Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001013433                                                           18    1135
NP_060785                                                              18    1135
NP_361014                                                              18    1135
NP_001073936                                                           18    1135
NP_000250                                                              17    2528
NP_001135967                                                           17    2528
XP_005254459                                                           17    2528
XP_005254458                                                           17    2528
XP_005254457                                                           17    2528
XP_005254456                                                           17    2528
XP_005254455                                                           17    2528
XP_005254454                                                           17    2528
NP_848622                                                              17    3301
NP_001307                                                              17    4312
NP_055543                                                              16    5631
NP_000005                                                              16    5631
NP_001036083                                                           16    5631
NP_005475                                                              16    5631
NP_065119                                                              16    5631
NP_001184225                                                           16    5631
NP_001184224                                                           16    5631
XP_006724587                                                           16    5631
XP_005274689                                                           16    5631
XP_005267304                                                           16    5631
XP_006719119                                                           16    5631
XP_005247715                                                           16    5631
NP_001384                                                              16    5631
NP_892006                                                              16    7355
NP_149062                                                              16    7355
NP_060386                                                              16    7355
NP_000696                                                              16    7355
XP_006726604                                                           16    7355
XP_006726603                                                           16    7355
XP_006725215                                                           16    7355
XP_006723317                                                           16    7355
XP_006719240                                                           16    7355
XP_006719237                                                           16    7355
XP_006715488                                                           16    7355
XP_006715487                                                           16    7355
XP_006715486                                                           16    7355
XP_006715485                                                           16    7355
XP_006715484                                                           16    7355
XP_006715483                                                           16    7355
XP_006715482                                                           16    7355
XP_006715481                                                           16    7355
XP_006715480                                                           16    7355
XP_006715479                                                           16    7355
XP_006715478                                                           16    7355
XP_006715477                                                           16    7355
XP_006715476                                                           16    7355
XP_006715475                                                           16    7355
XP_006715474                                                           16    7355
XP_006715473                                                           16    7355
XP_006715472                                                           16    7355
XP_006715471                                                           16    7355
XP_006715470                                                           16    7355
NP_001020276                                                           15    9605
NP_003312                                                              15    9605
NP_002855                                                              15    9605
NP_001258670                                                           15    9605
NP_001883                                                              15    9605
NP_065904                                                              15    9605
NP_065831                                                              15    9605
NP_061180                                                              15    9605
NP_001406                                                              15    9605
XP_005253507                                                           15    9605
>NP_001013433
          Length = 589

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   GMELKYNIL 9
           GMELK NIL
Sbjct: 468 GMELKDNIL 476
>NP_060785
          Length = 627

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   GMELKYNIL 9
           GMELK NIL
Sbjct: 506 GMELKDNIL 514
>NP_361014
          Length = 707

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   GMELKYNIL 9
           GMELK NIL
Sbjct: 586 GMELKDNIL 594
>NP_001073936
          Length = 1848

 Score = 18.5 bits (36), Expect =  1135
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1    GMELKYNI 8
            GM+L+YNI
Sbjct: 1709 GMQLRYNI 1716
>NP_000250
          Length = 1855

 Score = 17.3 bits (33), Expect =  2528
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1    GMELKYNI 8
            GM+++YN+
Sbjct: 1716 GMQIRYNV 1723
>NP_001135967
          Length = 1828

 Score = 17.3 bits (33), Expect =  2528
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1    GMELKYNI 8
            GM+++YN+
Sbjct: 1689 GMQIRYNV 1696
>XP_005254459
          Length = 1825

 Score = 17.3 bits (33), Expect =  2528
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1    GMELKYNI 8
            GM+++YN+
Sbjct: 1686 GMQIRYNV 1693
>XP_005254458
          Length = 1852

 Score = 17.3 bits (33), Expect =  2528
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1    GMELKYNI 8
            GM+++YN+
Sbjct: 1713 GMQIRYNV 1720
>XP_005254457
          Length = 1853

 Score = 17.3 bits (33), Expect =  2528
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1    GMELKYNI 8
            GM+++YN+
Sbjct: 1714 GMQIRYNV 1721
>XP_005254456
          Length = 1877

 Score = 17.3 bits (33), Expect =  2528
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1    GMELKYNI 8
            GM+++YN+
Sbjct: 1738 GMQIRYNV 1745
>XP_005254455
          Length = 1880

 Score = 17.3 bits (33), Expect =  2528
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1    GMELKYNI 8
            GM+++YN+
Sbjct: 1741 GMQIRYNV 1748
>XP_005254454
          Length = 1880

 Score = 17.3 bits (33), Expect =  2528
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1    GMELKYNI 8
            GM+++YN+
Sbjct: 1741 GMQIRYNV 1748
>NP_848622
          Length = 1124

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   GMELKYNIL 9
           G+EL Y+IL
Sbjct: 218 GIELSYDIL 226
>NP_001307
          Length = 971

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   GMELKYNIL 9
           G E+KY++L
Sbjct: 305 GQEVKYDLL 313
>NP_055543
          Length = 1322

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   GMELKYNI 8
           G ELKY+I
Sbjct: 322 GPELKYDI 329
>NP_000005
          Length = 1474

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    LKYNIL 9
            LKYNIL
Sbjct: 1328 LKYNIL 1333
>NP_001036083
          Length = 570

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   MELKYN 7
           ME+KYN
Sbjct: 243 MEMKYN 248
>NP_005475
          Length = 583

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   MELKYN 7
           ME+KYN
Sbjct: 256 MEMKYN 261
>NP_065119
          Length = 273

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   GMELKYNIL 9
           G E+ YN+L
Sbjct: 212 GQEVAYNLL 220
>NP_001184225
          Length = 643

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  GMELKYNIL 9
          G+E  YN+L
Sbjct: 88 GVESSYNVL 96
>NP_001184224
          Length = 677

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  GMELKYNIL 9
          G+E  YN+L
Sbjct: 88 GVESSYNVL 96
>XP_006724587
          Length = 1732

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   GMELKYNI 8
           G ELKY+I
Sbjct: 322 GPELKYDI 329
>XP_005274689
          Length = 1762

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   GMELKYNI 8
           G ELKY+I
Sbjct: 322 GPELKYDI 329
>XP_005267304
          Length = 500

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   MELKYN 7
           ME+KYN
Sbjct: 256 MEMKYN 261
>XP_006719119
          Length = 1512

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    LKYNIL 9
            LKYNIL
Sbjct: 1328 LKYNIL 1333
>XP_005247715
          Length = 203

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   GMELKYNIL 9
           G E+ YN+L
Sbjct: 107 GQEVAYNLL 115
>NP_001384
          Length = 699

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  GMELKYNIL 9
          G+E  YN+L
Sbjct: 88 GVESSYNVL 96
>NP_892006
          Length = 8797

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   MELKYNIL 9
           +ELKY +L
Sbjct: 506 LELKYRLL 513
>NP_149062
          Length = 8749

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   MELKYNIL 9
           +ELKY +L
Sbjct: 513 LELKYRLL 520
>NP_060386
          Length = 290

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   GMELKYNI 8
           G+E KYN+
Sbjct: 149 GLEDKYNL 156
>NP_000696
          Length = 291

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   GMELKYNI 8
           G+E+ YN+
Sbjct: 93  GLEIVYNV 100
>XP_006726604
          Length = 232

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   LKYNIL 9
           LKYN+L
Sbjct: 107 LKYNVL 112
>XP_006726603
          Length = 1264

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    LKYNIL 9
            LKYN+L
Sbjct: 1125 LKYNVL 1130
>XP_006725215
          Length = 1264

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    LKYNIL 9
            LKYN+L
Sbjct: 1125 LKYNVL 1130
>XP_006723317
          Length = 163

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  GMELKYNI 8
          G+E KYN+
Sbjct: 22 GLEDKYNL 29
>XP_006719240
          Length = 113

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  LKYNIL 9
          LKYN+L
Sbjct: 21 LKYNVL 26
>XP_006719237
          Length = 1263

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    LKYNIL 9
            LKYN+L
Sbjct: 1124 LKYNVL 1129
>XP_006715488
          Length = 8721

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   MELKYNIL 9
           +ELKY +L
Sbjct: 513 LELKYRLL 520
>XP_006715487
          Length = 8744

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   MELKYNIL 9
           +ELKY +L
Sbjct: 513 LELKYRLL 520
>XP_006715486
          Length = 8758

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   MELKYNIL 9
           +ELKY +L
Sbjct: 513 LELKYRLL 520
>XP_006715485
          Length = 8793

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   MELKYNIL 9
           +ELKY +L
Sbjct: 513 LELKYRLL 520
>XP_006715484
          Length = 8794

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   MELKYNIL 9
           +ELKY +L
Sbjct: 513 LELKYRLL 520
>XP_006715483
          Length = 8795

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   MELKYNIL 9
           +ELKY +L
Sbjct: 513 LELKYRLL 520
>XP_006715482
          Length = 8797

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   MELKYNIL 9
           +ELKY +L
Sbjct: 506 LELKYRLL 513
>XP_006715481
          Length = 8799

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   MELKYNIL 9
           +ELKY +L
Sbjct: 466 LELKYRLL 473
>XP_006715480
          Length = 8799

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   MELKYNIL 9
           +ELKY +L
Sbjct: 513 LELKYRLL 520
>XP_006715479
          Length = 8804

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   MELKYNIL 9
           +ELKY +L
Sbjct: 513 LELKYRLL 520
>XP_006715478
          Length = 8809

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   MELKYNIL 9
           +ELKY +L
Sbjct: 513 LELKYRLL 520
>XP_006715477
          Length = 8822

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   MELKYNIL 9
           +ELKY +L
Sbjct: 489 LELKYRLL 496
>XP_006715476
          Length = 8823

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   MELKYNIL 9
           +ELKY +L
Sbjct: 513 LELKYRLL 520
>XP_006715475
          Length = 8827

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   MELKYNIL 9
           +ELKY +L
Sbjct: 513 LELKYRLL 520
>XP_006715474
          Length = 8829

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   MELKYNIL 9
           +ELKY +L
Sbjct: 496 LELKYRLL 503
>XP_006715473
          Length = 8832

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   MELKYNIL 9
           +ELKY +L
Sbjct: 513 LELKYRLL 520
>XP_006715472
          Length = 8839

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   MELKYNIL 9
           +ELKY +L
Sbjct: 506 LELKYRLL 513
>XP_006715471
          Length = 8842

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   MELKYNIL 9
           +ELKY +L
Sbjct: 513 LELKYRLL 520
>XP_006715470
          Length = 8846

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   MELKYNIL 9
           +ELKY +L
Sbjct: 513 LELKYRLL 520
>NP_001020276
          Length = 365

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1  GMELKYNIL 9
          G E  YN+L
Sbjct: 80 GQEKDYNVL 88
>NP_003312
          Length = 455

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   GMELKYNIL 9
           G +LK+N++
Sbjct: 404 GEDLKFNLI 412
>NP_002855
          Length = 1482

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    LKYNIL 9
            +KYNIL
Sbjct: 1334 MKYNIL 1339
>NP_001258670
          Length = 325

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1  GMELKYNIL 9
          G E  YN+L
Sbjct: 80 GQEKDYNVL 88
>NP_001883
          Length = 337

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1  GMELKYNIL 9
          G E  YN+L
Sbjct: 80 GQEKDYNVL 88
>NP_065904
          Length = 622

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   GMELKYNIL 9
           G  +KYNI+
Sbjct: 301 GRPVKYNIV 309
>NP_065831
          Length = 1392

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   MELKYNI 8
           ++LKYN+
Sbjct: 770 LDLKYNL 776
>NP_061180
          Length = 257

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   MELKYNIL 9
           MEL++N L
Sbjct: 164 MELRFNTL 171
>NP_001406
          Length = 472

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   ELKYNI 8
           +LKYNI
Sbjct: 227 QLKYNI 232
>XP_005253507
          Length = 440

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   GMELKYNIL 9
           G  +KYNI+
Sbjct: 301 GRPVKYNIV 309
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.322    0.147    0.407 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 526,570
Number of extensions: 1025
Number of successful extensions: 66
Number of sequences better than 10000.0: 66
Number of HSP's gapped: 66
Number of HSP's successfully gapped: 66
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.8 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package