Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001245200                                                           18    1935
NP_000240                                                              18    1935
NP_001161089                                                           18    1935
NP_001171765                                                           18    1935
NP_001171764                                                           18    1935
NP_001073327                                                           18    1935
NP_001171766                                                           18    1935
NP_001171763                                                           18    1935
NP_001171762                                                           18    1935
NP_005747                                                              18    1935
NP_001073328                                                           18    1935
NP_001073329                                                           18    1935
NP_001002909                                                           18    1935
XP_006724519                                                           18    1935
XP_006724518                                                           18    1935
XP_006724517                                                           18    1935
XP_006724516                                                           18    1935
XP_006724515                                                           18    1935
XP_006724514                                                           18    1935
XP_006724513                                                           18    1935
XP_006724512                                                           18    1935
XP_006721846                                                           18    1935
XP_006721845                                                           18    1935
XP_006721844                                                           18    1935
XP_005265218                                                           18    1935
NP_067047                                                              17    2528
XP_006717281                                                           17    2528
XP_006717279                                                           17    2528
XP_006717278                                                           17    2528
XP_006717277                                                           17    2528
XP_006717276                                                           17    2528
XP_006717275                                                           17    2528
XP_006717274                                                           17    2528
XP_006717273                                                           17    2528
XP_006717272                                                           17    2528
NP_001273675                                                           17    4312
NP_001273676                                                           17    4312
NP_079084                                                              17    4312
XP_006719931                                                           17    4312
NP_001272984                                                           16    5631
NP_001830                                                              16    5631
NP_003239                                                              16    5631
XP_006722711                                                           16    5631
NP_001290                                                              16    5631
NP_002435                                                              16    7355
NP_001004757                                                           16    7355
NP_006181                                                              16    7355
NP_055646                                                              16    7355
XP_005262326                                                           16    7355
XP_006713495                                                           16    7355
XP_006712618                                                           16    7355
NP_001073291                                                           15    9605
NP_000417                                                              15    9605
NP_002448                                                              15    9605
NP_000607                                                              15    9605
NP_001181943                                                           15    9605
NP_001135997                                                           15    9605
NP_001135998                                                           15    9605
NP_085142                                                              15    9605
NP_001136000                                                           15    9605
NP_001135999                                                           15    9605
NP_001136001                                                           15    9605
NP_001136002                                                           15    9605
NP_001135996                                                           15    9605
NP_002526                                                              15    9605
NP_919247                                                              15    9605
NP_058197                                                              15    9605
NP_922932                                                              15    9605
NP_079402                                                              15    9605
XP_005267039                                                           15    9605
XP_005267038                                                           15    9605
>NP_001245200
          Length = 687

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   GISFSVKNK 9
           GISFSVK +
Sbjct: 189 GISFSVKKQ 197
>NP_000240
          Length = 756

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   GISFSVKNK 9
           GISFSVK +
Sbjct: 189 GISFSVKKQ 197
>NP_001161089
          Length = 658

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  GISFSVKNK 9
          GISFSVK +
Sbjct: 91 GISFSVKKQ 99
>NP_001171765
          Length = 993

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   GISFSVKN 8
           G+SFSV+N
Sbjct: 941 GVSFSVQN 948
>NP_001171764
          Length = 979

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   GISFSVKN 8
           G+SFSV+N
Sbjct: 927 GVSFSVQN 934
>NP_001073327
          Length = 1017

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   GISFSVKN 8
           G+SFSV+N
Sbjct: 965 GVSFSVQN 972
>NP_001171766
          Length = 987

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   GISFSVKN 8
           G+SFSV+N
Sbjct: 935 GVSFSVQN 942
>NP_001171763
          Length = 966

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   GISFSVKN 8
           G+SFSV+N
Sbjct: 914 GVSFSVQN 921
>NP_001171762
          Length = 1001

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   GISFSVKN 8
           G+SFSV+N
Sbjct: 949 GVSFSVQN 956
>NP_005747
          Length = 1014

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   GISFSVKN 8
           G+SFSV+N
Sbjct: 962 GVSFSVQN 969
>NP_001073328
          Length = 1003

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   GISFSVKN 8
           G+SFSV+N
Sbjct: 951 GVSFSVQN 958
>NP_001073329
          Length = 995

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   GISFSVKN 8
           G+SFSV+N
Sbjct: 943 GVSFSVQN 950
>NP_001002909
          Length = 1502

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   GISFSVKN 8
           GISF +KN
Sbjct: 282 GISFGIKN 289
>XP_006724519
          Length = 1017

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   GISFSVKN 8
           G+SFSV+N
Sbjct: 965 GVSFSVQN 972
>XP_006724518
          Length = 1017

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   GISFSVKN 8
           G+SFSV+N
Sbjct: 965 GVSFSVQN 972
>XP_006724517
          Length = 1025

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   GISFSVKN 8
           G+SFSV+N
Sbjct: 973 GVSFSVQN 980
>XP_006724516
          Length = 1031

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   GISFSVKN 8
           G+SFSV+N
Sbjct: 979 GVSFSVQN 986
>XP_006724515
          Length = 1039

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   GISFSVKN 8
           G+SFSV+N
Sbjct: 987 GVSFSVQN 994
>XP_006724514
          Length = 1041

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   GISFSVKN 8
           G+SFSV+N
Sbjct: 989 GVSFSVQN 996
>XP_006724513
          Length = 1052

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1    GISFSVKN 8
            G+SFSV+N
Sbjct: 1000 GVSFSVQN 1007
>XP_006724512
          Length = 1055

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1    GISFSVKN 8
            G+SFSV+N
Sbjct: 1003 GVSFSVQN 1010
>XP_006721846
          Length = 1424

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   GISFSVKN 8
           GISF +KN
Sbjct: 204 GISFGIKN 211
>XP_006721845
          Length = 1424

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   GISFSVKN 8
           GISF +KN
Sbjct: 204 GISFGIKN 211
>XP_006721844
          Length = 1424

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   GISFSVKN 8
           GISF +KN
Sbjct: 204 GISFGIKN 211
>XP_005265218
          Length = 687

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   GISFSVKNK 9
           GISFSVK +
Sbjct: 189 GISFSVKKQ 197
>NP_067047
          Length = 2506

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    GISFSVKNK 9
            GI FS+KN+
Sbjct: 2476 GIDFSLKNE 2484
>XP_006717281
          Length = 1702

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    GISFSVKNK 9
            GI FS+KN+
Sbjct: 1672 GIDFSLKNE 1680
>XP_006717279
          Length = 2506

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    GISFSVKNK 9
            GI FS+KN+
Sbjct: 2476 GIDFSLKNE 2484
>XP_006717278
          Length = 2566

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    GISFSVKNK 9
            GI FS+KN+
Sbjct: 2536 GIDFSLKNE 2544
>XP_006717277
          Length = 2567

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    GISFSVKNK 9
            GI FS+KN+
Sbjct: 2537 GIDFSLKNE 2545
>XP_006717276
          Length = 2567

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    GISFSVKNK 9
            GI FS+KN+
Sbjct: 2537 GIDFSLKNE 2545
>XP_006717275
          Length = 2567

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    GISFSVKNK 9
            GI FS+KN+
Sbjct: 2537 GIDFSLKNE 2545
>XP_006717274
          Length = 2567

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    GISFSVKNK 9
            GI FS+KN+
Sbjct: 2537 GIDFSLKNE 2545
>XP_006717273
          Length = 2567

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    GISFSVKNK 9
            GI FS+KN+
Sbjct: 2537 GIDFSLKNE 2545
>XP_006717272
          Length = 2567

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    GISFSVKNK 9
            GI FS+KN+
Sbjct: 2537 GIDFSLKNE 2545
>NP_001273675
          Length = 634

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   GISFSVKN 8
           GI+FS++N
Sbjct: 540 GIAFSIEN 547
>NP_001273676
          Length = 489

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   GISFSVKN 8
           GI+FS++N
Sbjct: 395 GIAFSIEN 402
>NP_079084
          Length = 619

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   GISFSVKN 8
           GI+FS++N
Sbjct: 525 GIAFSIEN 532
>XP_006719931
          Length = 508

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   GISFSVKN 8
           GI+FS++N
Sbjct: 414 GIAFSIEN 421
>NP_001272984
          Length = 283

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  GISFSVKNK 9
          G+S  VKNK
Sbjct: 11 GLSAEVKNK 19
>NP_001830
          Length = 329

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  GISFSVKNK 9
          G+S  VKNK
Sbjct: 11 GLSAEVKNK 19
>NP_003239
          Length = 961

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   GISFSVKNK 9
           GISF+  NK
Sbjct: 366 GISFAKSNK 374
>XP_006722711
          Length = 257

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  GISFSVKNK 9
          G+S  VKNK
Sbjct: 13 GLSAEVKNK 21
>NP_001290
          Length = 297

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  GISFSVKNK 9
          G+S  VKNK
Sbjct: 13 GLSAEVKNK 21
>NP_002435
          Length = 577

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   FSVKNK 9
           FS+KNK
Sbjct: 206 FSIKNK 211
>NP_001004757
          Length = 317

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ISFSVKNK 9
           I +SVKNK
Sbjct: 292 IIYSVKNK 299
>NP_006181
          Length = 577

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   ISFSVKN 8
           +SFS+KN
Sbjct: 121 VSFSLKN 127
>NP_055646
          Length = 2925

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   ISFSVKNK 9
           I+F++KNK
Sbjct: 575 INFNLKNK 582
>XP_005262326
          Length = 578

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   FSVKNK 9
           FS+KNK
Sbjct: 207 FSIKNK 212
>XP_006713495
          Length = 2969

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   ISFSVKNK 9
           I+F++KNK
Sbjct: 619 INFNLKNK 626
>XP_006712618
          Length = 577

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   ISFSVKN 8
           +SFS+KN
Sbjct: 121 VSFSLKN 127
>NP_001073291
          Length = 3118

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    ISFSVKNK 9
            +SFS KN+
Sbjct: 2548 LSFSTKNE 2555
>NP_000417
          Length = 3122

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    ISFSVKNK 9
            +SFS KN+
Sbjct: 2552 LSFSTKNE 2559
>NP_002448
          Length = 5179

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    GISFSVK 7
            G+SFSV+
Sbjct: 4602 GLSFSVR 4608
>NP_000607
          Length = 458

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ISFSVKNK 9
           I+F +KNK
Sbjct: 252 ITFDLKNK 259
>NP_001181943
          Length = 279

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  ISFSVKNK 9
          I+F +KNK
Sbjct: 73 ITFDLKNK 80
>NP_001135997
          Length = 547

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   GISFSVKN 8
           G SFS KN
Sbjct: 130 GNSFSTKN 137
>NP_001135998
          Length = 547

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   GISFSVKN 8
           G SFS KN
Sbjct: 130 GNSFSTKN 137
>NP_085142
          Length = 547

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   GISFSVKN 8
           G SFS KN
Sbjct: 130 GNSFSTKN 137
>NP_001136000
          Length = 547

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   GISFSVKN 8
           G SFS KN
Sbjct: 130 GNSFSTKN 137
>NP_001135999
          Length = 547

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   GISFSVKN 8
           G SFS KN
Sbjct: 130 GNSFSTKN 137
>NP_001136001
          Length = 547

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   GISFSVKN 8
           G SFS KN
Sbjct: 130 GNSFSTKN 137
>NP_001136002
          Length = 547

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   GISFSVKN 8
           G SFS KN
Sbjct: 130 GNSFSTKN 137
>NP_001135996
          Length = 547

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   GISFSVKN 8
           G SFS KN
Sbjct: 130 GNSFSTKN 137
>NP_002526
          Length = 687

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   ISFSVKNK 9
           +SFS+K+K
Sbjct: 465 LSFSLKSK 472
>NP_919247
          Length = 373

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  GISFSVKNK 9
          G+SFSV  K
Sbjct: 67 GLSFSVFRK 75
>NP_058197
          Length = 719

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   ISFSVKNK 9
           +SFS+K+K
Sbjct: 465 LSFSLKSK 472
>NP_922932
          Length = 1117

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  ISFSVKN 8
          +SF+VKN
Sbjct: 57 LSFTVKN 63
>NP_079402
          Length = 372

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  GISFSVKNK 9
          G+SFSV  K
Sbjct: 66 GLSFSVFRK 74
>XP_005267039
          Length = 3206

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    ISFSVKNK 9
            +SFS KN+
Sbjct: 2636 LSFSTKNE 2643
>XP_005267038
          Length = 3210

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    ISFSVKNK 9
            +SFS KN+
Sbjct: 2640 LSFSTKNE 2647
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.311    0.129    0.337 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 424,996
Number of extensions: 732
Number of successful extensions: 71
Number of sequences better than 10000.0: 71
Number of HSP's gapped: 71
Number of HSP's successfully gapped: 71
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.5 bits)
S2: 28 (15.4 bits)

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