Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_006715                                                              17    2528
NP_005913                                                              17    2528
XP_005267046                                                           17    2528
XP_005267045                                                           17    2528
NP_060549                                                              17    4312
XP_005264455                                                           17    4312
NP_113614                                                              16    5631
NP_001172025                                                           16    5631
NP_001172024                                                           16    5631
NP_001288                                                              16    7355
NP_001165375                                                           16    7355
NP_055518                                                              16    7355
NP_003310                                                              16    7355
NP_001273059                                                           16    7355
NP_597676                                                              16    7355
NP_001243779                                                           16    7355
NP_596869                                                              16    7355
NP_001248755                                                           16    7355
NP_003929                                                              16    7355
XP_006722995                                                           16    7355
XP_006721197                                                           16    7355
XP_005276812                                                           16    7355
XP_006713491                                                           16    7355
XP_005276811                                                           16    7355
XP_006713490                                                           16    7355
XP_005276810                                                           16    7355
XP_005276809                                                           16    7355
XP_006713489                                                           16    7355
XP_005276808                                                           16    7355
XP_005246888                                                           16    7355
XP_006712788                                                           16    7355
XP_006712787                                                           16    7355
XP_006712786                                                           16    7355
NP_001254479                                                           16    7355
NP_597681                                                              16    7355
NP_001018098                                                           15    9605
NP_060154                                                              15    9605
NP_060550                                                              15    9605
NP_065872                                                              15    9605
>NP_006715
          Length = 1558

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   GELSLLSIK 9
           GE SLLSIK
Sbjct: 641 GEPSLLSIK 649
>NP_005913
          Length = 1608

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   GELSLLSIK 9
           GE SLLSIK
Sbjct: 641 GEPSLLSIK 649
>XP_005267046
          Length = 1554

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   GELSLLSIK 9
           GE SLLSIK
Sbjct: 641 GEPSLLSIK 649
>XP_005267045
          Length = 1604

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   GELSLLSIK 9
           GE SLLSIK
Sbjct: 641 GEPSLLSIK 649
>NP_060549
          Length = 995

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   GELSLLS 7
           GELSLLS
Sbjct: 344 GELSLLS 350
>XP_005264455
          Length = 671

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   GELSLLS 7
           GELSLLS
Sbjct: 344 GELSLLS 350
>NP_113614
          Length = 150

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  GELSLLSIK 9
          GE+ L+S+K
Sbjct: 65 GEIDLMSLK 73
>NP_001172025
          Length = 102

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  GELSLLSIK 9
          GE+ L+S+K
Sbjct: 65 GEIDLMSLK 73
>NP_001172024
          Length = 176

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  GELSLLSIK 9
          GE+ L+S+K
Sbjct: 91 GEIDLMSLK 99
>NP_001288
          Length = 1251

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    GELSLLSI 8
            GE+SLL++
Sbjct: 1029 GEISLLAV 1036
>NP_001165375
          Length = 1506

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   LSLLSIK 9
           LSLLSIK
Sbjct: 738 LSLLSIK 744
>NP_055518
          Length = 1507

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   LSLLSIK 9
           LSLLSIK
Sbjct: 739 LSLLSIK 745
>NP_003310
          Length = 26926

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1     GELSLLSI 8
             GEL +LSI
Sbjct: 23938 GELEILSI 23945
>NP_001273059
          Length = 1245

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    GELSLLSI 8
            GE+SLL++
Sbjct: 1023 GEISLLAV 1030
>NP_597676
          Length = 27051

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1     GELSLLSI 8
             GEL +LSI
Sbjct: 24063 GELEILSI 24070
>NP_001243779
          Length = 34350

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1     GELSLLSI 8
             GEL +LSI
Sbjct: 31362 GELEILSI 31369
>NP_596869
          Length = 33423

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1     GELSLLSI 8
             GEL +LSI
Sbjct: 30435 GELEILSI 30442
>NP_001248755
          Length = 1215

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    GELSLLSIK 9
            G+LS+ SIK
Sbjct: 1127 GDLSMSSIK 1135
>NP_003929
          Length = 1153

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    GELSLLSIK 9
            G+LS+ SIK
Sbjct: 1065 GDLSMSSIK 1073
>XP_006722995
          Length = 1203

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    GELSLLSIK 9
            G+LS+ SIK
Sbjct: 1115 GDLSMSSIK 1123
>XP_006721197
          Length = 1251

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    GELSLLSI 8
            GE+SLL++
Sbjct: 1029 GEISLLAV 1036
>XP_005276812
          Length = 1507

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   LSLLSIK 9
           LSLLSIK
Sbjct: 739 LSLLSIK 745
>XP_006713491
          Length = 1425

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   LSLLSIK 9
           LSLLSIK
Sbjct: 657 LSLLSIK 663
>XP_005276811
          Length = 1507

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   LSLLSIK 9
           LSLLSIK
Sbjct: 739 LSLLSIK 745
>XP_006713490
          Length = 1507

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   LSLLSIK 9
           LSLLSIK
Sbjct: 739 LSLLSIK 745
>XP_005276810
          Length = 1507

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   LSLLSIK 9
           LSLLSIK
Sbjct: 739 LSLLSIK 745
>XP_005276809
          Length = 1507

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   LSLLSIK 9
           LSLLSIK
Sbjct: 739 LSLLSIK 745
>XP_006713489
          Length = 1507

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   LSLLSIK 9
           LSLLSIK
Sbjct: 739 LSLLSIK 745
>XP_005276808
          Length = 1507

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   LSLLSIK 9
           LSLLSIK
Sbjct: 739 LSLLSIK 745
>XP_005246888
          Length = 22663

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1     GELSLLSI 8
             GEL +LSI
Sbjct: 19675 GELEILSI 19682
>XP_006712788
          Length = 24022

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1     GELSLLSI 8
             GEL +LSI
Sbjct: 21034 GELEILSI 21041
>XP_006712787
          Length = 33978

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1     GELSLLSI 8
             GEL +LSI
Sbjct: 30990 GELEILSI 30997
>XP_006712786
          Length = 35484

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1     GELSLLSI 8
             GEL +LSI
Sbjct: 32496 GELEILSI 32503
>NP_001254479
          Length = 35991

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1     GELSLLSI 8
             GEL +LSI
Sbjct: 33003 GELEILSI 33010
>NP_597681
          Length = 27118

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1     GELSLLSI 8
             GEL +LSI
Sbjct: 24130 GELEILSI 24137
>NP_001018098
          Length = 3628

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   GELSLLS 7
           GELSLL+
Sbjct: 223 GELSLLT 229
>NP_060154
          Length = 3710

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   GELSLLS 7
           GELSLL+
Sbjct: 180 GELSLLT 186
>NP_060550
          Length = 3585

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   GELSLLS 7
           GELSLL+
Sbjct: 180 GELSLLT 186
>NP_065872
          Length = 3753

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   GELSLLS 7
           GELSLL+
Sbjct: 223 GELSLLT 229
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.310    0.136    0.321 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 306,165
Number of extensions: 372
Number of successful extensions: 39
Number of sequences better than 10000.0: 39
Number of HSP's gapped: 39
Number of HSP's successfully gapped: 39
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.4 bits)
S2: 28 (15.4 bits)

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