bits)

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