Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_006197                                                              20     390
XP_006714104                                                           20     390
XP_005265800                                                           20     390
XP_006714103                                                           20     390
XP_006714102                                                           20     390
NP_002178                                                              19     665
NP_003250                                                              19     665
NP_001186566                                                           18    1935
NP_001109                                                              18    1935
NP_001186564                                                           18    1935
NP_001186565                                                           18    1935
XP_006715710                                                           18    1935
XP_006715709                                                           18    1935
XP_006715708                                                           18    1935
NP_000177                                                              17    4312
NP_075556                                                              17    4312
XP_006723675                                                           17    4312
XP_006723674                                                           17    4312
XP_006723673                                                           17    4312
XP_006711345                                                           17    4312
NP_003732                                                              16    5631
XP_005247908                                                           16    5631
XP_005247907                                                           16    5631
XP_005247906                                                           16    5631
XP_005247905                                                           16    5631
NP_001123561                                                           16    7355
NP_005539                                                              16    7355
XP_006720785                                                           16    7355
NP_115821                                                              16    7355
NP_001243474                                                           15    9605
NP_060952                                                              15    9605
NP_115822                                                              15    9605
NP_001137139                                                           15    9605
NP_067034                                                              15    9605
NP_001234925                                                           15    9605
XP_006717378                                                           15    9605
XP_006716630                                                           15    9605
XP_006716629                                                           15    9605
XP_006716628                                                           15    9605
XP_006716627                                                           15    9605
XP_006716626                                                           15    9605
XP_005250982                                                           15    9605
NP_848543                                                              15    9605
>NP_006197
          Length = 1089

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   GEMIVVTCA 9
           GE IVVTCA
Sbjct: 228 GETIVVTCA 236
>XP_006714104
          Length = 832

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   GEMIVVTCA 9
           GE IVVTCA
Sbjct: 253 GETIVVTCA 261
>XP_005265800
          Length = 1089

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   GEMIVVTCA 9
           GE IVVTCA
Sbjct: 228 GETIVVTCA 236
>XP_006714103
          Length = 1111

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   GEMIVVTCA 9
           GE IVVTCA
Sbjct: 250 GETIVVTCA 258
>XP_006714102
          Length = 1114

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   GEMIVVTCA 9
           GE IVVTCA
Sbjct: 253 GETIVVTCA 261
>NP_002178
          Length = 328

 Score = 19.2 bits (38), Expect =   665
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1  GEMIVVTC 8
          GEM+V+TC
Sbjct: 43 GEMVVLTC 50
>NP_003250
          Length = 924

 Score = 19.2 bits (38), Expect =   665
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   GEMIVVTCA 9
           G+M+ VTCA
Sbjct: 337 GQMVTVTCA 345
>NP_001186566
          Length = 447

 Score = 17.7 bits (34), Expect =  1935
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  GEMIVVTC 8
          GEM++V+C
Sbjct: 70 GEMVLVSC 77
>NP_001109
          Length = 468

 Score = 17.7 bits (34), Expect =  1935
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  GEMIVVTC 8
          GEM++V+C
Sbjct: 70 GEMVLVSC 77
>NP_001186564
          Length = 496

 Score = 17.7 bits (34), Expect =  1935
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  GEMIVVTC 8
          GEM++V+C
Sbjct: 70 GEMVLVSC 77
>NP_001186565
          Length = 495

 Score = 17.7 bits (34), Expect =  1935
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  GEMIVVTC 8
          GEM++V+C
Sbjct: 70 GEMVLVSC 77
>XP_006715710
          Length = 475

 Score = 17.7 bits (34), Expect =  1935
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  GEMIVVTC 8
          GEM++V+C
Sbjct: 70 GEMVLVSC 77
>XP_006715709
          Length = 489

 Score = 17.7 bits (34), Expect =  1935
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  GEMIVVTC 8
          GEM++V+C
Sbjct: 70 GEMVLVSC 77
>XP_006715708
          Length = 496

 Score = 17.7 bits (34), Expect =  1935
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  GEMIVVTC 8
          GEM++V+C
Sbjct: 70 GEMVLVSC 77
>NP_000177
          Length = 1231

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1    GEMIVVTCA 9
            GE +  TCA
Sbjct: 1011 GEQVTYTCA 1019
>NP_075556
          Length = 1709

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   GEMIVVTC 8
           GE++ +TC
Sbjct: 255 GELVTLTC 262
>XP_006723675
          Length = 1623

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   GEMIVVTC 8
           GE++ +TC
Sbjct: 255 GELVTLTC 262
>XP_006723674
          Length = 1701

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   GEMIVVTC 8
           GE++ +TC
Sbjct: 255 GELVTLTC 262
>XP_006723673
          Length = 1709

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   GEMIVVTC 8
           GE++ +TC
Sbjct: 255 GELVTLTC 262
>XP_006711345
          Length = 1173

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   GEMIVVTCA 9
           GE +  TCA
Sbjct: 953 GEQVTYTCA 961
>NP_003732
          Length = 955

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   GEMIVVTC 8
           GEM  +TC
Sbjct: 893 GEMSCITC 900
>XP_005247908
          Length = 894

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   GEMIVVTC 8
           GEM  +TC
Sbjct: 832 GEMSCITC 839
>XP_005247907
          Length = 954

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   GEMIVVTC 8
           GEM  +TC
Sbjct: 893 GEMSCITC 900
>XP_005247906
          Length = 981

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   GEMIVVTC 8
           GEM  +TC
Sbjct: 920 GEMSCITC 927
>XP_005247905
          Length = 982

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   GEMIVVTC 8
           GEM  +TC
Sbjct: 920 GEMSCITC 927
>NP_001123561
          Length = 625

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   GEMIVVTC 8
           GE + VTC
Sbjct: 477 GEFLEVTC 484
>NP_005539
          Length = 597

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   GEMIVVTC 8
           GE + VTC
Sbjct: 449 GEFLEVTC 456
>XP_006720785
          Length = 1079

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   GEMIVVTCA 9
           GE+  V+CA
Sbjct: 369 GEVCAVSCA 377
>NP_115821
          Length = 1044

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   GEMIVVTCA 9
           GE+  V+CA
Sbjct: 430 GEVCAVSCA 438
>NP_001243474
          Length = 1140

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   GEMIVVTCA 9
           GEM V  CA
Sbjct: 102 GEMCVPHCA 110
>NP_060952
          Length = 1129

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    GEMIVVT 7
            GE+I+VT
Sbjct: 1091 GEVIIVT 1097
>NP_115822
          Length = 1140

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   GEMIVVTCA 9
           GEM V  CA
Sbjct: 102 GEMCVPHCA 110
>NP_001137139
          Length = 693

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   GEMIVVTCA 9
           GE+++  CA
Sbjct: 214 GELLIKPCA 222
>NP_067034
          Length = 693

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   GEMIVVTCA 9
           GE+++  CA
Sbjct: 214 GELLIKPCA 222
>NP_001234925
          Length = 1122

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    GEMIVVT 7
            GE+I+VT
Sbjct: 1084 GEVIIVT 1090
>XP_006717378
          Length = 355

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 6/9 (66%)

Query: 1   GEMIVVTCA 9
           GE++   CA
Sbjct: 303 GELLAAACA 311
>XP_006716630
          Length = 1073

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    GEMIVVT 7
            GE+I+VT
Sbjct: 1035 GEVIIVT 1041
>XP_006716629
          Length = 1075

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    GEMIVVT 7
            GE+I+VT
Sbjct: 1037 GEVIIVT 1043
>XP_006716628
          Length = 1076

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    GEMIVVT 7
            GE+I+VT
Sbjct: 1038 GEVIIVT 1044
>XP_006716627
          Length = 1125

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    GEMIVVT 7
            GE+I+VT
Sbjct: 1087 GEVIIVT 1093
>XP_006716626
          Length = 1132

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    GEMIVVT 7
            GE+I+VT
Sbjct: 1094 GEVIIVT 1100
>XP_005250982
          Length = 1132

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    GEMIVVT 7
            GE+I+VT
Sbjct: 1094 GEVIIVT 1100
>NP_848543
          Length = 394

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 6/9 (66%)

Query: 1   GEMIVVTCA 9
           GE++   CA
Sbjct: 303 GELLAAACA 311
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.330    0.137    0.423 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 441,844
Number of extensions: 761
Number of successful extensions: 43
Number of sequences better than 10000.0: 43
Number of HSP's gapped: 43
Number of HSP's successfully gapped: 43
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.2 bits)
S2: 28 (15.4 bits)

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