Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_073713                                                              20     390
NP_002429                                                              18    1935
NP_116107                                                              16    5631
XP_005264089                                                           16    5631
NP_079291                                                              16    7355
NP_001275949                                                           16    7355
NP_659464                                                              16    7355
NP_005059                                                              16    7355
NP_443202                                                              16    7355
NP_001184256                                                           16    7355
XP_005260713                                                           16    7355
XP_006717810                                                           16    7355
XP_006717809                                                           16    7355
XP_005269730                                                           16    7355
XP_005269729                                                           16    7355
XP_005267157                                                           16    7355
XP_005248961                                                           16    7355
NP_115627                                                              15    9605
NP_006868                                                              15    9605
NP_001138600                                                           15    9605
NP_000947                                                              15    9605
NP_056285                                                              15    9605
NP_663788                                                              15    9605
NP_001106984                                                           15    9605
NP_001106983                                                           15    9605
NP_116205                                                              15    9605
NP_079406                                                              15    9605
NP_002883                                                              15    9605
NP_075377                                                              15    9605
NP_075376                                                              15    9605
NP_060700                                                              15    9605
XP_005259403                                                           15    9605
XP_005259401                                                           15    9605
XP_005268022                                                           15    9605
XP_005268021                                                           15    9605
XP_006720022                                                           15    9605
XP_005254151                                                           15    9605
XP_005254150                                                           15    9605
XP_006720021                                                           15    9605
XP_005254149                                                           15    9605
XP_005254146                                                           15    9605
XP_006720020                                                           15    9605
XP_005254145                                                           15    9605
XP_005254143                                                           15    9605
XP_005254142                                                           15    9605
XP_006718583                                                           15    9605
XP_006718582                                                           15    9605
XP_006717419                                                           15    9605
XP_006715439                                                           15    9605
XP_005264310                                                           15    9605
XP_005264309                                                           15    9605
XP_005264308                                                           15    9605
XP_006712048                                                           15    9605
XP_005270437                                                           15    9605
NP_006408                                                              15    9605
NP_115828                                                              15    9605
NP_001139500                                                           15    9605
>NP_073713
          Length = 985

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  GRRSSLMYG 9
          GRRSSL YG
Sbjct: 36 GRRSSLTYG 44
>NP_002429
          Length = 1456

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1    GRRSSLMY 8
            GRRSSL Y
Sbjct: 1040 GRRSSLSY 1047
>NP_116107
          Length = 474

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   GRRSSLM 7
           GRRSSL+
Sbjct: 107 GRRSSLL 113
>XP_005264089
          Length = 413

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  GRRSSLM 7
          GRRSSL+
Sbjct: 46 GRRSSLL 52
>NP_079291
          Length = 675

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   RRSSLMYG 9
           RRS L YG
Sbjct: 531 RRSPLTYG 538
>NP_001275949
          Length = 797

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   GRRSSLMY 8
           G+RSSL++
Sbjct: 538 GKRSSLLH 545
>NP_659464
          Length = 814

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   GRRSSLMY 8
           G+RSSL++
Sbjct: 538 GKRSSLLH 545
>NP_005059
          Length = 766

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   RSSLMYG 9
           RSSL YG
Sbjct: 442 RSSLCYG 448
>NP_443202
          Length = 686

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   RRSSLMYG 9
           RRS L YG
Sbjct: 537 RRSPLTYG 544
>NP_001184256
          Length = 685

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   RRSSLMYG 9
           RRS L YG
Sbjct: 536 RRSPLTYG 543
>XP_005260713
          Length = 600

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   RRSSLMYG 9
           RRS L YG
Sbjct: 451 RRSPLTYG 458
>XP_006717810
          Length = 691

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   RRSSLMYG 9
           RRS L YG
Sbjct: 547 RRSPLTYG 554
>XP_006717809
          Length = 691

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   RRSSLMYG 9
           RRS L YG
Sbjct: 547 RRSPLTYG 554
>XP_005269730
          Length = 691

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   RRSSLMYG 9
           RRS L YG
Sbjct: 547 RRSPLTYG 554
>XP_005269729
          Length = 692

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   RRSSLMYG 9
           RRS L YG
Sbjct: 548 RRSPLTYG 555
>XP_005267157
          Length = 766

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   RSSLMYG 9
           RSSL YG
Sbjct: 442 RSSLCYG 448
>XP_005248961
          Length = 842

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   GRRSSLMY 8
           G+RSSL++
Sbjct: 538 GKRSSLLH 545
>NP_115627
          Length = 1476

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   GRRSSL 6
           GRRSSL
Sbjct: 593 GRRSSL 598
>NP_006868
          Length = 345

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   GRRSSLMYG 9
           GR+  L YG
Sbjct: 260 GRKLKLFYG 268
>NP_001138600
          Length = 1911

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    RRSSLMY 8
            RRS+L+Y
Sbjct: 1832 RRSALLY 1838
>NP_000947
          Length = 358

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  GRRSSL 6
          GRRSSL
Sbjct: 59 GRRSSL 64
>NP_056285
          Length = 653

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   GRRSSL 6
           GRRSSL
Sbjct: 478 GRRSSL 483
>NP_663788
          Length = 782

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   GRRSSL 6
           GRRSSL
Sbjct: 736 GRRSSL 741
>NP_001106984
          Length = 753

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   GRRSSL 6
           GRRSSL
Sbjct: 707 GRRSSL 712
>NP_001106983
          Length = 803

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   GRRSSL 6
           GRRSSL
Sbjct: 757 GRRSSL 762
>NP_116205
          Length = 783

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   GRRSSL 6
           GRRSSL
Sbjct: 110 GRRSSL 115
>NP_079406
          Length = 917

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   GRRSSLMY 8
           GRRS  MY
Sbjct: 548 GRRSVRMY 555
>NP_002883
          Length = 1257

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   GRRSSL 6
           GRRSSL
Sbjct: 143 GRRSSL 148
>NP_075377
          Length = 1188

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   GRRSSL 6
           GRRSSL
Sbjct: 143 GRRSSL 148
>NP_075376
          Length = 1203

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   GRRSSL 6
           GRRSSL
Sbjct: 143 GRRSSL 148
>NP_060700
          Length = 1156

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  GRRSSL 6
          GRRSSL
Sbjct: 53 GRRSSL 58
>XP_005259403
          Length = 475

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   GRRSSL 6
           GRRSSL
Sbjct: 110 GRRSSL 115
>XP_005259401
          Length = 759

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   GRRSSL 6
           GRRSSL
Sbjct: 110 GRRSSL 115
>XP_005268022
          Length = 1208

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   GRRSSL 6
           GRRSSL
Sbjct: 143 GRRSSL 148
>XP_005268021
          Length = 1277

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   GRRSSL 6
           GRRSSL
Sbjct: 143 GRRSSL 148
>XP_006720022
          Length = 717

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   GRRSSL 6
           GRRSSL
Sbjct: 591 GRRSSL 596
>XP_005254151
          Length = 717

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   GRRSSL 6
           GRRSSL
Sbjct: 591 GRRSSL 596
>XP_005254150
          Length = 717

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   GRRSSL 6
           GRRSSL
Sbjct: 591 GRRSSL 596
>XP_006720021
          Length = 717

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   GRRSSL 6
           GRRSSL
Sbjct: 591 GRRSSL 596
>XP_005254149
          Length = 717

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   GRRSSL 6
           GRRSSL
Sbjct: 591 GRRSSL 596
>XP_005254146
          Length = 792

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   GRRSSL 6
           GRRSSL
Sbjct: 666 GRRSSL 671
>XP_006720020
          Length = 798

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   GRRSSL 6
           GRRSSL
Sbjct: 672 GRRSSL 677
>XP_005254145
          Length = 802

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   GRRSSL 6
           GRRSSL
Sbjct: 676 GRRSSL 681
>XP_005254143
          Length = 862

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   GRRSSL 6
           GRRSSL
Sbjct: 736 GRRSSL 741
>XP_005254142
          Length = 874

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   GRRSSL 6
           GRRSSL
Sbjct: 748 GRRSSL 753
>XP_006718583
          Length = 1482

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   GRRSSL 6
           GRRSSL
Sbjct: 515 GRRSSL 520
>XP_006718582
          Length = 1560

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   GRRSSL 6
           GRRSSL
Sbjct: 593 GRRSSL 598
>XP_006717419
          Length = 382

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   GRRSSL 6
           GRRSSL
Sbjct: 284 GRRSSL 289
>XP_006715439
          Length = 1911

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    RRSSLMY 8
            RRS+L+Y
Sbjct: 1832 RRSALLY 1838
>XP_005264310
          Length = 531

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   GRRSSL 6
           GRRSSL
Sbjct: 478 GRRSSL 483
>XP_005264309
          Length = 1324

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   GRRSSL 6
           GRRSSL
Sbjct: 478 GRRSSL 483
>XP_005264308
          Length = 1218

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   GRRSSL 6
           GRRSSL
Sbjct: 478 GRRSSL 483
>XP_006712048
          Length = 1249

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   GRRSSL 6
           GRRSSL
Sbjct: 478 GRRSSL 483
>XP_005270437
          Length = 352

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  GRRSSLMY 8
          G+R SL+Y
Sbjct: 21 GKRLSLLY 28
>NP_006408
          Length = 444

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  GRRSSLMY 8
          G+R SL+Y
Sbjct: 21 GKRLSLLY 28
>NP_115828
          Length = 628

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   GRRSSL 6
           GRRSSL
Sbjct: 232 GRRSSL 237
>NP_001139500
          Length = 628

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   GRRSSL 6
           GRRSSL
Sbjct: 232 GRRSSL 237
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.322    0.138    0.400 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 367,992
Number of extensions: 467
Number of successful extensions: 57
Number of sequences better than 10000.0: 57
Number of HSP's gapped: 57
Number of HSP's successfully gapped: 57
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.9 bits)
S2: 28 (15.4 bits)

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