Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_036462                                                              19     869
XP_005269721                                                           19     869
NP_005111                                                              17    3301
NP_001273767                                                           17    3301
NP_001501                                                              17    3301
XP_005262376                                                           17    3301
XP_005262374                                                           17    3301
XP_006714258                                                           17    3301
NP_775913                                                              17    4312
NP_065785                                                              17    4312
NP_079002                                                              17    4312
NP_001257514                                                           17    4312
NP_001257513                                                           17    4312
XP_006719191                                                           17    4312
XP_006719190                                                           17    4312
XP_006719189                                                           17    4312
XP_006719188                                                           17    4312
XP_006719187                                                           17    4312
XP_006719186                                                           17    4312
XP_006719185                                                           17    4312
XP_006719184                                                           17    4312
XP_006719183                                                           17    4312
XP_006719182                                                           17    4312
XP_006719181                                                           17    4312
XP_006719180                                                           17    4312
XP_006719179                                                           17    4312
XP_006710648                                                           17    4312
NP_005349                                                              16    7355
XP_006719889                                                           16    7355
XP_005266454                                                           16    7355
XP_005266453                                                           16    7355
XP_006719887                                                           16    7355
XP_006719886                                                           16    7355
XP_006719885                                                           16    7355
XP_005266446                                                           16    7355
XP_005266444                                                           16    7355
XP_006719883                                                           16    7355
XP_006719882                                                           16    7355
XP_006719881                                                           16    7355
XP_006719880                                                           16    7355
XP_005266440                                                           16    7355
XP_006719879                                                           16    7355
XP_006719878                                                           16    7355
XP_006719877                                                           16    7355
XP_006719876                                                           16    7355
XP_006719875                                                           16    7355
XP_006719874                                                           16    7355
XP_006719873                                                           16    7355
XP_005266438                                                           16    7355
NP_005742                                                              15    9605
NP_671714                                                              15    9605
NP_775945                                                              15    9605
NP_001268885                                                           15    9605
NP_443128                                                              15    9605
NP_065937                                                              15    9605
XP_005271696                                                           15    9605
XP_005271695                                                           15    9605
XP_005271694                                                           15    9605
XP_005271693                                                           15    9605
XP_005271690                                                           15    9605
XP_005271689                                                           15    9605
XP_005271688                                                           15    9605
XP_005271687                                                           15    9605
XP_006715890                                                           15    9605
XP_005250160                                                           15    9605
XP_005250159                                                           15    9605
XP_006715526                                                           15    9605
XP_005266998                                                           15    9605
>NP_036462
          Length = 2073

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   GSLTDRRIK 9
           GSLTD RIK
Sbjct: 651 GSLTDGRIK 659
>XP_005269721
          Length = 2073

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   GSLTDRRIK 9
           GSLTD RIK
Sbjct: 651 GSLTDGRIK 659
>NP_005111
          Length = 2177

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   SLTDRRIK 9
           SLTD RIK
Sbjct: 382 SLTDSRIK 389
>NP_001273767
          Length = 912

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   GSLTDRRIK 9
           GSLTD++++
Sbjct: 332 GSLTDKKLE 340
>NP_001501
          Length = 1007

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   GSLTDRRIK 9
           GSLTD++++
Sbjct: 427 GSLTDKKLE 435
>XP_005262376
          Length = 2155

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   SLTDRRIK 9
           SLTD RIK
Sbjct: 382 SLTDSRIK 389
>XP_005262374
          Length = 2180

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   SLTDRRIK 9
           SLTD RIK
Sbjct: 382 SLTDSRIK 389
>XP_006714258
          Length = 994

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   GSLTDRRIK 9
           GSLTD++++
Sbjct: 443 GSLTDKKLE 451
>NP_775913
          Length = 391

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  LTDRRIK 9
          LTDRRI+
Sbjct: 8  LTDRRIR 14
>NP_065785
          Length = 386

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  LTDRRIK 9
          LTDRRI+
Sbjct: 12 LTDRRIR 18
>NP_079002
          Length = 822

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   GSLTDRRIK 9
           G LTD+RI+
Sbjct: 752 GVLTDQRIR 760
>NP_001257514
          Length = 830

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   GSLTDRRIK 9
           G LTD+RI+
Sbjct: 760 GVLTDQRIR 768
>NP_001257513
          Length = 781

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   GSLTDRRIK 9
           G LTD+RI+
Sbjct: 711 GVLTDQRIR 719
>XP_006719191
          Length = 287

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  LTDRRIK 9
          LTDRRI+
Sbjct: 12 LTDRRIR 18
>XP_006719190
          Length = 307

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  LTDRRIK 9
          LTDRRI+
Sbjct: 12 LTDRRIR 18
>XP_006719189
          Length = 307

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  LTDRRIK 9
          LTDRRI+
Sbjct: 12 LTDRRIR 18
>XP_006719188
          Length = 307

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  LTDRRIK 9
          LTDRRI+
Sbjct: 12 LTDRRIR 18
>XP_006719187
          Length = 386

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  LTDRRIK 9
          LTDRRI+
Sbjct: 12 LTDRRIR 18
>XP_006719186
          Length = 386

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  LTDRRIK 9
          LTDRRI+
Sbjct: 12 LTDRRIR 18
>XP_006719185
          Length = 386

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  LTDRRIK 9
          LTDRRI+
Sbjct: 12 LTDRRIR 18
>XP_006719184
          Length = 386

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  LTDRRIK 9
          LTDRRI+
Sbjct: 12 LTDRRIR 18
>XP_006719183
          Length = 386

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  LTDRRIK 9
          LTDRRI+
Sbjct: 12 LTDRRIR 18
>XP_006719182
          Length = 386

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  LTDRRIK 9
          LTDRRI+
Sbjct: 12 LTDRRIR 18
>XP_006719181
          Length = 386

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  LTDRRIK 9
          LTDRRI+
Sbjct: 12 LTDRRIR 18
>XP_006719180
          Length = 386

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  LTDRRIK 9
          LTDRRI+
Sbjct: 12 LTDRRIR 18
>XP_006719179
          Length = 386

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  LTDRRIK 9
          LTDRRI+
Sbjct: 12 LTDRRIR 18
>XP_006710648
          Length = 220

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  LTDRRIK 9
          LTDRRI+
Sbjct: 8  LTDRRIR 14
>NP_005349
          Length = 1349

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   TDRRIK 9
           TDRR+K
Sbjct: 162 TDRRVK 167
>XP_006719889
          Length = 1324

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   TDRRIK 9
           TDRR+K
Sbjct: 110 TDRRVK 115
>XP_005266454
          Length = 1285

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  TDRRIK 9
          TDRR+K
Sbjct: 81 TDRRVK 86
>XP_005266453
          Length = 1297

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   TDRRIK 9
           TDRR+K
Sbjct: 110 TDRRVK 115
>XP_006719887
          Length = 1328

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   TDRRIK 9
           TDRR+K
Sbjct: 110 TDRRVK 115
>XP_006719886
          Length = 1537

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   TDRRIK 9
           TDRR+K
Sbjct: 110 TDRRVK 115
>XP_006719885
          Length = 1578

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   TDRRIK 9
           TDRR+K
Sbjct: 110 TDRRVK 115
>XP_005266446
          Length = 1631

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   TDRRIK 9
           TDRR+K
Sbjct: 110 TDRRVK 115
>XP_005266444
          Length = 1672

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   TDRRIK 9
           TDRR+K
Sbjct: 110 TDRRVK 115
>XP_006719883
          Length = 1740

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   TDRRIK 9
           TDRR+K
Sbjct: 110 TDRRVK 115
>XP_006719882
          Length = 1767

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   TDRRIK 9
           TDRR+K
Sbjct: 110 TDRRVK 115
>XP_006719881
          Length = 1794

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   TDRRIK 9
           TDRR+K
Sbjct: 110 TDRRVK 115
>XP_006719880
          Length = 1802

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   TDRRIK 9
           TDRR+K
Sbjct: 110 TDRRVK 115
>XP_005266440
          Length = 1806

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  TDRRIK 9
          TDRR+K
Sbjct: 81 TDRRVK 86
>XP_006719879
          Length = 1808

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   TDRRIK 9
           TDRR+K
Sbjct: 110 TDRRVK 115
>XP_006719878
          Length = 1821

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   TDRRIK 9
           TDRR+K
Sbjct: 110 TDRRVK 115
>XP_006719877
          Length = 1827

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   TDRRIK 9
           TDRR+K
Sbjct: 110 TDRRVK 115
>XP_006719876
          Length = 1833

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   TDRRIK 9
           TDRR+K
Sbjct: 108 TDRRVK 113
>XP_006719875
          Length = 1834

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   TDRRIK 9
           TDRR+K
Sbjct: 110 TDRRVK 115
>XP_006719874
          Length = 1835

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   TDRRIK 9
           TDRR+K
Sbjct: 110 TDRRVK 115
>XP_006719873
          Length = 1835

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   TDRRIK 9
           TDRR+K
Sbjct: 110 TDRRVK 115
>XP_005266438
          Length = 1835

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   TDRRIK 9
           TDRR+K
Sbjct: 110 TDRRVK 115
>NP_005742
          Length = 3907

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    GSLTDRRIK 9
            GSLT+R ++
Sbjct: 3582 GSLTERLLR 3590
>NP_671714
          Length = 3899

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    GSLTDRRIK 9
            GSLT+R ++
Sbjct: 3574 GSLTERLLR 3582
>NP_775945
          Length = 539

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   GSLTDRR 7
           GSL+D+R
Sbjct: 241 GSLSDKR 247
>NP_001268885
          Length = 3631

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    GSLTDRR 7
            G+LT+RR
Sbjct: 1838 GNLTERR 1844
>NP_443128
          Length = 3487

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    GSLTDRR 7
            G+LT+RR
Sbjct: 1798 GNLTERR 1804
>NP_065937
          Length = 1077

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  LTDRRIK 9
          LTD R+K
Sbjct: 58 LTDERVK 64
>XP_005271696
          Length = 1045

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  LTDRRIK 9
          LTD R+K
Sbjct: 58 LTDERVK 64
>XP_005271695
          Length = 1046

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  LTDRRIK 9
          LTD R+K
Sbjct: 58 LTDERVK 64
>XP_005271694
          Length = 1078

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  LTDRRIK 9
          LTD R+K
Sbjct: 58 LTDERVK 64
>XP_005271693
          Length = 1080

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  LTDRRIK 9
          LTD R+K
Sbjct: 58 LTDERVK 64
>XP_005271690
          Length = 1118

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  LTDRRIK 9
          LTD R+K
Sbjct: 36 LTDERVK 42
>XP_005271689
          Length = 1137

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  LTDRRIK 9
          LTD R+K
Sbjct: 55 LTDERVK 61
>XP_005271688
          Length = 1139

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  LTDRRIK 9
          LTD R+K
Sbjct: 58 LTDERVK 64
>XP_005271687
          Length = 1140

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  LTDRRIK 9
          LTD R+K
Sbjct: 58 LTDERVK 64
>XP_006715890
          Length = 3860

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    GSLTDRRIK 9
            GSLT+R ++
Sbjct: 3535 GSLTERLLR 3543
>XP_005250160
          Length = 3939

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    GSLTDRRIK 9
            GSLT+R ++
Sbjct: 3614 GSLTERLLR 3622
>XP_005250159
          Length = 3952

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    GSLTDRRIK 9
            GSLT+R ++
Sbjct: 3627 GSLTERLLR 3635
>XP_006715526
          Length = 543

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   GSLTDRR 7
           GSL+D+R
Sbjct: 288 GSLSDKR 294
>XP_005266998
          Length = 762

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   GSLTDRR 7
           GSL+D+R
Sbjct: 288 GSLSDKR 294
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.319    0.139    0.370 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 452,984
Number of extensions: 778
Number of successful extensions: 68
Number of sequences better than 10000.0: 68
Number of HSP's gapped: 68
Number of HSP's successfully gapped: 68
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.8 bits)
S2: 28 (15.4 bits)

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