Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_733751                                                              20     299
XP_006716142                                                           20     299
XP_005250088                                                           20     299
XP_006716141                                                           20     299
XP_006716140                                                           20     299
XP_005250084                                                           20     299
XP_005250083                                                           20     299
XP_005250082                                                           20     299
XP_006710345                                                           17    2528
XP_006710344                                                           17    2528
XP_006710343                                                           17    2528
XP_006710342                                                           17    2528
NP_006305                                                              17    2528
NP_001243778                                                           17    4312
NP_002682                                                              17    4312
XP_005259065                                                           17    4312
XP_006723311                                                           17    4312
XP_005259064                                                           17    4312
XP_005259063                                                           17    4312
NP_001269                                                              16    5631
NP_001013765                                                           16    5631
NP_065748                                                              16    5631
XP_006718895                                                           16    5631
NP_001268442                                                           16    7355
NP_001268441                                                           16    7355
NP_000174                                                              16    7355
NP_001231509                                                           16    7355
NP_003487                                                              16    7355
NP_778231                                                              16    7355
NP_001268663                                                           16    7355
NP_071741                                                              16    7355
NP_071737                                                              16    7355
NP_067083                                                              16    7355
NP_878905                                                              16    7355
XP_005250085                                                           16    7355
XP_006715752                                                           16    7355
XP_006715719                                                           16    7355
XP_006714035                                                           16    7355
XP_006714034                                                           16    7355
XP_006713354                                                           16    7355
XP_005265446                                                           16    7355
XP_005265445                                                           16    7355
NP_001128350                                                           16    7355
NP_878185                                                              16    7355
NP_000401                                                              15    9605
NP_620572                                                              15    9605
NP_620575                                                              15    9605
NP_620573                                                              15    9605
NP_079350                                                              15    9605
NP_005976                                                              15    9605
NP_078962                                                              15    9605
NP_689777                                                              15    9605
NP_001274420                                                           15    9605
NP_060360                                                              15    9605
NP_835463                                                              15    9605
NP_055918                                                              15    9605
NP_777574                                                              15    9605
XP_006719408                                                           15    9605
XP_005250858                                                           15    9605
XP_005250857                                                           15    9605
XP_005266998                                                           15    9605
XP_006715138                                                           15    9605
XP_006714380                                                           15    9605
XP_006714379                                                           15    9605
XP_006714378                                                           15    9605
XP_006714377                                                           15    9605
XP_006712026                                                           15    9605
XP_005264244                                                           15    9605
XP_005271268                                                           15    9605
XP_006710966                                                           15    9605
XP_005271267                                                           15    9605
XP_005271266                                                           15    9605
XP_005271265                                                           15    9605
NP_001161788                                                           15    9605
>NP_733751
          Length = 4911

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    FVLRSHTLN 9
            FVLR HTLN
Sbjct: 4722 FVLRPHTLN 4730
>XP_006716142
          Length = 4927

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    FVLRSHTLN 9
            FVLR HTLN
Sbjct: 4738 FVLRPHTLN 4746
>XP_005250088
          Length = 4928

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    FVLRSHTLN 9
            FVLR HTLN
Sbjct: 4739 FVLRPHTLN 4747
>XP_006716141
          Length = 4959

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    FVLRSHTLN 9
            FVLR HTLN
Sbjct: 4770 FVLRPHTLN 4778
>XP_006716140
          Length = 4982

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    FVLRSHTLN 9
            FVLR HTLN
Sbjct: 4793 FVLRPHTLN 4801
>XP_005250084
          Length = 4982

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    FVLRSHTLN 9
            FVLR HTLN
Sbjct: 4793 FVLRPHTLN 4801
>XP_005250083
          Length = 4982

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    FVLRSHTLN 9
            FVLR HTLN
Sbjct: 4793 FVLRPHTLN 4801
>XP_005250082
          Length = 4983

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    FVLRSHTLN 9
            FVLR HTLN
Sbjct: 4794 FVLRPHTLN 4802
>XP_006710345
          Length = 455

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   FVLRSHTL 8
           FVL+ HTL
Sbjct: 164 FVLKGHTL 171
>XP_006710344
          Length = 720

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   FVLRSHTL 8
           FVL+ HTL
Sbjct: 429 FVLKGHTL 436
>XP_006710343
          Length = 754

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   FVLRSHTL 8
           FVL+ HTL
Sbjct: 463 FVLKGHTL 470
>XP_006710342
          Length = 761

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   FVLRSHTL 8
           FVL+ HTL
Sbjct: 470 FVLKGHTL 477
>NP_006305
          Length = 713

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   FVLRSHTL 8
           FVL+ HTL
Sbjct: 422 FVLKGHTL 429
>NP_001243778
          Length = 1107

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   FVLRSHTLN 9
           + LRS+TLN
Sbjct: 467 YKLRSYTLN 475
>NP_002682
          Length = 1107

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   FVLRSHTLN 9
           + LRS+TLN
Sbjct: 467 YKLRSYTLN 475
>XP_005259065
          Length = 1083

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   FVLRSHTLN 9
           + LRS+TLN
Sbjct: 467 YKLRSYTLN 475
>XP_006723311
          Length = 1109

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   FVLRSHTLN 9
           + LRS+TLN
Sbjct: 467 YKLRSYTLN 475
>XP_005259064
          Length = 1133

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   FVLRSHTLN 9
           + LRS+TLN
Sbjct: 467 YKLRSYTLN 475
>XP_005259063
          Length = 1133

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   FVLRSHTLN 9
           + LRS+TLN
Sbjct: 467 YKLRSYTLN 475
>NP_001269
          Length = 745

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   FVLRSHTLN 9
           FVL  H LN
Sbjct: 301 FVLMDHILN 309
>NP_001013765
          Length = 225

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   VLRSHTLN 9
           ++R+HT+N
Sbjct: 203 IVRAHTVN 210
>NP_065748
          Length = 477

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3  LRSHTL 8
          LRSHTL
Sbjct: 30 LRSHTL 35
>XP_006718895
          Length = 175

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   VLRSHTLN 9
           ++R+HT+N
Sbjct: 153 IVRAHTVN 160
>NP_001268442
          Length = 452

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   FVLRSHTL 8
           + LRSH+L
Sbjct: 222 YALRSHSL 229
>NP_001268441
          Length = 459

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   FVLRSHTL 8
           + LRSH+L
Sbjct: 229 YALRSHSL 236
>NP_000174
          Length = 474

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   FVLRSHTL 8
           + LRSH+L
Sbjct: 244 YALRSHSL 251
>NP_001231509
          Length = 3859

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   FVLRSHTL 8
           FVL+ HT+
Sbjct: 452 FVLKFHTI 459
>NP_003487
          Length = 3830

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   FVLRSHTL 8
           FVL+ HT+
Sbjct: 452 FVLKFHTI 459
>NP_778231
          Length = 243

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   LRSHTLN 9
           LR HT+N
Sbjct: 222 LRHHTIN 228
>NP_001268663
          Length = 763

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RSHTLN 9
           +SHTLN
Sbjct: 193 KSHTLN 198
>NP_071741
          Length = 1015

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   FVLRSHTLN 9
           F+L+SH  N
Sbjct: 102 FLLKSHEAN 110
>NP_071737
          Length = 725

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   VLRSHTLN 9
           ++ SHT+N
Sbjct: 203 IIASHTMN 210
>NP_067083
          Length = 777

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RSHTLN 9
           +SHTLN
Sbjct: 193 KSHTLN 198
>NP_878905
          Length = 790

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   VLRSHTLN 9
           ++ SHT+N
Sbjct: 203 IIASHTMN 210
>XP_005250085
          Length = 4979

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    VLRSHTLN 9
            V R HTLN
Sbjct: 4791 VKRPHTLN 4798
>XP_006715752
          Length = 1225

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RSHTLN 9
           RSHT+N
Sbjct: 805 RSHTVN 810
>XP_006715719
          Length = 179

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   LRSHTLN 9
           LR HT+N
Sbjct: 158 LRHHTIN 164
>XP_006714035
          Length = 941

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   FVLRSHTLN 9
           F+L+SH  N
Sbjct: 102 FLLKSHEAN 110
>XP_006714034
          Length = 941

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   FVLRSHTLN 9
           F+L+SH  N
Sbjct: 102 FLLKSHEAN 110
>XP_006713354
          Length = 748

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   VLRSHTLN 9
           ++ SHT+N
Sbjct: 161 IIASHTMN 168
>XP_005265446
          Length = 758

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   VLRSHTLN 9
           ++ SHT+N
Sbjct: 236 IIASHTMN 243
>XP_005265445
          Length = 823

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   VLRSHTLN 9
           ++ SHT+N
Sbjct: 236 IIASHTMN 243
>NP_001128350
          Length = 790

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   VLRSHTLN 9
           ++ SHT+N
Sbjct: 203 IIASHTMN 210
>NP_878185
          Length = 466

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   VLRSHTL 8
           +LR HTL
Sbjct: 454 ILRGHTL 460
>NP_000401
          Length = 348

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  VLRSHTLN 9
          +LRSH+L+
Sbjct: 24 LLRSHSLH 31
>NP_620572
          Length = 242

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  VLRSHTLN 9
          +LRSH+L+
Sbjct: 24 LLRSHSLH 31
>NP_620575
          Length = 334

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  VLRSHTLN 9
          +LRSH+L+
Sbjct: 24 LLRSHSLH 31
>NP_620573
          Length = 256

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  VLRSHTLN 9
          +LRSH+L+
Sbjct: 24 LLRSHSLH 31
>NP_079350
          Length = 4012

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    FVLRSHTL 8
            FV+  HTL
Sbjct: 3552 FVMEHHTL 3559
>NP_005976
          Length = 264

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   LRSHTL 8
           +RSHTL
Sbjct: 173 IRSHTL 178
>NP_078962
          Length = 887

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RSHTLN 9
           RSH+LN
Sbjct: 637 RSHSLN 642
>NP_689777
          Length = 3997

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1    FVLRSH 6
            F++RSH
Sbjct: 2822 FIMRSH 2827
>NP_001274420
          Length = 1795

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   FVLRSHTL 8
           +V+R HTL
Sbjct: 893 WVIRRHTL 900
>NP_060360
          Length = 4022

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1    FVLRSH 6
            F++RSH
Sbjct: 2847 FIMRSH 2852
>NP_835463
          Length = 238

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   FVLRSHTL 8
           FVLR H +
Sbjct: 180 FVLREHEI 187
>NP_055918
          Length = 1925

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    FVLRSHTLN 9
            +VL S TLN
Sbjct: 1371 YVLPSQTLN 1379
>NP_777574
          Length = 523

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   VLRSHTLN 9
           +LRSH L+
Sbjct: 443 ILRSHPLS 450
>XP_006719408
          Length = 228

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   FVLRSHTL 8
           FVLR H +
Sbjct: 170 FVLREHEI 177
>XP_005250858
          Length = 4022

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1    FVLRSH 6
            F++RSH
Sbjct: 2847 FIMRSH 2852
>XP_005250857
          Length = 4022

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1    FVLRSH 6
            F++RSH
Sbjct: 2847 FIMRSH 2852
>XP_005266998
          Length = 762

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   VLRSHTLN 9
           VLR+HT +
Sbjct: 656 VLRAHTFS 663
>XP_006715138
          Length = 337

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  VLRSHTLN 9
          +LRSH+L+
Sbjct: 24 LLRSHSLH 31
>XP_006714380
          Length = 3897

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    FVLRSHTL 8
            FV+  HTL
Sbjct: 3437 FVMEHHTL 3444
>XP_006714379
          Length = 3936

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    FVLRSHTL 8
            FV+  HTL
Sbjct: 3476 FVMEHHTL 3483
>XP_006714378
          Length = 3965

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    FVLRSHTL 8
            FV+  HTL
Sbjct: 3505 FVMEHHTL 3512
>XP_006714377
          Length = 4010

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    FVLRSHTL 8
            FV+  HTL
Sbjct: 3550 FVMEHHTL 3557
>XP_006712026
          Length = 937

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  FVLRSHTL 8
          +V+R HTL
Sbjct: 35 WVIRRHTL 42
>XP_005264244
          Length = 1795

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   FVLRSHTL 8
           +V+R HTL
Sbjct: 893 WVIRRHTL 900
>XP_005271268
          Length = 642

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RSHTLN 9
           RSH+LN
Sbjct: 392 RSHSLN 397
>XP_006710966
          Length = 792

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RSHTLN 9
           RSH+LN
Sbjct: 637 RSHSLN 642
>XP_005271267
          Length = 798

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RSHTLN 9
           RSH+LN
Sbjct: 548 RSHSLN 553
>XP_005271266
          Length = 798

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RSHTLN 9
           RSH+LN
Sbjct: 548 RSHSLN 553
>XP_005271265
          Length = 860

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RSHTLN 9
           RSH+LN
Sbjct: 610 RSHSLN 615
>NP_001161788
          Length = 489

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   VLRSHTLN 9
           +LRSH L+
Sbjct: 409 ILRSHPLS 416
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.335    0.140    0.413 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 623,096
Number of extensions: 1133
Number of successful extensions: 74
Number of sequences better than 10000.0: 74
Number of HSP's gapped: 74
Number of HSP's successfully gapped: 74
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.4 bits)
S2: 28 (15.4 bits)

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