Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001268421                                                           20     509
NP_000170                                                              20     509
NP_001268422                                                           20     509
NP_001268423                                                           20     509
XP_005264328                                                           20     509
NP_001139669                                                           18    1935
NP_001191448                                                           17    4312
NP_002552                                                              17    4312
NP_998771                                                              16    7355
NP_056392                                                              16    7355
NP_055211                                                              16    7355
NP_001138997                                                           16    7355
NP_001138995                                                           16    7355
NP_001138994                                                           16    7355
NP_001138993                                                           16    7355
NP_001138992                                                           16    7355
XP_006714532                                                           16    7355
NP_115511                                                              16    7355
NP_542198                                                              16    7355
NP_001121093                                                           15    9605
NP_000394                                                              15    9605
NP_001008217                                                           15    9605
NP_057313                                                              15    9605
NP_001269665                                                           15    9605
NP_116201                                                              15    9605
NP_001273428                                                           15    9605
NP_001273425                                                           15    9605
NP_079325                                                              15    9605
NP_005437                                                              15    9605
NP_001153026                                                           15    9605
NP_001273426                                                           15    9605
XP_006724432                                                           15    9605
XP_005261876                                                           15    9605
XP_005253033                                                           15    9605
XP_006718315                                                           15    9605
XP_005253032                                                           15    9605
XP_006718314                                                           15    9605
XP_005253031                                                           15    9605
XP_006718313                                                           15    9605
XP_005253030                                                           15    9605
>NP_001268421
          Length = 1230

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    GESIFFVEL 9
            GES FFVEL
Sbjct: 1056 GESTFFVEL 1064
>NP_000170
          Length = 1360

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    GESIFFVEL 9
            GES FFVEL
Sbjct: 1186 GESTFFVEL 1194
>NP_001268422
          Length = 1058

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   GESIFFVEL 9
           GES FFVEL
Sbjct: 884 GESTFFVEL 892
>NP_001268423
          Length = 1058

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   GESIFFVEL 9
           GES FFVEL
Sbjct: 884 GESTFFVEL 892
>XP_005264328
          Length = 1261

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    GESIFFVEL 9
            GES FFVEL
Sbjct: 1087 GESTFFVEL 1095
>NP_001139669
          Length = 7081

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    GESIFFVEL 9
            G++IFF EL
Sbjct: 3000 GQNIFFTEL 3008
>NP_001191448
          Length = 421

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   GESIFFV 7
           GE++FFV
Sbjct: 97  GENVFFV 103
>NP_002552
          Length = 422

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   GESIFFV 7
           GE++FFV
Sbjct: 97  GENVFFV 103
>NP_998771
          Length = 516

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3  SIFFVE 8
          SIFFVE
Sbjct: 70 SIFFVE 75
>NP_056392
          Length = 980

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   ESIFFVE 8
           ES+FF E
Sbjct: 303 ESVFFAE 309
>NP_055211
          Length = 854

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   GESIFFV 7
           GES+F++
Sbjct: 342 GESLFYI 348
>NP_001138997
          Length = 983

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   ESIFFVE 8
           ES+FF E
Sbjct: 306 ESVFFAE 312
>NP_001138995
          Length = 972

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   ESIFFVE 8
           ES+FF E
Sbjct: 295 ESVFFAE 301
>NP_001138994
          Length = 951

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   ESIFFVE 8
           ES+FF E
Sbjct: 274 ESVFFAE 280
>NP_001138993
          Length = 980

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   ESIFFVE 8
           ES+FF E
Sbjct: 303 ESVFFAE 309
>NP_001138992
          Length = 980

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   ESIFFVE 8
           ES+FF E
Sbjct: 303 ESVFFAE 309
>XP_006714532
          Length = 980

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   ESIFFVE 8
           ES+FF E
Sbjct: 303 ESVFFAE 309
>NP_115511
          Length = 825

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ESIFFVEL 9
           ES+F +EL
Sbjct: 811 ESVFHIEL 818
>NP_542198
          Length = 829

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   GESIFFV 7
           GES+F++
Sbjct: 317 GESLFYI 323
>NP_001121093
          Length = 348

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   GESIFFVE 8
           G+S FF+E
Sbjct: 158 GKSKFFIE 165
>NP_000394
          Length = 348

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   GESIFFVE 8
           G+S FF+E
Sbjct: 158 GKSKFFIE 165
>NP_001008217
          Length = 348

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   GESIFFVE 8
           G+S FF+E
Sbjct: 158 GKSKFFIE 165
>NP_057313
          Length = 276

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   GESIFF 6
           GE+IFF
Sbjct: 112 GETIFF 117
>NP_001269665
          Length = 480

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   SIFFVE 8
           SIFF+E
Sbjct: 437 SIFFIE 442
>NP_116201
          Length = 529

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   SIFFVE 8
           SIFF+E
Sbjct: 486 SIFFIE 491
>NP_001273428
          Length = 588

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   GESIFF 6
           G+SIFF
Sbjct: 168 GQSIFF 173
>NP_001273425
          Length = 641

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   GESIFF 6
           G+SIFF
Sbjct: 221 GQSIFF 226
>NP_079325
          Length = 641

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   GESIFF 6
           G+SIFF
Sbjct: 221 GQSIFF 226
>NP_005437
          Length = 441

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   GESIFFV 7
           GE++FF+
Sbjct: 106 GENVFFL 112
>NP_001153026
          Length = 415

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1  GESIFFV 7
          GE++FF+
Sbjct: 80 GENVFFL 86
>NP_001273426
          Length = 707

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   GESIFF 6
           G+SIFF
Sbjct: 221 GQSIFF 226
>XP_006724432
          Length = 447

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1  GESIFFV 7
          GE++FF+
Sbjct: 80 GENVFFL 86
>XP_005261876
          Length = 473

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   GESIFFV 7
           GE++FF+
Sbjct: 106 GENVFFL 112
>XP_005253033
          Length = 258

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   GESIFF 6
           GE+IFF
Sbjct: 172 GETIFF 177
>XP_006718315
          Length = 276

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   GESIFF 6
           GE+IFF
Sbjct: 112 GETIFF 117
>XP_005253032
          Length = 276

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   GESIFF 6
           GE+IFF
Sbjct: 112 GETIFF 117
>XP_006718314
          Length = 276

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   GESIFF 6
           GE+IFF
Sbjct: 112 GETIFF 117
>XP_005253031
          Length = 276

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   GESIFF 6
           GE+IFF
Sbjct: 112 GETIFF 117
>XP_006718313
          Length = 276

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   GESIFF 6
           GE+IFF
Sbjct: 112 GETIFF 117
>XP_005253030
          Length = 336

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   GESIFF 6
           GE+IFF
Sbjct: 172 GETIFF 177
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.330    0.155    0.426 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 435,679
Number of extensions: 660
Number of successful extensions: 40
Number of sequences better than 10000.0: 40
Number of HSP's gapped: 40
Number of HSP's successfully gapped: 40
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.0 bits)
S2: 28 (15.4 bits)

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