Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_722576                                                              20     509
XP_005262424                                                           20     509
NP_997290                                                              20     509
NP_001127854                                                           16    5631
NP_055684                                                              16    5631
NP_742056                                                              16    7355
NP_001275504                                                           16    7355
NP_001275503                                                           16    7355
NP_742055                                                              16    7355
NP_742057                                                              16    7355
NP_000494                                                              16    7355
NP_004091                                                              16    7355
NP_742103                                                              16    7355
NP_742101                                                              16    7355
NP_659404                                                              16    7355
NP_588614                                                              16    7355
NP_001269536                                                           16    7355
NP_001157861                                                           16    7355
NP_001157860                                                           16    7355
NP_001157859                                                           16    7355
NP_001157858                                                           16    7355
NP_057424                                                              16    7355
XP_006724792                                                           16    7355
XP_006720235                                                           16    7355
XP_006716500                                                           16    7355
XP_006716499                                                           16    7355
XP_005251241                                                           16    7355
XP_006716498                                                           16    7355
XP_005251239                                                           16    7355
XP_006715436                                                           16    7355
XP_005266910                                                           16    7355
XP_005266909                                                           16    7355
XP_005266908                                                           16    7355
XP_005266907                                                           16    7355
NP_004560                                                              16    7355
NP_073600                                                              15    9605
NP_001128567                                                           15    9605
XP_005267654                                                           15    9605
XP_006710110                                                           15    9605
>NP_722576
          Length = 3080

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    GIRMTSSNT 9
            G RMTSSNT
Sbjct: 1867 GTRMTSSNT 1875
>XP_005262424
          Length = 2875

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    GIRMTSSNT 9
            G RMTSSNT
Sbjct: 1662 GTRMTSSNT 1670
>NP_997290
          Length = 438

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   GIRMTSSN 8
           GIRMTSSN
Sbjct: 187 GIRMTSSN 194
>NP_001127854
          Length = 1114

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   GIRMTSS 7
           GIR+TSS
Sbjct: 810 GIRLTSS 816
>NP_055684
          Length = 963

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   GIRMTSS 7
           GIR+TSS
Sbjct: 824 GIRLTSS 830
>NP_742056
          Length = 557

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   MTSSNT 9
           MTSSNT
Sbjct: 235 MTSSNT 240
>NP_001275504
          Length = 470

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   MTSSNT 9
           MTSSNT
Sbjct: 118 MTSSNT 123
>NP_001275503
          Length = 586

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   MTSSNT 9
           MTSSNT
Sbjct: 234 MTSSNT 239
>NP_742055
          Length = 592

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   MTSSNT 9
           MTSSNT
Sbjct: 240 MTSSNT 245
>NP_742057
          Length = 559

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   MTSSNT 9
           MTSSNT
Sbjct: 207 MTSSNT 212
>NP_000494
          Length = 592

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   MTSSNT 9
           MTSSNT
Sbjct: 240 MTSSNT 245
>NP_004091
          Length = 639

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   GIRMTSSNT 9
           G  MTS+NT
Sbjct: 291 GAYMTSNNT 299
>NP_742103
          Length = 639

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   GIRMTSSNT 9
           G  MTS+NT
Sbjct: 291 GAYMTSNNT 299
>NP_742101
          Length = 616

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   GIRMTSSNT 9
           G  MTS+NT
Sbjct: 268 GAYMTSNNT 276
>NP_659404
          Length = 547

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   GIRMTSSN 8
           G RMTS+N
Sbjct: 371 GNRMTSTN 378
>NP_588614
          Length = 789

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   GIRMTSSN 8
           G+RM S+N
Sbjct: 589 GLRMNSAN 596
>NP_001269536
          Length = 535

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   GIRMTSSN 8
           G RMTS+N
Sbjct: 359 GNRMTSTN 366
>NP_001157861
          Length = 1391

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    IRMTSSN 8
            +RMTS+N
Sbjct: 1051 VRMTSAN 1057
>NP_001157860
          Length = 1504

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    IRMTSSN 8
            +RMTS+N
Sbjct: 1051 VRMTSAN 1057
>NP_001157859
          Length = 1509

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    IRMTSSN 8
            +RMTS+N
Sbjct: 1056 VRMTSAN 1062
>NP_001157858
          Length = 1609

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    IRMTSSN 8
            +RMTS+N
Sbjct: 1051 VRMTSAN 1057
>NP_057424
          Length = 1601

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    IRMTSSN 8
            +RMTS+N
Sbjct: 1051 VRMTSAN 1057
>XP_006724792
          Length = 411

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   GIRMTSSN 8
           G RMTS+N
Sbjct: 235 GNRMTSTN 242
>XP_006720235
          Length = 184

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  GIRMTSS 7
          GI+MTSS
Sbjct: 93 GIQMTSS 99
>XP_006716500
          Length = 475

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   MTSSNT 9
           MTSSNT
Sbjct: 123 MTSSNT 128
>XP_006716499
          Length = 559

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   MTSSNT 9
           MTSSNT
Sbjct: 207 MTSSNT 212
>XP_005251241
          Length = 571

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   MTSSNT 9
           MTSSNT
Sbjct: 219 MTSSNT 224
>XP_006716498
          Length = 591

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   MTSSNT 9
           MTSSNT
Sbjct: 239 MTSSNT 244
>XP_005251239
          Length = 621

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   MTSSNT 9
           MTSSNT
Sbjct: 269 MTSSNT 274
>XP_006715436
          Length = 585

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   GIRMTSSNT 9
           G  MTS+NT
Sbjct: 237 GAYMTSNNT 245
>XP_005266910
          Length = 616

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   GIRMTSSNT 9
           G  MTS+NT
Sbjct: 268 GAYMTSNNT 276
>XP_005266909
          Length = 620

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   GIRMTSSNT 9
           G  MTS+NT
Sbjct: 291 GAYMTSNNT 299
>XP_005266908
          Length = 645

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   GIRMTSSNT 9
           G  MTS+NT
Sbjct: 291 GAYMTSNNT 299
>XP_005266907
          Length = 645

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   GIRMTSSNT 9
           G  MTS+NT
Sbjct: 291 GAYMTSNNT 299
>NP_004560
          Length = 188

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   GIRMTSS 7
           GI+MTSS
Sbjct: 97  GIQMTSS 103
>NP_073600
          Length = 1204

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RMTSSNT 9
           R+T+SNT
Sbjct: 547 RLTASNT 553
>NP_001128567
          Length = 1204

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RMTSSNT 9
           R+T+SNT
Sbjct: 547 RLTASNT 553
>XP_005267654
          Length = 212

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   GIRMTSSN 8
           G+RM +SN
Sbjct: 179 GLRMRASN 186
>XP_006710110
          Length = 299

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RMTSSNT 9
           ++TSSNT
Sbjct: 101 KLTSSNT 107
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.305    0.114    0.287 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 289,675
Number of extensions: 332
Number of successful extensions: 39
Number of sequences better than 10000.0: 39
Number of HSP's gapped: 39
Number of HSP's successfully gapped: 39
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.5 bits)
S2: 28 (15.4 bits)

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