Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001013433                                                           20     509
NP_060785                                                              20     509
NP_361014                                                              20     509
NP_071750                                                              17    2528
XP_005256148                                                           17    2528
XP_006721307                                                           17    2528
XP_005256144                                                           17    2528
XP_005256143                                                           17    2528
XP_005256142                                                           17    2528
NP_149023                                                              17    4312
XP_005253240                                                           17    4312
XP_006714807                                                           17    4312
XP_006723843                                                           16    5631
XP_006723842                                                           16    5631
XP_006723841                                                           16    5631
XP_006723840                                                           16    5631
NP_055292                                                              16    5631
NP_000588                                                              16    7355
NP_061867                                                              16    7355
NP_001034464                                                           16    7355
NP_077025                                                              16    7355
NP_848599                                                              16    7355
NP_001265424                                                           16    7355
NP_003036                                                              16    7355
NP_057417                                                              16    7355
NP_001660                                                              16    7355
XP_005274573                                                           16    7355
XP_005274572                                                           16    7355
XP_005274571                                                           16    7355
XP_006723684                                                           16    7355
XP_006723683                                                           16    7355
XP_005255284                                                           16    7355
XP_005255283                                                           16    7355
XP_006720936                                                           16    7355
XP_006720935                                                           16    7355
XP_005255282                                                           16    7355
XP_005266564                                                           16    7355
XP_005270192                                                           16    7355
XP_005270168                                                           16    7355
XP_005249398                                                           16    7355
XP_005249397                                                           16    7355
XP_006713081                                                           16    7355
XP_006710761                                                           16    7355
NP_001723                                                              16    7355
NP_001092808                                                           16    7355
NP_803875                                                              16    7355
NP_005116                                                              15    9605
NP_078891                                                              15    9605
NP_001171526                                                           15    9605
NP_001171527                                                           15    9605
NP_001269462                                                           15    9605
NP_002548                                                              15    9605
XP_005260950                                                           15    9605
XP_005260949                                                           15    9605
XP_005260948                                                           15    9605
XP_005260947                                                           15    9605
XP_006720053                                                           15    9605
XP_005272473                                                           15    9605
XP_006720052                                                           15    9605
XP_006720051                                                           15    9605
XP_006720050                                                           15    9605
XP_006720048                                                           15    9605
XP_005272471                                                           15    9605
XP_006720047                                                           15    9605
XP_006720045                                                           15    9605
XP_005248654                                                           15    9605
XP_005248653                                                           15    9605
>NP_001013433
          Length = 589

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   GRQSLTSGM 9
           G QSLTSGM
Sbjct: 461 GHQSLTSGM 469
>NP_060785
          Length = 627

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   GRQSLTSGM 9
           G QSLTSGM
Sbjct: 499 GHQSLTSGM 507
>NP_361014
          Length = 707

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   GRQSLTSGM 9
           G QSLTSGM
Sbjct: 579 GHQSLTSGM 587
>NP_071750
          Length = 486

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2   RQSLTSG 8
           RQSLTSG
Sbjct: 436 RQSLTSG 442
>XP_005256148
          Length = 278

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2   RQSLTSG 8
           RQSLTSG
Sbjct: 228 RQSLTSG 234
>XP_006721307
          Length = 370

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2   RQSLTSG 8
           RQSLTSG
Sbjct: 320 RQSLTSG 326
>XP_005256144
          Length = 486

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2   RQSLTSG 8
           RQSLTSG
Sbjct: 436 RQSLTSG 442
>XP_005256143
          Length = 486

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2   RQSLTSG 8
           RQSLTSG
Sbjct: 436 RQSLTSG 442
>XP_005256142
          Length = 486

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2   RQSLTSG 8
           RQSLTSG
Sbjct: 436 RQSLTSG 442
>NP_149023
          Length = 493

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   GRQSLTSG 8
           G QS+TSG
Sbjct: 350 GSQSITSG 357
>XP_005253240
          Length = 493

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   GRQSLTSG 8
           G QS+TSG
Sbjct: 350 GSQSITSG 357
>XP_006714807
          Length = 194

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   GRQSLTSGM 9
           GR+ L SGM
Sbjct: 103 GREGLQSGM 111
>XP_006723843
          Length = 274

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   GRQSLTSG 8
           GRQ LT G
Sbjct: 158 GRQPLTEG 165
>XP_006723842
          Length = 274

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   GRQSLTSG 8
           GRQ LT G
Sbjct: 158 GRQPLTEG 165
>XP_006723841
          Length = 274

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   GRQSLTSG 8
           GRQ LT G
Sbjct: 158 GRQPLTEG 165
>XP_006723840
          Length = 281

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   GRQSLTSG 8
           GRQ LT G
Sbjct: 165 GRQPLTEG 172
>NP_055292
          Length = 290

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   GRQSLTSG 8
           GRQ LT G
Sbjct: 174 GRQPLTEG 181
>NP_000588
          Length = 328

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   GRQSLTSGM 9
           GR+ L SGM
Sbjct: 180 GRKPLKSGM 188
>NP_061867
          Length = 717

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   GRQSLTSG 8
           G QSL+SG
Sbjct: 589 GSQSLSSG 596
>NP_001034464
          Length = 317

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  GRQSLTSGM 9
          GR+ +TSG+
Sbjct: 25 GRREVTSGV 33
>NP_077025
          Length = 345

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  GRQSLTSGM 9
          GR+ +TSG+
Sbjct: 25 GRREVTSGV 33
>NP_848599
          Length = 3092

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    GRQSLT 6
            GRQSLT
Sbjct: 2262 GRQSLT 2267
>NP_001265424
          Length = 878

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   GRQSLTSGM 9
           G QSLT G+
Sbjct: 844 GEQSLTWGL 852
>NP_003036
          Length = 629

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   GRQSLTSG 8
           GR++LT G
Sbjct: 517 GREALTKG 524
>NP_057417
          Length = 2752

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    GRQSLTSG 8
            G QSL+SG
Sbjct: 2471 GSQSLSSG 2478
>NP_001660
          Length = 593

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   GRQSLTSGM 9
           GR S  SGM
Sbjct: 99  GRHSFRSGM 107
>XP_005274573
          Length = 382

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   GRQSLTSGM 9
           GR S  SGM
Sbjct: 99  GRHSFRSGM 107
>XP_005274572
          Length = 475

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   GRQSLTSGM 9
           GR S  SGM
Sbjct: 99  GRHSFRSGM 107
>XP_005274571
          Length = 548

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   GRQSLTSGM 9
           GR S  SGM
Sbjct: 99  GRHSFRSGM 107
>XP_006723684
          Length = 247

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  GRQSLTSGM 9
          GR+ +TSG+
Sbjct: 25 GRREVTSGV 33
>XP_006723683
          Length = 247

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  GRQSLTSGM 9
          GR+ +TSG+
Sbjct: 25 GRREVTSGV 33
>XP_005255284
          Length = 2581

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    GRQSLTSG 8
            G QSL+SG
Sbjct: 2471 GSQSLSSG 2478
>XP_005255283
          Length = 2751

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    GRQSLTSG 8
            G QSL+SG
Sbjct: 2471 GSQSLSSG 2478
>XP_006720936
          Length = 2751

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    GRQSLTSG 8
            G QSL+SG
Sbjct: 2470 GSQSLSSG 2477
>XP_006720935
          Length = 2752

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    GRQSLTSG 8
            G QSL+SG
Sbjct: 2471 GSQSLSSG 2478
>XP_005255282
          Length = 2752

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    GRQSLTSG 8
            G QSL+SG
Sbjct: 2471 GSQSLSSG 2478
>XP_005266564
          Length = 629

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   GRQSLTSG 8
           GR++LT G
Sbjct: 517 GREALTKG 524
>XP_005270192
          Length = 878

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   GRQSLTSGM 9
           G QSLT G+
Sbjct: 844 GEQSLTWGL 852
>XP_005270168
          Length = 756

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   GRQSLTSGM 9
           G QSLT G+
Sbjct: 722 GEQSLTWGL 730
>XP_005249398
          Length = 494

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   GRQSLTSG 8
           GR++ TSG
Sbjct: 349 GRETFTSG 356
>XP_005249397
          Length = 526

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   GRQSLTSG 8
           GR++ TSG
Sbjct: 349 GRETFTSG 356
>XP_006713081
          Length = 3964

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    GRQSLT 6
            GRQSLT
Sbjct: 2285 GRQSLT 2290
>XP_006710761
          Length = 717

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   GRQSLTSG 8
           G QSL+SG
Sbjct: 589 GSQSLSSG 596
>NP_001723
          Length = 526

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   GRQSLTSG 8
           GR++ TSG
Sbjct: 349 GRETFTSG 356
>NP_001092808
          Length = 878

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   GRQSLTSGM 9
           G QSLT G+
Sbjct: 844 GEQSLTWGL 852
>NP_803875
          Length = 4243

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    GRQSLTSG 8
            GRQ  TSG
Sbjct: 1458 GRQKSTSG 1465
>NP_005116
          Length = 274

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  GRQSLTSGM 9
          GRQ++  GM
Sbjct: 70 GRQAVLKGM 78
>NP_078891
          Length = 854

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RQSLTSGM 9
           R SLTSG+
Sbjct: 454 RLSLTSGL 461
>NP_001171526
          Length = 854

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RQSLTSGM 9
           R SLTSG+
Sbjct: 454 RLSLTSGL 461
>NP_001171527
          Length = 812

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RQSLTSGM 9
           R SLTSG+
Sbjct: 454 RLSLTSGL 461
>NP_001269462
          Length = 627

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   GRQSLTS 7
           GR SLTS
Sbjct: 220 GRNSLTS 226
>NP_002548
          Length = 678

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   GRQSLTSG 8
           G QS+T+G
Sbjct: 498 GHQSVTTG 505
>XP_005260950
          Length = 673

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   GRQSLTS 7
           GR SLTS
Sbjct: 220 GRNSLTS 226
>XP_005260949
          Length = 673

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   GRQSLTS 7
           GR SLTS
Sbjct: 220 GRNSLTS 226
>XP_005260948
          Length = 682

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   GRQSLTS 7
           GR SLTS
Sbjct: 250 GRNSLTS 256
>XP_005260947
          Length = 703

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   GRQSLTS 7
           GR SLTS
Sbjct: 250 GRNSLTS 256
>XP_006720053
          Length = 164

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  GRQSLTSGM 9
          GR++LTS +
Sbjct: 5  GRKNLTSSL 13
>XP_005272473
          Length = 186

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  GRQSLTSGM 9
          GR++LTS +
Sbjct: 5  GRKNLTSSL 13
>XP_006720052
          Length = 188

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  GRQSLTSGM 9
          GR++LTS +
Sbjct: 5  GRKNLTSSL 13
>XP_006720051
          Length = 188

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  GRQSLTSGM 9
          GR++LTS +
Sbjct: 5  GRKNLTSSL 13
>XP_006720050
          Length = 195

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  GRQSLTSGM 9
          GR++LTS +
Sbjct: 5  GRKNLTSSL 13
>XP_006720048
          Length = 311

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  GRQSLTSGM 9
          GR++LTS +
Sbjct: 5  GRKNLTSSL 13
>XP_005272471
          Length = 328

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  GRQSLTSGM 9
          GR++LTS +
Sbjct: 5  GRKNLTSSL 13
>XP_006720047
          Length = 329

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  GRQSLTSGM 9
          GR++LTS +
Sbjct: 5  GRKNLTSSL 13
>XP_006720045
          Length = 359

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  GRQSLTSGM 9
          GR++LTS +
Sbjct: 5  GRKNLTSSL 13
>XP_005248654
          Length = 607

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RQSLTSGM 9
           R SLTSG+
Sbjct: 207 RLSLTSGL 214
>XP_005248653
          Length = 895

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RQSLTSGM 9
           R SLTSG+
Sbjct: 495 RLSLTSGL 502
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.308    0.122    0.319 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 426,125
Number of extensions: 813
Number of successful extensions: 67
Number of sequences better than 10000.0: 67
Number of HSP's gapped: 67
Number of HSP's successfully gapped: 67
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.5 bits)
S2: 28 (15.4 bits)

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