Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001261                                                              19     869
XP_005271924                                                           19     869
XP_005271923                                                           19     869
NP_003803                                                              17    3301
XP_005246989                                                           17    3301
NP_653234                                                              17    4312
XP_006713027                                                           17    4312
XP_006713026                                                           17    4312
XP_006713025                                                           17    4312
XP_006713024                                                           17    4312
NP_694966                                                              16    5631
NP_150375                                                              16    7355
NP_001032402                                                           16    7355
NP_004632                                                              15    9605
NP_001182555                                                           15    9605
NP_001185471                                                           15    9605
NP_001185472                                                           15    9605
NP_060028                                                              15    9605
NP_002521                                                              15    9605
NP_002408                                                              15    9605
NP_001012338                                                           15    9605
NP_001139438                                                           15    9605
NP_001230030                                                           15    9605
NP_001257903                                                           15    9605
NP_859422                                                              15    9605
NP_001154992                                                           15    9605
NP_061198                                                              15    9605
NP_003310                                                              15    9605
NP_597676                                                              15    9605
NP_006339                                                              15    9605
NP_001243779                                                           15    9605
NP_596869                                                              15    9605
NP_001245245                                                           15    9605
NP_060568                                                              15    9605
NP_057023                                                              15    9605
XP_006721269                                                           15    9605
XP_005255684                                                           15    9605
XP_006720670                                                           15    9605
XP_006720615                                                           15    9605
XP_006720608                                                           15    9605
XP_006720607                                                           15    9605
XP_006720606                                                           15    9605
XP_006720605                                                           15    9605
XP_006717927                                                           15    9605
XP_005252669                                                           15    9605
XP_005252668                                                           15    9605
XP_006717572                                                           15    9605
XP_005252667                                                           15    9605
XP_005252666                                                           15    9605
XP_005252665                                                           15    9605
XP_005252663                                                           15    9605
XP_005252662                                                           15    9605
XP_006714207                                                           15    9605
XP_005247233                                                           15    9605
XP_005246888                                                           15    9605
XP_006712788                                                           15    9605
XP_006712787                                                           15    9605
XP_006712786                                                           15    9605
NP_115647                                                              15    9605
NP_001254479                                                           15    9605
NP_597681                                                              15    9605
>NP_001261
          Length = 1710

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    GSIKALKDS 9
            G IKALKDS
Sbjct: 1175 GCIKALKDS 1183
>XP_005271924
          Length = 1710

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    GSIKALKDS 9
            G IKALKDS
Sbjct: 1175 GCIKALKDS 1183
>XP_005271923
          Length = 1798

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    GSIKALKDS 9
            G IKALKDS
Sbjct: 1175 GCIKALKDS 1183
>NP_003803
          Length = 832

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   GSIKALKDS 9
           GSI+ +KDS
Sbjct: 200 GSIRGVKDS 208
>XP_005246989
          Length = 832

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   GSIKALKDS 9
           GSI+ +KDS
Sbjct: 200 GSIRGVKDS 208
>NP_653234
          Length = 1107

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   GSIKALKDS 9
           GS++ LKDS
Sbjct: 594 GSMEVLKDS 602
>XP_006713027
          Length = 930

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   GSIKALKDS 9
           GS++ LKDS
Sbjct: 416 GSMEVLKDS 424
>XP_006713026
          Length = 986

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   GSIKALKDS 9
           GS++ LKDS
Sbjct: 472 GSMEVLKDS 480
>XP_006713025
          Length = 1089

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   GSIKALKDS 9
           GS++ LKDS
Sbjct: 575 GSMEVLKDS 583
>XP_006713024
          Length = 1108

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   GSIKALKDS 9
           GS++ LKDS
Sbjct: 594 GSMEVLKDS 602
>NP_694966
          Length = 282

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   GSIKALKDS 9
           GS+KAL+++
Sbjct: 174 GSLKALRET 182
>NP_150375
          Length = 1196

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   GSIKALKD 8
           GSI+ LKD
Sbjct: 788 GSIEILKD 795
>NP_001032402
          Length = 211

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  GSIKALKDS 9
          GS+K L+D+
Sbjct: 37 GSLKPLRDT 45
>NP_004632
          Length = 1027

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   GSIKALKDS 9
           GS+K L+D+
Sbjct: 277 GSLKRLEDT 285
>NP_001182555
          Length = 1068

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   GSIKALKDS 9
           GS+K L+D+
Sbjct: 277 GSLKRLEDT 285
>NP_001185471
          Length = 950

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   GSIKALKDS 9
           G+I  LKDS
Sbjct: 842 GNIYVLKDS 850
>NP_001185472
          Length = 940

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   GSIKALKDS 9
           G+I  LKDS
Sbjct: 832 GNIYVLKDS 840
>NP_060028
          Length = 1017

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   GSIKALKDS 9
           G+I  LKDS
Sbjct: 815 GNIYVLKDS 823
>NP_002521
          Length = 825

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   SIKALKD 8
           ++KALKD
Sbjct: 570 AVKALKD 576
>NP_002408
          Length = 3256

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    SIKALKDS 9
            SIKA K+S
Sbjct: 2038 SIKAFKES 2045

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    SIKALKDS 9
            SIKA K+S
Sbjct: 2521 SIKAFKES 2528

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    IKALKDS 9
            IKALK+S
Sbjct: 2763 IKALKES 2769
>NP_001012338
          Length = 839

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   SIKALKD 8
           ++KALKD
Sbjct: 570 AVKALKD 576
>NP_001139438
          Length = 2896

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    SIKALKDS 9
            SIKA K+S
Sbjct: 1678 SIKAFKES 1685

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    SIKALKDS 9
            SIKA K+S
Sbjct: 2161 SIKAFKES 2168

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    IKALKDS 9
            IKALK+S
Sbjct: 2403 IKALKES 2409
>NP_001230030
          Length = 817

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   SIKALKD 8
           ++KALKD
Sbjct: 562 AVKALKD 568
>NP_001257903
          Length = 5121

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   GSIKALKDS 9
           G+I  LKDS
Sbjct: 815 GNIYVLKDS 823
>NP_859422
          Length = 839

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   KALKDS 9
           KALKDS
Sbjct: 472 KALKDS 477
>NP_001154992
          Length = 823

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   KALKDS 9
           KALKDS
Sbjct: 472 KALKDS 477
>NP_061198
          Length = 1742

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    IKALKD 8
            IKALKD
Sbjct: 1033 IKALKD 1038
>NP_003310
          Length = 26926

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2     SIKALKDS 9
             +IKA+KD+
Sbjct: 26443 TIKAIKDT 26450
>NP_597676
          Length = 27051

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2     SIKALKDS 9
             +IKA+KD+
Sbjct: 26568 TIKAIKDT 26575
>NP_006339
          Length = 860

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   KALKDS 9
           KALKDS
Sbjct: 472 KALKDS 477
>NP_001243779
          Length = 34350

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2     SIKALKDS 9
             +IKA+KD+
Sbjct: 33867 TIKAIKDT 33874
>NP_596869
          Length = 33423

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2     SIKALKDS 9
             +IKA+KD+
Sbjct: 32940 TIKAIKDT 32947
>NP_001245245
          Length = 883

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3  IKALKD 8
          IKALKD
Sbjct: 66 IKALKD 71
>NP_060568
          Length = 883

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3  IKALKD 8
          IKALKD
Sbjct: 66 IKALKD 71
>NP_057023
          Length = 497

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   IKALKD 8
           IKALKD
Sbjct: 111 IKALKD 116
>XP_006721269
          Length = 5138

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   GSIKALKDS 9
           G+I  LKDS
Sbjct: 832 GNIYVLKDS 840
>XP_005255684
          Length = 668

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   GSIKALK 7
           GS+KA+K
Sbjct: 493 GSLKAIK 499
>XP_006720670
          Length = 1712

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    IKALKD 8
            IKALKD
Sbjct: 1033 IKALKD 1038
>XP_006720615
          Length = 448

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   SIKALKD 8
           ++KALKD
Sbjct: 193 AVKALKD 199
>XP_006720608
          Length = 715

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   SIKALKD 8
           ++KALKD
Sbjct: 570 AVKALKD 576
>XP_006720607
          Length = 817

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   SIKALKD 8
           ++KALKD
Sbjct: 562 AVKALKD 568
>XP_006720606
          Length = 825

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   SIKALKD 8
           ++KALKD
Sbjct: 570 AVKALKD 576
>XP_006720605
          Length = 850

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   SIKALKD 8
           ++KALKD
Sbjct: 570 AVKALKD 576
>XP_006717927
          Length = 2406

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    SIKALKDS 9
            SIKA K+S
Sbjct: 1188 SIKAFKES 1195

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    SIKALKDS 9
            SIKA K+S
Sbjct: 1671 SIKAFKES 1678

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    IKALKDS 9
            IKALK+S
Sbjct: 1913 IKALKES 1919
>XP_005252669
          Length = 584

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   GSIKALKDS 9
           GS+K L+D+
Sbjct: 277 GSLKRLEDT 285
>XP_005252668
          Length = 839

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  GSIKALKDS 9
          GS+K L+D+
Sbjct: 32 GSLKRLEDT 40
>XP_006717572
          Length = 1003

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   GSIKALKDS 9
           GS+K L+D+
Sbjct: 277 GSLKRLEDT 285
>XP_005252667
          Length = 1052

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   GSIKALKDS 9
           GS+K L+D+
Sbjct: 245 GSLKRLEDT 253
>XP_005252666
          Length = 1057

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   GSIKALKDS 9
           GS+K L+D+
Sbjct: 277 GSLKRLEDT 285
>XP_005252665
          Length = 1068

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   GSIKALKDS 9
           GS+K L+D+
Sbjct: 277 GSLKRLEDT 285
>XP_005252663
          Length = 1084

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   GSIKALKDS 9
           GS+K L+D+
Sbjct: 277 GSLKRLEDT 285
>XP_005252662
          Length = 1084

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   GSIKALKDS 9
           GS+K L+D+
Sbjct: 277 GSLKRLEDT 285
>XP_006714207
          Length = 1220

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   KALKDS 9
           KALKDS
Sbjct: 503 KALKDS 508
>XP_005247233
          Length = 927

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3  IKALKD 8
          IKALKD
Sbjct: 66 IKALKD 71
>XP_005246888
          Length = 22663

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2     SIKALKDS 9
             +IKA+KD+
Sbjct: 22180 TIKAIKDT 22187
>XP_006712788
          Length = 24022

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2     SIKALKDS 9
             +IKA+KD+
Sbjct: 23539 TIKAIKDT 23546
>XP_006712787
          Length = 33978

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2     SIKALKDS 9
             +IKA+KD+
Sbjct: 33495 TIKAIKDT 33502
>XP_006712786
          Length = 35484

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2     SIKALKDS 9
             +IKA+KD+
Sbjct: 35001 TIKAIKDT 35008
>NP_115647
          Length = 670

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   GSIKALK 7
           GS+KA+K
Sbjct: 495 GSLKAIK 501
>NP_001254479
          Length = 35991

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2     SIKALKDS 9
             +IKA+KD+
Sbjct: 35508 TIKAIKDT 35515
>NP_597681
          Length = 27118

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2     SIKALKDS 9
             +IKA+KD+
Sbjct: 26635 TIKAIKDT 26642
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.300    0.122    0.297 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 468,839
Number of extensions: 1098
Number of successful extensions: 67
Number of sequences better than 10000.0: 61
Number of HSP's gapped: 67
Number of HSP's successfully gapped: 67
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.2 bits)
S2: 28 (15.4 bits)

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