Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001277144                                                           20     390
NP_001277143                                                           20     390
NP_001077383                                                           20     390
NP_001320                                                              20     390
NP_073713                                                              20     390
XP_005269629                                                           20     390
XP_005269628                                                           20     390
XP_005269627                                                           20     390
XP_005269626                                                           20     390
XP_006717706                                                           20     390
XP_005269625                                                           20     390
XP_005269624                                                           20     390
XP_006717705                                                           20     390
XP_005269622                                                           20     390
XP_005269621                                                           20     390
XP_006717704                                                           20     390
XP_005269619                                                           20     390
XP_005269618                                                           20     390
NP_001319                                                              19     869
NP_001012632                                                           19     869
XP_005272320                                                           19     869
XP_005272319                                                           19     869
XP_005272318                                                           19     869
NP_001269557                                                           17    3301
NP_001269560                                                           17    3301
NP_000038                                                              17    3301
XP_005274578                                                           17    3301
XP_005274576                                                           17    3301
XP_005274575                                                           17    3301
NP_005597                                                              17    4312
NP_001008530                                                           17    4312
XP_005267920                                                           17    4312
XP_005267919                                                           17    4312
NP_005236                                                              16    5631
NP_071417                                                              16    5631
XP_006714202                                                           16    5631
XP_005262892                                                           16    5631
XP_005262891                                                           16    5631
NP_878314                                                              16    7355
NP_001244068                                                           16    7355
NP_000076                                                              16    7355
NP_001180235                                                           16    7355
NP_001159417                                                           16    7355
NP_563615                                                              16    7355
NP_002020                                                              16    7355
NP_004061                                                              16    7355
XP_005245790                                                           16    7355
XP_006710134                                                           16    7355
XP_006710132                                                           16    7355
NP_001036169                                                           16    7355
NP_001161846                                                           15    9605
NP_001161849                                                           15    9605
NP_001161848                                                           15    9605
NP_054747                                                              15    9605
NP_055736                                                              15    9605
NP_055624                                                              15    9605
NP_001008701                                                           15    9605
NP_872394                                                              15    9605
NP_001136336                                                           15    9605
NP_001161847                                                           15    9605
XP_005259876                                                           15    9605
XP_006722752                                                           15    9605
XP_005259875                                                           15    9605
XP_006722751                                                           15    9605
XP_006721417                                                           15    9605
XP_006721416                                                           15    9605
XP_006715527                                                           15    9605
XP_006715351                                                           15    9605
XP_006715350                                                           15    9605
XP_006715349                                                           15    9605
XP_005249561                                                           15    9605
XP_006712517                                                           15    9605
>NP_001277144
          Length = 445

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  GAMMNHTIT 9
          GAMM HTIT
Sbjct: 78 GAMMYHTIT 86
>NP_001277143
          Length = 445

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  GAMMNHTIT 9
          GAMM HTIT
Sbjct: 78 GAMMYHTIT 86
>NP_001077383
          Length = 445

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  GAMMNHTIT 9
          GAMM HTIT
Sbjct: 78 GAMMYHTIT 86
>NP_001320
          Length = 445

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  GAMMNHTIT 9
          GAMM HTIT
Sbjct: 78 GAMMYHTIT 86
>NP_073713
          Length = 985

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   GAMMNHTIT 9
           GAMM HTIT
Sbjct: 618 GAMMYHTIT 626
>XP_005269629
          Length = 445

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  GAMMNHTIT 9
          GAMM HTIT
Sbjct: 78 GAMMYHTIT 86
>XP_005269628
          Length = 445

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  GAMMNHTIT 9
          GAMM HTIT
Sbjct: 78 GAMMYHTIT 86
>XP_005269627
          Length = 445

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  GAMMNHTIT 9
          GAMM HTIT
Sbjct: 78 GAMMYHTIT 86
>XP_005269626
          Length = 445

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  GAMMNHTIT 9
          GAMM HTIT
Sbjct: 78 GAMMYHTIT 86
>XP_006717706
          Length = 445

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  GAMMNHTIT 9
          GAMM HTIT
Sbjct: 78 GAMMYHTIT 86
>XP_005269625
          Length = 445

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  GAMMNHTIT 9
          GAMM HTIT
Sbjct: 78 GAMMYHTIT 86
>XP_005269624
          Length = 445

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  GAMMNHTIT 9
          GAMM HTIT
Sbjct: 78 GAMMYHTIT 86
>XP_006717705
          Length = 445

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  GAMMNHTIT 9
          GAMM HTIT
Sbjct: 78 GAMMYHTIT 86
>XP_005269622
          Length = 445

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  GAMMNHTIT 9
          GAMM HTIT
Sbjct: 78 GAMMYHTIT 86
>XP_005269621
          Length = 445

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  GAMMNHTIT 9
          GAMM HTIT
Sbjct: 78 GAMMYHTIT 86
>XP_006717704
          Length = 445

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  GAMMNHTIT 9
          GAMM HTIT
Sbjct: 78 GAMMYHTIT 86
>XP_005269619
          Length = 445

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  GAMMNHTIT 9
          GAMM HTIT
Sbjct: 78 GAMMYHTIT 86
>XP_005269618
          Length = 445

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  GAMMNHTIT 9
          GAMM HTIT
Sbjct: 78 GAMMYHTIT 86
>NP_001319
          Length = 440

 Score = 18.9 bits (37), Expect =   869
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  GAMMNHTIT 9
          GA+M HTIT
Sbjct: 72 GALMYHTIT 80
>NP_001012632
          Length = 429

 Score = 18.9 bits (37), Expect =   869
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  GAMMNHTIT 9
          GA+M HTIT
Sbjct: 61 GALMYHTIT 69
>XP_005272320
          Length = 430

 Score = 18.9 bits (37), Expect =   869
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  GAMMNHTIT 9
          GA+M HTIT
Sbjct: 61 GALMYHTIT 69
>XP_005272319
          Length = 430

 Score = 18.9 bits (37), Expect =   869
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  GAMMNHTIT 9
          GA+M HTIT
Sbjct: 61 GALMYHTIT 69
>XP_005272318
          Length = 441

 Score = 18.9 bits (37), Expect =   869
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  GAMMNHTIT 9
          GA+M HTIT
Sbjct: 72 GALMYHTIT 80
>NP_001269557
          Length = 614

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   MMNHTIT 9
           M NHTIT
Sbjct: 281 MRNHTIT 287
>NP_001269560
          Length = 544

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   MMNHTIT 9
           M NHTIT
Sbjct: 211 MRNHTIT 217
>NP_000038
          Length = 589

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   MMNHTIT 9
           M NHTIT
Sbjct: 256 MRNHTIT 262
>XP_005274578
          Length = 535

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   MMNHTIT 9
           M NHTIT
Sbjct: 202 MRNHTIT 208
>XP_005274576
          Length = 589

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   MMNHTIT 9
           M NHTIT
Sbjct: 256 MRNHTIT 262
>XP_005274575
          Length = 598

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   MMNHTIT 9
           M NHTIT
Sbjct: 265 MRNHTIT 271
>NP_005597
          Length = 433

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   GAMMNH 6
           G+MMNH
Sbjct: 192 GSMMNH 197
>NP_001008530
          Length = 433

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   GAMMNH 6
           G+MMNH
Sbjct: 192 GSMMNH 197
>XP_005267920
          Length = 372

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   GAMMNH 6
           G+MMNH
Sbjct: 192 GSMMNH 197
>XP_005267919
          Length = 376

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   GAMMNH 6
           G+MMNH
Sbjct: 192 GSMMNH 197
>NP_005236
          Length = 4588

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3    MMNHTI 8
            M+NHTI
Sbjct: 3638 MLNHTI 3643
>NP_071417
          Length = 398

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   GAMMNHT 7
           GA+ NHT
Sbjct: 326 GALKNHT 332
>XP_006714202
          Length = 4588

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3    MMNHTI 8
            M+NHTI
Sbjct: 3638 MLNHTI 3643
>XP_005262892
          Length = 4600

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3    MMNHTI 8
            M+NHTI
Sbjct: 3638 MLNHTI 3643
>XP_005262891
          Length = 4600

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3    MMNHTI 8
            M+NHTI
Sbjct: 3638 MLNHTI 3643
>NP_878314
          Length = 361

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   GAMMNHTI 8
           GAM+ H+I
Sbjct: 223 GAMVRHSI 230
>NP_001244068
          Length = 644

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   MNHTIT 9
           MNH+IT
Sbjct: 508 MNHSIT 513
>NP_000076
          Length = 687

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   MNHTIT 9
           MNH+IT
Sbjct: 551 MNHSIT 556
>NP_001180235
          Length = 350

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1  GAMMNHTIT 9
          G  M HT+T
Sbjct: 52 GFRMTHTVT 60
>NP_001159417
          Length = 517

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   MNHTIT 9
           MNH+IT
Sbjct: 382 MNHSIT 387
>NP_563615
          Length = 775

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   GAMMNHTI 8
           G  MNH+I
Sbjct: 151 GLQMNHSI 158
>NP_002020
          Length = 350

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1  GAMMNHTIT 9
          G  M HT+T
Sbjct: 52 GFRMTHTVT 60
>NP_004061
          Length = 687

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   MNHTIT 9
           MNH+IT
Sbjct: 551 MNHSIT 556
>XP_005245790
          Length = 686

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   MNHTIT 9
           MNH+IT
Sbjct: 551 MNHSIT 556
>XP_006710134
          Length = 326

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   MNHTIT 9
           MNH+IT
Sbjct: 198 MNHSIT 203
>XP_006710132
          Length = 518

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   MNHTIT 9
           MNH+IT
Sbjct: 382 MNHSIT 387
>NP_001036169
          Length = 686

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   MNHTIT 9
           MNH+IT
Sbjct: 551 MNHSIT 556
>NP_001161846
          Length = 1063

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 5   NHTIT 9
           NHTIT
Sbjct: 527 NHTIT 531
>NP_001161849
          Length = 1011

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 5   NHTIT 9
           NHTIT
Sbjct: 536 NHTIT 540
>NP_001161848
          Length = 1027

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 5   NHTIT 9
           NHTIT
Sbjct: 491 NHTIT 495
>NP_054747
          Length = 334

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3   MMNHTIT 9
           + NHT+T
Sbjct: 192 LFNHTLT 198
>NP_055736
          Length = 1469

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1    GAMMNHTIT 9
            G M NH +T
Sbjct: 1174 GTMGNHLLT 1182
>NP_055624
          Length = 1072

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 5   NHTIT 9
           NHTIT
Sbjct: 536 NHTIT 540
>NP_001008701
          Length = 1474

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1    GAMMNHTIT 9
            G M NH +T
Sbjct: 1179 GTMGNHLLT 1187
>NP_872394
          Length = 1758

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 5    NHTIT 9
            NHTIT
Sbjct: 1408 NHTIT 1412
>NP_001136336
          Length = 2521

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   GAMMNHTIT 9
           GAM+ +T+T
Sbjct: 517 GAMLLYTLT 525
>NP_001161847
          Length = 1072

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 5   NHTIT 9
           NHTIT
Sbjct: 536 NHTIT 540
>XP_005259876
          Length = 1498

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1    GAMMNHTIT 9
            G M NH +T
Sbjct: 1179 GTMGNHLLT 1187
>XP_006722752
          Length = 1462

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1    GAMMNHTIT 9
            G M NH +T
Sbjct: 1143 GTMGNHLLT 1151
>XP_005259875
          Length = 1493

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1    GAMMNHTIT 9
            G M NH +T
Sbjct: 1174 GTMGNHLLT 1182
>XP_006722751
          Length = 1498

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1    GAMMNHTIT 9
            G M NH +T
Sbjct: 1179 GTMGNHLLT 1187
>XP_006721417
          Length = 2497

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   GAMMNHTIT 9
           GAM+ +T+T
Sbjct: 517 GAMLLYTLT 525
>XP_006721416
          Length = 2504

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   GAMMNHTIT 9
           GAM+ +T+T
Sbjct: 500 GAMLLYTLT 508
>XP_006715527
          Length = 280

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3   MMNHTIT 9
           + NHT+T
Sbjct: 192 LFNHTLT 198
>XP_006715351
          Length = 920

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 5   NHTIT 9
           NHTIT
Sbjct: 384 NHTIT 388
>XP_006715350
          Length = 1040

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 5   NHTIT 9
           NHTIT
Sbjct: 598 NHTIT 602
>XP_006715349
          Length = 1101

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 5   NHTIT 9
           NHTIT
Sbjct: 565 NHTIT 569
>XP_005249561
          Length = 1134

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 5   NHTIT 9
           NHTIT
Sbjct: 598 NHTIT 602
>XP_006712517
          Length = 1757

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 5    NHTIT 9
            NHTIT
Sbjct: 1408 NHTIT 1412
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.323    0.123    0.365 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 445,461
Number of extensions: 441
Number of successful extensions: 72
Number of sequences better than 10000.0: 72
Number of HSP's gapped: 72
Number of HSP's successfully gapped: 72
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.1 bits)
S2: 28 (15.4 bits)

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