Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001099129                                                           18    1482
XP_005270510                                                           18    1482
XP_005270509                                                           18    1482
XP_005270508                                                           18    1482
XP_005273420                                                           17    4312
NP_597677                                                              16    5631
NP_056199                                                              16    5631
XP_005248340                                                           16    5631
XP_005248339                                                           16    5631
XP_005248337                                                           16    5631
XP_006714531                                                           16    5631
XP_006714530                                                           16    5631
NP_001166935                                                           16    7355
NP_060111                                                              16    7355
NP_001166934                                                           16    7355
NP_001166936                                                           16    7355
XP_006719559                                                           16    7355
XP_006719558                                                           16    7355
XP_005269072                                                           16    7355
XP_005269071                                                           16    7355
XP_005269070                                                           16    7355
XP_006719557                                                           16    7355
XP_005269069                                                           16    7355
XP_006719556                                                           16    7355
XP_005269068                                                           16    7355
XP_005269067                                                           16    7355
XP_005269066                                                           16    7355
XP_005269065                                                           16    7355
XP_005269064                                                           16    7355
XP_006710416                                                           16    7355
XP_006710415                                                           16    7355
XP_005270511                                                           16    7355
NP_001010860                                                           16    7355
NP_006024                                                              15    9605
NP_000120                                                              15    9605
NP_001258949                                                           15    9605
XP_005258447                                                           15    9605
XP_006720386                                                           15    9605
XP_006720385                                                           15    9605
XP_005268275                                                           15    9605
XP_006715073                                                           15    9605
>NP_001099129
          Length = 624

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1   GMKSETSR 8
           GMKS+TSR
Sbjct: 320 GMKSKTSR 327
>XP_005270510
          Length = 335

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1   GMKSETSR 8
           GMKS+TSR
Sbjct: 320 GMKSKTSR 327
>XP_005270509
          Length = 349

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1   GMKSETSR 8
           GMKS+TSR
Sbjct: 320 GMKSKTSR 327
>XP_005270508
          Length = 430

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1   GMKSETSR 8
           GMKS+TSR
Sbjct: 320 GMKSKTSR 327
>XP_005273420
          Length = 396

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2 MKSETSRT 9
         M+S+TSRT
Sbjct: 1 MESQTSRT 8
>NP_597677
          Length = 2804

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   GMKSETSRT 9
           G+KS++S+T
Sbjct: 855 GIKSDSSKT 863
>NP_056199
          Length = 2697

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   GMKSETSRT 9
           G+KS++S+T
Sbjct: 855 GIKSDSSKT 863
>XP_005248340
          Length = 2265

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   GMKSETSRT 9
           G+KS++S+T
Sbjct: 316 GIKSDSSKT 324
>XP_005248339
          Length = 2584

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   GMKSETSRT 9
           G+KS++S+T
Sbjct: 635 GIKSDSSKT 643
>XP_005248337
          Length = 2698

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   GMKSETSRT 9
           G+KS++S+T
Sbjct: 855 GIKSDSSKT 863
>XP_006714531
          Length = 2738

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   GMKSETSRT 9
           G+KS++S+T
Sbjct: 855 GIKSDSSKT 863
>XP_006714530
          Length = 2755

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   GMKSETSRT 9
           G+KS++S+T
Sbjct: 855 GIKSDSSKT 863
>NP_001166935
          Length = 1674

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    GMKSETSRT 9
            GM +ETS T
Sbjct: 1196 GMNTETSGT 1204
>NP_060111
          Length = 1661

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    GMKSETSRT 9
            GM +ETS T
Sbjct: 1183 GMNTETSGT 1191
>NP_001166934
          Length = 1637

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    GMKSETSRT 9
            GM +ETS T
Sbjct: 1176 GMNTETSGT 1184
>NP_001166936
          Length = 1621

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    GMKSETSRT 9
            GM +ETS T
Sbjct: 1160 GMNTETSGT 1168
>XP_006719559
          Length = 1650

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    GMKSETSRT 9
            GM +ETS T
Sbjct: 1176 GMNTETSGT 1184
>XP_006719558
          Length = 1644

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    GMKSETSRT 9
            GM +ETS T
Sbjct: 1183 GMNTETSGT 1191
>XP_005269072
          Length = 1607

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    GMKSETSRT 9
            GM +ETS T
Sbjct: 1189 GMNTETSGT 1197
>XP_005269071
          Length = 1614

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    GMKSETSRT 9
            GM +ETS T
Sbjct: 1196 GMNTETSGT 1204
>XP_005269070
          Length = 1627

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    GMKSETSRT 9
            GM +ETS T
Sbjct: 1196 GMNTETSGT 1204
>XP_006719557
          Length = 1631

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    GMKSETSRT 9
            GM +ETS T
Sbjct: 1196 GMNTETSGT 1204
>XP_005269069
          Length = 1632

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    GMKSETSRT 9
            GM +ETS T
Sbjct: 1196 GMNTETSGT 1204
>XP_006719556
          Length = 1655

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    GMKSETSRT 9
            GM +ETS T
Sbjct: 1176 GMNTETSGT 1184
>XP_005269068
          Length = 1657

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    GMKSETSRT 9
            GM +ETS T
Sbjct: 1196 GMNTETSGT 1204
>XP_005269067
          Length = 1662

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    GMKSETSRT 9
            GM +ETS T
Sbjct: 1183 GMNTETSGT 1191
>XP_005269066
          Length = 1668

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    GMKSETSRT 9
            GM +ETS T
Sbjct: 1189 GMNTETSGT 1197
>XP_005269065
          Length = 1670

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    GMKSETSRT 9
            GM +ETS T
Sbjct: 1196 GMNTETSGT 1204
>XP_005269064
          Length = 1675

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    GMKSETSRT 9
            GM +ETS T
Sbjct: 1196 GMNTETSGT 1204
>XP_006710416
          Length = 304

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2 MKSETSR 8
         MKS+TSR
Sbjct: 1 MKSKTSR 7
>XP_006710415
          Length = 304

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2 MKSETSR 8
         MKS+TSR
Sbjct: 1 MKSKTSR 7
>XP_005270511
          Length = 304

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2 MKSETSR 8
         MKS+TSR
Sbjct: 1 MKSKTSR 7
>NP_001010860
          Length = 674

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   MKSETSR 8
           +KSETSR
Sbjct: 107 VKSETSR 113
>NP_006024
          Length = 500

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   MKSETSRT 9
           MK+ETS T
Sbjct: 489 MKNETSPT 496
>NP_000120
          Length = 732

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4 SETSRT 9
         SETSRT
Sbjct: 2 SETSRT 7
>NP_001258949
          Length = 637

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   SETSRT 9
           SETSRT
Sbjct: 461 SETSRT 466
>XP_005258447
          Length = 536

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   MKSETSRT 9
           MK+ETS T
Sbjct: 525 MKNETSPT 532
>XP_006720386
          Length = 1571

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    SETSRT 9
            SETSRT
Sbjct: 1395 SETSRT 1400
>XP_006720385
          Length = 1683

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    SETSRT 9
            SETSRT
Sbjct: 1507 SETSRT 1512
>XP_005268275
          Length = 1684

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    SETSRT 9
            SETSRT
Sbjct: 1508 SETSRT 1513
>XP_006715073
          Length = 732

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4 SETSRT 9
         SETSRT
Sbjct: 2 SETSRT 7
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.291    0.103    0.247 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 365,647
Number of extensions: 431
Number of successful extensions: 41
Number of sequences better than 10000.0: 41
Number of HSP's gapped: 41
Number of HSP's successfully gapped: 41
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.0 bits)
S2: 28 (15.4 bits)

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