Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_008835                                                              20     299
NP_001075109                                                           20     299
NP_008995                                                              17    4312
NP_001019831                                                           17    4312
NP_009049                                                              17    4312
NP_065871                                                              17    4312
NP_079446                                                              17    4312
NP_079146                                                              17    4312
NP_699197                                                              17    4312
NP_001077005                                                           17    4312
NP_149077                                                              17    4312
NP_001273922                                                           17    4312
XP_006714558                                                           17    4312
XP_006713877                                                           17    4312
XP_006713876                                                           17    4312
XP_006713875                                                           17    4312
XP_006713874                                                           17    4312
XP_006713873                                                           17    4312
NP_001160135                                                           16    5631
XP_005260020                                                           16    5631
NP_060152                                                              16    5631
NP_006414                                                              16    7355
NP_003349                                                              15    9605
XP_005252243                                                           15    9605
>NP_008835
          Length = 4128

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    FVFESLVIY 9
            FVFE+LVIY
Sbjct: 1099 FVFEALVIY 1107
>NP_001075109
          Length = 4097

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    FVFESLVIY 9
            FVFE+LVIY
Sbjct: 1099 FVFEALVIY 1107
>NP_008995
          Length = 1289

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   FVFESLVIY 9
           F+FE +VI+
Sbjct: 451 FLFEQIVIF 459
>NP_001019831
          Length = 2986

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    FVFESLVIY 9
            F+FE +VI+
Sbjct: 2148 FLFEQIVIF 2156
>NP_009049
          Length = 3097

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    FVFESLVIY 9
            F+FE +VI+
Sbjct: 2189 FLFEQIVIF 2197
>NP_065871
          Length = 1659

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   FVFESLVIY 9
           F+F++L++Y
Sbjct: 292 FLFDNLLVY 300
>NP_079446
          Length = 979

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   FVFESLVIY 9
           F+F++L++Y
Sbjct: 266 FLFDNLLVY 274
>NP_079146
          Length = 1606

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   FVFESLVIY 9
           F+F++L++Y
Sbjct: 266 FLFDNLLVY 274
>NP_699197
          Length = 3571

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    FVFESLVIY 9
            + FES +IY
Sbjct: 3257 YTFESTIIY 3265
>NP_001077005
          Length = 725

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   FVFESLVIY 9
           F+F S+++Y
Sbjct: 393 FLFNSMILY 401
>NP_149077
          Length = 725

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   FVFESLVIY 9
           F+F S+++Y
Sbjct: 393 FLFNSMILY 401
>NP_001273922
          Length = 724

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   FVFESLVIY 9
           F+F S+++Y
Sbjct: 393 FLFNSMILY 401
>XP_006714558
          Length = 2612

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    FVFESLVIY 9
            F+FE +VI+
Sbjct: 1704 FLFEQIVIF 1712
>XP_006713877
          Length = 2956

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    FVFESLVIY 9
            F+FE +VI+
Sbjct: 2118 FLFEQIVIF 2126
>XP_006713876
          Length = 2966

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    FVFESLVIY 9
            F+FE +VI+
Sbjct: 2128 FLFEQIVIF 2136
>XP_006713875
          Length = 2975

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    FVFESLVIY 9
            F+FE +VI+
Sbjct: 2137 FLFEQIVIF 2145
>XP_006713874
          Length = 2979

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    FVFESLVIY 9
            F+FE +VI+
Sbjct: 2141 FLFEQIVIF 2149
>XP_006713873
          Length = 2988

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    FVFESLVIY 9
            F+FE +VI+
Sbjct: 2150 FLFEQIVIF 2158
>NP_001160135
          Length = 370

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   FVFESLV 7
           FVFESL+
Sbjct: 124 FVFESLL 130
>XP_005260020
          Length = 509

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  FESLVIY 9
          FE LVIY
Sbjct: 62 FEKLVIY 68
>NP_060152
          Length = 509

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  FESLVIY 9
          FE LVIY
Sbjct: 62 FEKLVIY 68
>NP_006414
          Length = 185

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  FVFESLVIY 9
          FVF  L++Y
Sbjct: 80 FVFLGLILY 88
>NP_003349
          Length = 394

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   FVFESLVIY 9
           F+ ES+ IY
Sbjct: 354 FIRESMTIY 362
>XP_005252243
          Length = 266

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   FVFESLVIY 9
           F+ ES+ IY
Sbjct: 226 FIRESMTIY 234
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.347    0.161    0.459 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 336,813
Number of extensions: 641
Number of successful extensions: 24
Number of sequences better than 10000.0: 24
Number of HSP's gapped: 24
Number of HSP's successfully gapped: 24
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 14 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.7 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package