Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_722576                                                              20     390
XP_005262424                                                           20     390
NP_001693                                                              18    1135
XP_005251072                                                           18    1135
NP_116176                                                              18    1482
XP_005247896                                                           18    1482
XP_006713857                                                           18    1482
XP_006710853                                                           18    1482
XP_006710852                                                           18    1482
XP_006710851                                                           18    1482
XP_006710850                                                           18    1482
XP_006710849                                                           18    1482
XP_005271124                                                           18    1482
XP_006710848                                                           18    1482
XP_006710847                                                           18    1482
XP_006710846                                                           18    1482
NP_001694                                                              18    1482
NP_056051                                                              18    1935
XP_006714219                                                           18    1935
XP_006714218                                                           18    1935
XP_006714217                                                           18    1935
XP_006714216                                                           18    1935
NP_038475                                                              17    3301
NP_115960                                                              17    3301
NP_740746                                                              17    3301
NP_001257981                                                           17    3301
NP_001276087                                                           17    3301
XP_005260175                                                           17    3301
XP_005259943                                                           17    3301
XP_005259942                                                           17    3301
XP_005259941                                                           17    3301
XP_005255899                                                           17    3301
NP_919227                                                              17    3301
NP_001276088                                                           17    3301
NP_000307                                                              17    4312
NP_001171673                                                           17    4312
XP_005265401                                                           17    4312
XP_005265400                                                           17    4312
XP_005265399                                                           17    4312
XP_006713335                                                           17    4312
NP_001072993                                                           16    7355
XP_006714098                                                           16    7355
NP_001072992                                                           16    7355
NP_006443                                                              16    7355
NP_001243412                                                           15    9605
NP_001243411                                                           15    9605
NP_001970                                                              15    9605
NP_001243413                                                           15    9605
NP_001167597                                                           15    9605
NP_001167601                                                           15    9605
NP_001167596                                                           15    9605
NP_001167600                                                           15    9605
NP_000608                                                              15    9605
NP_001167599                                                           15    9605
NP_001167598                                                           15    9605
XP_005268973                                                           15    9605
XP_005268971                                                           15    9605
XP_005268970                                                           15    9605
XP_005268969                                                           15    9605
XP_005268968                                                           15    9605
XP_005253766                                                           15    9605
XP_005253765                                                           15    9605
XP_005253764                                                           15    9605
NP_060933                                                              15    9605
>NP_722576
          Length = 3080

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    GIPALMVAI 9
            GIPA+MVAI
Sbjct: 2859 GIPAIMVAI 2867
>XP_005262424
          Length = 2875

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    GIPALMVAI 9
            GIPA+MVAI
Sbjct: 2654 GIPAIMVAI 2662
>NP_001693
          Length = 1584

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1    GIPALMVAI 9
            G+PAL+VAI
Sbjct: 1059 GLPALVVAI 1067
>XP_005251072
          Length = 1586

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1    GIPALMVAI 9
            G+PAL+VAI
Sbjct: 1056 GLPALVVAI 1064
>NP_116176
          Length = 797

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   GIPALMVAI 9
           G+PA++VAI
Sbjct: 576 GVPAIVVAI 584
>XP_005247896
          Length = 502

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   GIPALMVAI 9
           G+PA++VAI
Sbjct: 281 GVPAIVVAI 289
>XP_006713857
          Length = 560

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   GIPALMVAI 9
           G+PA++VAI
Sbjct: 339 GVPAIVVAI 347
>XP_006710853
          Length = 1478

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   GIPALMVAI 9
           G+PAL+VA+
Sbjct: 989 GLPALVVAV 997
>XP_006710852
          Length = 1497

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   GIPALMVAI 9
           G+PAL+VA+
Sbjct: 989 GLPALVVAV 997
>XP_006710851
          Length = 1511

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   GIPALMVAI 9
           G+PAL+VA+
Sbjct: 989 GLPALVVAV 997
>XP_006710850
          Length = 1530

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   GIPALMVAI 9
           G+PAL+VA+
Sbjct: 989 GLPALVVAV 997
>XP_006710849
          Length = 1530

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   GIPALMVAI 9
           G+PAL+VA+
Sbjct: 989 GLPALVVAV 997
>XP_005271124
          Length = 1551

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1    GIPALMVAI 9
            G+PAL+VA+
Sbjct: 1044 GLPALVVAV 1052
>XP_006710848
          Length = 1552

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1    GIPALMVAI 9
            G+PAL+VA+
Sbjct: 1044 GLPALVVAV 1052
>XP_006710847
          Length = 1566

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1    GIPALMVAI 9
            G+PAL+VA+
Sbjct: 1044 GLPALVVAV 1052
>XP_006710846
          Length = 1584

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1    GIPALMVAI 9
            G+PAL+VA+
Sbjct: 1044 GLPALVVAV 1052
>NP_001694
          Length = 1585

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1    GIPALMVAI 9
            G+PAL+VA+
Sbjct: 1044 GLPALVVAV 1052
>NP_056051
          Length = 1469

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   GIPALMVAI 9
           G+PAL+VA+
Sbjct: 989 GMPALIVAV 997
>XP_006714219
          Length = 806

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   GIPALMVAI 9
           G+PAL+VA+
Sbjct: 555 GMPALIVAV 563
>XP_006714218
          Length = 846

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   GIPALMVAI 9
           G+PAL+VA+
Sbjct: 360 GMPALIVAV 368
>XP_006714217
          Length = 1013

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   GIPALMVAI 9
           G+PAL+VA+
Sbjct: 542 GMPALIVAV 550
>XP_006714216
          Length = 1026

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   GIPALMVAI 9
           G+PAL+VA+
Sbjct: 555 GMPALIVAV 563
>NP_038475
          Length = 823

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   GIPALMVAI 9
           G+PA+ VAI
Sbjct: 653 GVPAVTVAI 661
>NP_115960
          Length = 652

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   GIPALMVAI 9
           G+PA+ VAI
Sbjct: 473 GVPAVTVAI 481
>NP_740746
          Length = 549

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   GIPALMV 7
           G+PALMV
Sbjct: 388 GLPALMV 394
>NP_001257981
          Length = 765

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   GIPALMVAI 9
           G+PA+ VAI
Sbjct: 595 GVPAVTVAI 603
>NP_001276087
          Length = 600

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   GIPALMVAI 9
           G+PA+ VAI
Sbjct: 421 GVPAVTVAI 429
>XP_005260175
          Length = 586

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   GIPALMVAI 9
           G+PA+ VAI
Sbjct: 407 GVPAVTVAI 415
>XP_005259943
          Length = 551

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   GIPALMVAI 9
           G+PA+ VAI
Sbjct: 381 GVPAVTVAI 389
>XP_005259942
          Length = 834

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   GIPALMVAI 9
           G+PA+ VAI
Sbjct: 664 GVPAVTVAI 672
>XP_005259941
          Length = 892

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   GIPALMVAI 9
           G+PA+ VAI
Sbjct: 722 GVPAVTVAI 730
>XP_005255899
          Length = 596

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   GIPALMV 7
           G+PALMV
Sbjct: 435 GLPALMV 441
>NP_919227
          Length = 419

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  IPALMVAI 9
          IPAL+VA+
Sbjct: 39 IPALLVAV 46
>NP_001276088
          Length = 526

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   GIPALMVAI 9
           G+PA+ VAI
Sbjct: 347 GVPAVTVAI 355
>NP_000307
          Length = 593

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   GIPALMVAI 9
           G+PA+ VA+
Sbjct: 330 GLPAVFVAV 338
>NP_001171673
          Length = 593

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   GIPALMVAI 9
           G+PA+ VA+
Sbjct: 330 GLPAVFVAV 338
>XP_005265401
          Length = 562

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   GIPALMVAI 9
           G+PA+ VA+
Sbjct: 299 GLPAVFVAV 307
>XP_005265400
          Length = 575

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   GIPALMVAI 9
           G+PA+ VA+
Sbjct: 312 GLPAVFVAV 320
>XP_005265399
          Length = 593

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   GIPALMVAI 9
           G+PA+ VA+
Sbjct: 330 GLPAVFVAV 338
>XP_006713335
          Length = 606

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   GIPALMVAI 9
           G+PA+ VA+
Sbjct: 343 GLPAVFVAV 351
>NP_001072993
          Length = 432

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   GIPALMVAI 9
           GIP + VA+
Sbjct: 327 GIPTVFVAV 335
>XP_006714098
          Length = 836

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   GIPALMVAI 9
           GIP + VA+
Sbjct: 731 GIPTVFVAV 739
>NP_001072992
          Length = 425

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   GIPALMVAI 9
           GIP + VA+
Sbjct: 320 GIPTVFVAV 328
>NP_006443
          Length = 425

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   GIPALMVAI 9
           GIP + VA+
Sbjct: 320 GIPTVFVAV 328
>NP_001243412
          Length = 489

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   IPALMV 7
           IPALMV
Sbjct: 420 IPALMV 425
>NP_001243411
          Length = 502

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   IPALMV 7
           IPALMV
Sbjct: 433 IPALMV 438
>NP_001970
          Length = 555

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   IPALMV 7
           IPALMV
Sbjct: 486 IPALMV 491
>NP_001243413
          Length = 502

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   IPALMV 7
           IPALMV
Sbjct: 433 IPALMV 438
>NP_001167597
          Length = 568

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IPALMVAI 9
           IP L+VA+
Sbjct: 421 IPTLLVAV 428
>NP_001167601
          Length = 557

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IPALMVAI 9
           IP L+VA+
Sbjct: 417 IPTLLVAV 424
>NP_001167596
          Length = 590

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IPALMVAI 9
           IP L+VA+
Sbjct: 450 IPTLLVAV 457
>NP_001167600
          Length = 561

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IPALMVAI 9
           IP L+VA+
Sbjct: 421 IPTLLVAV 428
>NP_000608
          Length = 561

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IPALMVAI 9
           IP L+VA+
Sbjct: 421 IPTLLVAV 428
>NP_001167599
          Length = 561

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IPALMVAI 9
           IP L+VA+
Sbjct: 421 IPTLLVAV 428
>NP_001167598
          Length = 568

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IPALMVAI 9
           IP L+VA+
Sbjct: 421 IPTLLVAV 428
>XP_005268973
          Length = 489

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IPALMVAI 9
           IP L+VA+
Sbjct: 342 IPTLLVAV 349
>XP_005268971
          Length = 531

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IPALMVAI 9
           IP L+VA+
Sbjct: 384 IPTLLVAV 391
>XP_005268970
          Length = 531

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IPALMVAI 9
           IP L+VA+
Sbjct: 384 IPTLLVAV 391
>XP_005268969
          Length = 564

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IPALMVAI 9
           IP L+VA+
Sbjct: 417 IPTLLVAV 424
>XP_005268968
          Length = 597

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IPALMVAI 9
           IP L+VA+
Sbjct: 450 IPTLLVAV 457
>XP_005253766
          Length = 270

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  GIPALMVA 8
          G+P LMV+
Sbjct: 17 GLPELMVS 24
>XP_005253765
          Length = 335

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  GIPALMVA 8
          G+P LMV+
Sbjct: 82 GLPELMVS 89
>XP_005253764
          Length = 438

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   GIPALMVA 8
           G+P LMV+
Sbjct: 194 GLPELMVS 201
>NP_060933
          Length = 447

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   GIPALMVA 8
           G+P LMV+
Sbjct: 194 GLPELMVS 201
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.334    0.149    0.423 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 430,738
Number of extensions: 313
Number of successful extensions: 64
Number of sequences better than 10000.0: 64
Number of HSP's gapped: 64
Number of HSP's successfully gapped: 64
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.2 bits)
S2: 28 (15.4 bits)

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