Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_733751                                                              19     665
XP_006716142                                                           19     665
XP_005250088                                                           19     665
XP_006716141                                                           19     665
XP_005250085                                                           19     665
XP_006716140                                                           19     665
XP_005250084                                                           19     665
XP_005250083                                                           19     665
XP_005250082                                                           19     665
NP_001103132                                                           17    2528
NP_003473                                                              17    3301
XP_006719679                                                           17    3301
XP_005269219                                                           17    3301
XP_006719678                                                           17    3301
XP_006719677                                                           17    3301
NP_061135                                                              17    4312
NP_003613                                                              17    4312
NP_001185845                                                           17    4312
NP_803193                                                              17    4312
NP_001185844                                                           17    4312
XP_006719224                                                           17    4312
XP_006719223                                                           17    4312
XP_006719222                                                           17    4312
XP_005253573                                                           17    4312
XP_005253572                                                           17    4312
XP_005253571                                                           17    4312
XP_005253568                                                           17    4312
XP_005253567                                                           17    4312
XP_005253566                                                           17    4312
XP_005253565                                                           17    4312
XP_005253564                                                           17    4312
XP_005253563                                                           17    4312
XP_005253562                                                           17    4312
XP_006715571                                                           17    4312
XP_003960842                                                           16    5631
XP_003846346                                                           16    5631
XP_003846679                                                           16    5631
NP_663748                                                              16    5631
NP_000662                                                              16    7355
NP_113652                                                              16    7355
XP_005268179                                                           16    7355
XP_005268177                                                           16    7355
XP_006720334                                                           16    7355
XP_006720333                                                           16    7355
XP_005268171                                                           16    7355
XP_006720331                                                           16    7355
XP_006720330                                                           16    7355
XP_006720329                                                           16    7355
XP_005268172                                                           16    7355
XP_006720328                                                           16    7355
NP_996816                                                              15    9605
NP_116206                                                              15    9605
NP_001258867                                                           15    9605
NP_705618                                                              15    9605
NP_004289                                                              15    9605
NP_001006635                                                           15    9605
NP_001401                                                              15    9605
NP_060524                                                              15    9605
NP_085046                                                              15    9605
NP_001265241                                                           15    9605
NP_060735                                                              15    9605
NP_001136041                                                           15    9605
XP_006721123                                                           15    9605
XP_006721122                                                           15    9605
XP_005255471                                                           15    9605
XP_006721121                                                           15    9605
XP_005255470                                                           15    9605
XP_006721120                                                           15    9605
XP_006711508                                                           15    9605
>NP_733751
          Length = 4911

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   GRGMSKLKS 9
           GRG SKLKS
Sbjct: 906 GRGRSKLKS 914
>XP_006716142
          Length = 4927

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   GRGMSKLKS 9
           GRG SKLKS
Sbjct: 907 GRGRSKLKS 915
>XP_005250088
          Length = 4928

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   GRGMSKLKS 9
           GRG SKLKS
Sbjct: 907 GRGRSKLKS 915
>XP_006716141
          Length = 4959

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   GRGMSKLKS 9
           GRG SKLKS
Sbjct: 907 GRGRSKLKS 915
>XP_005250085
          Length = 4979

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   GRGMSKLKS 9
           GRG SKLKS
Sbjct: 907 GRGRSKLKS 915
>XP_006716140
          Length = 4982

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   GRGMSKLKS 9
           GRG SKLKS
Sbjct: 907 GRGRSKLKS 915
>XP_005250084
          Length = 4982

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   GRGMSKLKS 9
           GRG SKLKS
Sbjct: 907 GRGRSKLKS 915
>XP_005250083
          Length = 4982

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   GRGMSKLKS 9
           GRG SKLKS
Sbjct: 906 GRGRSKLKS 914
>XP_005250082
          Length = 4983

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   GRGMSKLKS 9
           GRG SKLKS
Sbjct: 907 GRGRSKLKS 915
>NP_001103132
          Length = 4284

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   GRGMSKLKS 9
           GRG+SKL S
Sbjct: 183 GRGVSKLGS 191
>NP_003473
          Length = 5537

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    GRGMSKLKS 9
            GRG ++LKS
Sbjct: 1323 GRGRARLKS 1331
>XP_006719679
          Length = 5536

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    GRGMSKLKS 9
            GRG ++LKS
Sbjct: 1323 GRGRARLKS 1331
>XP_005269219
          Length = 5537

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    GRGMSKLKS 9
            GRG ++LKS
Sbjct: 1323 GRGRARLKS 1331
>XP_006719678
          Length = 5539

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    GRGMSKLKS 9
            GRG ++LKS
Sbjct: 1323 GRGRARLKS 1331
>XP_006719677
          Length = 5540

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    GRGMSKLKS 9
            GRG ++LKS
Sbjct: 1323 GRGRARLKS 1331
>NP_061135
          Length = 648

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  GRGMSKLKS 9
          GRG SK+K+
Sbjct: 84 GRGGSKIKN 92
>NP_003613
          Length = 1005

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   GRGMSKLKS 9
           GRG  K+KS
Sbjct: 509 GRGFFKIKS 517
>NP_001185845
          Length = 980

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   GRGMSKLKS 9
           GRG  K+KS
Sbjct: 495 GRGFFKIKS 503
>NP_803193
          Length = 1011

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   GRGMSKLKS 9
           GRG  K+KS
Sbjct: 526 GRGFFKIKS 534
>NP_001185844
          Length = 858

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   GRGMSKLKS 9
           GRG  K+KS
Sbjct: 373 GRGFFKIKS 381
>XP_006719224
          Length = 991

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   GRGMSKLKS 9
           GRG  K+KS
Sbjct: 506 GRGFFKIKS 514
>XP_006719223
          Length = 580

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   GRGMSKLKS 9
           GRG  K+KS
Sbjct: 540 GRGFFKIKS 548
>XP_006719222
          Length = 883

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   GRGMSKLKS 9
           GRG  K+KS
Sbjct: 387 GRGFFKIKS 395
>XP_005253573
          Length = 991

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   GRGMSKLKS 9
           GRG  K+KS
Sbjct: 495 GRGFFKIKS 503
>XP_005253572
          Length = 994

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   GRGMSKLKS 9
           GRG  K+KS
Sbjct: 498 GRGFFKIKS 506
>XP_005253571
          Length = 1002

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   GRGMSKLKS 9
           GRG  K+KS
Sbjct: 506 GRGFFKIKS 514
>XP_005253568
          Length = 1014

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   GRGMSKLKS 9
           GRG  K+KS
Sbjct: 529 GRGFFKIKS 537
>XP_005253567
          Length = 1025

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   GRGMSKLKS 9
           GRG  K+KS
Sbjct: 540 GRGFFKIKS 548
>XP_005253566
          Length = 1025

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   GRGMSKLKS 9
           GRG  K+KS
Sbjct: 529 GRGFFKIKS 537
>XP_005253565
          Length = 1026

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   GRGMSKLKS 9
           GRG  K+KS
Sbjct: 530 GRGFFKIKS 538
>XP_005253564
          Length = 1033

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   GRGMSKLKS 9
           GRG  K+KS
Sbjct: 537 GRGFFKIKS 545
>XP_005253563
          Length = 1036

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   GRGMSKLKS 9
           GRG  K+KS
Sbjct: 540 GRGFFKIKS 548
>XP_005253562
          Length = 1036

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   GRGMSKLKS 9
           GRG  K+KS
Sbjct: 540 GRGFFKIKS 548
>XP_006715571
          Length = 628

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  GRGMSKLKS 9
          GRG SK+K+
Sbjct: 84 GRGGSKIKN 92
>XP_003960842
          Length = 161

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   GRGMSKLKS 9
           G G SKLK+
Sbjct: 153 GSGQSKLKT 161
>XP_003846346
          Length = 161

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   GRGMSKLKS 9
           G G SKLK+
Sbjct: 153 GSGQSKLKT 161
>XP_003846679
          Length = 161

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   GRGMSKLKS 9
           G G SKLK+
Sbjct: 153 GSGQSKLKT 161
>NP_663748
          Length = 591

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   GRGMSKLKS 9
           G G SKLK+
Sbjct: 365 GSGQSKLKT 373
>NP_000662
          Length = 374

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  GRGMSKLKS 9
          G G++KLK+
Sbjct: 77 GEGVTKLKA 85
>NP_113652
          Length = 549

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   GMSKLKS 9
           G+SKLKS
Sbjct: 529 GVSKLKS 535
>XP_005268179
          Length = 315

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   GMSKLKS 9
           G+SKLKS
Sbjct: 295 GVSKLKS 301
>XP_005268177
          Length = 347

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   GMSKLKS 9
           G+SKLKS
Sbjct: 327 GVSKLKS 333
>XP_006720334
          Length = 355

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   GMSKLKS 9
           G+SKLKS
Sbjct: 297 GVSKLKS 303
>XP_006720333
          Length = 385

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   GMSKLKS 9
           G+SKLKS
Sbjct: 327 GVSKLKS 333
>XP_005268171
          Length = 549

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   GMSKLKS 9
           G+SKLKS
Sbjct: 529 GVSKLKS 535
>XP_006720331
          Length = 553

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   GMSKLKS 9
           G+SKLKS
Sbjct: 529 GVSKLKS 535
>XP_006720330
          Length = 555

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   GMSKLKS 9
           G+SKLKS
Sbjct: 497 GVSKLKS 503
>XP_006720329
          Length = 557

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   GMSKLKS 9
           G+SKLKS
Sbjct: 499 GVSKLKS 505
>XP_005268172
          Length = 587

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   GMSKLKS 9
           G+SKLKS
Sbjct: 529 GVSKLKS 535
>XP_006720328
          Length = 587

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   GMSKLKS 9
           G+SKLKS
Sbjct: 529 GVSKLKS 535
>NP_996816
          Length = 5202

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    GRGMSK 6
            GRG+SK
Sbjct: 3483 GRGLSK 3488
>NP_116206
          Length = 728

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   GRGMSK 6
           GRGMS+
Sbjct: 721 GRGMSR 726
>NP_001258867
          Length = 2845

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   GRGMSKLKS 9
           GRG   LKS
Sbjct: 934 GRGRGALKS 942
>NP_705618
          Length = 1391

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   GRGMSKLKS 9
           G+GMS++ S
Sbjct: 309 GQGMSRVAS 317
>NP_004289
          Length = 1332

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   GRGMSKLKS 9
           G+GMS++ S
Sbjct: 250 GQGMSRVAS 258
>NP_001006635
          Length = 881

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   GRGMSKLK 8
           G G SKLK
Sbjct: 290 GAGASKLK 297
>NP_001401
          Length = 2778

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   GRGMSKLKS 9
           GRG   LKS
Sbjct: 867 GRGRGALKS 875
>NP_060524
          Length = 803

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   GRGMSKLK 8
           G G SKLK
Sbjct: 290 GAGASKLK 297
>NP_085046
          Length = 942

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   GRGMSK 6
           GRGMS+
Sbjct: 935 GRGMSR 940
>NP_001265241
          Length = 1327

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   GRGMSKLKS 9
           G+GMS++ S
Sbjct: 309 GQGMSRVAS 317
>NP_060735
          Length = 677

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   GRGMSK 6
           GRG+SK
Sbjct: 591 GRGLSK 596
>NP_001136041
          Length = 578

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   GRGMSK 6
           GRG+SK
Sbjct: 492 GRGLSK 497
>XP_006721123
          Length = 775

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   GRGMSKLK 8
           G G SKLK
Sbjct: 290 GAGASKLK 297
>XP_006721122
          Length = 804

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   GRGMSKLK 8
           G G SKLK
Sbjct: 213 GAGASKLK 220
>XP_005255471
          Length = 840

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   GRGMSKLK 8
           G G SKLK
Sbjct: 290 GAGASKLK 297
>XP_006721121
          Length = 853

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   GRGMSKLK 8
           G G SKLK
Sbjct: 290 GAGASKLK 297
>XP_005255470
          Length = 853

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   GRGMSKLK 8
           G G SKLK
Sbjct: 290 GAGASKLK 297
>XP_006721120
          Length = 880

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   GRGMSKLK 8
           G G SKLK
Sbjct: 289 GAGASKLK 296
>XP_006711508
          Length = 662

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   GRGMSK 6
           GRG+SK
Sbjct: 576 GRGLSK 581
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.308    0.126    0.328 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 494,183
Number of extensions: 729
Number of successful extensions: 69
Number of sequences better than 10000.0: 69
Number of HSP's gapped: 69
Number of HSP's successfully gapped: 69
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.4 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package