Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_008835                                                              20     299
NP_001075109                                                           20     299
NP_001919                                                              17    2528
NP_005236                                                              17    4312
NP_002824                                                              17    4312
NP_064576                                                              17    4312
XP_006714202                                                           17    4312
XP_005262892                                                           17    4312
XP_005262891                                                           17    4312
XP_006713766                                                           17    4312
XP_005247697                                                           17    4312
NP_060800                                                              16    5631
NP_001120683                                                           16    5631
NP_056028                                                              16    5631
NP_001230183                                                           16    5631
NP_001245228                                                           16    5631
XP_006718232                                                           16    5631
XP_005252889                                                           16    5631
XP_005270059                                                           16    5631
XP_006717994                                                           16    5631
NP_079368                                                              16    7355
NP_940895                                                              16    7355
NP_001171600                                                           16    7355
NP_036563                                                              16    7355
NP_036296                                                              16    7355
NP_005867                                                              16    7355
NP_001099046                                                           16    7355
XP_006718399                                                           16    7355
XP_006718398                                                           16    7355
XP_006718397                                                           16    7355
XP_006718396                                                           16    7355
XP_006718395                                                           16    7355
XP_006718394                                                           16    7355
XP_006718393                                                           16    7355
XP_005251970                                                           16    7355
XP_005251969                                                           16    7355
XP_006717114                                                           16    7355
XP_005251967                                                           16    7355
XP_006717113                                                           16    7355
XP_006717112                                                           16    7355
XP_005251965                                                           16    7355
XP_006716250                                                           16    7355
XP_006712256                                                           16    7355
XP_005246298                                                           16    7355
XP_005246297                                                           16    7355
XP_005246299                                                           16    7355
XP_005246296                                                           16    7355
XP_006712254                                                           16    7355
XP_005246295                                                           16    7355
XP_006712253                                                           16    7355
XP_006712252                                                           16    7355
XP_005246294                                                           16    7355
XP_006712251                                                           16    7355
XP_005246293                                                           16    7355
XP_005246292                                                           16    7355
XP_006712250                                                           16    7355
NP_036224                                                              15    9605
NP_001188413                                                           15    9605
NP_116023                                                              15    9605
NP_690577                                                              15    9605
NP_077321                                                              15    9605
NP_001161946                                                           15    9605
NP_079161                                                              15    9605
NP_001273739                                                           15    9605
XP_005251676                                                           15    9605
XP_005251635                                                           15    9605
XP_005251634                                                           15    9605
XP_005246539                                                           15    9605
>NP_008835
          Length = 4128

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    GEYDVLRAI 9
            GEYDVLR I
Sbjct: 2934 GEYDVLRGI 2942
>NP_001075109
          Length = 4097

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    GEYDVLRAI 9
            GEYDVLR I
Sbjct: 2934 GEYDVLRGI 2942
>NP_001919
          Length = 253

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   YDVLRAI 9
           YDVLRA+
Sbjct: 95  YDVLRAV 101
>NP_005236
          Length = 4588

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    GEYDVL 6
            GEYD+L
Sbjct: 1318 GEYDIL 1323
>NP_002824
          Length = 593

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  EYDVLRAI 9
          ++DVLRAI
Sbjct: 55 KFDVLRAI 62
>NP_064576
          Length = 360

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   GEYDVLRA 8
           G+YD+LR+
Sbjct: 257 GKYDLLRS 264
>XP_006714202
          Length = 4588

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    GEYDVL 6
            GEYD+L
Sbjct: 1318 GEYDIL 1323
>XP_005262892
          Length = 4600

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    GEYDVL 6
            GEYD+L
Sbjct: 1318 GEYDIL 1323
>XP_005262891
          Length = 4600

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    GEYDVL 6
            GEYD+L
Sbjct: 1318 GEYDIL 1323
>XP_006713766
          Length = 342

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   GEYDVLRA 8
           G+YD+LR+
Sbjct: 239 GKYDLLRS 246
>XP_005247697
          Length = 359

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   GEYDVLRA 8
           G+YD+LR+
Sbjct: 256 GKYDLLRS 263
>NP_060800
          Length = 456

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  GEYDVLRA 8
          GEY+ LRA
Sbjct: 22 GEYEDLRA 29
>NP_001120683
          Length = 631

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  GEYDVLRA 8
          GEY+ LRA
Sbjct: 22 GEYEDLRA 29
>NP_056028
          Length = 1287

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   EYDVLRA 8
           EYDVL A
Sbjct: 160 EYDVLHA 166
>NP_001230183
          Length = 1241

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   EYDVLRA 8
           EYDVL A
Sbjct: 160 EYDVLHA 166
>NP_001245228
          Length = 558

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  GEYDVLRA 8
          GEY+ LRA
Sbjct: 22 GEYEDLRA 29
>XP_006718232
          Length = 1263

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   EYDVLRA 8
           EYDVL A
Sbjct: 136 EYDVLHA 142
>XP_005252889
          Length = 1307

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   EYDVLRA 8
           EYDVL A
Sbjct: 160 EYDVLHA 166
>XP_005270059
          Length = 573

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  GEYDVLRA 8
          GEY+ LRA
Sbjct: 22 GEYEDLRA 29
>XP_006717994
          Length = 617

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  GEYDVLRA 8
          GEY+ LRA
Sbjct: 22 GEYEDLRA 29
>NP_079368
          Length = 737

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   GEYDVLRAI 9
           G +DV+RA+
Sbjct: 395 GGWDVVRAV 403
>NP_940895
          Length = 266

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  GEYDVLRAI 9
          G+ DV+RA+
Sbjct: 88 GQSDVIRAL 96
>NP_001171600
          Length = 715

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   GEYDVL 6
           G+YDVL
Sbjct: 386 GQYDVL 391
>NP_036563
          Length = 775

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   GEYDVL 6
           G+YDVL
Sbjct: 446 GQYDVL 451
>NP_036296
          Length = 454

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   YDVLRAI 9
           YD+LR I
Sbjct: 355 YDILRVI 361
>NP_005867
          Length = 3267

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    EYDVLRAI 9
            EY+VLR +
Sbjct: 3010 EYEVLRTL 3017
>NP_001099046
          Length = 315

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   GEYDVLRAI 9
           G Y+VLR +
Sbjct: 124 GRYEVLREL 132
>XP_006718399
          Length = 487

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  GEYDVLRAI 9
          G +DV+RA+
Sbjct: 90 GGWDVVRAV 98
>XP_006718398
          Length = 557

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   GEYDVLRAI 9
           G +DV+RA+
Sbjct: 395 GGWDVVRAV 403
>XP_006718397
          Length = 737

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   GEYDVLRAI 9
           G +DV+RA+
Sbjct: 395 GGWDVVRAV 403
>XP_006718396
          Length = 774

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   GEYDVLRAI 9
           G +DV+RA+
Sbjct: 395 GGWDVVRAV 403
>XP_006718395
          Length = 792

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   GEYDVLRAI 9
           G +DV+RA+
Sbjct: 395 GGWDVVRAV 403
>XP_006718394
          Length = 792

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   GEYDVLRAI 9
           G +DV+RA+
Sbjct: 395 GGWDVVRAV 403
>XP_006718393
          Length = 792

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   GEYDVLRAI 9
           G +DV+RA+
Sbjct: 395 GGWDVVRAV 403
>XP_005251970
          Length = 325

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   YDVLRAI 9
           YD+LR I
Sbjct: 226 YDILRVI 232
>XP_005251969
          Length = 389

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   YDVLRAI 9
           YD+LR I
Sbjct: 290 YDILRVI 296
>XP_006717114
          Length = 421

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   YDVLRAI 9
           YD+LR I
Sbjct: 322 YDILRVI 328
>XP_005251967
          Length = 454

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   YDVLRAI 9
           YD+LR I
Sbjct: 355 YDILRVI 361
>XP_006717113
          Length = 486

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   YDVLRAI 9
           YD+LR I
Sbjct: 387 YDILRVI 393
>XP_006717112
          Length = 486

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   YDVLRAI 9
           YD+LR I
Sbjct: 387 YDILRVI 393
>XP_005251965
          Length = 486

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   YDVLRAI 9
           YD+LR I
Sbjct: 387 YDILRVI 393
>XP_006716250
          Length = 583

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   GEYDVL 6
           G+YDVL
Sbjct: 446 GQYDVL 451
>XP_006712256
          Length = 2418

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    EYDVLRAI 9
            EY+VLR +
Sbjct: 2161 EYEVLRTL 2168
>XP_005246298
          Length = 2418

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    EYDVLRAI 9
            EY+VLR +
Sbjct: 2161 EYEVLRTL 2168
>XP_005246297
          Length = 2418

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    EYDVLRAI 9
            EY+VLR +
Sbjct: 2161 EYEVLRTL 2168
>XP_005246299
          Length = 2480

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    EYDVLRAI 9
            EY+VLR +
Sbjct: 2223 EYEVLRTL 2230
>XP_005246296
          Length = 2475

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    EYDVLRAI 9
            EY+VLR +
Sbjct: 2218 EYEVLRTL 2225
>XP_006712254
          Length = 2475

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    EYDVLRAI 9
            EY+VLR +
Sbjct: 2218 EYEVLRTL 2225
>XP_005246295
          Length = 3114

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    EYDVLRAI 9
            EY+VLR +
Sbjct: 2857 EYEVLRTL 2864
>XP_006712253
          Length = 3117

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    EYDVLRAI 9
            EY+VLR +
Sbjct: 2860 EYEVLRTL 2867
>XP_006712252
          Length = 3163

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    EYDVLRAI 9
            EY+VLR +
Sbjct: 2906 EYEVLRTL 2913
>XP_005246294
          Length = 3173

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    EYDVLRAI 9
            EY+VLR +
Sbjct: 2916 EYEVLRTL 2923
>XP_006712251
          Length = 3176

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    EYDVLRAI 9
            EY+VLR +
Sbjct: 2919 EYEVLRTL 2926
>XP_005246293
          Length = 3206

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    EYDVLRAI 9
            EY+VLR +
Sbjct: 2949 EYEVLRTL 2956
>XP_005246292
          Length = 3208

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    EYDVLRAI 9
            EY+VLR +
Sbjct: 2951 EYEVLRTL 2958
>XP_006712250
          Length = 3248

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    EYDVLRAI 9
            EY+VLR +
Sbjct: 2991 EYEVLRTL 2998
>NP_036224
          Length = 199

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   GEYDVLRAI 9
           GEY  +RA+
Sbjct: 178 GEYMFMRAV 186
>NP_001188413
          Length = 672

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   GEYDVLRA 8
           GE+DVL A
Sbjct: 222 GEWDVLIA 229
>NP_116023
          Length = 1089

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   GEYDVLRA 8
           GE+DVL A
Sbjct: 222 GEWDVLIA 229
>NP_690577
          Length = 672

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   GEYDVLRA 8
           GE+DVL A
Sbjct: 222 GEWDVLIA 229
>NP_077321
          Length = 559

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   GEYDVLRA 8
           G Y +LRA
Sbjct: 337 GSYPILRA 344
>NP_001161946
          Length = 376

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   EYDVLR 7
           EYD+LR
Sbjct: 231 EYDMLR 236
>NP_079161
          Length = 462

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   EYDVLR 7
           EYD+LR
Sbjct: 317 EYDMLR 322
>NP_001273739
          Length = 386

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   GEYDVLRA 8
           G Y +LRA
Sbjct: 164 GSYPILRA 171
>XP_005251676
          Length = 1089

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   GEYDVLRA 8
           GE+DVL A
Sbjct: 222 GEWDVLIA 229
>XP_005251635
          Length = 493

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   GEYDVLRA 8
           G Y +LRA
Sbjct: 271 GSYPILRA 278
>XP_005251634
          Length = 522

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   GEYDVLRA 8
           G Y +LRA
Sbjct: 337 GSYPILRA 344
>XP_005246539
          Length = 198

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   GEYDVLRAI 9
           GEY  +RA+
Sbjct: 177 GEYMFMRAV 185
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.324    0.150    0.421 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 465,654
Number of extensions: 728
Number of successful extensions: 68
Number of sequences better than 10000.0: 68
Number of HSP's gapped: 68
Number of HSP's successfully gapped: 68
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.8 bits)
S2: 28 (15.4 bits)

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