Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001273718                                                           17    2528
NP_001748                                                              17    2528
NP_057116                                                              17    3301
NP_001008223                                                           17    3301
NP_001243846                                                           17    4312
NP_775871                                                              17    4312
NP_001182054                                                           17    4312
NP_056161                                                              16    5631
NP_001726                                                              16    5631
NP_036565                                                              16    5631
NP_056227                                                              16    5631
NP_115823                                                              16    5631
NP_001233                                                              16    5631
XP_006722988                                                           16    5631
XP_005247330                                                           16    5631
XP_005246485                                                           16    5631
NP_037450                                                              16    7355
NP_001274187                                                           16    7355
NP_001277247                                                           16    7355
NP_065708                                                              16    7355
NP_001277248                                                           16    7355
NP_001274189                                                           16    7355
NP_001274188                                                           16    7355
NP_001011720                                                           16    7355
NP_001136205                                                           16    7355
XP_006726491                                                           16    7355
XP_006716510                                                           16    7355
XP_006715877                                                           16    7355
XP_006713045                                                           16    7355
XP_005264942                                                           16    7355
XP_005264941                                                           16    7355
XP_006710244                                                           16    7355
NP_620482                                                              15    9605
NP_001077084                                                           15    9605
NP_783322                                                              15    9605
NP_001265331                                                           15    9605
NP_001019818                                                           15    9605
NP_783324                                                              15    9605
NP_071901                                                              15    9605
NP_783323                                                              15    9605
NP_689986                                                              15    9605
NP_001013860                                                           15    9605
NP_057438                                                              15    9605
XP_005260260                                                           15    9605
XP_006721205                                                           15    9605
XP_005255864                                                           15    9605
XP_006721204                                                           15    9605
XP_006721203                                                           15    9605
XP_006721202                                                           15    9605
XP_006721201                                                           15    9605
XP_006719291                                                           15    9605
XP_006719290                                                           15    9605
XP_006719289                                                           15    9605
XP_006712362                                                           15    9605
NP_003183                                                              15    9605
>NP_001273718
          Length = 173

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  GAAIVKDCC 9
          G AIV+D C
Sbjct: 18 GLAIVRDLC 26
>NP_001748
          Length = 277

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  GAAIVKDCC 9
          G AIV+D C
Sbjct: 18 GLAIVRDLC 26
>NP_057116
          Length = 364

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   IVKDCC 9
           IVK+CC
Sbjct: 279 IVKNCC 284
>NP_001008223
          Length = 364

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   IVKDCC 9
           IVK+CC
Sbjct: 279 IVKNCC 284
>NP_001243846
          Length = 143

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   GAAIVKDCC 9
           G+A++  CC
Sbjct: 109 GSAVMSACC 117
>NP_775871
          Length = 8384

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    AAIVKDC 8
            AA+V+DC
Sbjct: 8260 AAVVQDC 8266
>NP_001182054
          Length = 158

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   GAAIVKDCC 9
           G+A++  CC
Sbjct: 124 GSAVMSACC 132
>NP_056161
          Length = 2539

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    GAAIVKDCC 9
            G A+V+D C
Sbjct: 2512 GDAVVQDIC 2520
>NP_001726
          Length = 1676

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3   AIVKDCC 9
           ++VK CC
Sbjct: 693 SVVKKCC 699
>NP_036565
          Length = 1304

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/6 (66%), Positives = 5/6 (83%)

Query: 4   IVKDCC 9
           +VK CC
Sbjct: 791 VVKQCC 796
>NP_056227
          Length = 567

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2  AAIVKDC 8
          AA++K+C
Sbjct: 40 AAVIKEC 46
>NP_115823
          Length = 2809

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   GAAIVKDCC 9
           GA++  +CC
Sbjct: 827 GASLRSECC 835
>NP_001233
          Length = 260

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1  GAAIVKDC 8
          G  +VKDC
Sbjct: 46 GTFLVKDC 53
>XP_006722988
          Length = 2818

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   GAAIVKDCC 9
           GA++  +CC
Sbjct: 836 GASLRSECC 844
>XP_005247330
          Length = 497

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2  AAIVKDC 8
          AA++K+C
Sbjct: 40 AAVIKEC 46
>XP_005246485
          Length = 1158

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/6 (66%), Positives = 5/6 (83%)

Query: 4   IVKDCC 9
           +VK CC
Sbjct: 645 VVKQCC 650
>NP_037450
          Length = 2229

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1    GAAIVKDC 8
            G+AI+++C
Sbjct: 1537 GSAIIENC 1544
>NP_001274187
          Length = 241

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2  AAIVKDCC 9
          AAI+  CC
Sbjct: 34 AAIMVSCC 41
>NP_001277247
          Length = 706

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   GAAIVKDC 8
           GA+ VK C
Sbjct: 198 GASFVKSC 205
>NP_065708
          Length = 659

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   GAAIVKDC 8
           GA+ VK C
Sbjct: 151 GASFVKSC 158
>NP_001277248
          Length = 617

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   GAAIVKDC 8
           GA+ VK C
Sbjct: 109 GASFVKSC 116
>NP_001274189
          Length = 373

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   AAIVKDCC 9
           AAI+  CC
Sbjct: 166 AAIMVSCC 173
>NP_001274188
          Length = 373

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   AAIVKDCC 9
           AAI+  CC
Sbjct: 166 AAIMVSCC 173
>NP_001011720
          Length = 373

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   AAIVKDCC 9
           AAI+  CC
Sbjct: 166 AAIMVSCC 173
>NP_001136205
          Length = 587

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   AAIVKDC 8
           AA+++DC
Sbjct: 156 AAVLRDC 162
>XP_006726491
          Length = 230

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1  GAAIVKDC 8
          GAA+ K C
Sbjct: 38 GAALTKGC 45
>XP_006716510
          Length = 241

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2  AAIVKDCC 9
          AAI+  CC
Sbjct: 34 AAIMVSCC 41
>XP_006715877
          Length = 230

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1  GAAIVKDC 8
          GAA+ K C
Sbjct: 38 GAALTKGC 45
>XP_006713045
          Length = 587

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   AAIVKDC 8
           AA+++DC
Sbjct: 156 AAVLRDC 162
>XP_005264942
          Length = 599

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   AAIVKDC 8
           AA+++DC
Sbjct: 156 AAVLRDC 162
>XP_005264941
          Length = 599

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   AAIVKDC 8
           AA+++DC
Sbjct: 156 AAVLRDC 162
>XP_006710244
          Length = 230

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1  GAAIVKDC 8
          GAA+ K C
Sbjct: 38 GAALTKGC 45
>NP_620482
          Length = 1341

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    GAAIVKDC 8
            G+A V+DC
Sbjct: 1143 GSAEVQDC 1150
>NP_001077084
          Length = 1314

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    GAAIVKDC 8
            G+A V+DC
Sbjct: 1116 GSAEVQDC 1123
>NP_783322
          Length = 476

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 4   IVKDC 8
           IVKDC
Sbjct: 306 IVKDC 310
>NP_001265331
          Length = 254

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 4  IVKDC 8
          IVKDC
Sbjct: 84 IVKDC 88
>NP_001019818
          Length = 254

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 4  IVKDC 8
          IVKDC
Sbjct: 84 IVKDC 88
>NP_783324
          Length = 411

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 4   IVKDC 8
           IVKDC
Sbjct: 306 IVKDC 310
>NP_071901
          Length = 460

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 4   IVKDC 8
           IVKDC
Sbjct: 290 IVKDC 294
>NP_783323
          Length = 395

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 4   IVKDC 8
           IVKDC
Sbjct: 290 IVKDC 294
>NP_689986
          Length = 142

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 3  AIVKDC 8
          ++VKDC
Sbjct: 42 SVVKDC 47
>NP_001013860
          Length = 1435

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 2   AAIVKDCC 9
           AA+ + CC
Sbjct: 422 AAVSRGCC 429
>NP_057438
          Length = 722

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   GAAIVKDC 8
           G+A++K C
Sbjct: 451 GSAVIKFC 458
>XP_005260260
          Length = 684

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   GAAIVKDC 8
           G+A++K C
Sbjct: 451 GSAVIKFC 458
>XP_006721205
          Length = 1441

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 2   AAIVKDCC 9
           AA+ + CC
Sbjct: 422 AAVSRGCC 429
>XP_005255864
          Length = 1372

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 2   AAIVKDCC 9
           AA+ + CC
Sbjct: 386 AAVSRGCC 393
>XP_006721204
          Length = 1405

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 2   AAIVKDCC 9
           AA+ + CC
Sbjct: 386 AAVSRGCC 393
>XP_006721203
          Length = 1408

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 2   AAIVKDCC 9
           AA+ + CC
Sbjct: 422 AAVSRGCC 429
>XP_006721202
          Length = 1424

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 2   AAIVKDCC 9
           AA+ + CC
Sbjct: 422 AAVSRGCC 429
>XP_006721201
          Length = 1430

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 2   AAIVKDCC 9
           AA+ + CC
Sbjct: 422 AAVSRGCC 429
>XP_006719291
          Length = 387

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 4   IVKDC 8
           IVKDC
Sbjct: 340 IVKDC 344
>XP_006719290
          Length = 445

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 4   IVKDC 8
           IVKDC
Sbjct: 340 IVKDC 344
>XP_006719289
          Length = 510

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 4   IVKDC 8
           IVKDC
Sbjct: 340 IVKDC 344
>XP_006712362
          Length = 1350

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    GAAIVKDC 8
            G+A V+DC
Sbjct: 1152 GSAEVQDC 1159
>NP_003183
          Length = 346

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   AIVKDC 8
           AIV+DC
Sbjct: 279 AIVEDC 284
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.332    0.143    0.527 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 515,768
Number of extensions: 679
Number of successful extensions: 55
Number of sequences better than 10000.0: 55
Number of HSP's gapped: 55
Number of HSP's successfully gapped: 55
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.2 bits)
S2: 28 (15.4 bits)

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