Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_919047                                                              19     869
XP_005250598                                                           19     869
NP_060105                                                              17    3301
XP_005274094                                                           17    3301
XP_006718644                                                           17    3301
XP_005274093                                                           17    3301
XP_005274092                                                           17    3301
NP_733751                                                              17    4312
XP_006716142                                                           17    4312
XP_005250088                                                           17    4312
XP_006716141                                                           17    4312
XP_005250085                                                           17    4312
XP_006716140                                                           17    4312
XP_005250084                                                           17    4312
XP_005250083                                                           17    4312
XP_005250082                                                           17    4312
NP_056075                                                              16    5631
NP_000687                                                              16    5631
XP_006722767                                                           16    5631
XP_005259889                                                           16    5631
NP_001495                                                              16    7355
NP_001136269                                                           16    7355
NP_001034456                                                           16    7355
NP_001034455                                                           16    7355
NP_001687                                                              16    7355
NP_542384                                                              16    7355
XP_005262313                                                           16    7355
XP_005272199                                                           16    7355
XP_005264691                                                           16    7355
XP_005264690                                                           16    7355
NP_079290                                                              15    9605
NP_776089                                                              15    9605
NP_001128144                                                           15    9605
NP_071346                                                              15    9605
NP_001092740                                                           15    9605
NP_037498                                                              15    9605
NP_002239                                                              15    9605
NP_001244088                                                           15    9605
NP_115627                                                              15    9605
NP_008949                                                              15    9605
XP_005259964                                                           15    9605
XP_005259963                                                           15    9605
XP_005259962                                                           15    9605
XP_006721537                                                           15    9605
XP_006718583                                                           15    9605
XP_006718582                                                           15    9605
XP_006718002                                                           15    9605
XP_005270081                                                           15    9605
XP_005252046                                                           15    9605
XP_006717007                                                           15    9605
XP_006717005                                                           15    9605
XP_006717004                                                           15    9605
XP_006717003                                                           15    9605
XP_005251736                                                           15    9605
>NP_919047
          Length = 520

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   GLESRLDVD 9
           GLESR DVD
Sbjct: 464 GLESRPDVD 472
>XP_005250598
          Length = 457

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   GLESRLDVD 9
           GLESR DVD
Sbjct: 401 GLESRPDVD 409
>NP_060105
          Length = 885

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   LESRLDVD 9
           LESR++VD
Sbjct: 809 LESRMEVD 816
>XP_005274094
          Length = 713

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   LESRLDVD 9
           LESR++VD
Sbjct: 637 LESRMEVD 644
>XP_006718644
          Length = 862

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   LESRLDVD 9
           LESR++VD
Sbjct: 786 LESRMEVD 793
>XP_005274093
          Length = 862

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   LESRLDVD 9
           LESR++VD
Sbjct: 786 LESRMEVD 793
>XP_005274092
          Length = 885

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   LESRLDVD 9
           LESR++VD
Sbjct: 809 LESRMEVD 816
>NP_733751
          Length = 4911

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    GLESRLDVD 9
            GLE +LD D
Sbjct: 2684 GLEEKLDSD 2692
>XP_006716142
          Length = 4927

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    GLESRLDVD 9
            GLE +LD D
Sbjct: 2701 GLEEKLDSD 2709
>XP_005250088
          Length = 4928

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    GLESRLDVD 9
            GLE +LD D
Sbjct: 2701 GLEEKLDSD 2709
>XP_006716141
          Length = 4959

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    GLESRLDVD 9
            GLE +LD D
Sbjct: 2701 GLEEKLDSD 2709
>XP_005250085
          Length = 4979

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    GLESRLDVD 9
            GLE +LD D
Sbjct: 2701 GLEEKLDSD 2709
>XP_006716140
          Length = 4982

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    GLESRLDVD 9
            GLE +LD D
Sbjct: 2701 GLEEKLDSD 2709
>XP_005250084
          Length = 4982

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    GLESRLDVD 9
            GLE +LD D
Sbjct: 2701 GLEEKLDSD 2709
>XP_005250083
          Length = 4982

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    GLESRLDVD 9
            GLE +LD D
Sbjct: 2700 GLEEKLDSD 2708
>XP_005250082
          Length = 4983

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    GLESRLDVD 9
            GLE +LD D
Sbjct: 2701 GLEEKLDSD 2709
>NP_056075
          Length = 1162

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    GLESRLDVD 9
            G+ES  DVD
Sbjct: 1047 GVESACDVD 1055
>NP_000687
          Length = 518

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   ESRLDVD 9
           E+RLD+D
Sbjct: 129 EARLDID 135
>XP_006722767
          Length = 645

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   GLESRLDVD 9
           G+ES  DVD
Sbjct: 530 GVESACDVD 538
>XP_005259889
          Length = 1130

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    GLESRLDVD 9
            G+ES  DVD
Sbjct: 1015 GVESACDVD 1023
>NP_001495
          Length = 368

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   GLESRLDV 8
           G ESR+DV
Sbjct: 291 GRESRVDV 298
>NP_001136269
          Length = 415

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   GLESRLDV 8
           G ESR+DV
Sbjct: 338 GRESRVDV 345
>NP_001034456
          Length = 196

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   LESRLDV 8
           LESRLD+
Sbjct: 166 LESRLDL 172
>NP_001034455
          Length = 204

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   LESRLDV 8
           LESRLD+
Sbjct: 174 LESRLDL 180
>NP_001687
          Length = 226

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   LESRLDV 8
           LESRLD+
Sbjct: 196 LESRLDL 202
>NP_542384
          Length = 226

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   LESRLDV 8
           LESRLD+
Sbjct: 196 LESRLDL 202
>XP_005262313
          Length = 378

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   GLESRLDV 8
           G ESR+DV
Sbjct: 301 GRESRVDV 308
>XP_005272199
          Length = 1032

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   GLESRLDV 8
           G+ES++DV
Sbjct: 866 GIESQVDV 873
>XP_005264691
          Length = 226

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   LESRLDV 8
           LESRLD+
Sbjct: 196 LESRLDL 202
>XP_005264690
          Length = 226

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   LESRLDV 8
           LESRLD+
Sbjct: 196 LESRLDL 202
>NP_079290
          Length = 841

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   GLESRLDVD 9
           GL++R DV+
Sbjct: 174 GLQARADVN 182
>NP_776089
          Length = 841

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   GLESRLDVD 9
           GL++R DV+
Sbjct: 174 GLQARADVN 182
>NP_001128144
          Length = 233

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   GLESRLD 7
           GLE R+D
Sbjct: 153 GLEKRID 159
>NP_071346
          Length = 233

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   GLESRLD 7
           GLE R+D
Sbjct: 153 GLEKRID 159
>NP_001092740
          Length = 500

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   GLESRLDV 8
           GL+SR+++
Sbjct: 485 GLDSRMEI 492
>NP_037498
          Length = 822

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   LESRLD 7
           LESRLD
Sbjct: 118 LESRLD 123
>NP_002239
          Length = 543

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   LESRLD 7
           LESRLD
Sbjct: 485 LESRLD 490
>NP_001244088
          Length = 285

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  LESRLDVD 9
          ++SRLD D
Sbjct: 26 IKSRLDTD 33
>NP_115627
          Length = 1476

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   GLESRLDVD 9
           GLE RL+ +
Sbjct: 918 GLEQRLEAE 926
>NP_008949
          Length = 2325

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   LESRLD 7
           LESRLD
Sbjct: 574 LESRLD 579
>XP_005259964
          Length = 623

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   LESRLD 7
           LESRLD
Sbjct: 565 LESRLD 570
>XP_005259963
          Length = 626

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   LESRLD 7
           LESRLD
Sbjct: 568 LESRLD 573
>XP_005259962
          Length = 629

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   LESRLD 7
           LESRLD
Sbjct: 571 LESRLD 576
>XP_006721537
          Length = 777

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   GLESRLDVD 9
           GL++R DV+
Sbjct: 174 GLQARADVN 182
>XP_006718583
          Length = 1482

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   GLESRLDVD 9
           GLE RL+ +
Sbjct: 840 GLEQRLEAE 848
>XP_006718582
          Length = 1560

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   GLESRLDVD 9
           GLE RL+ +
Sbjct: 918 GLEQRLEAE 926
>XP_006718002
          Length = 233

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   GLESRLD 7
           GLE R+D
Sbjct: 153 GLEKRID 159
>XP_005270081
          Length = 240

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   GLESRLD 7
           GLE R+D
Sbjct: 160 GLEKRID 166
>XP_005252046
          Length = 514

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   GLESRLDV 8
           GL+SR+++
Sbjct: 499 GLDSRMEI 506
>XP_006717007
          Length = 1499

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   LESRLD 7
           LESRLD
Sbjct: 574 LESRLD 579
>XP_006717005
          Length = 1788

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  LESRLD 7
          LESRLD
Sbjct: 22 LESRLD 27
>XP_006717004
          Length = 2240

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   LESRLD 7
           LESRLD
Sbjct: 574 LESRLD 579
>XP_006717003
          Length = 2278

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   LESRLD 7
           LESRLD
Sbjct: 574 LESRLD 579
>XP_005251736
          Length = 2325

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   LESRLD 7
           LESRLD
Sbjct: 574 LESRLD 579
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.312    0.142    0.375 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 454,059
Number of extensions: 731
Number of successful extensions: 54
Number of sequences better than 10000.0: 54
Number of HSP's gapped: 54
Number of HSP's successfully gapped: 54
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.4 bits)
S2: 28 (15.4 bits)

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