Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_009297                                                              21     175
NP_001822                                                              17    3301
XP_006716347                                                           17    3301
NP_071737                                                              17    4312
NP_878905                                                              17    4312
NP_000311                                                              17    4312
XP_006713354                                                           17    4312
XP_005265446                                                           17    4312
XP_005265445                                                           17    4312
NP_001128350                                                           17    4312
NP_001193928                                                           16    5631
NP_004236                                                              16    5631
NP_963925                                                              16    5631
NP_009105                                                              16    5631
XP_005253886                                                           16    5631
XP_006719269                                                           16    5631
NP_001035351                                                           16    7355
NP_001035350                                                           16    7355
NP_078792                                                              16    7355
NP_066267                                                              16    7355
NP_001261                                                              16    7355
NP_001172029                                                           16    7355
NP_694995                                                              16    7355
NP_001186224                                                           16    7355
NP_006718                                                              16    7355
NP_001172028                                                           16    7355
NP_001074003                                                           16    7355
NP_001762                                                              16    7355
NP_001172030                                                           16    7355
XP_006726435                                                           16    7355
XP_005276248                                                           16    7355
XP_003960174                                                           16    7355
XP_006723191                                                           16    7355
XP_005254452                                                           16    7355
XP_005254451                                                           16    7355
XP_006717852                                                           16    7355
XP_006717851                                                           16    7355
XP_006717850                                                           16    7355
XP_006717849                                                           16    7355
XP_006717848                                                           16    7355
XP_006717847                                                           16    7355
XP_006717846                                                           16    7355
XP_006717845                                                           16    7355
XP_005271924                                                           16    7355
XP_005271923                                                           16    7355
XP_005262843                                                           16    7355
XP_005262842                                                           16    7355
XP_006711782                                                           16    7355
XP_005245759                                                           16    7355
XP_003846539                                                           16    7355
NP_001017975                                                           15    9605
NP_932327                                                              15    9605
NP_003860                                                              15    9605
NP_001035364                                                           15    9605
NP_060903                                                              15    9605
NP_001140160                                                           15    9605
NP_065922                                                              15    9605
NP_055565                                                              15    9605
NP_078800                                                              15    9605
NP_001139487                                                           15    9605
NP_001230892                                                           15    9605
NP_997221                                                              15    9605
XP_006724787                                                           15    9605
XP_006720493                                                           15    9605
XP_005272460                                                           15    9605
XP_006713805                                                           15    9605
XP_005269417                                                           15    9605
XP_005269415                                                           15    9605
XP_005269414                                                           15    9605
>NP_009297
          Length = 1149

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1  GKVLGDQKR 9
          GKVLGDQ+R
Sbjct: 6  GKVLGDQRR 14
>NP_001822
          Length = 449

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  GKVLGDQ 7
          G+VLGDQ
Sbjct: 18 GQVLGDQ 24
>XP_006716347
          Length = 501

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  GKVLGDQ 7
          G+VLGDQ
Sbjct: 70 GQVLGDQ 76
>NP_071737
          Length = 725

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   LGDQKR 9
           LGDQKR
Sbjct: 282 LGDQKR 287
>NP_878905
          Length = 790

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   LGDQKR 9
           LGDQKR
Sbjct: 282 LGDQKR 287
>NP_000311
          Length = 244

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  GKVLGDQK 8
          GK+LG++K
Sbjct: 72 GKLLGEEK 79
>XP_006713354
          Length = 748

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   LGDQKR 9
           LGDQKR
Sbjct: 240 LGDQKR 245
>XP_005265446
          Length = 758

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   LGDQKR 9
           LGDQKR
Sbjct: 315 LGDQKR 320
>XP_005265445
          Length = 823

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   LGDQKR 9
           LGDQKR
Sbjct: 315 LGDQKR 320
>NP_001128350
          Length = 790

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   LGDQKR 9
           LGDQKR
Sbjct: 282 LGDQKR 287
>NP_001193928
          Length = 2069

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   GKVLGDQK 8
           GK+L +QK
Sbjct: 799 GKILSEQK 806
>NP_004236
          Length = 638

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   GKVLGDQKR 9
           G++LG++K+
Sbjct: 240 GRILGNKKK 248
>NP_963925
          Length = 720

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   GKVLGDQKR 9
           G++LG++K+
Sbjct: 322 GRILGNKKK 330
>NP_009105
          Length = 2027

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   GKVLGDQK 8
           GK+L +QK
Sbjct: 757 GKILSEQK 764
>XP_005253886
          Length = 1545

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   GKVLGDQK 8
           GK+L +QK
Sbjct: 291 GKILSEQK 298
>XP_006719269
          Length = 2054

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   GKVLGDQK 8
           GK+L +QK
Sbjct: 799 GKILSEQK 806
>NP_001035351
          Length = 783

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   GKVLGD 6
           GKV+GD
Sbjct: 414 GKVIGD 419
>NP_001035350
          Length = 766

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   GKVLGD 6
           GKV+GD
Sbjct: 397 GKVIGD 402
>NP_078792
          Length = 254

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   KVLGDQKR 9
           KVL D KR
Sbjct: 203 KVLSDMKR 210
>NP_066267
          Length = 4377

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    KVLGDQKR 9
            KVLG+Q++
Sbjct: 3845 KVLGEQQK 3852
>NP_001261
          Length = 1710

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KVLGDQKR 9
           K+LG +KR
Sbjct: 204 KILGQKKR 211
>NP_001172029
          Length = 751

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  GKVLGDQKR 9
          GKV  +QKR
Sbjct: 83 GKVPSEQKR 91
>NP_694995
          Length = 627

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   GKVLGDQKR 9
           GKV   QKR
Sbjct: 522 GKVFSHQKR 530
>NP_001186224
          Length = 640

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   GKVLGDQKR 9
           GKV   QKR
Sbjct: 535 GKVFSHQKR 543
>NP_006718
          Length = 788

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  GKVLGDQKR 9
          GK+L  QKR
Sbjct: 46 GKILHRQKR 54
>NP_001172028
          Length = 759

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  GKVLGDQKR 9
          GKV  +QKR
Sbjct: 83 GKVPSEQKR 91
>NP_001074003
          Length = 2214

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    GKVLGDQKR 9
            G  LGD+KR
Sbjct: 2091 GPNLGDKKR 2099
>NP_001762
          Length = 847

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  GKVLGDQKR 9
          GKV  +QKR
Sbjct: 83 GKVPSEQKR 91
>NP_001172030
          Length = 670

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  GKVLGDQKR 9
          GKV  +QKR
Sbjct: 83 GKVPSEQKR 91
>XP_006726435
          Length = 274

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  GKVLGDQKR 9
          G++LG Q+R
Sbjct: 52 GRLLGAQRR 60
>XP_005276248
          Length = 224

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  GKVLGDQKR 9
          G++LG Q+R
Sbjct: 2  GRLLGAQRR 10
>XP_003960174
          Length = 299

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  GKVLGDQKR 9
          G++LG Q+R
Sbjct: 77 GRLLGAQRR 85
>XP_006723191
          Length = 618

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   GKVLGDQKR 9
           GKV   QKR
Sbjct: 513 GKVFSHQKR 521
>XP_005254452
          Length = 2188

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    GKVLGDQKR 9
            G  LGD+KR
Sbjct: 2065 GPNLGDKKR 2073
>XP_005254451
          Length = 2214

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    GKVLGDQKR 9
            G  LGD+KR
Sbjct: 2091 GPNLGDKKR 2099
>XP_006717852
          Length = 3508

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    KVLGDQKR 9
            KVLG+Q++
Sbjct: 2976 KVLGEQQK 2983
>XP_006717851
          Length = 3513

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    KVLGDQKR 9
            KVLG+Q++
Sbjct: 2981 KVLGEQQK 2988
>XP_006717850
          Length = 4364

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    KVLGDQKR 9
            KVLG+Q++
Sbjct: 3832 KVLGEQQK 3839
>XP_006717849
          Length = 4383

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    KVLGDQKR 9
            KVLG+Q++
Sbjct: 3851 KVLGEQQK 3858
>XP_006717848
          Length = 4392

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    KVLGDQKR 9
            KVLG+Q++
Sbjct: 3860 KVLGEQQK 3867
>XP_006717847
          Length = 4395

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    KVLGDQKR 9
            KVLG+Q++
Sbjct: 3863 KVLGEQQK 3870
>XP_006717846
          Length = 4396

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    KVLGDQKR 9
            KVLG+Q++
Sbjct: 3864 KVLGEQQK 3871
>XP_006717845
          Length = 4397

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    KVLGDQKR 9
            KVLG+Q++
Sbjct: 3865 KVLGEQQK 3872
>XP_005271924
          Length = 1710

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KVLGDQKR 9
           K+LG +KR
Sbjct: 204 KILGQKKR 211
>XP_005271923
          Length = 1798

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KVLGDQKR 9
           K+LG +KR
Sbjct: 204 KILGQKKR 211
>XP_005262843
          Length = 765

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   GKVLGD 6
           GKV+GD
Sbjct: 396 GKVIGD 401
>XP_005262842
          Length = 782

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   GKVLGD 6
           GKV+GD
Sbjct: 413 GKVIGD 418
>XP_006711782
          Length = 274

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  GKVLGDQKR 9
          G++LG Q+R
Sbjct: 52 GRLLGAQRR 60
>XP_005245759
          Length = 224

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  GKVLGDQKR 9
          G++LG Q+R
Sbjct: 2  GRLLGAQRR 10
>XP_003846539
          Length = 299

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  GKVLGDQKR 9
          G++LG Q+R
Sbjct: 77 GRLLGAQRR 85
>NP_001017975
          Length = 1435

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  KVLGDQKR 9
          K+LG +KR
Sbjct: 59 KLLGQEKR 66
>NP_932327
          Length = 607

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  GKVLGDQKR 9
          G+ LG+Q+R
Sbjct: 44 GQPLGEQQR 52
>NP_003860
          Length = 623

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  GKVLGDQKR 9
          G+ LG+Q+R
Sbjct: 44 GQPLGEQQR 52
>NP_001035364
          Length = 812

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   LGDQKR 9
           LGDQ+R
Sbjct: 286 LGDQRR 291
>NP_060903
          Length = 1321

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KVLGDQKR 9
           + LGDQ+R
Sbjct: 132 RFLGDQQR 139
>NP_001140160
          Length = 1321

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KVLGDQKR 9
           + LGDQ+R
Sbjct: 132 RFLGDQQR 139
>NP_065922
          Length = 765

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   LGDQKR 9
           LGD+KR
Sbjct: 447 LGDEKR 452
>NP_055565
          Length = 846

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3  VLGDQKR 9
          +LGDQ++
Sbjct: 85 ILGDQRK 91
>NP_078800
          Length = 1226

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   KVLGDQK 8
           +VLGD+K
Sbjct: 640 RVLGDRK 646
>NP_001139487
          Length = 842

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3  VLGDQKR 9
          +LGDQ++
Sbjct: 85 ILGDQRK 91
>NP_001230892
          Length = 748

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   LGDQKR 9
           LGD+KR
Sbjct: 447 LGDEKR 452
>NP_997221
          Length = 567

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  GKVLGDQ 7
          GKVLG++
Sbjct: 75 GKVLGNE 81
>XP_006724787
          Length = 601

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   LGDQKR 9
           LGD+KR
Sbjct: 283 LGDEKR 288
>XP_006720493
          Length = 567

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  GKVLGDQ 7
          GKVLG++
Sbjct: 75 GKVLGNE 81
>XP_005272460
          Length = 563

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   GKVLGD 6
           GK+LGD
Sbjct: 254 GKLLGD 259
>XP_006713805
          Length = 1074

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   KVLGDQK 8
           +VLGD+K
Sbjct: 458 RVLGDRK 464
>XP_005269417
          Length = 1104

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   KVLGDQK 8
           +VLGD+K
Sbjct: 640 RVLGDRK 646
>XP_005269415
          Length = 1229

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   KVLGDQK 8
           +VLGD+K
Sbjct: 613 RVLGDRK 619
>XP_005269414
          Length = 1256

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   KVLGDQK 8
           +VLGD+K
Sbjct: 640 RVLGDRK 646
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.313    0.142    0.396 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 651,246
Number of extensions: 1288
Number of successful extensions: 69
Number of sequences better than 10000.0: 69
Number of HSP's gapped: 69
Number of HSP's successfully gapped: 69
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.5 bits)
S2: 28 (15.4 bits)

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