Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001277144                                                           20     509
NP_001277143                                                           20     509
NP_001319                                                              20     509
NP_001012632                                                           20     509
NP_001077383                                                           20     509
NP_001320                                                              20     509
NP_073713                                                              20     509
XP_005269629                                                           20     509
XP_005269628                                                           20     509
XP_005269627                                                           20     509
XP_005269626                                                           20     509
XP_006717706                                                           20     509
XP_005269625                                                           20     509
XP_005269624                                                           20     509
XP_006717705                                                           20     509
XP_005269622                                                           20     509
XP_005269621                                                           20     509
XP_006717704                                                           20     509
XP_005269619                                                           20     509
XP_005269618                                                           20     509
XP_005272320                                                           20     509
XP_005272319                                                           20     509
XP_005272318                                                           20     509
NP_005794                                                              16    5631
XP_006726135                                                           16    5631
XP_005275560                                                           16    5631
XP_005275559                                                           16    5631
XP_006726034                                                           16    5631
XP_005275393                                                           16    5631
XP_005275392                                                           16    5631
XP_006725735                                                           16    5631
XP_005274967                                                           16    5631
XP_005274966                                                           16    5631
XP_006725528                                                           16    5631
XP_005272817                                                           16    5631
XP_005272816                                                           16    5631
XP_006715010                                                           16    5631
XP_005248838                                                           16    5631
XP_005248837                                                           16    5631
NP_001278017                                                           16    7355
NP_114157                                                              16    7355
NP_001074008                                                           16    7355
XP_006723474                                                           16    7355
XP_005259362                                                           16    7355
XP_006712501                                                           16    7355
NP_004804                                                              15    9605
NP_476515                                                              15    9605
NP_005106                                                              15    9605
NP_059447                                                              15    9605
NP_699192                                                              15    9605
NP_071417                                                              15    9605
XP_005262467                                                           15    9605
XP_005262466                                                           15    9605
XP_005262465                                                           15    9605
XP_006714513                                                           15    9605
NP_001094827                                                           15    9605
NP_001257530                                                           15    9605
>NP_001277144
          Length = 445

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   GAARIRGE 8
           GAARIRGE
Sbjct: 174 GAARIRGE 181
>NP_001277143
          Length = 445

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   GAARIRGE 8
           GAARIRGE
Sbjct: 174 GAARIRGE 181
>NP_001319
          Length = 440

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   GAARIRGE 8
           GAARIRGE
Sbjct: 168 GAARIRGE 175
>NP_001012632
          Length = 429

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   GAARIRGE 8
           GAARIRGE
Sbjct: 157 GAARIRGE 164
>NP_001077383
          Length = 445

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   GAARIRGE 8
           GAARIRGE
Sbjct: 174 GAARIRGE 181
>NP_001320
          Length = 445

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   GAARIRGE 8
           GAARIRGE
Sbjct: 174 GAARIRGE 181
>NP_073713
          Length = 985

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   GAARIRGE 8
           GAARIRGE
Sbjct: 714 GAARIRGE 721
>XP_005269629
          Length = 445

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   GAARIRGE 8
           GAARIRGE
Sbjct: 174 GAARIRGE 181
>XP_005269628
          Length = 445

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   GAARIRGE 8
           GAARIRGE
Sbjct: 174 GAARIRGE 181
>XP_005269627
          Length = 445

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   GAARIRGE 8
           GAARIRGE
Sbjct: 174 GAARIRGE 181
>XP_005269626
          Length = 445

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   GAARIRGE 8
           GAARIRGE
Sbjct: 174 GAARIRGE 181
>XP_006717706
          Length = 445

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   GAARIRGE 8
           GAARIRGE
Sbjct: 174 GAARIRGE 181
>XP_005269625
          Length = 445

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   GAARIRGE 8
           GAARIRGE
Sbjct: 174 GAARIRGE 181
>XP_005269624
          Length = 445

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   GAARIRGE 8
           GAARIRGE
Sbjct: 174 GAARIRGE 181
>XP_006717705
          Length = 445

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   GAARIRGE 8
           GAARIRGE
Sbjct: 174 GAARIRGE 181
>XP_005269622
          Length = 445

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   GAARIRGE 8
           GAARIRGE
Sbjct: 174 GAARIRGE 181
>XP_005269621
          Length = 445

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   GAARIRGE 8
           GAARIRGE
Sbjct: 174 GAARIRGE 181
>XP_006717704
          Length = 445

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   GAARIRGE 8
           GAARIRGE
Sbjct: 174 GAARIRGE 181
>XP_005269619
          Length = 445

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   GAARIRGE 8
           GAARIRGE
Sbjct: 174 GAARIRGE 181
>XP_005269618
          Length = 445

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   GAARIRGE 8
           GAARIRGE
Sbjct: 174 GAARIRGE 181
>XP_005272320
          Length = 430

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   GAARIRGE 8
           GAARIRGE
Sbjct: 157 GAARIRGE 164
>XP_005272319
          Length = 430

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   GAARIRGE 8
           GAARIRGE
Sbjct: 157 GAARIRGE 164
>XP_005272318
          Length = 441

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   GAARIRGE 8
           GAARIRGE
Sbjct: 168 GAARIRGE 175
>NP_005794
          Length = 427

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   GAARIRGEM 9
           GAA++ GE+
Sbjct: 389 GAAKVTGEV 397
>XP_006726135
          Length = 374

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   GAARIRGEM 9
           GAA++ GE+
Sbjct: 336 GAAKVTGEV 344
>XP_005275560
          Length = 379

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   GAARIRGEM 9
           GAA++ GE+
Sbjct: 341 GAAKVTGEV 349
>XP_005275559
          Length = 427

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   GAARIRGEM 9
           GAA++ GE+
Sbjct: 389 GAAKVTGEV 397
>XP_006726034
          Length = 374

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   GAARIRGEM 9
           GAA++ GE+
Sbjct: 336 GAAKVTGEV 344
>XP_005275393
          Length = 379

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   GAARIRGEM 9
           GAA++ GE+
Sbjct: 341 GAAKVTGEV 349
>XP_005275392
          Length = 427

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   GAARIRGEM 9
           GAA++ GE+
Sbjct: 389 GAAKVTGEV 397
>XP_006725735
          Length = 374

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   GAARIRGEM 9
           GAA++ GE+
Sbjct: 336 GAAKVTGEV 344
>XP_005274967
          Length = 379

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   GAARIRGEM 9
           GAA++ GE+
Sbjct: 341 GAAKVTGEV 349
>XP_005274966
          Length = 427

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   GAARIRGEM 9
           GAA++ GE+
Sbjct: 389 GAAKVTGEV 397
>XP_006725528
          Length = 374

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   GAARIRGEM 9
           GAA++ GE+
Sbjct: 336 GAAKVTGEV 344
>XP_005272817
          Length = 379

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   GAARIRGEM 9
           GAA++ GE+
Sbjct: 341 GAAKVTGEV 349
>XP_005272816
          Length = 427

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   GAARIRGEM 9
           GAA++ GE+
Sbjct: 389 GAAKVTGEV 397
>XP_006715010
          Length = 374

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   GAARIRGEM 9
           GAA++ GE+
Sbjct: 336 GAAKVTGEV 344
>XP_005248838
          Length = 379

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   GAARIRGEM 9
           GAA++ GE+
Sbjct: 341 GAAKVTGEV 349
>XP_005248837
          Length = 427

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   GAARIRGEM 9
           GAA++ GE+
Sbjct: 389 GAAKVTGEV 397
>NP_001278017
          Length = 2912

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    GAARIRGEM 9
            G  R+RGE+
Sbjct: 1985 GKKRLRGEL 1993
>NP_114157
          Length = 2873

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    GAARIRGEM 9
            G  R+RGE+
Sbjct: 1946 GKKRLRGEL 1954
>NP_001074008
          Length = 1101

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   ARIRGEM 9
           AR+RGE+
Sbjct: 454 ARLRGEL 460
>XP_006723474
          Length = 2737

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    GAARIRGEM 9
            G  R+RGE+
Sbjct: 1810 GKKRLRGEL 1818
>XP_005259362
          Length = 2855

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    GAARIRGEM 9
            G  R+RGE+
Sbjct: 1928 GKKRLRGEL 1936
>XP_006712501
          Length = 1080

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   ARIRGEM 9
           AR+RGE+
Sbjct: 454 ARLRGEL 460
>NP_004804
          Length = 336

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   GAARIRGEM 9
           GAA++ GE+
Sbjct: 99  GAAKVWGEV 107
>NP_476515
          Length = 346

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   GAARIRGEM 9
           GAA++ GE+
Sbjct: 99  GAAKVWGEV 107
>NP_005106
          Length = 893

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   AARIRGE 8
           AARI GE
Sbjct: 732 AARIEGE 738
>NP_059447
          Length = 893

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   AARIRGE 8
           AARI GE
Sbjct: 732 AARIEGE 738
>NP_699192
          Length = 436

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  GAARIRGEM 9
          G  RIRGE+
Sbjct: 72 GFYRIRGEI 80
>NP_071417
          Length = 398

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   GAARIRGEM 9
           G  R+RGE+
Sbjct: 299 GPRRLRGEV 307
>XP_005262467
          Length = 325

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   ARIRGEM 9
           A+IRGE+
Sbjct: 272 AKIRGEL 278
>XP_005262466
          Length = 325

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   ARIRGEM 9
           A+IRGE+
Sbjct: 272 AKIRGEL 278
>XP_005262465
          Length = 334

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   ARIRGEM 9
           A+IRGE+
Sbjct: 281 AKIRGEL 287
>XP_006714513
          Length = 436

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  GAARIRGEM 9
          G  RIRGE+
Sbjct: 72 GFYRIRGEI 80
>NP_001094827
          Length = 325

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   ARIRGEM 9
           A+IRGE+
Sbjct: 272 AKIRGEL 278
>NP_001257530
          Length = 206

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   GAARIRGEM 9
           G AR+RG +
Sbjct: 102 GYARLRGHL 110
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.324    0.139    0.383 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 405,457
Number of extensions: 691
Number of successful extensions: 57
Number of sequences better than 10000.0: 57
Number of HSP's gapped: 57
Number of HSP's successfully gapped: 57
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.9 bits)
S2: 28 (15.4 bits)

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