Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_008835                                                              20     390
NP_001075109                                                           20     390
NP_000332                                                              17    3301
NP_620177                                                              17    4312
NP_000910                                                              17    4312
NP_620121                                                              17    4312
NP_620176                                                              17    4312
NP_001170777                                                           17    4312
NP_922932                                                              17    4312
XP_006714703                                                           17    4312
XP_006714702                                                           17    4312
XP_006714701                                                           17    4312
XP_006714700                                                           17    4312
XP_006714699                                                           17    4312
XP_006714698                                                           17    4312
XP_006714697                                                           17    4312
XP_006714696                                                           17    4312
XP_006714695                                                           17    4312
NP_848599                                                              16    5631
NP_001257637                                                           16    5631
NP_009174                                                              16    5631
NP_001257638                                                           16    5631
NP_001257636                                                           16    5631
XP_006713081                                                           16    5631
NP_000135                                                              16    7355
NP_075053                                                              16    7355
NP_001139732                                                           16    7355
NP_001139731                                                           16    7355
NP_001139730                                                           16    7355
NP_079055                                                              16    7355
XP_006721061                                                           16    7355
XP_006719667                                                           16    7355
XP_005269209                                                           16    7355
XP_006714735                                                           16    7355
XP_005248626                                                           16    7355
XP_006710064                                                           16    7355
NP_001275676                                                           15    9605
NP_001135935                                                           15    9605
NP_001354                                                              15    9605
NP_660160                                                              15    9605
NP_001186704                                                           15    9605
NP_001264890                                                           15    9605
NP_001295                                                              15    9605
NP_001264891                                                           15    9605
NP_005883                                                              15    9605
NP_079143                                                              15    9605
NP_001229588                                                           15    9605
NP_003147                                                              15    9605
XP_006722133                                                           15    9605
XP_006722132                                                           15    9605
XP_006722131                                                           15    9605
XP_006722130                                                           15    9605
XP_006722129                                                           15    9605
XP_006722128                                                           15    9605
XP_006722127                                                           15    9605
XP_006722126                                                           15    9605
XP_006722125                                                           15    9605
XP_005248435                                                           15    9605
XP_006714564                                                           15    9605
XP_006714563                                                           15    9605
XP_005248434                                                           15    9605
XP_005248433                                                           15    9605
NP_071387                                                              15    9605
NP_036474                                                              15    9605
>NP_008835
          Length = 4128

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    MHDIIAAE 9
            MHDIIAAE
Sbjct: 1303 MHDIIAAE 1310
>NP_001075109
          Length = 4097

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    MHDIIAAE 9
            MHDIIAAE
Sbjct: 1303 MHDIIAAE 1310
>NP_000332
          Length = 685

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   GMHDII 6
           GMHDI+
Sbjct: 356 GMHDIV 361
>NP_620177
          Length = 887

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   HDIIAAE 9
           HDI+A+E
Sbjct: 783 HDIVASE 789
>NP_000910
          Length = 974

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   HDIIAAE 9
           HDI+A+E
Sbjct: 783 HDIVASE 789
>NP_620121
          Length = 905

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   HDIIAAE 9
           HDI+A+E
Sbjct: 783 HDIVASE 789
>NP_620176
          Length = 866

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   HDIIAAE 9
           HDI+A+E
Sbjct: 676 HDIVASE 682
>NP_001170777
          Length = 973

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   HDIIAAE 9
           HDI+A+E
Sbjct: 783 HDIVASE 789
>NP_922932
          Length = 1117

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   GMHDIIAAE 9
           G+H +IA E
Sbjct: 153 GLHGVIATE 161
>XP_006714703
          Length = 866

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   HDIIAAE 9
           HDI+A+E
Sbjct: 676 HDIVASE 682
>XP_006714702
          Length = 867

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   HDIIAAE 9
           HDI+A+E
Sbjct: 676 HDIVASE 682
>XP_006714701
          Length = 905

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   HDIIAAE 9
           HDI+A+E
Sbjct: 783 HDIVASE 789
>XP_006714700
          Length = 906

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   HDIIAAE 9
           HDI+A+E
Sbjct: 783 HDIVASE 789
>XP_006714699
          Length = 972

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   HDIIAAE 9
           HDI+A+E
Sbjct: 783 HDIVASE 789
>XP_006714698
          Length = 973

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   HDIIAAE 9
           HDI+A+E
Sbjct: 783 HDIVASE 789
>XP_006714697
          Length = 973

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   HDIIAAE 9
           HDI+A+E
Sbjct: 783 HDIVASE 789
>XP_006714696
          Length = 974

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   HDIIAAE 9
           HDI+A+E
Sbjct: 783 HDIVASE 789
>XP_006714695
          Length = 974

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   HDIIAAE 9
           HDI+A+E
Sbjct: 783 HDIVASE 789
>NP_848599
          Length = 3092

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    MHDIIAA 8
            +HD+IAA
Sbjct: 1080 VHDVIAA 1086
>NP_001257637
          Length = 111

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  GMHDIIAAE 9
          G H ++AAE
Sbjct: 75 GQHSLMAAE 83
>NP_009174
          Length = 262

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  GMHDIIAAE 9
          G H ++AAE
Sbjct: 75 GQHSLMAAE 83
>NP_001257638
          Length = 203

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  GMHDIIAAE 9
          G H ++AAE
Sbjct: 75 GQHSLMAAE 83
>NP_001257636
          Length = 268

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  GMHDIIAAE 9
          G H ++AAE
Sbjct: 75 GQHSLMAAE 83
>XP_006713081
          Length = 3964

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    MHDIIAA 8
            +HD+IAA
Sbjct: 1103 VHDVIAA 1109
>NP_000135
          Length = 210

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   MHDIIAAE 9
           +H+++AAE
Sbjct: 182 LHELLAAE 189
>NP_075053
          Length = 765

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1   GMHDIIA 7
           G HD++A
Sbjct: 741 GFHDVLA 747
>NP_001139732
          Length = 373

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   GMHDII 6
           G+HDII
Sbjct: 238 GIHDII 243
>NP_001139731
          Length = 403

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   GMHDII 6
           G+HDII
Sbjct: 268 GIHDII 273
>NP_001139730
          Length = 421

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   GMHDII 6
           G+HDII
Sbjct: 286 GIHDII 291
>NP_079055
          Length = 421

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   GMHDII 6
           G+HDII
Sbjct: 286 GIHDII 291
>XP_006721061
          Length = 688

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   GMHDII 6
           G+HDI+
Sbjct: 676 GLHDIV 681
>XP_006719667
          Length = 251

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   GMHDII 6
           G+HDII
Sbjct: 116 GIHDII 121
>XP_005269209
          Length = 408

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   GMHDII 6
           G+HDII
Sbjct: 273 GIHDII 278
>XP_006714735
          Length = 722

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1   GMHDIIA 7
           G HD++A
Sbjct: 698 GFHDVLA 704
>XP_005248626
          Length = 724

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1   GMHDIIA 7
           G HD++A
Sbjct: 700 GFHDVLA 706
>XP_006710064
          Length = 688

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   GMHDII 6
           G+HDI+
Sbjct: 676 GLHDIV 681
>NP_001275676
          Length = 420

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   MHDIIAAE 9
           MHD++ A+
Sbjct: 263 MHDVLDAQ 270
>NP_001135935
          Length = 509

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   MHDIIAAE 9
           MHD++ A+
Sbjct: 263 MHDVLDAQ 270
>NP_001354
          Length = 514

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   MHDIIAAE 9
           MHD++ A+
Sbjct: 263 MHDVLDAQ 270
>NP_660160
          Length = 330

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1  GMHDIIA 7
          GMH IIA
Sbjct: 67 GMHVIIA 73
>NP_001186704
          Length = 1133

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    GMHDIIA 7
            G+H+IIA
Sbjct: 1008 GVHNIIA 1014
>NP_001264890
          Length = 791

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   GMHDIIAA 8
           G+H ++AA
Sbjct: 446 GIHSLVAA 453
>NP_001295
          Length = 1380

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    GMHDIIA 7
            G+H+IIA
Sbjct: 1255 GVHNIIA 1261
>NP_001264891
          Length = 540

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   GMHDIIAA 8
           G+H ++AA
Sbjct: 446 GIHSLVAA 453
>NP_005883
          Length = 1100

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   GMHDIIAA 8
           G HDII A
Sbjct: 284 GGHDIILA 291
>NP_079143
          Length = 1822

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   MHDIIAAE 9
           M+DIIA E
Sbjct: 795 MNDIIAEE 802
>NP_001229588
          Length = 226

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   GMHDIIAA 8
           GM DI+ A
Sbjct: 179 GMQDIVVA 186
>NP_003147
          Length = 685

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   GMHDIIAA 8
           G+H ++AA
Sbjct: 446 GIHSLVAA 453
>XP_006722133
          Length = 1104

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   GMHDIIAA 8
           G HDII A
Sbjct: 284 GGHDIILA 291
>XP_006722132
          Length = 1076

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   GMHDIIAA 8
           G HDII A
Sbjct: 290 GGHDIILA 297
>XP_006722131
          Length = 1100

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   GMHDIIAA 8
           G HDII A
Sbjct: 284 GGHDIILA 291
>XP_006722130
          Length = 1106

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   GMHDIIAA 8
           G HDII A
Sbjct: 290 GGHDIILA 297
>XP_006722129
          Length = 1110

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   GMHDIIAA 8
           G HDII A
Sbjct: 290 GGHDIILA 297
>XP_006722128
          Length = 1148

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   GMHDIIAA 8
           G HDII A
Sbjct: 274 GGHDIILA 281
>XP_006722127
          Length = 1154

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   GMHDIIAA 8
           G HDII A
Sbjct: 280 GGHDIILA 287
>XP_006722126
          Length = 1158

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   GMHDIIAA 8
           G HDII A
Sbjct: 284 GGHDIILA 291
>XP_006722125
          Length = 1164

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   GMHDIIAA 8
           G HDII A
Sbjct: 290 GGHDIILA 297
>XP_005248435
          Length = 972

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   MHDIIAAE 9
           M+DIIA E
Sbjct: 795 MNDIIAEE 802
>XP_006714564
          Length = 1537

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   MHDIIAAE 9
           M+DIIA E
Sbjct: 795 MNDIIAEE 802
>XP_006714563
          Length = 1766

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   MHDIIAAE 9
           M+DIIA E
Sbjct: 738 MNDIIAEE 745
>XP_005248434
          Length = 1818

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   MHDIIAAE 9
           M+DIIA E
Sbjct: 790 MNDIIAEE 797
>XP_005248433
          Length = 1823

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   MHDIIAAE 9
           M+DIIA E
Sbjct: 795 MNDIIAEE 802
>NP_071387
          Length = 704

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1  GMHDIIA 7
          G HD+I+
Sbjct: 78 GQHDVIS 84
>NP_036474
          Length = 260

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/7 (42%), Positives = 7/7 (100%)

Query: 1   GMHDIIA 7
           G+HD+++
Sbjct: 108 GLHDVLS 114
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.323    0.137    0.394 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 431,897
Number of extensions: 406
Number of successful extensions: 64
Number of sequences better than 10000.0: 64
Number of HSP's gapped: 64
Number of HSP's successfully gapped: 64
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.9 bits)
S2: 28 (15.4 bits)

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