Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_036462                                                              21     229
NP_001243397                                                           21     229
NP_001092882                                                           21     229
NP_006757                                                              21     229
NP_001092883                                                           21     229
XP_005269721                                                           21     229
XP_005273706                                                           21     229
NP_065802                                                              17    2528
NP_001138551                                                           17    2528
NP_001140171                                                           17    3301
NP_001140170                                                           17    3301
NP_057280                                                              17    3301
NP_056271                                                              17    4312
NP_009007                                                              17    4312
NP_001273001                                                           16    5631
NP_001123551                                                           16    5631
NP_997304                                                              16    5631
NP_066014                                                              16    5631
XP_006710707                                                           16    5631
XP_005270926                                                           16    5631
XP_005270927                                                           16    5631
XP_005270925                                                           16    5631
NP_001104026                                                           16    7355
NP_001447                                                              16    7355
NP_114113                                                              16    7355
NP_037450                                                              16    7355
NP_004450                                                              16    7355
NP_872579                                                              16    7355
XP_005257219                                                           16    7355
XP_005257218                                                           16    7355
XP_005257217                                                           16    7355
XP_005257216                                                           16    7355
XP_005257215                                                           16    7355
XP_005257214                                                           16    7355
XP_005257213                                                           16    7355
XP_005257212                                                           16    7355
XP_006721834                                                           16    7355
XP_005257211                                                           16    7355
XP_005257210                                                           16    7355
XP_005257209                                                           16    7355
XP_005257208                                                           16    7355
XP_006721833                                                           16    7355
XP_005257207                                                           16    7355
NP_001139110                                                           15    9605
NP_001018048                                                           15    9605
NP_056001                                                              15    9605
NP_001018047                                                           15    9605
NP_150648                                                              15    9605
NP_060619                                                              15    9605
NP_055970                                                              15    9605
NP_002220                                                              15    9605
NP_056069                                                              15    9605
NP_056163                                                              15    9605
NP_001136430                                                           15    9605
NP_116019                                                              15    9605
NP_001014305                                                           15    9605
NP_001482                                                              15    9605
XP_006720038                                                           15    9605
XP_005268377                                                           15    9605
XP_005268378                                                           15    9605
XP_006720037                                                           15    9605
XP_006717499                                                           15    9605
XP_005252492                                                           15    9605
XP_005252490                                                           15    9605
XP_005252489                                                           15    9605
XP_005252488                                                           15    9605
XP_006716380                                                           15    9605
XP_006716379                                                           15    9605
XP_005273516                                                           15    9605
XP_005273515                                                           15    9605
XP_006715118                                                           15    9605
XP_005249054                                                           15    9605
XP_005263969                                                           15    9605
XP_005263968                                                           15    9605
XP_005263967                                                           15    9605
XP_005263966                                                           15    9605
>NP_036462
          Length = 2073

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   GFIDGLTKF 9
           G IDGLTKF
Sbjct: 433 GLIDGLTKF 441
>NP_001243397
          Length = 1890

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   GFIDGLTKF 9
           G IDGLTKF
Sbjct: 433 GLIDGLTKF 441
>NP_001092882
          Length = 2004

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   GFIDGLTKF 9
           G IDGLTKF
Sbjct: 408 GLIDGLTKF 416
>NP_006757
          Length = 2004

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   GFIDGLTKF 9
           G IDGLTKF
Sbjct: 408 GLIDGLTKF 416
>NP_001092883
          Length = 2004

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   GFIDGLTKF 9
           G IDGLTKF
Sbjct: 408 GLIDGLTKF 416
>XP_005269721
          Length = 2073

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   GFIDGLTKF 9
           G IDGLTKF
Sbjct: 433 GLIDGLTKF 441
>XP_005273706
          Length = 1997

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   GFIDGLTKF 9
           G IDGLTKF
Sbjct: 401 GLIDGLTKF 409
>NP_065802
          Length = 657

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   GFIDGLTK 8
           GFID LT+
Sbjct: 280 GFIDALTR 287
>NP_001138551
          Length = 615

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   GFIDGLTK 8
           GFID LT+
Sbjct: 280 GFIDALTR 287
>NP_001140171
          Length = 960

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   GFIDGLTK 8
           GF+D LTK
Sbjct: 877 GFVDFLTK 884
>NP_001140170
          Length = 960

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   GFIDGLTK 8
           GF+D LTK
Sbjct: 877 GFVDFLTK 884
>NP_057280
          Length = 960

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   GFIDGLTK 8
           GF+D LTK
Sbjct: 877 GFVDFLTK 884
>NP_056271
          Length = 580

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   GFIDGLTK 8
           GF+DG+ K
Sbjct: 285 GFLDGVKK 292
>NP_009007
          Length = 458

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   FIDGLTKF 9
           F+D LT+F
Sbjct: 139 FVDALTEF 146
>NP_001273001
          Length = 947

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   FIDGLT 7
           F+DGLT
Sbjct: 381 FVDGLT 386
>NP_001123551
          Length = 1003

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   FIDGLT 7
           F+DGLT
Sbjct: 437 FVDGLT 442
>NP_997304
          Length = 694

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   GFIDGLTK 8
           GF+D +TK
Sbjct: 327 GFVDTVTK 334
>NP_066014
          Length = 1003

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   FIDGLT 7
           F+DGLT
Sbjct: 437 FVDGLT 442
>XP_006710707
          Length = 898

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   FIDGLT 7
           F+DGLT
Sbjct: 437 FVDGLT 442
>XP_005270926
          Length = 947

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   FIDGLT 7
           F+DGLT
Sbjct: 381 FVDGLT 386
>XP_005270927
          Length = 947

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   FIDGLT 7
           F+DGLT
Sbjct: 381 FVDGLT 386
>XP_005270925
          Length = 1003

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   FIDGLT 7
           F+DGLT
Sbjct: 437 FVDGLT 442
>NP_001104026
          Length = 2647

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    FIDGLTK 8
            F+D LTK
Sbjct: 2534 FVDSLTK 2540
>NP_001447
          Length = 2639

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    FIDGLTK 8
            F+D LTK
Sbjct: 2526 FVDSLTK 2532
>NP_114113
          Length = 913

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   GFIDGLTKF 9
           G+ DG TK+
Sbjct: 271 GYSDGYTKW 279
>NP_037450
          Length = 2229

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    GFIDGLTK 8
            GFI+ LTK
Sbjct: 1561 GFIEVLTK 1568
>NP_004450
          Length = 2903

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   FIDGLT 7
           FIDG+T
Sbjct: 320 FIDGMT 325
>NP_872579
          Length = 2920

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   FIDGLT 7
           FIDG+T
Sbjct: 320 FIDGMT 325
>XP_005257219
          Length = 2038

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   FIDGLT 7
           FIDG+T
Sbjct: 320 FIDGMT 325
>XP_005257218
          Length = 2957

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   FIDGLT 7
           FIDG+T
Sbjct: 320 FIDGMT 325
>XP_005257217
          Length = 2961

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   FIDGLT 7
           FIDG+T
Sbjct: 320 FIDGMT 325
>XP_005257216
          Length = 3015

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   FIDGLT 7
           FIDG+T
Sbjct: 320 FIDGMT 325
>XP_005257215
          Length = 3032

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   FIDGLT 7
           FIDG+T
Sbjct: 320 FIDGMT 325
>XP_005257214
          Length = 3094

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   FIDGLT 7
           FIDG+T
Sbjct: 320 FIDGMT 325
>XP_005257213
          Length = 3095

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   FIDGLT 7
           FIDG+T
Sbjct: 320 FIDGMT 325
>XP_005257212
          Length = 3095

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   FIDGLT 7
           FIDG+T
Sbjct: 320 FIDGMT 325
>XP_006721834
          Length = 3100

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   FIDGLT 7
           FIDG+T
Sbjct: 320 FIDGMT 325
>XP_005257211
          Length = 3100

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   FIDGLT 7
           FIDG+T
Sbjct: 320 FIDGMT 325
>XP_005257210
          Length = 3104

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   FIDGLT 7
           FIDG+T
Sbjct: 320 FIDGMT 325
>XP_005257209
          Length = 3148

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   FIDGLT 7
           FIDG+T
Sbjct: 320 FIDGMT 325
>XP_005257208
          Length = 3157

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   FIDGLT 7
           FIDG+T
Sbjct: 320 FIDGMT 325
>XP_006721833
          Length = 3158

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   FIDGLT 7
           FIDG+T
Sbjct: 320 FIDGMT 325
>XP_005257207
          Length = 3158

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   FIDGLT 7
           FIDG+T
Sbjct: 320 FIDGMT 325
>NP_001139110
          Length = 675

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   FIDGLTKF 9
           F D LTKF
Sbjct: 498 FFDLLTKF 505
>NP_001018048
          Length = 3069

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1    GFIDGLT 7
            GF+ G+T
Sbjct: 2970 GFVSGIT 2976
>NP_056001
          Length = 3095

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1    GFIDGLT 7
            GF+ G+T
Sbjct: 2970 GFVSGIT 2976
>NP_001018047
          Length = 3135

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1    GFIDGLT 7
            GF+ G+T
Sbjct: 2931 GFVSGIT 2937
>NP_150648
          Length = 3174

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1    GFIDGLT 7
            GF+ G+T
Sbjct: 2970 GFVSGIT 2976
>NP_060619
          Length = 991

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   GFIDGLTKF 9
           GF+D  TKF
Sbjct: 487 GFLDIDTKF 495
>NP_055970
          Length = 738

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   GFIDGLT 7
           GFI+G T
Sbjct: 383 GFINGFT 389
>NP_002220
          Length = 347

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 5/8 (62%)

Query: 1   GFIDGLTK 8
           GF DG  K
Sbjct: 134 GFADGFVK 141
>NP_056069
          Length = 1826

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   FIDGLTK 8
           ++DGL+K
Sbjct: 182 YVDGLSK 188
>NP_056163
          Length = 1883

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   GFIDGLTK 8
           GF++GL++
Sbjct: 915 GFMEGLSR 922
>NP_001136430
          Length = 510

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1  GFIDGL 6
          GF+DG+
Sbjct: 72 GFLDGM 77
>NP_116019
          Length = 212

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   IDGLTK 8
           +DGLTK
Sbjct: 99  LDGLTK 104
>NP_001014305
          Length = 259

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   FIDGLTK 8
           F+DG+T+
Sbjct: 122 FLDGMTE 128
>NP_001482
          Length = 400

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  FIDGLTKF 9
          FI+G T+F
Sbjct: 51 FINGKTRF 58
>XP_006720038
          Length = 244

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   FIDGLTK 8
           F+DG+T+
Sbjct: 107 FLDGMTE 113
>XP_005268377
          Length = 244

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   FIDGLTK 8
           F+DG+T+
Sbjct: 107 FLDGMTE 113
>XP_005268378
          Length = 244

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   FIDGLTK 8
           F+DG+T+
Sbjct: 107 FLDGMTE 113
>XP_006720037
          Length = 244

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   FIDGLTK 8
           F+DG+T+
Sbjct: 107 FLDGMTE 113
>XP_006717499
          Length = 616

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   GFIDGLT 7
           GFI+G T
Sbjct: 226 GFINGFT 232
>XP_005252492
          Length = 650

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   GFIDGLT 7
           GFI+G T
Sbjct: 260 GFINGFT 266
>XP_005252490
          Length = 761

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   GFIDGLT 7
           GFI+G T
Sbjct: 406 GFINGFT 412
>XP_005252489
          Length = 773

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   GFIDGLT 7
           GFI+G T
Sbjct: 383 GFINGFT 389
>XP_005252488
          Length = 796

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   GFIDGLT 7
           GFI+G T
Sbjct: 406 GFINGFT 412
>XP_006716380
          Length = 1762

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   FIDGLTK 8
           ++DGL+K
Sbjct: 118 YVDGLSK 124
>XP_006716379
          Length = 1762

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   FIDGLTK 8
           ++DGL+K
Sbjct: 118 YVDGLSK 124
>XP_005273516
          Length = 1762

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   FIDGLTK 8
           ++DGL+K
Sbjct: 118 YVDGLSK 124
>XP_005273515
          Length = 1805

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   FIDGLTK 8
           ++DGL+K
Sbjct: 182 YVDGLSK 188
>XP_006715118
          Length = 311

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  FIDGLTKF 9
          FI+G T+F
Sbjct: 51 FINGKTRF 58
>XP_005249054
          Length = 363

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  FIDGLTKF 9
          FI+G T+F
Sbjct: 51 FINGKTRF 58
>XP_005263969
          Length = 1844

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   GFIDGLTK 8
           GF++GL++
Sbjct: 876 GFMEGLSR 883
>XP_005263968
          Length = 1861

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   GFIDGLTK 8
           GF++GL++
Sbjct: 893 GFMEGLSR 900
>XP_005263967
          Length = 1899

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   GFIDGLTK 8
           GF++GL++
Sbjct: 932 GFMEGLSR 939
>XP_005263966
          Length = 1900

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   GFIDGLTK 8
           GF++GL++
Sbjct: 932 GFMEGLSR 939
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.334    0.163    0.514 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 444,038
Number of extensions: 611
Number of successful extensions: 76
Number of sequences better than 10000.0: 76
Number of HSP's gapped: 76
Number of HSP's successfully gapped: 76
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.1 bits)
S2: 28 (15.4 bits)

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