Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001275701                                                           18    1482
NP_004561                                                              18    1482
NP_001275703                                                           18    1482
XP_005253450                                                           18    1482
XP_006719151                                                           18    1482
NP_078858                                                              18    1935
NP_001278232                                                           18    1935
NP_001278214                                                           18    1935
NP_113689                                                              16    5631
NP_061731                                                              16    5631
NP_001071160                                                           16    7355
NP_001071159                                                           16    7355
NP_079016                                                              16    7355
NP_001071158                                                           16    7355
NP_060109                                                              16    7355
NP_001185890                                                           16    7355
NP_060751                                                              16    7355
NP_079111                                                              16    7355
NP_001185891                                                           16    7355
XP_005276966                                                           16    7355
XP_005257746                                                           16    7355
XP_006718976                                                           16    7355
XP_005277781                                                           16    7355
XP_005277780                                                           16    7355
XP_005269436                                                           16    7355
XP_005271059                                                           16    7355
XP_006710811                                                           16    7355
XP_006710809                                                           16    7355
XP_006710808                                                           16    7355
XP_006710807                                                           16    7355
XP_006710806                                                           16    7355
XP_006710805                                                           16    7355
XP_006710804                                                           16    7355
XP_006710803                                                           16    7355
XP_006710802                                                           16    7355
NP_039227                                                              16    7355
NP_039228                                                              16    7355
NP_005720                                                              16    7355
NP_001004466                                                           16    7355
NP_056164                                                              15    9605
NP_071896                                                              15    9605
XP_005252905                                                           15    9605
XP_005252904                                                           15    9605
XP_005249030                                                           15    9605
XP_005249029                                                           15    9605
NP_036326                                                              15    9605
>NP_001275701
          Length = 1486

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    LLSTTRSI 9
            LLSTTRSI
Sbjct: 1239 LLSTTRSI 1246
>NP_004561
          Length = 1445

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    LLSTTRSI 9
            LLSTTRSI
Sbjct: 1198 LLSTTRSI 1205
>NP_001275703
          Length = 1264

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    LLSTTRSI 9
            LLSTTRSI
Sbjct: 1017 LLSTTRSI 1024
>XP_005253450
          Length = 1486

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    LLSTTRSI 9
            LLSTTRSI
Sbjct: 1239 LLSTTRSI 1246
>XP_006719151
          Length = 1486

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    LLSTTRSI 9
            LLSTTRSI
Sbjct: 1239 LLSTTRSI 1246
>NP_078858
          Length = 4981

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    GLLSTTRSI 9
            G+LSTTR I
Sbjct: 3564 GVLSTTREI 3572
>NP_001278232
          Length = 4983

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    GLLSTTRSI 9
            G+LSTTR I
Sbjct: 3566 GVLSTTREI 3574
>NP_001278214
          Length = 4982

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    GLLSTTRSI 9
            G+LSTTR I
Sbjct: 3566 GVLSTTREI 3574
>NP_113689
          Length = 816

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   GLLSTTRSI 9
           G +STTRS+
Sbjct: 628 GEISTTRSL 636
>NP_061731
          Length = 936

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   GLLSTTRSI 9
           G +STTRS+
Sbjct: 628 GEISTTRSL 636
>NP_001071160
          Length = 440

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   GLLSTTRSI 9
           GLLS +RS+
Sbjct: 251 GLLSFSRSV 259
>NP_001071159
          Length = 447

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   GLLSTTRSI 9
           GLLS +RS+
Sbjct: 258 GLLSFSRSV 266
>NP_079016
          Length = 618

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   GLLSTTRSI 9
           GLLS +RS+
Sbjct: 429 GLLSFSRSV 437
>NP_001071158
          Length = 611

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   GLLSTTRSI 9
           GLLS +RS+
Sbjct: 422 GLLSFSRSV 430
>NP_060109
          Length = 2916

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    GLLSTTRSI 9
            G LSTTR++
Sbjct: 1428 GELSTTRAL 1436
>NP_001185890
          Length = 292

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   GLLSTTRSI 9
           GL+ TTR +
Sbjct: 159 GLIETTRGL 167
>NP_060751
          Length = 261

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   GLLSTTRSI 9
           GL+ TTR +
Sbjct: 128 GLIETTRGL 136
>NP_079111
          Length = 697

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   GLLSTTRS 8
           G+LS TRS
Sbjct: 120 GVLSVTRS 127
>NP_001185891
          Length = 244

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   GLLSTTRSI 9
           GL+ TTR +
Sbjct: 128 GLIETTRGL 136
>XP_005276966
          Length = 699

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   GLLSTTRS 8
           G+LS TRS
Sbjct: 120 GVLSVTRS 127
>XP_005257746
          Length = 699

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   GLLSTTRS 8
           G+LS TRS
Sbjct: 120 GVLSVTRS 127
>XP_006718976
          Length = 598

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   GLLSTTRSI 9
           GLLS +RS+
Sbjct: 429 GLLSFSRSV 437
>XP_005277781
          Length = 622

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   GLLSTTRSI 9
           GLLS +RS+
Sbjct: 422 GLLSFSRSV 430
>XP_005277780
          Length = 629

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   GLLSTTRSI 9
           GLLS +RS+
Sbjct: 429 GLLSFSRSV 437
>XP_005269436
          Length = 201

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  GLLSTTRSI 9
          GLLS  RS+
Sbjct: 12 GLLSVPRSV 20
>XP_005271059
          Length = 215

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  GLLSTTRSI 9
          GL+ TTR +
Sbjct: 82 GLIETTRGL 90
>XP_006710811
          Length = 215

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  GLLSTTRSI 9
          GL+ TTR +
Sbjct: 82 GLIETTRGL 90
>XP_006710809
          Length = 246

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   GLLSTTRSI 9
           GL+ TTR +
Sbjct: 113 GLIETTRGL 121
>XP_006710808
          Length = 246

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   GLLSTTRSI 9
           GL+ TTR +
Sbjct: 113 GLIETTRGL 121
>XP_006710807
          Length = 246

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   GLLSTTRSI 9
           GL+ TTR +
Sbjct: 113 GLIETTRGL 121
>XP_006710806
          Length = 246

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   GLLSTTRSI 9
           GL+ TTR +
Sbjct: 113 GLIETTRGL 121
>XP_006710805
          Length = 246

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   GLLSTTRSI 9
           GL+ TTR +
Sbjct: 113 GLIETTRGL 121
>XP_006710804
          Length = 246

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   GLLSTTRSI 9
           GL+ TTR +
Sbjct: 113 GLIETTRGL 121
>XP_006710803
          Length = 256

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   GLLSTTRSI 9
           GL+ TTR +
Sbjct: 159 GLIETTRGL 167
>XP_006710802
          Length = 276

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   GLLSTTRSI 9
           GL+ TTR +
Sbjct: 159 GLIETTRGL 167
>NP_039227
          Length = 315

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2  LLSTTRSI 9
          LLST RSI
Sbjct: 85 LLSTQRSI 92
>NP_039228
          Length = 318

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2  LLSTTRSI 9
          LLST RSI
Sbjct: 85 LLSTQRSI 92
>NP_005720
          Length = 207

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  GLLSTTRSI 9
          GLLS  RS+
Sbjct: 12 GLLSVPRSV 20
>NP_001004466
          Length = 315

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2  LLSTTRSI 9
          LLST RSI
Sbjct: 85 LLSTQRSI 92
>NP_056164
          Length = 1079

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   GLLSTT 6
           GLLSTT
Sbjct: 641 GLLSTT 646
>NP_071896
          Length = 800

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   GLLSTTR 7
           G+L+TTR
Sbjct: 644 GILATTR 650
>XP_005252905
          Length = 1854

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   GLLSTT 6
           GLLSTT
Sbjct: 743 GLLSTT 748
>XP_005252904
          Length = 1855

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   GLLSTT 6
           GLLSTT
Sbjct: 743 GLLSTT 748
>XP_005249030
          Length = 1079

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   GLLSTT 6
           GLLSTT
Sbjct: 641 GLLSTT 646
>XP_005249029
          Length = 1079

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   GLLSTT 6
           GLLSTT
Sbjct: 641 GLLSTT 646
>NP_036326
          Length = 1849

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   GLLSTT 6
           GLLSTT
Sbjct: 737 GLLSTT 742
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.315    0.129    0.319 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 320,731
Number of extensions: 453
Number of successful extensions: 46
Number of sequences better than 10000.0: 46
Number of HSP's gapped: 46
Number of HSP's successfully gapped: 46
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.7 bits)
S2: 28 (15.4 bits)

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