Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001245200                                                           22     134
NP_000240                                                              22     134
NP_001161089                                                           22     134
XP_005265218                                                           22     134
NP_697019                                                              18    1482
NP_001138845                                                           17    3301
NP_065684                                                              17    4312
NP_149037                                                              17    4312
NP_001121138                                                           17    4312
NP_001121139                                                           17    4312
NP_001121137                                                           17    4312
NP_001121135                                                           17    4312
NP_001121134                                                           17    4312
NP_003137                                                              17    4312
NP_001244959                                                           17    4312
NP_001244958                                                           17    4312
NP_001171700                                                           17    4312
XP_005274251                                                           17    4312
XP_005252002                                                           17    4312
XP_005252001                                                           17    4312
XP_006717142                                                           17    4312
XP_005252000                                                           17    4312
XP_006717141                                                           17    4312
XP_006717140                                                           17    4312
XP_006717139                                                           17    4312
XP_005251997                                                           17    4312
XP_006717138                                                           17    4312
NP_001121136                                                           17    4312
NP_000168                                                              17    4312
NP_937895                                                              17    4312
NP_653197                                                              16    5631
NP_001275710                                                           16    5631
NP_938051                                                              16    5631
NP_938052                                                              16    5631
NP_001275711                                                           16    5631
NP_653312                                                              16    5631
NP_001186219                                                           16    5631
NP_663627                                                              16    5631
XP_006720100                                                           16    5631
XP_006720099                                                           16    5631
XP_006720098                                                           16    5631
NP_997217                                                              16    5631
NP_060140                                                              16    7355
NP_001265577                                                           16    7355
NP_001139811                                                           16    7355
NP_997203                                                              16    7355
NP_075601                                                              16    7355
NP_937878                                                              16    7355
NP_001265576                                                           16    7355
NP_005332                                                              16    7355
XP_003960787                                                           16    7355
XP_006725234                                                           16    7355
XP_003118801                                                           16    7355
XP_005268112                                                           16    7355
XP_006710655                                                           16    7355
XP_003119723                                                           16    7355
NP_937875                                                              16    7355
NP_002924                                                              16    7355
NP_937877                                                              16    7355
NP_004906                                                              15    9605
NP_997511                                                              15    9605
NP_058198                                                              15    9605
NP_997512                                                              15    9605
NP_997510                                                              15    9605
NP_997057                                                              15    9605
NP_001014440                                                           15    9605
NP_001229877                                                           15    9605
XP_006724480                                                           15    9605
XP_005261978                                                           15    9605
XP_006724479                                                           15    9605
XP_005261975                                                           15    9605
XP_006724478                                                           15    9605
NP_001135938                                                           15    9605
NP_597700                                                              15    9605
>NP_001245200
          Length = 687

 Score = 21.6 bits (44), Expect =   134
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   GKCAYRAS 8
           GKCAYRAS
Sbjct: 122 GKCAYRAS 129
>NP_000240
          Length = 756

 Score = 21.6 bits (44), Expect =   134
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   GKCAYRAS 8
           GKCAYRAS
Sbjct: 122 GKCAYRAS 129
>NP_001161089
          Length = 658

 Score = 21.6 bits (44), Expect =   134
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1  GKCAYRAS 8
          GKCAYRAS
Sbjct: 24 GKCAYRAS 31
>XP_005265218
          Length = 687

 Score = 21.6 bits (44), Expect =   134
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   GKCAYRAS 8
           GKCAYRAS
Sbjct: 122 GKCAYRAS 129
>NP_697019
          Length = 67

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1  GKCAYRAS 8
          GKC YR S
Sbjct: 30 GKCRYRCS 37
>NP_001138845
          Length = 481

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   GKCAYRASS 9
           G C YRA S
Sbjct: 318 GNCLYRAVS 326
>NP_065684
          Length = 353

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   GKCAYRAS 8
           G C+Y+AS
Sbjct: 206 GYCSYKAS 213
>NP_149037
          Length = 301

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   GKCAYRA 7
           GKC +RA
Sbjct: 225 GKCRFRA 231
>NP_001121138
          Length = 742

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   GKCAYRAS 8
           GK AYR S
Sbjct: 607 GKAAYRTS 614
>NP_001121139
          Length = 742

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   GKCAYRAS 8
           GK AYR S
Sbjct: 607 GKAAYRTS 614
>NP_001121137
          Length = 731

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   GKCAYRAS 8
           GK AYR S
Sbjct: 596 GKAAYRTS 603
>NP_001121135
          Length = 767

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   GKCAYRAS 8
           GK AYR S
Sbjct: 632 GKAAYRTS 639
>NP_001121134
          Length = 731

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   GKCAYRAS 8
           GK AYR S
Sbjct: 596 GKAAYRTS 603
>NP_003137
          Length = 709

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   CAYRASS 9
           C+Y+ASS
Sbjct: 343 CSYKASS 349
>NP_001244959
          Length = 739

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   GKCAYRAS 8
           GK AYR S
Sbjct: 604 GKAAYRTS 611
>NP_001244958
          Length = 748

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   GKCAYRAS 8
           GK AYR S
Sbjct: 613 GKAAYRTS 620
>NP_001171700
          Length = 301

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   GKCAYRA 7
           GKC +RA
Sbjct: 225 GKCRFRA 231
>XP_005274251
          Length = 712

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   CAYRASS 9
           C+Y+ASS
Sbjct: 343 CSYKASS 349
>XP_005252002
          Length = 731

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   GKCAYRAS 8
           GK AYR S
Sbjct: 596 GKAAYRTS 603
>XP_005252001
          Length = 742

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   GKCAYRAS 8
           GK AYR S
Sbjct: 607 GKAAYRTS 614
>XP_006717142
          Length = 742

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   GKCAYRAS 8
           GK AYR S
Sbjct: 607 GKAAYRTS 614
>XP_005252000
          Length = 742

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   GKCAYRAS 8
           GK AYR S
Sbjct: 607 GKAAYRTS 614
>XP_006717141
          Length = 742

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   GKCAYRAS 8
           GK AYR S
Sbjct: 607 GKAAYRTS 614
>XP_006717140
          Length = 742

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   GKCAYRAS 8
           GK AYR S
Sbjct: 607 GKAAYRTS 614
>XP_006717139
          Length = 742

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   GKCAYRAS 8
           GK AYR S
Sbjct: 607 GKAAYRTS 614
>XP_005251997
          Length = 752

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   GKCAYRAS 8
           GK AYR S
Sbjct: 617 GKAAYRTS 624
>XP_006717138
          Length = 820

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   GKCAYRAS 8
           GK AYR S
Sbjct: 685 GKAAYRTS 692
>NP_001121136
          Length = 731

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   GKCAYRAS 8
           GK AYR S
Sbjct: 596 GKAAYRTS 603
>NP_000168
          Length = 782

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   GKCAYRAS 8
           GK AYR S
Sbjct: 647 GKAAYRTS 654
>NP_937895
          Length = 731

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   GKCAYRAS 8
           GK AYR S
Sbjct: 596 GKAAYRTS 603
>NP_653197
          Length = 515

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   GKCAYR 6
           GKC YR
Sbjct: 232 GKCYYR 237
>NP_001275710
          Length = 531

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   GKCAYR 6
           GKC YR
Sbjct: 248 GKCYYR 253
>NP_938051
          Length = 505

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   GKCAYR 6
           GKC YR
Sbjct: 222 GKCYYR 227
>NP_938052
          Length = 475

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   GKCAYR 6
           GKC YR
Sbjct: 192 GKCYYR 197
>NP_001275711
          Length = 317

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1  GKCAYR 6
          GKC YR
Sbjct: 34 GKCYYR 39
>NP_653312
          Length = 558

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 5/8 (62%)

Query: 1   GKCAYRAS 8
           G C YR S
Sbjct: 423 GHCGYRGS 430
>NP_001186219
          Length = 558

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 5/8 (62%)

Query: 1   GKCAYRAS 8
           G C YR S
Sbjct: 423 GHCGYRGS 430
>NP_663627
          Length = 123

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 2  KCAYRA 7
          KC YRA
Sbjct: 60 KCCYRA 65
>XP_006720100
          Length = 475

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   GKCAYR 6
           GKC YR
Sbjct: 192 GKCYYR 197
>XP_006720099
          Length = 477

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   GKCAYR 6
           GKC YR
Sbjct: 222 GKCYYR 227
>XP_006720098
          Length = 505

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   GKCAYR 6
           GKC YR
Sbjct: 222 GKCYYR 227
>NP_997217
          Length = 329

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 2   KCAYR 6
           KCAYR
Sbjct: 243 KCAYR 247
>NP_060140
          Length = 271

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 1  GKCAYRA 7
          G C YRA
Sbjct: 89 GNCFYRA 95
>NP_001265577
          Length = 688

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KCAYRASS 9
           +C +RASS
Sbjct: 440 ECGHRASS 447
>NP_001139811
          Length = 285

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  CAYRAS 8
          CA+RAS
Sbjct: 49 CAFRAS 54
>NP_997203
          Length = 288

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 1   GKCAYRA 7
           G C YRA
Sbjct: 150 GHCMYRA 156
>NP_075601
          Length = 234

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 1  GKCAYRA 7
          G C YRA
Sbjct: 49 GNCFYRA 55
>NP_937878
          Length = 156

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 3   CAYRAS 8
           CAYR S
Sbjct: 123 CAYRTS 128
>NP_001265576
          Length = 688

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KCAYRASS 9
           +C +RASS
Sbjct: 440 ECGHRASS 447
>NP_005332
          Length = 688

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KCAYRASS 9
           +C +RASS
Sbjct: 440 ECGHRASS 447
>XP_003960787
          Length = 675

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 5/6 (83%)

Query: 1   GKCAYR 6
           G+C YR
Sbjct: 467 GRCTYR 472
>XP_006725234
          Length = 235

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 1  GKCAYRA 7
          G C YRA
Sbjct: 50 GNCFYRA 56
>XP_003118801
          Length = 675

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 5/6 (83%)

Query: 1   GKCAYR 6
           G+C YR
Sbjct: 467 GRCTYR 472
>XP_005268112
          Length = 235

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 1  GKCAYRA 7
          G C YRA
Sbjct: 50 GNCFYRA 56
>XP_006710655
          Length = 346

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KCAYRASS 9
           +C +RASS
Sbjct: 98  ECGHRASS 105
>XP_003119723
          Length = 675

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 5/6 (83%)

Query: 1   GKCAYR 6
           G+C YR
Sbjct: 467 GRCTYR 472
>NP_937875
          Length = 156

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 3   CAYRAS 8
           CAYR S
Sbjct: 123 CAYRTS 128
>NP_002924
          Length = 156

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 3   CAYRAS 8
           CAYR S
Sbjct: 123 CAYRTS 128
>NP_937877
          Length = 156

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 3   CAYRAS 8
           CAYR S
Sbjct: 123 CAYRTS 128
>NP_004906
          Length = 678

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 5/6 (83%)

Query: 1   GKCAYR 6
           G+C YR
Sbjct: 293 GQCVYR 298
>NP_997511
          Length = 644

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 5/6 (83%)

Query: 1   GKCAYR 6
           G+C YR
Sbjct: 271 GQCVYR 276
>NP_058198
          Length = 666

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 5/6 (83%)

Query: 1   GKCAYR 6
           G+C YR
Sbjct: 293 GQCVYR 298
>NP_997512
          Length = 663

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 5/6 (83%)

Query: 1   GKCAYR 6
           G+C YR
Sbjct: 290 GQCVYR 295
>NP_997510
          Length = 668

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 5/6 (83%)

Query: 1   GKCAYR 6
           G+C YR
Sbjct: 295 GQCVYR 300
>NP_997057
          Length = 677

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 5/6 (83%)

Query: 1   GKCAYR 6
           G+C YR
Sbjct: 304 GQCVYR 309
>NP_001014440
          Length = 253

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   GKCAYRASS 9
           G CAY+  S
Sbjct: 183 GPCAYQVVS 191
>NP_001229877
          Length = 163

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1  GKCAYR 6
          G+CA+R
Sbjct: 7  GRCAHR 12
>XP_006724480
          Length = 178

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   GKCAYRASS 9
           G CAY+  S
Sbjct: 108 GPCAYQVVS 116
>XP_005261978
          Length = 185

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   GKCAYRASS 9
           G CAY+  S
Sbjct: 115 GPCAYQVVS 123
>XP_006724479
          Length = 204

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   GKCAYRASS 9
           G CAY+  S
Sbjct: 143 GPCAYQVVS 151
>XP_005261975
          Length = 253

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   GKCAYRASS 9
           G CAY+  S
Sbjct: 183 GPCAYQVVS 191
>XP_006724478
          Length = 272

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   GKCAYRASS 9
           G CAY+  S
Sbjct: 211 GPCAYQVVS 219
>NP_001135938
          Length = 423

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 5/6 (83%)

Query: 1   GKCAYR 6
           G+C YR
Sbjct: 245 GECGYR 250
>NP_597700
          Length = 523

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 5/6 (83%)

Query: 1   GKCAYR 6
           G+C YR
Sbjct: 345 GECGYR 350
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.316    0.120    0.378 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 594,346
Number of extensions: 679
Number of successful extensions: 74
Number of sequences better than 10000.0: 74
Number of HSP's gapped: 74
Number of HSP's successfully gapped: 74
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.8 bits)
S2: 28 (15.4 bits)

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