Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_775771                                                              21     229
NP_115927                                                              21     229
XP_006720466                                                           21     229
XP_005254230                                                           21     229
XP_006720465                                                           21     229
XP_005254228                                                           21     229
XP_006715292                                                           21     229
NP_061028                                                              16    5631
NP_001273653                                                           16    5631
NP_004268                                                              16    5631
NP_001190981                                                           16    5631
NP_001190980                                                           16    5631
NP_001273651                                                           16    5631
NP_055427                                                              16    5631
NP_001273652                                                           16    5631
XP_005251899                                                           16    5631
XP_006715337                                                           16    5631
XP_005249541                                                           16    5631
XP_005249540                                                           16    5631
NP_000258                                                              16    7355
NP_001035957                                                           16    7355
XP_006721990                                                           16    7355
XP_006721989                                                           16    7355
XP_005258041                                                           16    7355
XP_006721988                                                           16    7355
XP_006721987                                                           16    7355
XP_006721986                                                           16    7355
XP_005258040                                                           16    7355
XP_006721985                                                           16    7355
NP_001159532                                                           15    9605
NP_000815                                                              15    9605
NP_001243342                                                           15    9605
NP_001035196                                                           15    9605
NP_115745                                                              15    9605
NP_444282                                                              15    9605
NP_004808                                                              15    9605
NP_001164101                                                           15    9605
NP_963923                                                              15    9605
NP_005525                                                              15    9605
NP_001163886                                                           15    9605
NP_057112                                                              15    9605
NP_079461                                                              15    9605
NP_060105                                                              15    9605
NP_001154879                                                           15    9605
XP_005261026                                                           15    9605
XP_005257260                                                           15    9605
XP_005257258                                                           15    9605
XP_006721872                                                           15    9605
XP_006721871                                                           15    9605
XP_006721870                                                           15    9605
XP_006721869                                                           15    9605
XP_006719903                                                           15    9605
XP_006719703                                                           15    9605
XP_005254005                                                           15    9605
XP_005274095                                                           15    9605
XP_006718644                                                           15    9605
XP_005274093                                                           15    9605
XP_005274092                                                           15    9605
XP_005273812                                                           15    9605
XP_005252372                                                           15    9605
XP_006717387                                                           15    9605
XP_005252371                                                           15    9605
XP_005252370                                                           15    9605
XP_005252369                                                           15    9605
XP_005252368                                                           15    9605
XP_005250261                                                           15    9605
XP_005250260                                                           15    9605
NP_061953                                                              15    9605
NP_690852                                                              15    9605
NP_001163885                                                           15    9605
NP_001163887                                                           15    9605
>NP_775771
          Length = 1244

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   GFRGMVRYA 9
           GFRG VRYA
Sbjct: 185 GFRGTVRYA 193
>NP_115927
          Length = 1321

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   GFRGMVRYA 9
           GFRG VRYA
Sbjct: 198 GFRGTVRYA 206
>XP_006720466
          Length = 1175

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   GFRGMVRYA 9
           GFRG VRYA
Sbjct: 116 GFRGTVRYA 124
>XP_005254230
          Length = 1175

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   GFRGMVRYA 9
           GFRG VRYA
Sbjct: 116 GFRGTVRYA 124
>XP_006720465
          Length = 1239

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   GFRGMVRYA 9
           GFRG VRYA
Sbjct: 180 GFRGTVRYA 188
>XP_005254228
          Length = 1250

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   GFRGMVRYA 9
           GFRG VRYA
Sbjct: 191 GFRGTVRYA 199
>XP_006715292
          Length = 759

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   GFRGMVRYA 9
           GFRG VRYA
Sbjct: 185 GFRGTVRYA 193
>NP_061028
          Length = 632

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  GFRGMVRYA 9
          G RGM+R A
Sbjct: 2  GIRGMLRAA 10
>NP_001273653
          Length = 628

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   GFRGMVRY 8
           GF G+V Y
Sbjct: 178 GFHGLVAY 185
>NP_004268
          Length = 323

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  FRGMVRYA 9
          +RGMVR A
Sbjct: 68 YRGMVRTA 75
>NP_001190981
          Length = 245

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  FRGMVRYA 9
          +RGMVR A
Sbjct: 68 YRGMVRTA 75
>NP_001190980
          Length = 300

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  FRGMVRYA 9
          +RGMVR A
Sbjct: 68 YRGMVRTA 75
>NP_001273651
          Length = 1117

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   GFRGMVRY 8
           GF G+V Y
Sbjct: 178 GFHGLVAY 185
>NP_055427
          Length = 1118

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   GFRGMVRY 8
           GF G+V Y
Sbjct: 178 GFHGLVAY 185
>NP_001273652
          Length = 651

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   GFRGMVRY 8
           GF G+V Y
Sbjct: 178 GFHGLVAY 185
>XP_005251899
          Length = 1117

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   GFRGMVRY 8
           GF G+V Y
Sbjct: 178 GFHGLVAY 185
>XP_006715337
          Length = 266

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  FRGMVRYA 9
          +RGMVR A
Sbjct: 68 YRGMVRTA 75
>XP_005249541
          Length = 275

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  FRGMVRYA 9
          +RGMVR A
Sbjct: 20 YRGMVRTA 27
>XP_005249540
          Length = 310

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  FRGMVRYA 9
          +RGMVR A
Sbjct: 68 YRGMVRTA 75
>NP_000258
          Length = 2818

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    GFRGMVRYA 9
            GF G+ R+A
Sbjct: 2686 GFNGLWRFA 2694
>NP_001035957
          Length = 2839

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    GFRGMVRYA 9
            GF G+ R+A
Sbjct: 2707 GFNGLWRFA 2715
>XP_006721990
          Length = 2823

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    GFRGMVRYA 9
            GF G+ R+A
Sbjct: 2717 GFNGLWRFA 2725
>XP_006721989
          Length = 2823

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    GFRGMVRYA 9
            GF G+ R+A
Sbjct: 2717 GFNGLWRFA 2725
>XP_005258041
          Length = 2836

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    GFRGMVRYA 9
            GF G+ R+A
Sbjct: 2686 GFNGLWRFA 2694
>XP_006721988
          Length = 2846

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    GFRGMVRYA 9
            GF G+ R+A
Sbjct: 2696 GFNGLWRFA 2704
>XP_006721987
          Length = 2849

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    GFRGMVRYA 9
            GF G+ R+A
Sbjct: 2717 GFNGLWRFA 2725
>XP_006721986
          Length = 2854

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    GFRGMVRYA 9
            GF G+ R+A
Sbjct: 2704 GFNGLWRFA 2712
>XP_005258040
          Length = 2857

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    GFRGMVRYA 9
            GF G+ R+A
Sbjct: 2707 GFNGLWRFA 2715
>XP_006721985
          Length = 2867

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    GFRGMVRYA 9
            GF G+ R+A
Sbjct: 2717 GFNGLWRFA 2725
>NP_001159532
          Length = 497

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   GFRGMVRYA 9
           GF  +V YA
Sbjct: 340 GFASLVEYA 348
>NP_000815
          Length = 497

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   GFRGMVRYA 9
           GF  +V YA
Sbjct: 340 GFASLVEYA 348
>NP_001243342
          Length = 253

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  FRGMVR 7
          FRGM+R
Sbjct: 68 FRGMLR 73
>NP_001035196
          Length = 273

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  FRGMVR 7
          FRGM+R
Sbjct: 88 FRGMLR 93
>NP_115745
          Length = 273

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  FRGMVR 7
          FRGM+R
Sbjct: 88 FRGMLR 93
>NP_444282
          Length = 780

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   GFRGMVR 7
           GFR M+R
Sbjct: 435 GFREMIR 441
>NP_004808
          Length = 1190

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   FRGMVR 7
           FRG+VR
Sbjct: 563 FRGLVR 568
>NP_001164101
          Length = 993

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   FRGMVR 7
           FRG+VR
Sbjct: 563 FRGLVR 568
>NP_963923
          Length = 1043

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   FRGMVR 7
           FRG+VR
Sbjct: 563 FRGLVR 568
>NP_005525
          Length = 337

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/7 (42%), Positives = 7/7 (100%)

Query: 2   FRGMVRY 8
           +RG+++Y
Sbjct: 273 YRGLIKY 279
>NP_001163886
          Length = 1157

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   FRGMVR 7
           FRG+VR
Sbjct: 567 FRGLVR 572
>NP_057112
          Length = 393

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 5/8 (62%)

Query: 1  GFRGMVRY 8
          GF G  RY
Sbjct: 59 GFEGQSRY 66
>NP_079461
          Length = 1990

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    FRGMVRYA 9
            +RG VRY+
Sbjct: 1705 YRGGVRYS 1712
>NP_060105
          Length = 885

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 5/8 (62%)

Query: 1  GFRGMVRY 8
          GF G  RY
Sbjct: 59 GFEGQSRY 66
>NP_001154879
          Length = 316

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 2   FRGMVRY 8
           FRG V Y
Sbjct: 288 FRGFVNY 294
>XP_005261026
          Length = 356

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/7 (42%), Positives = 7/7 (100%)

Query: 2   FRGMVRY 8
           +RG+++Y
Sbjct: 292 YRGLIKY 298
>XP_005257260
          Length = 1990

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    FRGMVRYA 9
            +RG VRY+
Sbjct: 1705 YRGGVRYS 1712
>XP_005257258
          Length = 2000

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    FRGMVRYA 9
            +RG VRY+
Sbjct: 1715 YRGGVRYS 1722
>XP_006721872
          Length = 2037

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    FRGMVRYA 9
            +RG VRY+
Sbjct: 1752 YRGGVRYS 1759
>XP_006721871
          Length = 2037

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    FRGMVRYA 9
            +RG VRY+
Sbjct: 1752 YRGGVRYS 1759
>XP_006721870
          Length = 2064

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    FRGMVRYA 9
            +RG VRY+
Sbjct: 1779 YRGGVRYS 1786
>XP_006721869
          Length = 2074

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    FRGMVRYA 9
            +RG VRY+
Sbjct: 1789 YRGGVRYS 1796
>XP_006719903
          Length = 335

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 2   FRGMVRY 8
           FRG V Y
Sbjct: 307 FRGFVNY 313
>XP_006719703
          Length = 273

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  FRGMVR 7
          FRGM+R
Sbjct: 88 FRGMLR 93
>XP_005254005
          Length = 273

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  FRGMVR 7
          FRGM+R
Sbjct: 88 FRGMLR 93
>XP_005274095
          Length = 402

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 5/8 (62%)

Query: 1  GFRGMVRY 8
          GF G  RY
Sbjct: 59 GFEGQSRY 66
>XP_006718644
          Length = 862

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 5/8 (62%)

Query: 1  GFRGMVRY 8
          GF G  RY
Sbjct: 59 GFEGQSRY 66
>XP_005274093
          Length = 862

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 5/8 (62%)

Query: 1  GFRGMVRY 8
          GF G  RY
Sbjct: 59 GFEGQSRY 66
>XP_005274092
          Length = 885

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 5/8 (62%)

Query: 1  GFRGMVRY 8
          GF G  RY
Sbjct: 59 GFEGQSRY 66
>XP_005273812
          Length = 649

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   GFRGMVR 7
           GFR M+R
Sbjct: 304 GFREMIR 310
>XP_005252372
          Length = 1102

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   FRGMVR 7
           FRG+VR
Sbjct: 622 FRGLVR 627
>XP_006717387
          Length = 1188

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   FRGMVR 7
           FRG+VR
Sbjct: 561 FRGLVR 566
>XP_005252371
          Length = 1194

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   FRGMVR 7
           FRG+VR
Sbjct: 567 FRGLVR 572
>XP_005252370
          Length = 1212

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   FRGMVR 7
           FRG+VR
Sbjct: 622 FRGLVR 627
>XP_005252369
          Length = 1213

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   FRGMVR 7
           FRG+VR
Sbjct: 586 FRGLVR 591
>XP_005252368
          Length = 1249

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   FRGMVR 7
           FRG+VR
Sbjct: 622 FRGLVR 627
>XP_005250261
          Length = 495

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   GFRGMVR 7
           G RG+VR
Sbjct: 217 GLRGLVR 223
>XP_005250260
          Length = 595

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   GFRGMVR 7
           G RG+VR
Sbjct: 369 GLRGLVR 375
>NP_061953
          Length = 336

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 2   FRGMVRY 8
           FRG V Y
Sbjct: 308 FRGFVNY 314
>NP_690852
          Length = 647

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   GFRGMVR 7
           G RG+VR
Sbjct: 369 GLRGLVR 375
>NP_001163885
          Length = 1020

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   FRGMVR 7
           FRG+VR
Sbjct: 540 FRGLVR 545
>NP_001163887
          Length = 1221

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   FRGMVR 7
           FRG+VR
Sbjct: 594 FRGLVR 599
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.342    0.155    0.502 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 482,526
Number of extensions: 1095
Number of successful extensions: 71
Number of sequences better than 10000.0: 71
Number of HSP's gapped: 71
Number of HSP's successfully gapped: 71
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.5 bits)
S2: 28 (15.4 bits)

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