Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_789765                                                              21     229
NP_001123914                                                           21     229
NP_005334                                                              21     229
NP_004976                                                              21     229
NP_203524                                                              21     229
NP_002515                                                              21     229
XP_006725199                                                           21     229
XP_006719132                                                           21     229
XP_006718280                                                           21     229
NP_001078518                                                           19     665
NP_036351                                                              19     665
NP_001239019                                                           19     665
XP_005247286                                                           19     665
XP_005247285                                                           19     665
NP_001170785                                                           18    1935
NP_036382                                                              18    1935
NP_006261                                                              18    1935
XP_006716564                                                           17    2528
NP_005393                                                              17    3301
NP_002872                                                              17    3301
XP_006715826                                                           17    3301
XP_006715825                                                           17    3301
XP_005263786                                                           17    3301
XP_005263785                                                           17    3301
XP_005263784                                                           17    3301
XP_005263781                                                           17    3301
NP_002429                                                              17    4312
NP_115597                                                              17    4312
XP_006723946                                                           17    4312
XP_005260632                                                           17    4312
XP_005260631                                                           17    4312
XP_005260630                                                           17    4312
NP_001238850                                                           16    5631
NP_001656                                                              16    5631
XP_005252973                                                           16    5631
NP_060250                                                              16    7355
NP_001810                                                              16    7355
XP_006726478                                                           16    7355
XP_006716523                                                           16    7355
XP_006716522                                                           16    7355
XP_005251324                                                           16    7355
XP_005251323                                                           16    7355
XP_006714496                                                           16    7355
XP_006710224                                                           16    7355
NP_573400                                                              15    9605
NP_008981                                                              15    9605
NP_079510                                                              15    9605
NP_055719                                                              15    9605
NP_001166169                                                           15    9605
NP_001026883                                                           15    9605
NP_573570                                                              15    9605
NP_001166170                                                           15    9605
NP_003105                                                              15    9605
NP_757367                                                              15    9605
NP_001189358                                                           15    9605
NP_057455                                                              15    9605
XP_006725228                                                           15    9605
XP_006723752                                                           15    9605
XP_006723751                                                           15    9605
XP_006723750                                                           15    9605
XP_006723749                                                           15    9605
XP_006723748                                                           15    9605
XP_005254755                                                           15    9605
XP_005267815                                                           15    9605
XP_005269686                                                           15    9605
XP_006716682                                                           15    9605
XP_005268429                                                           15    9605
XP_006711443                                                           15    9605
>NP_789765
          Length = 170

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1  GKEEYSAMR 9
          G+EEYSAMR
Sbjct: 60 GQEEYSAMR 68
>NP_001123914
          Length = 189

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1  GKEEYSAMR 9
          G+EEYSAMR
Sbjct: 60 GQEEYSAMR 68
>NP_005334
          Length = 189

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1  GKEEYSAMR 9
          G+EEYSAMR
Sbjct: 60 GQEEYSAMR 68
>NP_004976
          Length = 188

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1  GKEEYSAMR 9
          G+EEYSAMR
Sbjct: 60 GQEEYSAMR 68
>NP_203524
          Length = 189

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1  GKEEYSAMR 9
          G+EEYSAMR
Sbjct: 60 GQEEYSAMR 68
>NP_002515
          Length = 189

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1  GKEEYSAMR 9
          G+EEYSAMR
Sbjct: 60 GQEEYSAMR 68
>XP_006725199
          Length = 170

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1  GKEEYSAMR 9
          G+EEYSAMR
Sbjct: 60 GQEEYSAMR 68
>XP_006719132
          Length = 189

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1  GKEEYSAMR 9
          G+EEYSAMR
Sbjct: 60 GQEEYSAMR 68
>XP_006718280
          Length = 170

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1  GKEEYSAMR 9
          G+EEYSAMR
Sbjct: 60 GQEEYSAMR 68
>NP_001078518
          Length = 208

 Score = 19.2 bits (38), Expect =   665
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1  GKEEYSAMR 9
          G+EE+SAMR
Sbjct: 70 GQEEFSAMR 78
>NP_036351
          Length = 208

 Score = 19.2 bits (38), Expect =   665
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1  GKEEYSAMR 9
          G+EE+SAMR
Sbjct: 70 GQEEFSAMR 78
>NP_001239019
          Length = 208

 Score = 19.2 bits (38), Expect =   665
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1  GKEEYSAMR 9
          G+EE+SAMR
Sbjct: 70 GQEEFSAMR 78
>XP_005247286
          Length = 170

 Score = 19.2 bits (38), Expect =   665
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1  GKEEYSAMR 9
          G+EE+SAMR
Sbjct: 70 GQEEFSAMR 78
>XP_005247285
          Length = 208

 Score = 19.2 bits (38), Expect =   665
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1  GKEEYSAMR 9
          G+EE+SAMR
Sbjct: 70 GQEEFSAMR 78
>NP_001170785
          Length = 169

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  GKEEYSAMR 9
          G+EE+ AMR
Sbjct: 36 GQEEFGAMR 44
>NP_036382
          Length = 204

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  GKEEYSAMR 9
          G+EE+ AMR
Sbjct: 71 GQEEFGAMR 79
>NP_006261
          Length = 218

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  GKEEYSAMR 9
          G+EE+ AMR
Sbjct: 86 GQEEFGAMR 94
>XP_006716564
          Length = 1185

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   GKEEYSAMR 9
           GK+ YS MR
Sbjct: 634 GKQNYSQMR 642
>NP_005393
          Length = 206

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1  GKEEYSAMR 9
          G+E+Y+A+R
Sbjct: 71 GQEDYAAIR 79
>NP_002872
          Length = 206

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1  GKEEYSAMR 9
          G+E+Y+A+R
Sbjct: 71 GQEDYAAIR 79
>XP_006715826
          Length = 206

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1  GKEEYSAMR 9
          G+E+Y+A+R
Sbjct: 71 GQEDYAAIR 79
>XP_006715825
          Length = 206

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1  GKEEYSAMR 9
          G+E+Y+A+R
Sbjct: 71 GQEDYAAIR 79
>XP_005263786
          Length = 206

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1  GKEEYSAMR 9
          G+E+Y+A+R
Sbjct: 71 GQEDYAAIR 79
>XP_005263785
          Length = 206

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1  GKEEYSAMR 9
          G+E+Y+A+R
Sbjct: 71 GQEDYAAIR 79
>XP_005263784
          Length = 206

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1  GKEEYSAMR 9
          G+E+Y+A+R
Sbjct: 71 GQEDYAAIR 79
>XP_005263781
          Length = 228

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   GKEEYSAMR 9
           G+E+Y+A+R
Sbjct: 93  GQEDYAAIR 101
>NP_002429
          Length = 1456

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    GKEEYSAMR 9
            GK  YS MR
Sbjct: 1103 GKSSYSLMR 1111
>NP_115597
          Length = 2715

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    GKEEYSAMR 9
            G E Y+AMR
Sbjct: 1293 GYERYNAMR 1301
>XP_006723946
          Length = 1414

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    GKEEYSAMR 9
            G E Y+AMR
Sbjct: 1293 GYERYNAMR 1301
>XP_005260632
          Length = 2377

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    GKEEYSAMR 9
            G E Y+AMR
Sbjct: 1293 GYERYNAMR 1301
>XP_005260631
          Length = 2667

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    GKEEYSAMR 9
            G E Y+AMR
Sbjct: 1245 GYERYNAMR 1253
>XP_005260630
          Length = 2693

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    GKEEYSAMR 9
            G E Y+AMR
Sbjct: 1271 GYERYNAMR 1279
>NP_001238850
          Length = 165

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  KEEYSAMR 9
          KE+++AMR
Sbjct: 42 KEQFTAMR 49
>NP_001656
          Length = 191

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  GKEEYSAMR 9
          G+EEY  +R
Sbjct: 60 GQEEYDRLR 68
>XP_005252973
          Length = 191

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  GKEEYSAMR 9
          G+EEY  +R
Sbjct: 60 GQEEYDRLR 68
>NP_060250
          Length = 2997

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    GKEEYSAMR 9
            G E+Y++MR
Sbjct: 1802 GYEKYNSMR 1810
>NP_001810
          Length = 677

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   GKEEYSAMR 9
           G EEY A R
Sbjct: 366 GSEEYRAPR 374
>XP_006726478
          Length = 532

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   GKEEYSAM 8
           GKE+YS +
Sbjct: 462 GKEKYSEL 469
>XP_006716523
          Length = 1912

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   GKEEYSAMR 9
           G E+Y++MR
Sbjct: 717 GYEKYNSMR 725
>XP_006716522
          Length = 2192

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    GKEEYSAMR 9
            G E+Y++MR
Sbjct: 997  GYEKYNSMR 1005
>XP_005251324
          Length = 2996

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    GKEEYSAMR 9
            G E+Y++MR
Sbjct: 1802 GYEKYNSMR 1810
>XP_005251323
          Length = 2997

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    GKEEYSAMR 9
            G E+Y++MR
Sbjct: 1802 GYEKYNSMR 1810
>XP_006714496
          Length = 532

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   GKEEYSAM 8
           GKE+YS +
Sbjct: 462 GKEKYSEL 469
>XP_006710224
          Length = 532

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   GKEEYSAM 8
           GKE+YS +
Sbjct: 462 GKEKYSEL 469
>NP_573400
          Length = 1460

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   KEEYSAM 8
           KEEY A+
Sbjct: 909 KEEYEAL 915
>NP_008981
          Length = 1441

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   KEEYSAM 8
           KEEY A+
Sbjct: 890 KEEYEAL 896
>NP_079510
          Length = 305

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   GKEEYS 6
           GK+EYS
Sbjct: 138 GKKEYS 143
>NP_055719
          Length = 512

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  GKEEYS 6
          GKE+YS
Sbjct: 43 GKEKYS 48
>NP_001166169
          Length = 984

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   GKEEYSAM 8
           GK +Y AM
Sbjct: 963 GKSKYEAM 970
>NP_001026883
          Length = 359

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KEEYSAMR 9
           K E+SA+R
Sbjct: 236 KSEFSALR 243
>NP_573570
          Length = 1023

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    GKEEYSAM 8
            GK +Y AM
Sbjct: 1002 GKSKYEAM 1009
>NP_001166170
          Length = 959

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   GKEEYSAM 8
           GK +Y AM
Sbjct: 938 GKSKYEAM 945
>NP_003105
          Length = 926

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   GKEEYS 6
           GKE+YS
Sbjct: 141 GKEKYS 146
>NP_757367
          Length = 926

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   GKEEYS 6
           GKE+YS
Sbjct: 141 GKEKYS 146
>NP_001189358
          Length = 635

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  GKEEYS 6
          G+EEYS
Sbjct: 15 GQEEYS 20
>NP_057455
          Length = 341

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   GKEEYSAMR 9
           GKE YS+ +
Sbjct: 189 GKEPYSSSK 197
>XP_006725228
          Length = 635

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  GKEEYS 6
          G+EEYS
Sbjct: 15 GQEEYS 20
>XP_006723752
          Length = 1387

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   KEEYSAM 8
           KEEY A+
Sbjct: 836 KEEYEAL 842
>XP_006723751
          Length = 1427

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   KEEYSAM 8
           KEEY A+
Sbjct: 835 KEEYEAL 841
>XP_006723750
          Length = 1427

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   KEEYSAM 8
           KEEY A+
Sbjct: 835 KEEYEAL 841
>XP_006723749
          Length = 1428

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   KEEYSAM 8
           KEEY A+
Sbjct: 836 KEEYEAL 842
>XP_006723748
          Length = 1437

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   KEEYSAM 8
           KEEY A+
Sbjct: 845 KEEYEAL 851
>XP_005254755
          Length = 305

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   GKEEYS 6
           GK+EYS
Sbjct: 138 GKKEYS 143
>XP_005267815
          Length = 635

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  GKEEYS 6
          G+EEYS
Sbjct: 15 GQEEYS 20
>XP_005269686
          Length = 532

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  GKEEYS 6
          GKE+YS
Sbjct: 43 GKEKYS 48
>XP_006716682
          Length = 926

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   GKEEYS 6
           GKE+YS
Sbjct: 141 GKEKYS 146
>XP_005268429
          Length = 1002

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   GKEEYSAM 8
           GK +Y AM
Sbjct: 981 GKSKYEAM 988
>XP_006711443
          Length = 218

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   GKEEYSAMR 9
           GKE YS+ +
Sbjct: 189 GKEPYSSSK 197
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.302    0.119    0.309 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 690,899
Number of extensions: 1373
Number of successful extensions: 68
Number of sequences better than 10000.0: 68
Number of HSP's gapped: 68
Number of HSP's successfully gapped: 68
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.3 bits)
S2: 28 (15.4 bits)

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