Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001277144                                                           19     869
NP_001277143                                                           19     869
NP_001077383                                                           19     869
NP_001320                                                              19     869
NP_073713                                                              19     869
XP_005269629                                                           19     869
XP_005269628                                                           19     869
XP_005269627                                                           19     869
XP_005269626                                                           19     869
XP_006717706                                                           19     869
XP_005269625                                                           19     869
XP_005269624                                                           19     869
XP_006717705                                                           19     869
XP_005269622                                                           19     869
XP_005269621                                                           19     869
XP_006717704                                                           19     869
XP_005269619                                                           19     869
XP_005269618                                                           19     869
NP_001319                                                              18    1935
NP_001012632                                                           18    1935
XP_005272320                                                           18    1935
XP_005272319                                                           18    1935
XP_005272318                                                           18    1935
NP_570123                                                              17    3301
NP_113676                                                              17    3301
XP_006714595                                                           17    3301
XP_006714594                                                           17    3301
NP_671517                                                              17    4312
NP_056362                                                              17    4312
XP_005258110                                                           16    5631
NP_001009565                                                           16    7355
XP_006715292                                                           16    7355
XP_006712067                                                           16    7355
XP_006712066                                                           16    7355
NP_116056                                                              15    9605
NP_001124174                                                           15    9605
NP_001116427                                                           15    9605
NP_001243241                                                           15    9605
NP_001272997                                                           15    9605
NP_001272998                                                           15    9605
NP_001272996                                                           15    9605
NP_001272999                                                           15    9605
NP_006272                                                              15    9605
NP_001243242                                                           15    9605
XP_006718887                                                           15    9605
XP_005273992                                                           15    9605
>NP_001277144
          Length = 445

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   GQVVAVRAK 9
           GQ VAVRAK
Sbjct: 192 GQAVAVRAK 200
>NP_001277143
          Length = 445

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   GQVVAVRAK 9
           GQ VAVRAK
Sbjct: 192 GQAVAVRAK 200
>NP_001077383
          Length = 445

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   GQVVAVRAK 9
           GQ VAVRAK
Sbjct: 192 GQAVAVRAK 200
>NP_001320
          Length = 445

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   GQVVAVRAK 9
           GQ VAVRAK
Sbjct: 192 GQAVAVRAK 200
>NP_073713
          Length = 985

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   GQVVAVRAK 9
           GQ VAVRAK
Sbjct: 732 GQAVAVRAK 740
>XP_005269629
          Length = 445

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   GQVVAVRAK 9
           GQ VAVRAK
Sbjct: 192 GQAVAVRAK 200
>XP_005269628
          Length = 445

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   GQVVAVRAK 9
           GQ VAVRAK
Sbjct: 192 GQAVAVRAK 200
>XP_005269627
          Length = 445

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   GQVVAVRAK 9
           GQ VAVRAK
Sbjct: 192 GQAVAVRAK 200
>XP_005269626
          Length = 445

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   GQVVAVRAK 9
           GQ VAVRAK
Sbjct: 192 GQAVAVRAK 200
>XP_006717706
          Length = 445

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   GQVVAVRAK 9
           GQ VAVRAK
Sbjct: 192 GQAVAVRAK 200
>XP_005269625
          Length = 445

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   GQVVAVRAK 9
           GQ VAVRAK
Sbjct: 192 GQAVAVRAK 200
>XP_005269624
          Length = 445

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   GQVVAVRAK 9
           GQ VAVRAK
Sbjct: 192 GQAVAVRAK 200
>XP_006717705
          Length = 445

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   GQVVAVRAK 9
           GQ VAVRAK
Sbjct: 192 GQAVAVRAK 200
>XP_005269622
          Length = 445

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   GQVVAVRAK 9
           GQ VAVRAK
Sbjct: 192 GQAVAVRAK 200
>XP_005269621
          Length = 445

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   GQVVAVRAK 9
           GQ VAVRAK
Sbjct: 192 GQAVAVRAK 200
>XP_006717704
          Length = 445

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   GQVVAVRAK 9
           GQ VAVRAK
Sbjct: 192 GQAVAVRAK 200
>XP_005269619
          Length = 445

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   GQVVAVRAK 9
           GQ VAVRAK
Sbjct: 192 GQAVAVRAK 200
>XP_005269618
          Length = 445

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   GQVVAVRAK 9
           GQ VAVRAK
Sbjct: 192 GQAVAVRAK 200
>NP_001319
          Length = 440

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   GQVVAVRAK 9
           GQ VA+RAK
Sbjct: 186 GQAVALRAK 194
>NP_001012632
          Length = 429

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   GQVVAVRAK 9
           GQ VA+RAK
Sbjct: 175 GQAVALRAK 183
>XP_005272320
          Length = 430

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   GQVVAVRAK 9
           GQ VA+RAK
Sbjct: 175 GQAVALRAK 183
>XP_005272319
          Length = 430

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   GQVVAVRAK 9
           GQ VA+RAK
Sbjct: 175 GQAVALRAK 183
>XP_005272318
          Length = 441

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   GQVVAVRAK 9
           GQ VA+RAK
Sbjct: 186 GQAVALRAK 194
>NP_570123
          Length = 555

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  GQVVAVRAK 9
          GQV+ ++AK
Sbjct: 68 GQVITIKAK 76
>NP_113676
          Length = 705

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   GQVVAVRAK 9
           G+++AVR K
Sbjct: 667 GEIIAVRVK 675
>XP_006714595
          Length = 378

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  GQVVAVRAK 9
          GQV+ ++AK
Sbjct: 68 GQVITIKAK 76
>XP_006714594
          Length = 527

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  GQVVAVRAK 9
          GQV+ ++AK
Sbjct: 68 GQVITIKAK 76
>NP_671517
          Length = 594

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   GQVVAVRAK 9
           GQVV ++AK
Sbjct: 106 GQVVNIKAK 114
>NP_056362
          Length = 607

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   GQVVAVRAK 9
           GQVV ++AK
Sbjct: 106 GQVVNIKAK 114
>XP_005258110
          Length = 262

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   GQVVAVRA 8
           GQVVAV A
Sbjct: 207 GQVVAVSA 214
>NP_001009565
          Length = 315

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  GQVVAVR 7
          GQVVAV+
Sbjct: 27 GQVVAVK 33
>XP_006715292
          Length = 759

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   GQVVAVRAK 9
           G+V A RAK
Sbjct: 402 GKVTAARAK 410
>XP_006712067
          Length = 175

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  GQVVAVR 7
          GQVVAV+
Sbjct: 27 GQVVAVK 33
>XP_006712066
          Length = 342

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  GQVVAVR 7
          GQVVAV+
Sbjct: 27 GQVVAVK 33
>NP_116056
          Length = 398

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  GQVVAVRAK 9
          GQV+A RA+
Sbjct: 17 GQVLAGRAR 25
>NP_001124174
          Length = 287

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  GQVVAVRAK 9
          GQV+A RA+
Sbjct: 17 GQVLAGRAR 25
>NP_001116427
          Length = 462

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  GQVVAVRAK 9
          GQV+A RA+
Sbjct: 81 GQVLAGRAR 89
>NP_001243241
          Length = 519

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  GQVVAVR 7
          GQVVA++
Sbjct: 78 GQVVAIK 84
>NP_001272997
          Length = 315

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   GQVVAVRAK 9
           G+V+ V+AK
Sbjct: 168 GKVIEVKAK 176
>NP_001272998
          Length = 315

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   GQVVAVRAK 9
           G+V+ V+AK
Sbjct: 168 GKVIEVKAK 176
>NP_001272996
          Length = 315

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   GQVVAVRAK 9
           G+V+ V+AK
Sbjct: 168 GKVIEVKAK 176
>NP_001272999
          Length = 296

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   GQVVAVRAK 9
           G+V+ V+AK
Sbjct: 149 GKVIEVKAK 157
>NP_006272
          Length = 491

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  GQVVAVR 7
          GQVVA++
Sbjct: 50 GQVVAIK 56
>NP_001243242
          Length = 380

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  GQVVAVR 7
          GQVVA++
Sbjct: 50 GQVVAIK 56
>XP_006718887
          Length = 315

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   GQVVAVRAK 9
           G+V+ V+AK
Sbjct: 168 GKVIEVKAK 176
>XP_005273992
          Length = 315

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   GQVVAVRAK 9
           G+V+ V+AK
Sbjct: 168 GKVIEVKAK 176
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.321    0.129    0.324 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 250,840
Number of extensions: 344
Number of successful extensions: 46
Number of sequences better than 10000.0: 46
Number of HSP's gapped: 46
Number of HSP's successfully gapped: 46
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.9 bits)
S2: 28 (15.4 bits)

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