Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001245200                                                           19     665
NP_000240                                                              19     665
NP_001161089                                                           19     665
NP_001099043                                                           18    1482
NP_006434                                                              17    2528
NP_954653                                                              17    2528
NP_076986                                                              17    2528
XP_006718377                                                           17    2528
XP_006718376                                                           17    2528
XP_005253188                                                           17    2528
NP_078925                                                              17    4312
NP_009187                                                              17    4312
NP_002069                                                              17    4312
NP_005984                                                              17    4312
NP_001166184                                                           17    4312
XP_006722353                                                           17    4312
XP_005256453                                                           17    4312
XP_006718490                                                           17    4312
XP_005265132                                                           17    4312
XP_005265131                                                           17    4312
XP_006713173                                                           17    4312
XP_005265130                                                           17    4312
XP_005265129                                                           17    4312
XP_005265128                                                           17    4312
XP_005265127                                                           17    4312
XP_005265126                                                           17    4312
NP_001138684                                                           17    4312
NP_001138683                                                           17    4312
NP_056441                                                              16    5631
NP_005860                                                              16    5631
NP_065394                                                              16    7355
NP_653303                                                              16    7355
NP_065871                                                              16    7355
NP_940876                                                              16    7355
XP_005276745                                                           16    7355
XP_006724409                                                           16    7355
XP_005261851                                                           16    7355
XP_005261850                                                           16    7355
XP_005260689                                                           16    7355
XP_005260528                                                           16    7355
XP_005252935                                                           16    7355
XP_006711253                                                           16    7355
XP_006711252                                                           16    7355
XP_006711251                                                           16    7355
XP_005244985                                                           16    7355
XP_006711248                                                           16    7355
XP_005244983                                                           16    7355
XP_005270777                                                           16    7355
XP_006710615                                                           16    7355
XP_005270776                                                           16    7355
XP_005275950                                                           16    7355
NP_694991                                                              16    7355
NP_001138678                                                           16    7355
NP_852091                                                              15    9605
NP_001138593                                                           15    9605
NP_001273270                                                           15    9605
NP_689932                                                              15    9605
NP_001273359                                                           15    9605
NP_620147                                                              15    9605
NP_001273271                                                           15    9605
XP_005261857                                                           15    9605
XP_005261856                                                           15    9605
XP_006724410                                                           15    9605
XP_005261855                                                           15    9605
XP_005261854                                                           15    9605
XP_006719837                                                           15    9605
XP_006710958                                                           15    9605
NP_004601                                                              15    9605
>NP_001245200
          Length = 687

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   GREDKTLAF 9
           G EDKTLAF
Sbjct: 232 GCEDKTLAF 240
>NP_000240
          Length = 756

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   GREDKTLAF 9
           G EDKTLAF
Sbjct: 232 GCEDKTLAF 240
>NP_001161089
          Length = 658

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   GREDKTLAF 9
           G EDKTLAF
Sbjct: 134 GCEDKTLAF 142
>NP_001099043
          Length = 286

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   EDKTLAF 9
           EDKTLAF
Sbjct: 237 EDKTLAF 243
>NP_006434
          Length = 174

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  GREDKTL 7
          GRED+TL
Sbjct: 32 GREDRTL 38
>NP_954653
          Length = 148

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  GREDKTL 7
          GRED+TL
Sbjct: 32 GREDRTL 38
>NP_076986
          Length = 226

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  EDKTLAF 9
          EDKT+AF
Sbjct: 86 EDKTIAF 92
>XP_006718377
          Length = 226

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  EDKTLAF 9
          EDKT+AF
Sbjct: 86 EDKTIAF 92
>XP_006718376
          Length = 288

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   EDKTLAF 9
           EDKT+AF
Sbjct: 224 EDKTIAF 230
>XP_005253188
          Length = 364

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   EDKTLAF 9
           EDKT+AF
Sbjct: 224 EDKTIAF 230
>NP_078925
          Length = 593

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   GREDKTL 7
           GRED TL
Sbjct: 382 GREDNTL 388
>NP_009187
          Length = 709

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   REDKTLA 8
           +EDKTLA
Sbjct: 592 KEDKTLA 598
>NP_002069
          Length = 2230

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    GREDKTLA 8
            GRE KT+A
Sbjct: 2188 GRETKTMA 2195
>NP_005984
          Length = 1192

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  EDKTLAF 9
          ED+TLAF
Sbjct: 17 EDETLAF 23
>NP_001166184
          Length = 2243

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    GREDKTLA 8
            GRE KT+A
Sbjct: 2203 GRETKTMA 2210
>XP_006722353
          Length = 1165

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  EDKTLAF 9
          ED+TLAF
Sbjct: 17 EDETLAF 23
>XP_005256453
          Length = 1175

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  EDKTLAF 9
          ED+TLAF
Sbjct: 17 EDETLAF 23
>XP_006718490
          Length = 635

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   REDKTLA 8
           +EDKTLA
Sbjct: 592 KEDKTLA 598
>XP_005265132
          Length = 2214

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    GREDKTLA 8
            GRE KT+A
Sbjct: 2172 GRETKTMA 2179
>XP_005265131
          Length = 2245

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    GREDKTLA 8
            GRE KT+A
Sbjct: 2203 GRETKTMA 2210
>XP_006713173
          Length = 2250

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    GREDKTLA 8
            GRE KT+A
Sbjct: 2208 GRETKTMA 2215
>XP_005265130
          Length = 2252

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    GREDKTLA 8
            GRE KT+A
Sbjct: 2210 GRETKTMA 2217
>XP_005265129
          Length = 2269

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    GREDKTLA 8
            GRE KT+A
Sbjct: 2227 GRETKTMA 2234
>XP_005265128
          Length = 2278

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    GREDKTLA 8
            GRE KT+A
Sbjct: 2236 GRETKTMA 2243
>XP_005265127
          Length = 2283

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    GREDKTLA 8
            GRE KT+A
Sbjct: 2243 GRETKTMA 2250
>XP_005265126
          Length = 2285

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    GREDKTLA 8
            GRE KT+A
Sbjct: 2243 GRETKTMA 2250
>NP_001138684
          Length = 565

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   REDKTLA 8
           +EDKTLA
Sbjct: 448 KEDKTLA 454
>NP_001138683
          Length = 687

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   REDKTLA 8
           +EDKTLA
Sbjct: 570 KEDKTLA 576
>NP_056441
          Length = 421

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  GREDKTLAF 9
          GRE+ T+AF
Sbjct: 34 GRENWTVAF 42
>NP_005860
          Length = 472

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   REDKTLA 8
           RED+TLA
Sbjct: 381 REDQTLA 387
>NP_065394
          Length = 580

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   REDKTLAF 9
           RE+ T+AF
Sbjct: 94  REENTIAF 101
>NP_653303
          Length = 559

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   REDKTLAF 9
           RED+ +AF
Sbjct: 550 REDEAMAF 557
>NP_065871
          Length = 1659

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    GREDKTLAF 9
            G+ED+ L+F
Sbjct: 1058 GQEDRGLSF 1066
>NP_940876
          Length = 402

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   EDKTLA 8
           EDKTLA
Sbjct: 115 EDKTLA 120
>XP_005276745
          Length = 271

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   GREDKTL 7
           G+ED+TL
Sbjct: 135 GKEDETL 141
>XP_006724409
          Length = 1806

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   REDKTLA 8
           RED TLA
Sbjct: 445 REDSTLA 451
>XP_005261851
          Length = 1806

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   REDKTLA 8
           RED TLA
Sbjct: 445 REDSTLA 451
>XP_005261850
          Length = 1806

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   REDKTLA 8
           RED TLA
Sbjct: 445 REDSTLA 451
>XP_005260689
          Length = 271

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   GREDKTL 7
           G+ED+TL
Sbjct: 135 GKEDETL 141
>XP_005260528
          Length = 956

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   GREDKTLAF 9
           G+ED+ L+F
Sbjct: 355 GQEDRGLSF 363
>XP_005252935
          Length = 402

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   EDKTLA 8
           EDKTLA
Sbjct: 115 EDKTLA 120
>XP_006711253
          Length = 345

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   REDKTLAF 9
           RED+ +AF
Sbjct: 336 REDEAMAF 343
>XP_006711252
          Length = 345

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   REDKTLAF 9
           RED+ +AF
Sbjct: 336 REDEAMAF 343
>XP_006711251
          Length = 466

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   REDKTLAF 9
           RED+ +AF
Sbjct: 457 REDEAMAF 464
>XP_005244985
          Length = 481

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   REDKTLAF 9
           RED+ +AF
Sbjct: 472 REDEAMAF 479
>XP_006711248
          Length = 533

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   REDKTLAF 9
           RED+ +AF
Sbjct: 524 REDEAMAF 531
>XP_005244983
          Length = 560

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   REDKTLAF 9
           RED+ +AF
Sbjct: 551 REDEAMAF 558
>XP_005270777
          Length = 453

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   REDKTLAF 9
           +ED T+AF
Sbjct: 94  KEDNTVAF 101
>XP_006710615
          Length = 538

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  REDKTLAF 9
          +ED T+AF
Sbjct: 66 KEDNTVAF 73
>XP_005270776
          Length = 538

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  REDKTLAF 9
          +ED T+AF
Sbjct: 66 KEDNTVAF 73
>XP_005275950
          Length = 271

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   GREDKTL 7
           G+ED+TL
Sbjct: 135 GKEDETL 141
>NP_694991
          Length = 566

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   REDKTLAF 9
           +ED T+AF
Sbjct: 94  KEDNTVAF 101
>NP_001138678
          Length = 1806

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   REDKTLA 8
           RED TLA
Sbjct: 445 REDSTLA 451
>NP_852091
          Length = 941

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   GREDKTLAF 9
           G E+KT A+
Sbjct: 654 GEEEKTQAY 662
>NP_001138593
          Length = 353

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   GREDKTLA 8
           GRE  TLA
Sbjct: 114 GRESHTLA 121
>NP_001273270
          Length = 421

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   GREDKTL 7
           G+ED TL
Sbjct: 214 GKEDSTL 220
>NP_689932
          Length = 448

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   GREDKTL 7
           G+ED TL
Sbjct: 241 GKEDSTL 247
>NP_001273359
          Length = 606

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   GREDKT 6
           GREDK+
Sbjct: 146 GREDKS 151
>NP_620147
          Length = 666

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   GREDKT 6
           GREDK+
Sbjct: 146 GREDKS 151
>NP_001273271
          Length = 412

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   GREDKTL 7
           G+ED TL
Sbjct: 205 GKEDSTL 211
>XP_005261857
          Length = 410

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  REDKTLA 8
          R+DKTL+
Sbjct: 8  RQDKTLS 14
>XP_005261856
          Length = 694

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   REDKTLA 8
           R+DKTL+
Sbjct: 292 RQDKTLS 298
>XP_006724410
          Length = 694

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   REDKTLA 8
           R+DKTL+
Sbjct: 292 RQDKTLS 298
>XP_005261855
          Length = 694

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   REDKTLA 8
           R+DKTL+
Sbjct: 292 RQDKTLS 298
>XP_005261854
          Length = 694

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   REDKTLA 8
           R+DKTL+
Sbjct: 292 RQDKTLS 298
>XP_006719837
          Length = 412

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   GREDKTL 7
           G+ED TL
Sbjct: 205 GKEDSTL 211
>XP_006710958
          Length = 367

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  GREDKT 6
          GREDK+
Sbjct: 20 GREDKS 25
>NP_004601
          Length = 326

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1  GREDKTLA 8
          GRE  TLA
Sbjct: 87 GRESHTLA 94
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.319    0.139    0.388 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 604,098
Number of extensions: 978
Number of successful extensions: 68
Number of sequences better than 10000.0: 68
Number of HSP's gapped: 68
Number of HSP's successfully gapped: 68
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.7 bits)
S2: 28 (15.4 bits)

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