Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000042                                                              20     299
XP_006718908                                                           20     299
XP_005271621                                                           20     299
XP_006718907                                                           20     299
XP_006718906                                                           20     299
XP_005271619                                                           20     299
XP_005271618                                                           20     299
NP_060921                                                              17    2528
NP_001265719                                                           17    2528
NP_001265718                                                           17    2528
NP_114105                                                              17    2528
NP_001053                                                              17    2528
NP_001070650                                                           17    3301
NP_036550                                                              17    3301
NP_665894                                                              17    3301
NP_665893                                                              17    3301
XP_005257253                                                           17    3301
XP_005257252                                                           17    3301
XP_005253065                                                           17    3301
XP_006718321                                                           17    3301
XP_005253064                                                           17    3301
XP_005253063                                                           17    3301
XP_005253062                                                           17    3301
NP_821174                                                              17    4312
NP_001116151                                                           17    4312
NP_065850                                                              17    4312
NP_060340                                                              17    4312
XP_006717993                                                           17    4312
XP_006717992                                                           17    4312
XP_006717991                                                           17    4312
XP_005266009                                                           17    4312
XP_006714961                                                           17    4312
XP_006714960                                                           17    4312
XP_005266007                                                           17    4312
NP_689785                                                              16    5631
XP_006717028                                                           16    5631
XP_006717027                                                           16    5631
XP_005272226                                                           16    5631
NP_001077077                                                           16    7355
NP_114174                                                              16    7355
NP_036468                                                              16    7355
NP_005923                                                              16    7355
NP_001136095                                                           16    7355
NP_001136094                                                           16    7355
NP_115873                                                              16    7355
XP_006722341                                                           16    7355
NP_003822                                                              16    7355
NP_001166122                                                           15    9605
NP_689737                                                              15    9605
NP_001153518                                                           15    9605
NP_001153505                                                           15    9605
NP_009121                                                              15    9605
NP_005906                                                              15    9605
NP_001159506                                                           15    9605
NP_940940                                                              15    9605
NP_001438                                                              15    9605
NP_001243089                                                           15    9605
NP_079273                                                              15    9605
NP_001093328                                                           15    9605
NP_443132                                                              15    9605
NP_937757                                                              15    9605
NP_937756                                                              15    9605
XP_006721016                                                           15    9605
XP_005269527                                                           15    9605
XP_005269526                                                           15    9605
XP_005249901                                                           15    9605
XP_006714824                                                           15    9605
XP_005246402                                                           15    9605
XP_006712393                                                           15    9605
XP_005246401                                                           15    9605
NP_076959                                                              15    9605
>NP_000042
          Length = 3056

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    GINISADQP 9
            GINI ADQP
Sbjct: 2644 GINIPADQP 2652
>XP_006718908
          Length = 1708

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    GINISADQP 9
            GINI ADQP
Sbjct: 1296 GINIPADQP 1304
>XP_005271621
          Length = 2708

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    GINISADQP 9
            GINI ADQP
Sbjct: 2296 GINIPADQP 2304
>XP_006718907
          Length = 3050

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    GINISADQP 9
            GINI ADQP
Sbjct: 2638 GINIPADQP 2646
>XP_006718906
          Length = 3056

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    GINISADQP 9
            GINI ADQP
Sbjct: 2644 GINIPADQP 2652
>XP_005271619
          Length = 3056

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    GINISADQP 9
            GINI ADQP
Sbjct: 2644 GINIPADQP 2652
>XP_005271618
          Length = 3056

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    GINISADQP 9
            GINI ADQP
Sbjct: 2644 GINIPADQP 2652
>NP_060921
          Length = 1338

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   INISADQP 9
           +NIS DQP
Sbjct: 889 LNISQDQP 896
>NP_001265719
          Length = 285

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  GINISADQP 9
          G+ +SA+QP
Sbjct: 2  GLGVSAEQP 10
>NP_001265718
          Length = 345

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  GINISADQP 9
          G+ +SA+QP
Sbjct: 2  GLGVSAEQP 10
>NP_114105
          Length = 440

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  GINISADQP 9
          G+ +SA+QP
Sbjct: 2  GLGVSAEQP 10
>NP_001053
          Length = 433

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   NISADQP 9
           NISAD+P
Sbjct: 316 NISADEP 322
>NP_001070650
          Length = 516

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   GINISADQ 8
           G+N+SA+Q
Sbjct: 276 GVNVSANQ 283
>NP_036550
          Length = 492

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   GINISADQ 8
           G+N+SA+Q
Sbjct: 276 GVNVSANQ 283
>NP_665894
          Length = 893

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   GINISADQP 9
           GI++ AD+P
Sbjct: 675 GIDVDADRP 683
>NP_665893
          Length = 910

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   GINISADQP 9
           GI++ AD+P
Sbjct: 675 GIDVDADRP 683
>XP_005257253
          Length = 492

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   GINISADQ 8
           G+N+SA+Q
Sbjct: 276 GVNVSANQ 283
>XP_005257252
          Length = 516

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   GINISADQ 8
           G+N+SA+Q
Sbjct: 276 GVNVSANQ 283
>XP_005253065
          Length = 788

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   GINISADQP 9
           GI++ AD+P
Sbjct: 553 GIDVDADRP 561
>XP_006718321
          Length = 917

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   GINISADQP 9
           GI++ AD+P
Sbjct: 699 GIDVDADRP 707
>XP_005253064
          Length = 934

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   GINISADQP 9
           GI++ AD+P
Sbjct: 699 GIDVDADRP 707
>XP_005253063
          Length = 934

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   GINISADQP 9
           GI++ AD+P
Sbjct: 699 GIDVDADRP 707
>XP_005253062
          Length = 934

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   GINISADQP 9
           GI++ AD+P
Sbjct: 699 GIDVDADRP 707
>NP_821174
          Length = 1023

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   GINISADQP 9
           G+++SA++P
Sbjct: 703 GLSVSAEEP 711
>NP_001116151
          Length = 2765

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1    GINISADQP 9
            G+N++  QP
Sbjct: 2637 GVNVTVSQP 2645
>NP_065850
          Length = 436

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   INISADQP 9
           +N+ ADQP
Sbjct: 223 LNVFADQP 230
>NP_060340
          Length = 1024

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   GINISADQP 9
           G+++SA++P
Sbjct: 704 GLSVSAEEP 712
>XP_006717993
          Length = 436

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   INISADQP 9
           +N+ ADQP
Sbjct: 223 LNVFADQP 230
>XP_006717992
          Length = 436

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   INISADQP 9
           +N+ ADQP
Sbjct: 223 LNVFADQP 230
>XP_006717991
          Length = 436

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   INISADQP 9
           +N+ ADQP
Sbjct: 223 LNVFADQP 230
>XP_005266009
          Length = 2378

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1    GINISADQP 9
            G+N++  QP
Sbjct: 2250 GVNVTVSQP 2258
>XP_006714961
          Length = 2548

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1    GINISADQP 9
            G+N++  QP
Sbjct: 2420 GVNVTVSQP 2428
>XP_006714960
          Length = 2758

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1    GINISADQP 9
            G+N++  QP
Sbjct: 2630 GVNVTVSQP 2638
>XP_005266007
          Length = 2765

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1    GINISADQP 9
            G+N++  QP
Sbjct: 2637 GVNVTVSQP 2645
>NP_689785
          Length = 479

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   ISADQP 9
           ISADQP
Sbjct: 240 ISADQP 245
>XP_006717028
          Length = 407

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   ISADQP 9
           ISADQP
Sbjct: 168 ISADQP 173
>XP_006717027
          Length = 434

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   ISADQP 9
           ISADQP
Sbjct: 195 ISADQP 200
>XP_005272226
          Length = 491

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   ISADQP 9
           ISADQP
Sbjct: 252 ISADQP 257
>NP_001077077
          Length = 408

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  NISADQP 9
          N+SAD P
Sbjct: 22 NVSADAP 28
>NP_114174
          Length = 502

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  NISADQP 9
          N+SAD P
Sbjct: 22 NVSADAP 28
>NP_036468
          Length = 456

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  NISADQP 9
          N+SAD P
Sbjct: 22 NVSADAP 28
>NP_005923
          Length = 713

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   GINISADQP 9
           GI++ A+QP
Sbjct: 399 GISLYAEQP 407
>NP_001136095
          Length = 474

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   GINISADQP 9
           G+N+  +QP
Sbjct: 300 GLNLQPEQP 308
>NP_001136094
          Length = 491

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   GINISADQP 9
           G+N+  +QP
Sbjct: 261 GLNLQPEQP 269
>NP_115873
          Length = 530

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   GINISADQP 9
           G+N+  +QP
Sbjct: 300 GLNLQPEQP 308
>XP_006722341
          Length = 411

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  NISADQP 9
          N+SAD P
Sbjct: 22 NVSADAP 28
>NP_003822
          Length = 519

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   GINISAD 7
           G+NI+AD
Sbjct: 470 GLNITAD 476
>NP_001166122
          Length = 481

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   GINISADQP 9
           GIN + +QP
Sbjct: 109 GINTAENQP 117
>NP_689737
          Length = 1265

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   NISADQP 9
           N+SAD P
Sbjct: 284 NLSADTP 290
>NP_001153518
          Length = 1261

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   NISADQP 9
           N+SAD P
Sbjct: 284 NLSADTP 290
>NP_001153505
          Length = 1260

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   NISADQP 9
           N+SAD P
Sbjct: 284 NLSADTP 290
>NP_009121
          Length = 1000

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   INISADQP 9
           +NIS +QP
Sbjct: 991 MNISPEQP 998
>NP_005906
          Length = 821

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   GINISADQP 9
           GIN  AD P
Sbjct: 682 GINGHADSP 690
>NP_001159506
          Length = 590

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   GINISADQ 8
           G+N +ADQ
Sbjct: 497 GVNHAADQ 504
>NP_940940
          Length = 247

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   GINISADQ 8
           G+N +ADQ
Sbjct: 154 GVNHAADQ 161
>NP_001438
          Length = 4349

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   INISADQP 9
           IN++A QP
Sbjct: 626 INLTAGQP 633
>NP_001243089
          Length = 543

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   INISADQ 8
           IN+S+DQ
Sbjct: 438 INLSSDQ 444
>NP_079273
          Length = 682

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   INISADQ 8
           IN+S+DQ
Sbjct: 438 INLSSDQ 444
>NP_001093328
          Length = 479

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   INISADQP 9
           IN+  DQP
Sbjct: 392 INVVPDQP 399
>NP_443132
          Length = 3538

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    GINISA 6
            GINISA
Sbjct: 1174 GINISA 1179
>NP_937757
          Length = 3667

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    GINISA 6
            GINISA
Sbjct: 1238 GINISA 1243
>NP_937756
          Length = 3707

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    GINISA 6
            GINISA
Sbjct: 1278 GINISA 1283
>XP_006721016
          Length = 682

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   INISADQ 8
           IN+S+DQ
Sbjct: 438 INLSSDQ 444
>XP_005269527
          Length = 953

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   INISADQP 9
           +NIS +QP
Sbjct: 944 MNISPEQP 951
>XP_005269526
          Length = 999

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   INISADQP 9
           +NIS +QP
Sbjct: 990 MNISPEQP 997
>XP_005249901
          Length = 421

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   INISADQP 9
           IN+  DQP
Sbjct: 334 INVVPDQP 341
>XP_006714824
          Length = 4349

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   INISADQP 9
           IN++A QP
Sbjct: 626 INLTAGQP 633
>XP_005246402
          Length = 1265

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   NISADQP 9
           N+SAD P
Sbjct: 284 NLSADTP 290
>XP_006712393
          Length = 1267

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   NISADQP 9
           N+SAD P
Sbjct: 290 NLSADTP 296
>XP_005246401
          Length = 1271

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   NISADQP 9
           N+SAD P
Sbjct: 290 NLSADTP 296
>NP_076959
          Length = 421

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   INISADQP 9
           IN+  DQP
Sbjct: 334 INVVPDQP 341
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.307    0.133    0.374 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 497,547
Number of extensions: 945
Number of successful extensions: 71
Number of sequences better than 10000.0: 71
Number of HSP's gapped: 71
Number of HSP's successfully gapped: 71
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.3 bits)
S2: 28 (15.4 bits)

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