Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_006197                                                              19     869
XP_006714104                                                           19     869
XP_005265800                                                           19     869
XP_006714103                                                           19     869
XP_006714102                                                           19     869
NP_006816                                                              17    2528
NP_001273171                                                           17    2528
NP_001511                                                              17    2528
XP_006721105                                                           17    2528
NP_112506                                                              17    4312
NP_006453                                                              17    4312
NP_775832                                                              17    4312
NP_001243727                                                           17    4312
NP_001164056                                                           17    4312
NP_694566                                                              17    4312
XP_005260706                                                           17    4312
XP_005260703                                                           17    4312
XP_005260702                                                           17    4312
NP_004000                                                              16    7355
NP_004001                                                              16    7355
NP_003997                                                              16    7355
NP_000100                                                              16    7355
NP_001138619                                                           16    7355
NP_001138618                                                           16    7355
NP_001138620                                                           16    7355
NP_054831                                                              16    7355
NP_001243228                                                           16    7355
NP_004373                                                              16    7355
NP_001269832                                                           16    7355
NP_001269831                                                           16    7355
XP_006724539                                                           16    7355
XP_006724538                                                           16    7355
XP_006724537                                                           16    7355
XP_006724536                                                           16    7355
XP_006724535                                                           16    7355
XP_006724534                                                           16    7355
XP_006724533                                                           16    7355
XP_006724532                                                           16    7355
XP_006724531                                                           16    7355
XP_005251106                                                           16    7355
XP_006716688                                                           16    7355
XP_006716687                                                           16    7355
NP_003961                                                              15    9605
NP_001243084                                                           15    9605
NP_003493                                                              15    9605
NP_851393                                                              15    9605
NP_060696                                                              15    9605
XP_005255666                                                           15    9605
XP_005255665                                                           15    9605
XP_005255664                                                           15    9605
XP_006716300                                                           15    9605
XP_005247093                                                           15    9605
>NP_006197
          Length = 1089

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  GESEVSRQY 9
          GESEVS QY
Sbjct: 51 GESEVSWQY 59
>XP_006714104
          Length = 832

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  GESEVSRQY 9
          GESEVS QY
Sbjct: 76 GESEVSWQY 84
>XP_005265800
          Length = 1089

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  GESEVSRQY 9
          GESEVS QY
Sbjct: 51 GESEVSWQY 59
>XP_006714103
          Length = 1111

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  GESEVSRQY 9
          GESEVS QY
Sbjct: 73 GESEVSWQY 81
>XP_006714102
          Length = 1114

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  GESEVSRQY 9
          GESEVS QY
Sbjct: 76 GESEVSWQY 84
>NP_006816
          Length = 602

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   GESEVSR 7
           GESEVSR
Sbjct: 193 GESEVSR 199
>NP_001273171
          Length = 2084

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   ESEVSRQY 9
           ES++SRQY
Sbjct: 436 ESDLSRQY 443
>NP_001511
          Length = 2109

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   ESEVSRQY 9
           ES++SRQY
Sbjct: 436 ESDLSRQY 443
>XP_006721105
          Length = 2046

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   ESEVSRQY 9
           ES++SRQY
Sbjct: 436 ESDLSRQY 443
>NP_112506
          Length = 510

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   GESEVSRQY 9
           GE E  RQY
Sbjct: 242 GEEEALRQY 250
>NP_006453
          Length = 468

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   GESEVSRQY 9
           GE E  RQY
Sbjct: 200 GEEEALRQY 208
>NP_775832
          Length = 518

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  ESEVSRQY 9
          E+EVSRQ+
Sbjct: 61 ENEVSRQH 68
>NP_001243727
          Length = 680

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  GESEVSRQY 9
          G+SE+ RQ+
Sbjct: 19 GDSELGRQF 27
>NP_001164056
          Length = 1447

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   SEVSRQY 9
           +EVSRQY
Sbjct: 232 AEVSRQY 238
>NP_694566
          Length = 1458

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   SEVSRQY 9
           +EVSRQY
Sbjct: 221 AEVSRQY 227
>XP_005260706
          Length = 321

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   GESEVSRQY 9
           GE E  RQY
Sbjct: 259 GEEEALRQY 267
>XP_005260703
          Length = 461

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   GESEVSRQY 9
           GE E  RQY
Sbjct: 259 GEEEALRQY 267
>XP_005260702
          Length = 527

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   GESEVSRQY 9
           GE E  RQY
Sbjct: 259 GEEEALRQY 267
>NP_004000
          Length = 3681

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    SEVSRQY 9
            SE+SR+Y
Sbjct: 1008 SEISRKY 1014
>NP_004001
          Length = 3562

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   SEVSRQY 9
           SE+SR+Y
Sbjct: 889 SEISRKY 895
>NP_003997
          Length = 3685

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    SEVSRQY 9
            SE+SR+Y
Sbjct: 1012 SEISRKY 1018
>NP_000100
          Length = 3677

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    SEVSRQY 9
            SE+SR+Y
Sbjct: 1004 SEISRKY 1010
>NP_001138619
          Length = 375

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   GESEVSR 7
           GE EVSR
Sbjct: 295 GEDEVSR 301
>NP_001138618
          Length = 444

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   GESEVSR 7
           GE EVSR
Sbjct: 364 GEDEVSR 370
>NP_001138620
          Length = 401

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   GESEVSR 7
           GE EVSR
Sbjct: 335 GEDEVSR 341
>NP_054831
          Length = 1294

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   ESEVSRQY 9
           E E+SR Y
Sbjct: 691 EEEISRHY 698
>NP_001243228
          Length = 240

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   GESEVSR 7
           GE EVSR
Sbjct: 160 GEDEVSR 166
>NP_004373
          Length = 415

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   GESEVSR 7
           GE EVSR
Sbjct: 335 GEDEVSR 341
>NP_001269832
          Length = 1287

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   ESEVSRQY 9
           E E+SR Y
Sbjct: 684 EEEISRHY 691
>NP_001269831
          Length = 1285

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   ESEVSRQY 9
           E E+SR Y
Sbjct: 682 EEEISRHY 689
>XP_006724539
          Length = 2913

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   SEVSRQY 9
           SE+SR+Y
Sbjct: 222 SEISRKY 228
>XP_006724538
          Length = 3575

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    SEVSRQY 9
            SE+SR+Y
Sbjct: 1012 SEISRKY 1018
>XP_006724537
          Length = 3593

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    SEVSRQY 9
            SE+SR+Y
Sbjct: 1012 SEISRKY 1018
>XP_006724536
          Length = 3657

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    SEVSRQY 9
            SE+SR+Y
Sbjct: 1012 SEISRKY 1018
>XP_006724535
          Length = 3660

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   SEVSRQY 9
           SE+SR+Y
Sbjct: 969 SEISRKY 975
>XP_006724534
          Length = 3668

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    SEVSRQY 9
            SE+SR+Y
Sbjct: 1012 SEISRKY 1018
>XP_006724533
          Length = 3690

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    SEVSRQY 9
            SE+SR+Y
Sbjct: 1012 SEISRKY 1018
>XP_006724532
          Length = 3695

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    SEVSRQY 9
            SE+SR+Y
Sbjct: 1004 SEISRKY 1010
>XP_006724531
          Length = 3703

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    SEVSRQY 9
            SE+SR+Y
Sbjct: 1012 SEISRKY 1018
>XP_005251106
          Length = 1281

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   ESEVSRQY 9
           E E+SR Y
Sbjct: 678 EEEISRHY 685
>XP_006716688
          Length = 1294

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   ESEVSRQY 9
           E E+SR Y
Sbjct: 691 EEEISRHY 698
>XP_006716687
          Length = 1294

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   ESEVSRQY 9
           E E+SR Y
Sbjct: 691 EEEISRHY 698
>NP_003961
          Length = 1465

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   SEVSRQY 9
           SE+SR Y
Sbjct: 520 SEISRNY 526
>NP_001243084
          Length = 2290

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    GESEVSRQ 8
            GE E+SR+
Sbjct: 1883 GEDELSRE 1890
>NP_003493
          Length = 862

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   GESEVSR 7
           GE E+SR
Sbjct: 639 GEKEISR 645
>NP_851393
          Length = 826

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   GESEVSR 7
           GE E+SR
Sbjct: 639 GEKEISR 645
>NP_060696
          Length = 725

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ESEVSRQY 9
           ES++SR Y
Sbjct: 626 ESQMSRMY 633
>XP_005255666
          Length = 862

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   GESEVSR 7
           GE E+SR
Sbjct: 639 GEKEISR 645
>XP_005255665
          Length = 875

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   GESEVSR 7
           GE E+SR
Sbjct: 688 GEKEISR 694
>XP_005255664
          Length = 911

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   GESEVSR 7
           GE E+SR
Sbjct: 688 GEKEISR 694
>XP_006716300
          Length = 1445

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   SEVSRQY 9
           SE+SR Y
Sbjct: 520 SEISRNY 526
>XP_005247093
          Length = 714

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ESEVSRQY 9
           ES++SR Y
Sbjct: 615 ESQMSRMY 622
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.295    0.117    0.292 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 475,514
Number of extensions: 1024
Number of successful extensions: 52
Number of sequences better than 10000.0: 52
Number of HSP's gapped: 52
Number of HSP's successfully gapped: 52
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.0 bits)
S2: 28 (15.4 bits)

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