Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_733751                                                              20     509
XP_006716142                                                           20     509
XP_005250088                                                           20     509
XP_006716141                                                           20     509
XP_005250085                                                           20     509
XP_006716140                                                           20     509
XP_005250084                                                           20     509
XP_005250083                                                           20     509
XP_005250082                                                           20     509
NP_872293                                                              18    1482
XP_005251817                                                           18    1482
XP_006717052                                                           18    1482
NP_001035879                                                           18    1935
XP_006719908                                                           18    1935
XP_006719907                                                           18    1935
NP_002329                                                              17    4312
XP_006713701                                                           17    4312
XP_005247511                                                           17    4312
XP_005255685                                                           16    5631
XP_006721025                                                           16    5631
XP_006721024                                                           16    5631
XP_006721023                                                           16    5631
XP_006721022                                                           16    5631
NP_115672                                                              16    5631
NP_054706                                                              16    7355
NP_003364                                                              16    7355
NP_001278298                                                           16    7355
NP_001278297                                                           16    7355
NP_001004334                                                           16    7355
NP_056023                                                              16    7355
NP_001190985                                                           16    7355
NP_001077094                                                           16    7355
NP_002646                                                              16    7355
NP_001108106                                                           16    7355
NP_060547                                                              16    7355
XP_005258153                                                           16    7355
XP_005258152                                                           16    7355
XP_005258151                                                           16    7355
XP_005258150                                                           16    7355
XP_005258149                                                           16    7355
XP_005270200                                                           16    7355
XP_005270199                                                           16    7355
XP_005251317                                                           16    7355
XP_006716105                                                           16    7355
NP_001159607                                                           16    7355
NP_000490                                                              15    9605
NP_000752                                                              15    9605
NP_001156372                                                           15    9605
NP_001273330                                                           15    9605
NP_001078823                                                           15    9605
NP_004938                                                              15    9605
NP_055520                                                              15    9605
NP_078933                                                              15    9605
NP_954983                                                              15    9605
XP_006724755                                                           15    9605
XP_006724754                                                           15    9605
XP_005262247                                                           15    9605
XP_005254242                                                           15    9605
XP_006719870                                                           15    9605
XP_006716252                                                           15    9605
XP_006716251                                                           15    9605
XP_006713073                                                           15    9605
XP_005264975                                                           15    9605
XP_006713072                                                           15    9605
XP_006713071                                                           15    9605
XP_005264974                                                           15    9605
XP_005264973                                                           15    9605
XP_005264972                                                           15    9605
XP_005264971                                                           15    9605
NP_660359                                                              15    9605
>NP_733751
          Length = 4911

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   GDLKQVRIT 9
           GDLKQ RIT
Sbjct: 148 GDLKQFRIT 156
>XP_006716142
          Length = 4927

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   GDLKQVRIT 9
           GDLKQ RIT
Sbjct: 149 GDLKQFRIT 157
>XP_005250088
          Length = 4928

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   GDLKQVRIT 9
           GDLKQ RIT
Sbjct: 149 GDLKQFRIT 157
>XP_006716141
          Length = 4959

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   GDLKQVRIT 9
           GDLKQ RIT
Sbjct: 149 GDLKQFRIT 157
>XP_005250085
          Length = 4979

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   GDLKQVRIT 9
           GDLKQ RIT
Sbjct: 149 GDLKQFRIT 157
>XP_006716140
          Length = 4982

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   GDLKQVRIT 9
           GDLKQ RIT
Sbjct: 149 GDLKQFRIT 157
>XP_005250084
          Length = 4982

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   GDLKQVRIT 9
           GDLKQ RIT
Sbjct: 149 GDLKQFRIT 157
>XP_005250083
          Length = 4982

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   GDLKQVRIT 9
           GDLKQ RIT
Sbjct: 148 GDLKQFRIT 156
>XP_005250082
          Length = 4983

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   GDLKQVRIT 9
           GDLKQ RIT
Sbjct: 149 GDLKQFRIT 157
>NP_872293
          Length = 652

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  GDLKQVRIT 9
          GDL QVR+T
Sbjct: 33 GDLDQVRMT 41
>XP_005251817
          Length = 569

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  GDLKQVRIT 9
          GDL QVR+T
Sbjct: 33 GDLDQVRMT 41
>XP_006717052
          Length = 616

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  GDLKQVRIT 9
          GDL QVR+T
Sbjct: 33 GDLDQVRMT 41
>NP_001035879
          Length = 523

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1  GDLKQVRI 8
          G+LKQVRI
Sbjct: 5  GNLKQVRI 12
>XP_006719908
          Length = 427

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1  GDLKQVRI 8
          G+LKQVRI
Sbjct: 5  GNLKQVRI 12
>XP_006719907
          Length = 523

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1  GDLKQVRI 8
          G+LKQVRI
Sbjct: 5  GNLKQVRI 12
>NP_002329
          Length = 338

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   DLKQVRIT 9
           D+KQV++T
Sbjct: 207 DVKQVKVT 214
>XP_006713701
          Length = 338

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   DLKQVRIT 9
           D+KQV++T
Sbjct: 207 DVKQVKVT 214
>XP_005247511
          Length = 361

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   DLKQVRIT 9
           D+KQV++T
Sbjct: 207 DVKQVKVT 214
>XP_005255685
          Length = 716

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   GDLKQVRI 8
           GD+K VR+
Sbjct: 704 GDIKDVRL 711
>XP_006721025
          Length = 765

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   GDLKQVRI 8
           GD+K VR+
Sbjct: 753 GDIKDVRL 760
>XP_006721024
          Length = 766

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   GDLKQVRI 8
           GD+K VR+
Sbjct: 754 GDIKDVRL 761
>XP_006721023
          Length = 813

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   GDLKQVRI 8
           GD+K VR+
Sbjct: 801 GDIKDVRL 808
>XP_006721022
          Length = 814

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   GDLKQVRI 8
           GD+K VR+
Sbjct: 802 GDIKDVRL 809
>NP_115672
          Length = 715

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   GDLKQVRI 8
           GD+K VR+
Sbjct: 703 GDIKDVRL 710
>NP_054706
          Length = 1134

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   DLKQVRIT 9
           DL+Q+R+T
Sbjct: 848 DLEQLRLT 855
>NP_003364
          Length = 1066

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   DLKQVRIT 9
           DL+Q+R+T
Sbjct: 848 DLEQLRLT 855
>NP_001278298
          Length = 150

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   GDLKQVRIT 9
           GD K+ R+T
Sbjct: 102 GDAKRARLT 110
>NP_001278297
          Length = 193

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   GDLKQVRIT 9
           GD K+ R+T
Sbjct: 145 GDAKRARLT 153
>NP_001004334
          Length = 2367

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   GDLKQVRIT 9
           GD +QVR++
Sbjct: 222 GDTQQVRLS 230
>NP_056023
          Length = 2062

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   GDLKQVR 7
           GD+KQV+
Sbjct: 196 GDVKQVK 202
>NP_001190985
          Length = 2039

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   GDLKQVR 7
           GD+KQV+
Sbjct: 173 GDVKQVK 179
>NP_001077094
          Length = 2039

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   GDLKQVR 7
           GD+KQV+
Sbjct: 173 GDVKQVK 179
>NP_002646
          Length = 500

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  GDLKQVRIT 9
          GDL +VR T
Sbjct: 7  GDLSEVRDT 15
>NP_001108106
          Length = 500

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  GDLKQVRIT 9
          GDL +VR T
Sbjct: 7  GDLSEVRDT 15
>NP_060547
          Length = 759

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   GDLKQVRI 8
           G+LK VRI
Sbjct: 359 GELKYVRI 366
>XP_005258153
          Length = 2037

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   GDLKQVR 7
           GD+KQV+
Sbjct: 171 GDVKQVK 177
>XP_005258152
          Length = 2060

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   GDLKQVR 7
           GD+KQV+
Sbjct: 194 GDVKQVK 200
>XP_005258151
          Length = 2062

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   GDLKQVR 7
           GD+KQV+
Sbjct: 196 GDVKQVK 202
>XP_005258150
          Length = 2062

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   GDLKQVR 7
           GD+KQV+
Sbjct: 196 GDVKQVK 202
>XP_005258149
          Length = 2062

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   GDLKQVR 7
           GD+KQV+
Sbjct: 196 GDVKQVK 202
>XP_005270200
          Length = 1067

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   DLKQVRIT 9
           DL+Q+R+T
Sbjct: 849 DLEQLRLT 856
>XP_005270199
          Length = 1135

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   DLKQVRIT 9
           DL+Q+R+T
Sbjct: 849 DLEQLRLT 856
>XP_005251317
          Length = 500

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  GDLKQVRIT 9
          GDL +VR T
Sbjct: 7  GDLSEVRDT 15
>XP_006716105
          Length = 734

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   GDLKQVRI 8
           G+LK VRI
Sbjct: 359 GELKYVRI 366
>NP_001159607
          Length = 618

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   GDLKQVRI 8
           G+LK VRI
Sbjct: 218 GELKYVRI 225
>NP_000490
          Length = 512

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  GDLKQVRI 8
          GD+ Q+RI
Sbjct: 71 GDVLQIRI 78
>NP_000752
          Length = 516

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  GDLKQVRI 8
          GD+ Q+RI
Sbjct: 73 GDVLQIRI 80
>NP_001156372
          Length = 202

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   DLKQVRI 8
           D+K+VRI
Sbjct: 120 DIKEVRI 126
>NP_001273330
          Length = 211

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   DLKQVRI 8
           D+K+VRI
Sbjct: 120 DIKEVRI 126
>NP_001078823
          Length = 900

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   KQVRIT 9
           KQVRIT
Sbjct: 314 KQVRIT 319
>NP_004938
          Length = 2030

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   GDLKQVR 7
           GD++Q+R
Sbjct: 386 GDMEQIR 392
>NP_055520
          Length = 1966

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   GDLKQVR 7
           GD++Q+R
Sbjct: 366 GDIEQIR 372
>NP_078933
          Length = 937

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   KQVRIT 9
           KQVRIT
Sbjct: 314 KQVRIT 319
>NP_954983
          Length = 708

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   DLKQVRI 8
           DLKQ+R+
Sbjct: 554 DLKQMRL 560
>XP_006724755
          Length = 532

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   KQVRIT 9
           KQVRIT
Sbjct: 314 KQVRIT 319
>XP_006724754
          Length = 815

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   KQVRIT 9
           KQVRIT
Sbjct: 192 KQVRIT 197
>XP_005262247
          Length = 845

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   KQVRIT 9
           KQVRIT
Sbjct: 222 KQVRIT 227
>XP_005254242
          Length = 512

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  GDLKQVRI 8
          GD+ Q+RI
Sbjct: 71 GDVLQIRI 78
>XP_006719870
          Length = 683

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   DLKQVRI 8
           DLKQ+R+
Sbjct: 529 DLKQMRL 535
>XP_006716252
          Length = 1937

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   GDLKQVR 7
           GD++Q+R
Sbjct: 366 GDIEQIR 372
>XP_006716251
          Length = 1975

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   GDLKQVR 7
           GD++Q+R
Sbjct: 366 GDIEQIR 372
>XP_006713073
          Length = 1869

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   GDLKQVR 7
           GD++Q+R
Sbjct: 386 GDMEQIR 392
>XP_005264975
          Length = 2022

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   GDLKQVR 7
           GD++Q+R
Sbjct: 386 GDMEQIR 392
>XP_006713072
          Length = 2042

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   GDLKQVR 7
           GD++Q+R
Sbjct: 386 GDMEQIR 392
>XP_006713071
          Length = 2050

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   GDLKQVR 7
           GD++Q+R
Sbjct: 386 GDMEQIR 392
>XP_005264974
          Length = 2057

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   GDLKQVR 7
           GD++Q+R
Sbjct: 386 GDMEQIR 392
>XP_005264973
          Length = 2062

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   GDLKQVR 7
           GD++Q+R
Sbjct: 386 GDMEQIR 392
>XP_005264972
          Length = 2065

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   GDLKQVR 7
           GD++Q+R
Sbjct: 386 GDMEQIR 392
>XP_005264971
          Length = 2071

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   GDLKQVR 7
           GD++Q+R
Sbjct: 386 GDMEQIR 392
>NP_660359
          Length = 229

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   DLKQVRI 8
           D+K+VRI
Sbjct: 120 DIKEVRI 126
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.321    0.143    0.380 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 433,500
Number of extensions: 795
Number of successful extensions: 70
Number of sequences better than 10000.0: 70
Number of HSP's gapped: 70
Number of HSP's successfully gapped: 70
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.8 bits)
S2: 28 (15.4 bits)

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