Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000305                                                              21     175
XP_006717990                                                           21     175
XP_006717989                                                           21     175
NP_001229269                                                           18    1935
NP_776168                                                              18    1935
NP_001124429                                                           18    1935
XP_006711820                                                           18    1935
XP_005273147                                                           18    1935
XP_006711819                                                           18    1935
NP_878918                                                              17    4312
NP_055995                                                              17    4312
NP_478072                                                              17    4312
XP_006720147                                                           17    4312
XP_005267516                                                           17    4312
XP_005267515                                                           17    4312
XP_005267514                                                           17    4312
XP_005267513                                                           17    4312
XP_005267512                                                           17    4312
XP_005267511                                                           17    4312
NP_006717                                                              16    5631
NP_056493                                                              16    5631
NP_055907                                                              16    5631
NP_001186211                                                           16    5631
NP_001006109                                                           16    5631
XP_005255242                                                           16    5631
XP_005255241                                                           16    5631
XP_005255240                                                           16    5631
XP_005255239                                                           16    5631
XP_006719869                                                           16    5631
XP_006719868                                                           16    5631
XP_005266408                                                           16    5631
XP_005266403                                                           16    5631
XP_006719867                                                           16    5631
XP_006719866                                                           16    5631
XP_005266405                                                           16    5631
XP_005266404                                                           16    5631
XP_005263434                                                           16    5631
XP_005263433                                                           16    5631
XP_005263432                                                           16    5631
XP_005263431                                                           16    5631
XP_006714492                                                           16    5631
XP_005263430                                                           16    5631
XP_005263429                                                           16    5631
XP_005247694                                                           16    5631
XP_005247693                                                           16    5631
NP_064572                                                              16    5631
NP_001156002                                                           16    7355
XP_005271262                                                           16    7355
XP_006710965                                                           16    7355
XP_006710964                                                           16    7355
XP_005271261                                                           16    7355
NP_078952                                                              16    7355
NP_002964                                                              15    9605
NP_061172                                                              15    9605
NP_001243625                                                           15    9605
NP_001243624                                                           15    9605
XP_005257881                                                           15    9605
NP_002207                                                              15    9605
NP_115267                                                              15    9605
NP_061746                                                              15    9605
NP_116035                                                              15    9605
>NP_000305
          Length = 403

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   FYGEVSTRD 9
           FYGEV TRD
Sbjct: 154 FYGEVRTRD 162
>XP_006717990
          Length = 175

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   FYGEVSTRD 9
           FYGEV TRD
Sbjct: 139 FYGEVRTRD 147
>XP_006717989
          Length = 388

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   FYGEVSTRD 9
           FYGEV TRD
Sbjct: 139 FYGEVRTRD 147
>NP_001229269
          Length = 800

 Score = 17.7 bits (34), Expect =  1935
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   FYGEVSTRD 9
           FY +++TRD
Sbjct: 367 FYSKINTRD 375
>NP_776168
          Length = 832

 Score = 17.7 bits (34), Expect =  1935
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   FYGEVSTRD 9
           FY +++TRD
Sbjct: 518 FYSKINTRD 526
>NP_001124429
          Length = 951

 Score = 17.7 bits (34), Expect =  1935
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   FYGEVSTRD 9
           FY +++TRD
Sbjct: 518 FYSKINTRD 526
>XP_006711820
          Length = 809

 Score = 17.7 bits (34), Expect =  1935
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   FYGEVSTRD 9
           FY +++TRD
Sbjct: 376 FYSKINTRD 384
>XP_005273147
          Length = 809

 Score = 17.7 bits (34), Expect =  1935
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   FYGEVSTRD 9
           FY +++TRD
Sbjct: 376 FYSKINTRD 384
>XP_006711819
          Length = 884

 Score = 17.7 bits (34), Expect =  1935
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   FYGEVSTRD 9
           FY +++TRD
Sbjct: 451 FYSKINTRD 459
>NP_878918
          Length = 6907

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    YGEVSTRD 9
            YG++ST D
Sbjct: 4167 YGKISTSD 4174
>NP_055995
          Length = 6885

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    YGEVSTRD 9
            YG++ST D
Sbjct: 4167 YGKISTSD 4174
>NP_478072
          Length = 312

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   YGEVSTRD 9
           YGEVS R+
Sbjct: 193 YGEVSGRE 200
>XP_006720147
          Length = 4788

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    YGEVSTRD 9
            YG++ST D
Sbjct: 4167 YGKISTSD 4174
>XP_005267516
          Length = 6884

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    YGEVSTRD 9
            YG++ST D
Sbjct: 4167 YGKISTSD 4174
>XP_005267515
          Length = 6899

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    YGEVSTRD 9
            YG++ST D
Sbjct: 4167 YGKISTSD 4174
>XP_005267514
          Length = 6908

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    YGEVSTRD 9
            YG++ST D
Sbjct: 4167 YGKISTSD 4174
>XP_005267513
          Length = 6921

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    YGEVSTRD 9
            YG++ST D
Sbjct: 4167 YGKISTSD 4174
>XP_005267512
          Length = 6922

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    YGEVSTRD 9
            YG++ST D
Sbjct: 4167 YGKISTSD 4174
>XP_005267511
          Length = 6922

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    YGEVSTRD 9
            YG++ST D
Sbjct: 4167 YGKISTSD 4174
>NP_006717
          Length = 2863

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  GEVSTRD 9
          GEVS RD
Sbjct: 58 GEVSNRD 64
>NP_056493
          Length = 2946

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  GEVSTRD 9
          GEVS RD
Sbjct: 84 GEVSNRD 90
>NP_055907
          Length = 3661

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3    GEVSTRD 9
            GEVS RD
Sbjct: 2111 GEVSARD 2117
>NP_001186211
          Length = 2851

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  GEVSTRD 9
          GEVS RD
Sbjct: 58 GEVSNRD 64
>NP_001006109
          Length = 354

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   YGEVSTRD 9
           +GEVST++
Sbjct: 229 FGEVSTQE 236
>XP_005255242
          Length = 3609

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3    GEVSTRD 9
            GEVS RD
Sbjct: 2059 GEVSARD 2065
>XP_005255241
          Length = 3637

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3    GEVSTRD 9
            GEVS RD
Sbjct: 2059 GEVSARD 2065
>XP_005255240
          Length = 3663

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3    GEVSTRD 9
            GEVS RD
Sbjct: 2085 GEVSARD 2091
>XP_005255239
          Length = 3689

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3    GEVSTRD 9
            GEVS RD
Sbjct: 2111 GEVSARD 2117
>XP_006719869
          Length = 2943

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  GEVSTRD 9
          GEVS RD
Sbjct: 84 GEVSNRD 90
>XP_006719868
          Length = 2938

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  GEVSTRD 9
          GEVS RD
Sbjct: 84 GEVSNRD 90
>XP_005266408
          Length = 1934

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  GEVSTRD 9
          GEVS RD
Sbjct: 84 GEVSNRD 90
>XP_005266403
          Length = 2941

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  GEVSTRD 9
          GEVS RD
Sbjct: 84 GEVSNRD 90
>XP_006719867
          Length = 2961

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  GEVSTRD 9
          GEVS RD
Sbjct: 84 GEVSNRD 90
>XP_006719866
          Length = 2962

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  GEVSTRD 9
          GEVS RD
Sbjct: 84 GEVSNRD 90
>XP_005266405
          Length = 2964

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  GEVSTRD 9
          GEVS RD
Sbjct: 84 GEVSNRD 90
>XP_005266404
          Length = 2967

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  GEVSTRD 9
          GEVS RD
Sbjct: 84 GEVSNRD 90
>XP_005263434
          Length = 1557

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  GEVSTRD 9
          GEVS RD
Sbjct: 58 GEVSNRD 64
>XP_005263433
          Length = 2832

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  GEVSTRD 9
          GEVS RD
Sbjct: 58 GEVSNRD 64
>XP_005263432
          Length = 2852

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  GEVSTRD 9
          GEVS RD
Sbjct: 58 GEVSNRD 64
>XP_005263431
          Length = 2857

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  GEVSTRD 9
          GEVS RD
Sbjct: 58 GEVSNRD 64
>XP_006714492
          Length = 2867

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  GEVSTRD 9
          GEVS RD
Sbjct: 58 GEVSNRD 64
>XP_005263430
          Length = 2868

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  GEVSTRD 9
          GEVS RD
Sbjct: 58 GEVSNRD 64
>XP_005263429
          Length = 2868

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  GEVSTRD 9
          GEVS RD
Sbjct: 58 GEVSNRD 64
>XP_005247694
          Length = 312

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   YGEVSTRD 9
           +GEVST++
Sbjct: 187 FGEVSTQE 194
>XP_005247693
          Length = 354

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   YGEVSTRD 9
           +GEVST++
Sbjct: 229 FGEVSTQE 236
>NP_064572
          Length = 354

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   YGEVSTRD 9
           +GEVST++
Sbjct: 229 FGEVSTQE 236
>NP_001156002
          Length = 756

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   EVSTRD 9
           EVSTRD
Sbjct: 494 EVSTRD 499
>XP_005271262
          Length = 603

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   EVSTRD 9
           EVSTRD
Sbjct: 291 EVSTRD 296
>XP_006710965
          Length = 770

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   EVSTRD 9
           EVSTRD
Sbjct: 494 EVSTRD 499
>XP_006710964
          Length = 781

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   EVSTRD 9
           EVSTRD
Sbjct: 494 EVSTRD 499
>XP_005271261
          Length = 806

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   EVSTRD 9
           EVSTRD
Sbjct: 494 EVSTRD 499
>NP_078952
          Length = 645

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   EVSTRD 9
           EVSTRD
Sbjct: 383 EVSTRD 388
>NP_002964
          Length = 1313

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   YGEVSTRD 9
           YG VST D
Sbjct: 409 YGVVSTYD 416
>NP_061172
          Length = 739

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   YGEVSTR 8
           YG +STR
Sbjct: 679 YGRLSTR 685
>NP_001243625
          Length = 477

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   FYGEVSTRD 9
           + G++ST+D
Sbjct: 145 YEGQISTQD 153
>NP_001243624
          Length = 1177

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   FYGEVSTRD 9
           + G++ST+D
Sbjct: 145 YEGQISTQD 153
>XP_005257881
          Length = 513

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 5/9 (55%)

Query: 1  FYGEVSTRD 9
          FYG   T D
Sbjct: 87 FYGNSETND 95
>NP_002207
          Length = 946

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   FYGEVST 7
           FY +VST
Sbjct: 489 FYNQVST 495
>NP_115267
          Length = 811

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   GEVSTRD 9
           GE++T+D
Sbjct: 299 GEITTKD 305
>NP_061746
          Length = 931

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   GEVSTRD 9
           GE++T+D
Sbjct: 299 GEITTKD 305
>NP_116035
          Length = 534

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 5/9 (55%)

Query: 1   FYGEVSTRD 9
           FYG   T D
Sbjct: 108 FYGNSETND 116
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.318    0.139    0.407 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 466,504
Number of extensions: 707
Number of successful extensions: 61
Number of sequences better than 10000.0: 61
Number of HSP's gapped: 61
Number of HSP's successfully gapped: 61
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.7 bits)
S2: 28 (15.4 bits)

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