Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001188358                                                           18    1935
NP_036427                                                              18    1935
NP_001186210                                                           18    1935
XP_006724246                                                           18    1935
XP_006724245                                                           18    1935
XP_006724244                                                           18    1935
XP_006724243                                                           18    1935
XP_005261477                                                           18    1935
XP_005261476                                                           18    1935
XP_005261474                                                           18    1935
XP_006724242                                                           18    1935
XP_005261473                                                           18    1935
XP_005261472                                                           18    1935
NP_000093                                                              17    2528
NP_075378                                                              16    5631
NP_060236                                                              16    5631
NP_001073312                                                           16    5631
NP_073713                                                              16    5631
XP_006710775                                                           16    5631
XP_005263536                                                           16    5631
NP_612395                                                              16    7355
NP_055178                                                              16    7355
NP_001264984                                                           16    7355
NP_056364                                                              16    7355
NP_001001788                                                           16    7355
XP_005267570                                                           16    7355
XP_006720171                                                           16    7355
XP_005267569                                                           16    7355
XP_005267568                                                           16    7355
XP_006720170                                                           16    7355
XP_006720169                                                           16    7355
XP_005266395                                                           16    7355
XP_006714066                                                           16    7355
NP_689935                                                              15    9605
NP_078796                                                              15    9605
NP_056986                                                              15    9605
NP_001269802                                                           15    9605
NP_056467                                                              15    9605
NP_777358                                                              15    9605
NP_004126                                                              15    9605
NP_079076                                                              15    9605
NP_116176                                                              15    9605
NP_665917                                                              15    9605
NP_001139475                                                           15    9605
NP_009217                                                              15    9605
XP_005267366                                                           15    9605
XP_006720083                                                           15    9605
XP_006720082                                                           15    9605
XP_005271506                                                           15    9605
XP_006718849                                                           15    9605
XP_005251019                                                           15    9605
XP_005251017                                                           15    9605
XP_005251016                                                           15    9605
XP_005251014                                                           15    9605
XP_005251013                                                           15    9605
XP_005268428                                                           15    9605
XP_005268427                                                           15    9605
XP_005268426                                                           15    9605
XP_006714818                                                           15    9605
XP_005247896                                                           15    9605
XP_006713857                                                           15    9605
XP_006713813                                                           15    9605
XP_006713812                                                           15    9605
XP_005247840                                                           15    9605
XP_005246909                                                           15    9605
NP_694591                                                              15    9605
>NP_001188358
          Length = 2170

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    AARYPKSL 9
            AARYPK +
Sbjct: 1191 AARYPKKI 1198
>NP_036427
          Length = 2220

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    AARYPKSL 9
            AARYPK +
Sbjct: 1241 AARYPKKI 1248
>NP_001186210
          Length = 2220

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    AARYPKSL 9
            AARYPK +
Sbjct: 1241 AARYPKKI 1248
>XP_006724246
          Length = 2103

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    AARYPKSL 9
            AARYPK +
Sbjct: 1241 AARYPKKI 1248
>XP_006724245
          Length = 2191

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    AARYPKSL 9
            AARYPK +
Sbjct: 1241 AARYPKKI 1248
>XP_006724244
          Length = 2191

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    AARYPKSL 9
            AARYPK +
Sbjct: 1241 AARYPKKI 1248
>XP_006724243
          Length = 2196

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    AARYPKSL 9
            AARYPK +
Sbjct: 1241 AARYPKKI 1248
>XP_005261477
          Length = 2200

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    AARYPKSL 9
            AARYPK +
Sbjct: 1241 AARYPKKI 1248
>XP_005261476
          Length = 2210

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    AARYPKSL 9
            AARYPK +
Sbjct: 1196 AARYPKKI 1203
>XP_005261474
          Length = 2225

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    AARYPKSL 9
            AARYPK +
Sbjct: 1241 AARYPKKI 1248
>XP_006724242
          Length = 2226

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    AARYPKSL 9
            AARYPK +
Sbjct: 1241 AARYPKKI 1248
>XP_005261473
          Length = 2250

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    AARYPKSL 9
            AARYPK +
Sbjct: 1241 AARYPKKI 1248
>XP_005261472
          Length = 2255

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    AARYPKSL 9
            AARYPK +
Sbjct: 1241 AARYPKKI 1248
>NP_000093
          Length = 508

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  ARYPKSL 9
          A+YPKSL
Sbjct: 25 AKYPKSL 31
>NP_075378
          Length = 402

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   GAARYP 6
           G+ARYP
Sbjct: 326 GSARYP 331
>NP_060236
          Length = 1166

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  GAARYPKS 8
          GAAR P+S
Sbjct: 72 GAARAPRS 79
>NP_001073312
          Length = 1759

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  GAARYPKS 8
          GAAR P+S
Sbjct: 72 GAARAPRS 79
>NP_073713
          Length = 985

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   GAARYPK 7
           GAAR PK
Sbjct: 116 GAARVPK 122
>XP_006710775
          Length = 1759

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  GAARYPKS 8
          GAAR P+S
Sbjct: 72 GAARAPRS 79
>XP_005263536
          Length = 1783

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   GAARYPKS 8
           GAAR P+S
Sbjct: 96  GAARAPRS 103
>NP_612395
          Length = 494

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   ARYPKS 8
           ARYP+S
Sbjct: 380 ARYPRS 385
>NP_055178
          Length = 4579

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   AARYPKSL 9
           +A YP+SL
Sbjct: 693 SAEYPRSL 700
>NP_001264984
          Length = 4432

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   AARYPKSL 9
           +A YP+SL
Sbjct: 546 SAEYPRSL 553
>NP_056364
          Length = 1163

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   GAARYPKSL 9
           GAA+ P+SL
Sbjct: 529 GAAQEPESL 537
>NP_001001788
          Length = 334

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   GAARYPKSL 9
           GAARY + L
Sbjct: 321 GAARYSEPL 329
>XP_005267570
          Length = 1219

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   GAARYPKSL 9
           GAA+ P+SL
Sbjct: 585 GAAQEPESL 593
>XP_006720171
          Length = 1240

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   GAARYPKSL 9
           GAA+ P+SL
Sbjct: 606 GAAQEPESL 614
>XP_005267569
          Length = 1340

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   GAARYPKSL 9
           GAA+ P+SL
Sbjct: 706 GAAQEPESL 714
>XP_005267568
          Length = 1340

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   GAARYPKSL 9
           GAA+ P+SL
Sbjct: 706 GAAQEPESL 714
>XP_006720170
          Length = 1354

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   GAARYPKSL 9
           GAA+ P+SL
Sbjct: 720 GAAQEPESL 728
>XP_006720169
          Length = 1361

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   GAARYPKSL 9
           GAA+ P+SL
Sbjct: 727 GAAQEPESL 735
>XP_005266395
          Length = 4588

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   AARYPKSL 9
           +A YP+SL
Sbjct: 693 SAEYPRSL 700
>XP_006714066
          Length = 544

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  RYPKSL 9
          RYP+SL
Sbjct: 10 RYPRSL 15
>NP_689935
          Length = 416

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   AARYPKS 8
           A RYP+S
Sbjct: 358 ARRYPRS 364
>NP_078796
          Length = 291

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  GAARYPKS 8
          GAA +P+S
Sbjct: 50 GAALFPRS 57
>NP_056986
          Length = 2799

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    GAARYPKSL 9
            GAA+ P+S+
Sbjct: 1706 GAAQAPRSM 1714
>NP_001269802
          Length = 2798

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    GAARYPKSL 9
            GAA+ P+S+
Sbjct: 1706 GAAQAPRSM 1714
>NP_056467
          Length = 1247

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   AARYPKSL 9
           AAR PKS+
Sbjct: 713 AARAPKSV 720
>NP_777358
          Length = 380

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   AARYPK 7
           AARYP+
Sbjct: 240 AARYPQ 245
>NP_004126
          Length = 393

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   AARYPK 7
           AARYP+
Sbjct: 240 AARYPQ 245
>NP_079076
          Length = 645

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   RYPKSL 9
           RYPK L
Sbjct: 255 RYPKEL 260
>NP_116176
          Length = 797

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RYPKSL 9
           +YPKSL
Sbjct: 429 QYPKSL 434
>NP_665917
          Length = 470

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   RYPKSL 9
           RYPK L
Sbjct: 255 RYPKEL 260
>NP_001139475
          Length = 599

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   RYPKSL 9
           RYPK L
Sbjct: 255 RYPKEL 260
>NP_009217
          Length = 903

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   GAARYPKSL 9
           GA+R P SL
Sbjct: 691 GASRPPSSL 699
>XP_005267366
          Length = 1330

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 1   GAARYPK 7
           G  RYPK
Sbjct: 678 GELRYPK 684
>XP_006720083
          Length = 1355

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 1   GAARYPK 7
           G  RYPK
Sbjct: 651 GELRYPK 657
>XP_006720082
          Length = 1363

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 1   GAARYPK 7
           G  RYPK
Sbjct: 678 GELRYPK 684
>XP_005271506
          Length = 415

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   AARYPKS 8
           A RYP+S
Sbjct: 357 ARRYPRS 363
>XP_006718849
          Length = 423

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   AARYPKS 8
           A RYP+S
Sbjct: 365 ARRYPRS 371
>XP_005251019
          Length = 1811

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   GAARYPKSL 9
           GAA+ P+S+
Sbjct: 716 GAAQAPRSM 724
>XP_005251017
          Length = 2792

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    GAARYPKSL 9
            GAA+ P+S+
Sbjct: 1700 GAAQAPRSM 1708
>XP_005251016
          Length = 2795

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    GAARYPKSL 9
            GAA+ P+S+
Sbjct: 1700 GAAQAPRSM 1708
>XP_005251014
          Length = 2800

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    GAARYPKSL 9
            GAA+ P+S+
Sbjct: 1706 GAAQAPRSM 1714
>XP_005251013
          Length = 2801

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    GAARYPKSL 9
            GAA+ P+S+
Sbjct: 1706 GAAQAPRSM 1714
>XP_005268428
          Length = 903

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   GAARYPKSL 9
           GA+R P SL
Sbjct: 691 GASRPPSSL 699
>XP_005268427
          Length = 903

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   GAARYPKSL 9
           GA+R P SL
Sbjct: 691 GASRPPSSL 699
>XP_005268426
          Length = 903

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   GAARYPKSL 9
           GA+R P SL
Sbjct: 691 GASRPPSSL 699
>XP_006714818
          Length = 1147

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   GAARYPKSL 9
           GA+R P SL
Sbjct: 935 GASRPPSSL 943
>XP_005247896
          Length = 502

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RYPKSL 9
           +YPKSL
Sbjct: 134 QYPKSL 139
>XP_006713857
          Length = 560

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RYPKSL 9
           +YPKSL
Sbjct: 192 QYPKSL 197
>XP_006713813
          Length = 482

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   RYPKSL 9
           RYPK L
Sbjct: 255 RYPKEL 260
>XP_006713812
          Length = 539

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   RYPKSL 9
           RYPK L
Sbjct: 149 RYPKEL 154
>XP_005247840
          Length = 645

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   RYPKSL 9
           RYPK L
Sbjct: 255 RYPKEL 260
>XP_005246909
          Length = 225

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  GAARYPKS 8
          GAA +P+S
Sbjct: 50 GAALFPRS 57
>NP_694591
          Length = 1382

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 1   GAARYPK 7
           G  RYPK
Sbjct: 678 GELRYPK 684
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.314    0.131    0.382 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 648,477
Number of extensions: 824
Number of successful extensions: 66
Number of sequences better than 10000.0: 66
Number of HSP's gapped: 66
Number of HSP's successfully gapped: 66
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.6 bits)
S2: 28 (15.4 bits)

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