Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000236                                                              21     175
NP_001120972                                                           21     175
XP_006716054                                                           21     175
XP_006716053                                                           21     175
XP_006716052                                                           21     175
XP_006716051                                                           21     175
NP_640338                                                              19     869
NP_899631                                                              17    2528
NP_612429                                                              17    2528
XP_005267356                                                           17    2528
XP_006713438                                                           17    2528
XP_006713430                                                           17    2528
XP_006713427                                                           17    2528
NP_056384                                                              17    3301
NP_001129599                                                           17    3301
NP_001265181                                                           17    3301
XP_006711331                                                           17    3301
XP_005245141                                                           17    3301
XP_005245139                                                           17    3301
XP_005245138                                                           17    3301
XP_005245137                                                           17    3301
XP_005245136                                                           17    3301
NP_055835                                                              17    4312
NP_001275932                                                           17    4312
NP_008846                                                              16    5631
NP_055917                                                              16    5631
XP_006710633                                                           16    5631
XP_006710632                                                           16    5631
XP_006710631                                                           16    5631
XP_006710630                                                           16    5631
XP_006710629                                                           16    5631
XP_006710628                                                           16    5631
XP_006710627                                                           16    5631
XP_006710626                                                           16    5631
NP_001275668                                                           16    7355
NP_004399                                                              16    7355
NP_001275667                                                           16    7355
NP_001005336                                                           16    7355
NP_001275666                                                           16    7355
NP_001136151                                                           16    7355
NP_001020527                                                           16    7355
NP_002824                                                              16    7355
NP_004237                                                              16    7355
NP_078928                                                              16    7355
XP_005256918                                                           16    7355
XP_006719334                                                           16    7355
XP_006717057                                                           16    7355
XP_005251826                                                           16    7355
XP_005251825                                                           16    7355
XP_005251821                                                           16    7355
XP_005251820                                                           16    7355
XP_006717055                                                           16    7355
NP_068598                                                              16    7355
NP_055886                                                              15    9605
NP_001129080                                                           15    9605
NP_078881                                                              15    9605
NP_066288                                                              15    9605
NP_000422                                                              15    9605
XP_005253941                                                           15    9605
XP_005253940                                                           15    9605
XP_005268459                                                           15    9605
XP_006714836                                                           15    9605
XP_005268457                                                           15    9605
XP_006714835                                                           15    9605
XP_006714834                                                           15    9605
XP_006714833                                                           15    9605
XP_006714832                                                           15    9605
XP_005268456                                                           15    9605
XP_006714831                                                           15    9605
XP_005268455                                                           15    9605
XP_005263273                                                           15    9605
XP_005263272                                                           15    9605
XP_005263271                                                           15    9605
NP_001107657                                                           15    9605
>NP_000236
          Length = 1390

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   GDLTIANIG 9
           GDLTIAN+G
Sbjct: 448 GDLTIANLG 456
>NP_001120972
          Length = 1408

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   GDLTIANIG 9
           GDLTIAN+G
Sbjct: 448 GDLTIANLG 456
>XP_006716054
          Length = 960

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1  GDLTIANIG 9
          GDLTIAN+G
Sbjct: 18 GDLTIANLG 26
>XP_006716053
          Length = 960

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1  GDLTIANIG 9
          GDLTIAN+G
Sbjct: 18 GDLTIANLG 26
>XP_006716052
          Length = 1409

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   GDLTIANIG 9
           GDLTIAN+G
Sbjct: 467 GDLTIANLG 475
>XP_006716051
          Length = 1427

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   GDLTIANIG 9
           GDLTIAN+G
Sbjct: 467 GDLTIANLG 475
>NP_640338
          Length = 360

 Score = 18.9 bits (37), Expect =   869
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   DLTIANIG 9
           DLT+AN+G
Sbjct: 204 DLTVANVG 211
>NP_899631
          Length = 1314

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   DLTIANIG 9
           DLTI N+G
Sbjct: 880 DLTIQNVG 887
>NP_612429
          Length = 5795

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    GDLTIAN 7
            GDLT+AN
Sbjct: 2137 GDLTLAN 2143
>XP_005267356
          Length = 5695

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    GDLTIAN 7
            GDLT+AN
Sbjct: 2037 GDLTLAN 2043
>XP_006713438
          Length = 1148

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   DLTIANIG 9
           DLTI N+G
Sbjct: 714 DLTIQNVG 721
>XP_006713430
          Length = 1197

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   DLTIANIG 9
           DLTI N+G
Sbjct: 714 DLTIQNVG 721
>XP_006713427
          Length = 1207

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   DLTIANIG 9
           DLTI N+G
Sbjct: 714 DLTIQNVG 721
>NP_056384
          Length = 863

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   GDLTIANIG 9
           G LTI+NIG
Sbjct: 520 GWLTISNIG 528
>NP_001129599
          Length = 859

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   GDLTIANIG 9
           G LTI+NIG
Sbjct: 520 GWLTISNIG 528
>NP_001265181
          Length = 555

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   GDLTIANIG 9
           G LTI+NIG
Sbjct: 520 GWLTISNIG 528
>XP_006711331
          Length = 565

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   GDLTIANIG 9
           G LTI+NIG
Sbjct: 530 GWLTISNIG 538
>XP_005245141
          Length = 608

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   GDLTIANIG 9
           G LTI+NIG
Sbjct: 530 GWLTISNIG 538
>XP_005245139
          Length = 763

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   GDLTIANIG 9
           G LTI+NIG
Sbjct: 420 GWLTISNIG 428
>XP_005245138
          Length = 862

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   GDLTIANIG 9
           G LTI+NIG
Sbjct: 530 GWLTISNIG 538
>XP_005245137
          Length = 869

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   GDLTIANIG 9
           G LTI+NIG
Sbjct: 530 GWLTISNIG 538
>XP_005245136
          Length = 873

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   GDLTIANIG 9
           G LTI+NIG
Sbjct: 530 GWLTISNIG 538
>NP_055835
          Length = 1323

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LTIANIG 9
           LT+AN+G
Sbjct: 893 LTVANVG 899
>NP_001275932
          Length = 1256

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LTIANIG 9
           LT+AN+G
Sbjct: 826 LTVANVG 832
>NP_008846
          Length = 350

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   GDLTIAN 7
           GD TIAN
Sbjct: 243 GDYTIAN 249
>NP_055917
          Length = 1426

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LTIANIG 9
           LT+AN+G
Sbjct: 823 LTLANVG 829
>XP_006710633
          Length = 1250

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LTIANIG 9
           LT+AN+G
Sbjct: 647 LTLANVG 653
>XP_006710632
          Length = 1389

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LTIANIG 9
           LT+AN+G
Sbjct: 786 LTLANVG 792
>XP_006710631
          Length = 1412

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LTIANIG 9
           LT+AN+G
Sbjct: 823 LTLANVG 829
>XP_006710630
          Length = 1424

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LTIANIG 9
           LT+AN+G
Sbjct: 823 LTLANVG 829
>XP_006710629
          Length = 1425

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LTIANIG 9
           LT+AN+G
Sbjct: 822 LTLANVG 828
>XP_006710628
          Length = 1426

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LTIANIG 9
           LT+AN+G
Sbjct: 823 LTLANVG 829
>XP_006710627
          Length = 1426

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LTIANIG 9
           LT+AN+G
Sbjct: 823 LTLANVG 829
>XP_006710626
          Length = 1426

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LTIANIG 9
           LT+AN+G
Sbjct: 823 LTLANVG 829
>NP_001275668
          Length = 864

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   GDLTIANIG 9
           G LTI NIG
Sbjct: 524 GWLTINNIG 532
>NP_004399
          Length = 864

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   GDLTIANIG 9
           G LTI NIG
Sbjct: 524 GWLTINNIG 532
>NP_001275667
          Length = 851

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   GDLTIANIG 9
           G LTI NIG
Sbjct: 524 GWLTINNIG 532
>NP_001005336
          Length = 851

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   GDLTIANIG 9
           G LTI NIG
Sbjct: 524 GWLTINNIG 532
>NP_001275666
          Length = 851

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   GDLTIANIG 9
           G LTI NIG
Sbjct: 524 GWLTINNIG 532
>NP_001136151
          Length = 929

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1  GDLTIANIG 9
          GD+ + N+G
Sbjct: 21 GDIVLENLG 29
>NP_001020527
          Length = 910

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1  GDLTIANIG 9
          GD+ + N+G
Sbjct: 21 GDIVLENLG 29
>NP_002824
          Length = 593

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   GDLTIANIG 9
           G LT+ N+G
Sbjct: 427 GFLTVTNLG 435
>NP_004237
          Length = 553

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   GDLTIAN 7
           GD+T+AN
Sbjct: 536 GDVTMAN 542
>NP_078928
          Length = 2015

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   DLTIANI 8
           DLTI+N+
Sbjct: 604 DLTISNV 610
>XP_005256918
          Length = 400

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   GDLTIAN 7
           GD+T+AN
Sbjct: 383 GDVTMAN 389
>XP_006719334
          Length = 812

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1  GDLTIANIG 9
          GD+ + N+G
Sbjct: 21 GDIVLENLG 29
>XP_006717057
          Length = 867

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   GDLTIANIG 9
           G LTI NIG
Sbjct: 524 GWLTINNIG 532
>XP_005251826
          Length = 851

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   GDLTIANIG 9
           G LTI NIG
Sbjct: 524 GWLTINNIG 532
>XP_005251825
          Length = 851

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   GDLTIANIG 9
           G LTI NIG
Sbjct: 524 GWLTINNIG 532
>XP_005251821
          Length = 867

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   GDLTIANIG 9
           G LTI NIG
Sbjct: 524 GWLTINNIG 532
>XP_005251820
          Length = 868

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   GDLTIANIG 9
           G LTI NIG
Sbjct: 524 GWLTINNIG 532
>XP_006717055
          Length = 868

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   GDLTIANIG 9
           G LTI NIG
Sbjct: 524 GWLTINNIG 532
>NP_068598
          Length = 764

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   GDLTIANI 8
           GDL  ANI
Sbjct: 341 GDLACANI 348
>NP_055886
          Length = 814

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   LTIANIG 9
           +T+AN+G
Sbjct: 523 MTVANLG 529
>NP_001129080
          Length = 759

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   LTIANIG 9
           +T+AN+G
Sbjct: 523 MTVANLG 529
>NP_078881
          Length = 786

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   LTIANIG 9
           +T+AN+G
Sbjct: 529 MTVANLG 535
>NP_066288
          Length = 565

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   LTIANIG 9
           +T+AN+G
Sbjct: 101 VTVANVG 107
>NP_000422
          Length = 396

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  DLTIANIG 9
          DL++ NIG
Sbjct: 50 DLSLPNIG 57
>XP_005253941
          Length = 344

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  DLTIANIG 9
          DL++ NIG
Sbjct: 50 DLSLPNIG 57
>XP_005253940
          Length = 396

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  DLTIANIG 9
          DL++ NIG
Sbjct: 50 DLSLPNIG 57
>XP_005268459
          Length = 722

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   LTIANIG 9
           +T+AN+G
Sbjct: 523 MTVANLG 529
>XP_006714836
          Length = 725

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   LTIANIG 9
           +T+AN+G
Sbjct: 566 MTVANLG 572
>XP_005268457
          Length = 765

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   LTIANIG 9
           +T+AN+G
Sbjct: 566 MTVANLG 572
>XP_006714835
          Length = 768

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   LTIANIG 9
           +T+AN+G
Sbjct: 477 MTVANLG 483
>XP_006714834
          Length = 769

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   LTIANIG 9
           +T+AN+G
Sbjct: 523 MTVANLG 529
>XP_006714833
          Length = 774

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   LTIANIG 9
           +T+AN+G
Sbjct: 566 MTVANLG 572
>XP_006714832
          Length = 801

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   LTIANIG 9
           +T+AN+G
Sbjct: 510 MTVANLG 516
>XP_005268456
          Length = 802

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   LTIANIG 9
           +T+AN+G
Sbjct: 566 MTVANLG 572
>XP_006714831
          Length = 812

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   LTIANIG 9
           +T+AN+G
Sbjct: 566 MTVANLG 572
>XP_005268455
          Length = 857

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   LTIANIG 9
           +T+AN+G
Sbjct: 566 MTVANLG 572
>XP_005263273
          Length = 694

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   LTIANIG 9
           +T+AN+G
Sbjct: 437 MTVANLG 443
>XP_005263272
          Length = 735

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   LTIANIG 9
           +T+AN+G
Sbjct: 529 MTVANLG 535
>XP_005263271
          Length = 762

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   LTIANIG 9
           +T+AN+G
Sbjct: 505 MTVANLG 511
>NP_001107657
          Length = 396

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  DLTIANIG 9
          DL++ NIG
Sbjct: 50 DLSLPNIG 57
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.316    0.146    0.412 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 356,333
Number of extensions: 632
Number of successful extensions: 74
Number of sequences better than 10000.0: 74
Number of HSP's gapped: 74
Number of HSP's successfully gapped: 74
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.5 bits)
S2: 28 (15.4 bits)

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