Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001895                                                              20     299
NP_001091680                                                           20     299
NP_001091679                                                           20     299
XP_006713048                                                           20     299
XP_006713047                                                           20     299
XP_006713046                                                           20     299
XP_005264943                                                           20     299
NP_001124295                                                           17    4312
NP_001370                                                              17    4312
NP_003939                                                              17    4312
XP_006722744                                                           17    4312
XP_006714470                                                           17    4312
XP_006714469                                                           17    4312
XP_005263392                                                           17    4312
NP_001265478                                                           16    5631
NP_002601                                                              16    5631
NP_061903                                                              16    5631
XP_005248601                                                           16    5631
XP_006714716                                                           16    5631
XP_006712657                                                           16    5631
NP_001004727                                                           16    5631
NP_004303                                                              16    7355
NP_001014443                                                           16    7355
NP_036607                                                              16    7355
NP_061963                                                              16    7355
NP_055832                                                              16    7355
NP_963920                                                              16    7355
NP_963918                                                              16    7355
XP_006724714                                                           16    7355
XP_006711337                                                           16    7355
XP_006711336                                                           16    7355
XP_005270706                                                           16    7355
XP_005270705                                                           16    7355
NP_001018125                                                           15    9605
NP_149075                                                              15    9605
NP_055865                                                              15    9605
XP_005276286                                                           15    9605
XP_005277590                                                           15    9605
XP_006715091                                                           15    9605
XP_005249012                                                           15    9605
XP_005265698                                                           15    9605
XP_005265004                                                           15    9605
XP_006713088                                                           15    9605
XP_006713087                                                           15    9605
XP_005265003                                                           15    9605
XP_006713086                                                           15    9605
XP_006713085                                                           15    9605
XP_006713084                                                           15    9605
XP_005276004                                                           15    9605
NP_037377                                                              15    9605
>NP_001895
          Length = 781

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  GFSQSFAQE 9
          GFSQSF QE
Sbjct: 69 GFSQSFTQE 77
>NP_001091680
          Length = 781

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  GFSQSFAQE 9
          GFSQSF QE
Sbjct: 69 GFSQSFTQE 77
>NP_001091679
          Length = 781

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  GFSQSFAQE 9
          GFSQSF QE
Sbjct: 69 GFSQSFTQE 77
>XP_006713048
          Length = 720

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  GFSQSFAQE 9
          GFSQSF QE
Sbjct: 69 GFSQSFTQE 77
>XP_006713047
          Length = 774

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  GFSQSFAQE 9
          GFSQSF QE
Sbjct: 62 GFSQSFTQE 70
>XP_006713046
          Length = 774

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  GFSQSFAQE 9
          GFSQSF QE
Sbjct: 62 GFSQSFTQE 70
>XP_005264943
          Length = 781

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  GFSQSFAQE 9
          GFSQSF QE
Sbjct: 69 GFSQSFTQE 77
>NP_001124295
          Length = 1632

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   GFSQSFAQ 8
           GFS SFA+
Sbjct: 494 GFSTSFAE 501
>NP_001370
          Length = 1616

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   GFSQSFAQ 8
           GFS SFA+
Sbjct: 478 GFSTSFAE 485
>NP_003939
          Length = 493

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   GFSQSFAQE 9
           GF++ F+QE
Sbjct: 291 GFAERFSQE 299
>XP_006722744
          Length = 1495

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   GFSQSFAQ 8
           GFS SFA+
Sbjct: 357 GFSTSFAE 364
>XP_006714470
          Length = 477

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   GFSQSFAQE 9
           GF++ F+QE
Sbjct: 291 GFAERFSQE 299
>XP_006714469
          Length = 530

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   GFSQSFAQE 9
           GF++ F+QE
Sbjct: 291 GFAERFSQE 299
>XP_005263392
          Length = 570

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   GFSQSFAQE 9
           GF++ F+QE
Sbjct: 291 GFAERFSQE 299
>NP_001265478
          Length = 456

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  GFSQSFAQE 9
          GFS+SF+ +
Sbjct: 23 GFSRSFSSD 31
>NP_002601
          Length = 436

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  GFSQSFAQE 9
          GFS+SF+ +
Sbjct: 23 GFSRSFSSD 31
>NP_061903
          Length = 1369

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   GFSQSFAQE 9
           GFSQ F ++
Sbjct: 174 GFSQEFEEQ 182
>XP_005248601
          Length = 899

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   GFSQSFAQE 9
           GFSQ F ++
Sbjct: 174 GFSQEFEEQ 182
>XP_006714716
          Length = 1318

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   GFSQSFAQE 9
           GFSQ F ++
Sbjct: 174 GFSQEFEEQ 182
>XP_006712657
          Length = 281

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  GFSQSFAQE 9
          GFS+SF+ +
Sbjct: 23 GFSRSFSSD 31
>NP_001004727
          Length = 303

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   GFSQSFAQ 8
           GF  SFAQ
Sbjct: 144 GFMHSFAQ 151
>NP_004303
          Length = 388

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   FSQSFA 7
           FSQSFA
Sbjct: 265 FSQSFA 270
>NP_001014443
          Length = 565

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   GFSQSFAQE 9
           G+SQ  AQE
Sbjct: 296 GYSQQDAQE 304
>NP_036607
          Length = 565

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   GFSQSFAQE 9
           G+SQ  AQE
Sbjct: 296 GYSQQDAQE 304
>NP_061963
          Length = 1047

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   GFSQSFAQ 8
           GFS SFA+
Sbjct: 125 GFSFSFAE 132
>NP_055832
          Length = 942

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   GFSQSFAQE 9
           G+SQ  AQE
Sbjct: 266 GYSQQDAQE 274
>NP_963920
          Length = 828

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   GFSQSFAQE 9
           G+SQ  AQE
Sbjct: 266 GYSQQDAQE 274
>NP_963918
          Length = 911

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   GFSQSFAQE 9
           G+SQ  AQE
Sbjct: 235 GYSQQDAQE 243
>XP_006724714
          Length = 343

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   FSQSFA 7
           FSQSFA
Sbjct: 220 FSQSFA 225
>XP_006711337
          Length = 381

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   GFSQSFAQE 9
           G+SQ  AQE
Sbjct: 112 GYSQQDAQE 120
>XP_006711336
          Length = 386

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   GFSQSFAQE 9
           G+SQ  AQE
Sbjct: 296 GYSQQDAQE 304
>XP_005270706
          Length = 851

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   GFSQSFAQE 9
           G+SQ  AQE
Sbjct: 266 GYSQQDAQE 274
>XP_005270705
          Length = 934

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   GFSQSFAQE 9
           G+SQ  AQE
Sbjct: 266 GYSQQDAQE 274
>NP_001018125
          Length = 1451

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   FSQSFAQE 9
           FSQ FA++
Sbjct: 704 FSQDFAKD 711
>NP_149075
          Length = 1471

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   FSQSFAQE 9
           FSQ FA++
Sbjct: 704 FSQDFAKD 711
>NP_055865
          Length = 835

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   GFSQSFAQE 9
           GFS+SF ++
Sbjct: 761 GFSKSFKKK 769
>XP_005276286
          Length = 642

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   FSQSFAQE 9
           FSQ FA++
Sbjct: 251 FSQDFAKD 258
>XP_005277590
          Length = 900

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   FSQSFAQE 9
           FSQ FA++
Sbjct: 451 FSQDFAKD 458
>XP_006715091
          Length = 779

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   GFSQSFAQE 9
           GFS+SF ++
Sbjct: 705 GFSKSFKKK 713
>XP_005249012
          Length = 803

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   GFSQSFAQE 9
           GFS+SF ++
Sbjct: 761 GFSKSFKKK 769
>XP_005265698
          Length = 577

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   FSQSFAQE 9
           FSQ FA++
Sbjct: 235 FSQDFAKD 242
>XP_005265004
          Length = 806

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  FSQSFAQE 9
          FSQ FA++
Sbjct: 39 FSQDFAKD 46
>XP_006713088
          Length = 1382

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   FSQSFAQE 9
           FSQ FA++
Sbjct: 615 FSQDFAKD 622
>XP_006713087
          Length = 1432

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   FSQSFAQE 9
           FSQ FA++
Sbjct: 704 FSQDFAKD 711
>XP_005265003
          Length = 1451

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   FSQSFAQE 9
           FSQ FA++
Sbjct: 704 FSQDFAKD 711
>XP_006713086
          Length = 1458

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   FSQSFAQE 9
           FSQ FA++
Sbjct: 704 FSQDFAKD 711
>XP_006713085
          Length = 1471

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   FSQSFAQE 9
           FSQ FA++
Sbjct: 704 FSQDFAKD 711
>XP_006713084
          Length = 1471

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   FSQSFAQE 9
           FSQ FA++
Sbjct: 704 FSQDFAKD 711
>XP_005276004
          Length = 584

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   FSQSFAQE 9
           FSQ FA++
Sbjct: 242 FSQDFAKD 249
>NP_037377
          Length = 437

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   FSQSFAQE 9
           FS+ F QE
Sbjct: 429 FSEDFGQE 436
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.314    0.123    0.328 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 393,920
Number of extensions: 570
Number of successful extensions: 50
Number of sequences better than 10000.0: 50
Number of HSP's gapped: 50
Number of HSP's successfully gapped: 50
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.7 bits)
S2: 28 (15.4 bits)

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