Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005091                                                              19     665
NP_653080                                                              19     665
XP_005267292                                                           19     665
XP_005267291                                                           19     665
XP_005267290                                                           19     665
NP_001263347                                                           17    3301
NP_055681                                                              17    3301
XP_005266194                                                           17    3301
XP_005266193                                                           17    3301
XP_005266191                                                           17    3301
XP_005266190                                                           17    3301
XP_005266189                                                           17    3301
NP_443132                                                              17    4312
NP_937756                                                              17    4312
NP_001166028                                                           16    5631
NP_001188358                                                           16    5631
NP_036427                                                              16    5631
NP_001186210                                                           16    5631
NP_005886                                                              16    5631
XP_006724247                                                           16    5631
XP_006724246                                                           16    5631
XP_006724245                                                           16    5631
XP_006724244                                                           16    5631
XP_006724243                                                           16    5631
XP_005261477                                                           16    5631
XP_005261476                                                           16    5631
XP_005261474                                                           16    5631
XP_006724242                                                           16    5631
XP_005261473                                                           16    5631
XP_005261472                                                           16    5631
XP_006721104                                                           16    5631
XP_005266224                                                           16    5631
XP_006719803                                                           16    5631
XP_005266222                                                           16    5631
XP_005266221                                                           16    5631
XP_006719802                                                           16    5631
XP_006719801                                                           16    5631
XP_006719800                                                           16    5631
XP_006719799                                                           16    5631
XP_005266219                                                           16    5631
NP_001161870                                                           16    7355
NP_006407                                                              16    7355
NP_659436                                                              16    7355
NP_203746                                                              16    7355
NP_003793                                                              16    7355
NP_003600                                                              16    7355
NP_001184252                                                           16    7355
XP_006722338                                                           16    7355
XP_006718797                                                           16    7355
XP_005274435                                                           16    7355
XP_006718795                                                           16    7355
XP_005274433                                                           16    7355
NP_004553                                                              15    9605
NP_054642                                                              15    9605
NP_054643                                                              15    9605
NP_065099                                                              15    9605
NP_004699                                                              15    9605
NP_060903                                                              15    9605
NP_001140160                                                           15    9605
XP_005259449                                                           15    9605
XP_006712114                                                           15    9605
>NP_005091
          Length = 1782

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   GEAASKESK 9
           GEAASKES+
Sbjct: 223 GEAASKESE 231
>NP_653080
          Length = 1684

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   GEAASKESK 9
           GEAASKES+
Sbjct: 125 GEAASKESE 133
>XP_005267292
          Length = 1677

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   GEAASKESK 9
           GEAASKES+
Sbjct: 118 GEAASKESE 126
>XP_005267291
          Length = 1684

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   GEAASKESK 9
           GEAASKES+
Sbjct: 125 GEAASKESE 133
>XP_005267290
          Length = 1782

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   GEAASKESK 9
           GEAASKES+
Sbjct: 223 GEAASKESE 231
>NP_001263347
          Length = 2334

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    GEAASKESK 9
            G+AA KE+K
Sbjct: 2092 GQAAKKETK 2100
>NP_055681
          Length = 2357

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    GEAASKESK 9
            G+AA KE+K
Sbjct: 2092 GQAAKKETK 2100
>XP_005266194
          Length = 2379

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    GEAASKESK 9
            G+AA KE+K
Sbjct: 2092 GQAAKKETK 2100
>XP_005266193
          Length = 2248

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    GEAASKESK 9
            G+AA KE+K
Sbjct: 2003 GQAAKKETK 2011
>XP_005266191
          Length = 2379

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    GEAASKESK 9
            G+AA KE+K
Sbjct: 2092 GQAAKKETK 2100
>XP_005266190
          Length = 2485

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    GEAASKESK 9
            G+AA KE+K
Sbjct: 2240 GQAAKKETK 2248
>XP_005266189
          Length = 2505

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    GEAASKESK 9
            G+AA KE+K
Sbjct: 2240 GQAAKKETK 2248
>NP_443132
          Length = 3538

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  GEAASKESK 9
          GE+ +KESK
Sbjct: 7  GESRAKESK 15
>NP_937756
          Length = 3707

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  GEAASKESK 9
          GE+ +KESK
Sbjct: 7  GESRAKESK 15
>NP_001166028
          Length = 1134

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   GEAASKE 7
           GEAAS+E
Sbjct: 759 GEAASRE 765
>NP_001188358
          Length = 2170

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   GEAASKE 7
           GEAA+KE
Sbjct: 725 GEAAAKE 731
>NP_036427
          Length = 2220

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   GEAASKE 7
           GEAA+KE
Sbjct: 775 GEAAAKE 781
>NP_001186210
          Length = 2220

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   GEAASKE 7
           GEAA+KE
Sbjct: 775 GEAAAKE 781
>NP_005886
          Length = 1498

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   GEAASKE 7
           GEAAS+E
Sbjct: 759 GEAASRE 765
>XP_006724247
          Length = 1189

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   GEAASKE 7
           GEAA+KE
Sbjct: 775 GEAAAKE 781
>XP_006724246
          Length = 2103

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   GEAASKE 7
           GEAA+KE
Sbjct: 775 GEAAAKE 781
>XP_006724245
          Length = 2191

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   GEAASKE 7
           GEAA+KE
Sbjct: 775 GEAAAKE 781
>XP_006724244
          Length = 2191

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   GEAASKE 7
           GEAA+KE
Sbjct: 775 GEAAAKE 781
>XP_006724243
          Length = 2196

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   GEAASKE 7
           GEAA+KE
Sbjct: 775 GEAAAKE 781
>XP_005261477
          Length = 2200

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   GEAASKE 7
           GEAA+KE
Sbjct: 775 GEAAAKE 781
>XP_005261476
          Length = 2210

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   GEAASKE 7
           GEAA+KE
Sbjct: 730 GEAAAKE 736
>XP_005261474
          Length = 2225

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   GEAASKE 7
           GEAA+KE
Sbjct: 775 GEAAAKE 781
>XP_006724242
          Length = 2226

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   GEAASKE 7
           GEAA+KE
Sbjct: 775 GEAAAKE 781
>XP_005261473
          Length = 2250

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   GEAASKE 7
           GEAA+KE
Sbjct: 775 GEAAAKE 781
>XP_005261472
          Length = 2255

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   GEAASKE 7
           GEAA+KE
Sbjct: 775 GEAAAKE 781
>XP_006721104
          Length = 193

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   GEAASKES 8
           GEAA +ES
Sbjct: 185 GEAAGRES 192
>XP_005266224
          Length = 1307

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   GEAASKE 7
           GEAAS+E
Sbjct: 568 GEAASRE 574
>XP_006719803
          Length = 1407

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   GEAASKE 7
           GEAAS+E
Sbjct: 668 GEAASRE 674
>XP_005266222
          Length = 1458

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   GEAASKE 7
           GEAAS+E
Sbjct: 719 GEAASRE 725
>XP_005266221
          Length = 1458

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   GEAASKE 7
           GEAAS+E
Sbjct: 719 GEAASRE 725
>XP_006719802
          Length = 1458

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   GEAASKE 7
           GEAAS+E
Sbjct: 719 GEAASRE 725
>XP_006719801
          Length = 1498

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   GEAASKE 7
           GEAAS+E
Sbjct: 759 GEAASRE 765
>XP_006719800
          Length = 1498

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   GEAASKE 7
           GEAAS+E
Sbjct: 759 GEAASRE 765
>XP_006719799
          Length = 1498

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   GEAASKE 7
           GEAAS+E
Sbjct: 759 GEAASRE 765
>XP_005266219
          Length = 1498

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   GEAASKE 7
           GEAAS+E
Sbjct: 759 GEAASRE 765
>NP_001161870
          Length = 278

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   GEAASKE 7
           GE ASKE
Sbjct: 267 GETASKE 273
>NP_006407
          Length = 337

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   GEAASKE 7
           GE ASKE
Sbjct: 326 GETASKE 332
>NP_659436
          Length = 670

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   EAASKESK 9
           EAA +ESK
Sbjct: 350 EAAERESK 357
>NP_203746
          Length = 619

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   GEAASKES 8
           GEA SKE+
Sbjct: 410 GEAQSKET 417
>NP_003793
          Length = 1938

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    EAASKESK 9
            EAA KES+
Sbjct: 1472 EAAQKESR 1479
>NP_003600
          Length = 556

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  EAASKESK 9
          EAAS+E K
Sbjct: 65 EAASREDK 72
>NP_001184252
          Length = 175

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  EAASKESK 9
          EAAS+E K
Sbjct: 65 EAASREDK 72
>XP_006722338
          Length = 473

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   EAASKESK 9
           EAA +ESK
Sbjct: 350 EAAERESK 357
>XP_006718797
          Length = 334

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   GEAASKES 8
           GEA SKE+
Sbjct: 125 GEAQSKET 132
>XP_005274435
          Length = 513

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   GEAASKES 8
           GEA SKE+
Sbjct: 304 GEAQSKET 311
>XP_006718795
          Length = 598

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   GEAASKES 8
           GEA SKE+
Sbjct: 389 GEAQSKET 396
>XP_005274433
          Length = 604

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   GEAASKES 8
           GEA SKE+
Sbjct: 410 GEAQSKET 417
>NP_004553
          Length = 465

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   EAASKES 8
           EAASKE+
Sbjct: 404 EAASKET 410
>NP_054642
          Length = 437

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   EAASKES 8
           EAASKE+
Sbjct: 376 EAASKET 382
>NP_054643
          Length = 316

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   EAASKES 8
           EAASKE+
Sbjct: 255 EAASKET 261
>NP_065099
          Length = 1286

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   GEAASKESK 9
           GE ASK S+
Sbjct: 187 GEVASKPSE 195
>NP_004699
          Length = 125

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  GEAASKESK 9
          G+AA +E+K
Sbjct: 25 GDAAQQEAK 33
>NP_060903
          Length = 1321

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   GEAASK 6
           GEAASK
Sbjct: 800 GEAASK 805
>NP_001140160
          Length = 1321

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   GEAASK 6
           GEAASK
Sbjct: 800 GEAASK 805
>XP_005259449
          Length = 129

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  GEAASKESK 9
          G+AA +E+K
Sbjct: 25 GDAAQQEAK 33
>XP_006712114
          Length = 661

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   GEAASK 6
           GEAASK
Sbjct: 140 GEAASK 145
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.270   0.0940    0.206 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 400,842
Number of extensions: 613
Number of successful extensions: 61
Number of sequences better than 10000.0: 61
Number of HSP's gapped: 61
Number of HSP's successfully gapped: 61
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 18 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (14.3 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package