Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000042                                                              18    1135
XP_006718908                                                           18    1135
XP_005271621                                                           18    1135
XP_006718907                                                           18    1135
XP_006718906                                                           18    1135
XP_005271619                                                           18    1135
XP_005271618                                                           18    1135
NP_001245245                                                           16    7355
NP_060568                                                              16    7355
NP_001245244                                                           16    7355
NP_115544                                                              16    7355
XP_005247237                                                           16    7355
XP_006713587                                                           16    7355
XP_005247233                                                           16    7355
XP_006713586                                                           16    7355
NP_001360                                                              15    9605
NP_001153844                                                           15    9605
NP_113654                                                              15    9605
NP_775760                                                              15    9605
NP_001193856                                                           15    9605
XP_006716727                                                           15    9605
XP_005251134                                                           15    9605
XP_006715067                                                           15    9605
XP_005248319                                                           15    9605
>NP_000042
          Length = 3056

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    VNLLQLSK 9
            VNLLQLSK
Sbjct: 1649 VNLLQLSK 1656
>XP_006718908
          Length = 1708

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   VNLLQLSK 9
           VNLLQLSK
Sbjct: 301 VNLLQLSK 308
>XP_005271621
          Length = 2708

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    VNLLQLSK 9
            VNLLQLSK
Sbjct: 1301 VNLLQLSK 1308
>XP_006718907
          Length = 3050

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    VNLLQLSK 9
            VNLLQLSK
Sbjct: 1643 VNLLQLSK 1650
>XP_006718906
          Length = 3056

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    VNLLQLSK 9
            VNLLQLSK
Sbjct: 1649 VNLLQLSK 1656
>XP_005271619
          Length = 3056

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    VNLLQLSK 9
            VNLLQLSK
Sbjct: 1649 VNLLQLSK 1656
>XP_005271618
          Length = 3056

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    VNLLQLSK 9
            VNLLQLSK
Sbjct: 1649 VNLLQLSK 1656
>NP_001245245
          Length = 883

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   FVNLLQLSK 9
           FVN  ++SK
Sbjct: 519 FVNFFEMSK 527
>NP_060568
          Length = 883

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   FVNLLQLSK 9
           FVN  ++SK
Sbjct: 519 FVNFFEMSK 527
>NP_001245244
          Length = 914

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   FVNLLQLSK 9
           FVN  ++SK
Sbjct: 550 FVNFFEMSK 558
>NP_115544
          Length = 830

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   FVNLLQLSK 9
           FVN L LSK
Sbjct: 751 FVNSLLLSK 759
>XP_005247237
          Length = 757

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   FVNLLQLSK 9
           FVN  ++SK
Sbjct: 349 FVNFFEMSK 357
>XP_006713587
          Length = 889

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   FVNLLQLSK 9
           FVN  ++SK
Sbjct: 550 FVNFFEMSK 558
>XP_005247233
          Length = 927

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   FVNLLQLSK 9
           FVN  ++SK
Sbjct: 519 FVNFFEMSK 527
>XP_006713586
          Length = 958

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   FVNLLQLSK 9
           FVN  ++SK
Sbjct: 550 FVNFFEMSK 558
>NP_001360
          Length = 4624

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1    FVNLLQLSK 9
            ++NL++LSK
Sbjct: 3943 WLNLVELSK 3951
>NP_001153844
          Length = 1148

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   FVNLLQLSK 9
           ++NL QLS+
Sbjct: 373 YINLRQLSE 381
>NP_113654
          Length = 1246

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   FVNLLQLSK 9
           ++NL QLS+
Sbjct: 471 YINLRQLSE 479
>NP_775760
          Length = 1585

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   FVNLLQ 6
           F+NLLQ
Sbjct: 277 FINLLQ 282
>NP_001193856
          Length = 4707

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1    FVNLLQLSK 9
            ++NL++LSK
Sbjct: 4025 WLNLVELSK 4033
>XP_006716727
          Length = 1139

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   FVNLLQLSK 9
           ++NL QLS+
Sbjct: 364 YINLRQLSE 372
>XP_005251134
          Length = 1148

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   FVNLLQLSK 9
           ++NL QLS+
Sbjct: 373 YINLRQLSE 381
>XP_006715067
          Length = 4707

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1    FVNLLQLSK 9
            ++NL++LSK
Sbjct: 4025 WLNLVELSK 4033
>XP_005248319
          Length = 4609

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1    FVNLLQLSK 9
            ++NL++LSK
Sbjct: 3928 WLNLVELSK 3936
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.330    0.143    0.361 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 341,166
Number of extensions: 349
Number of successful extensions: 24
Number of sequences better than 10000.0: 24
Number of HSP's gapped: 24
Number of HSP's successfully gapped: 24
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.1 bits)
S2: 28 (15.4 bits)

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