Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000236                                                              20     509
NP_001120972                                                           20     509
XP_006716052                                                           20     509
XP_006716051                                                           20     509
NP_291032                                                              17    3301
NP_001229453                                                           17    3301
NP_001229454                                                           17    3301
NP_001804                                                              16    5631
NP_001273663                                                           16    5631
NP_001127945                                                           16    7355
NP_003809                                                              16    7355
NP_001265113                                                           16    7355
NP_055430                                                              16    7355
XP_006723723                                                           16    7355
XP_005255922                                                           16    7355
XP_006721236                                                           16    7355
XP_006721235                                                           16    7355
XP_005255921                                                           16    7355
XP_005255920                                                           16    7355
XP_005255919                                                           16    7355
XP_005255918                                                           16    7355
XP_005255917                                                           16    7355
XP_005255916                                                           16    7355
NP_060626                                                              15    9605
NP_056193                                                              15    9605
NP_001822                                                              15    9605
NP_001157569                                                           15    9605
NP_004376                                                              15    9605
XP_006716347                                                           15    9605
>NP_000236
          Length = 1390

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1  FTLVQRSN 8
          FTLVQRSN
Sbjct: 16 FTLVQRSN 23
>NP_001120972
          Length = 1408

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1  FTLVQRSN 8
          FTLVQRSN
Sbjct: 16 FTLVQRSN 23
>XP_006716052
          Length = 1409

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1  FTLVQRSN 8
          FTLVQRSN
Sbjct: 35 FTLVQRSN 42
>XP_006716051
          Length = 1427

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1  FTLVQRSN 8
          FTLVQRSN
Sbjct: 35 FTLVQRSN 42
>NP_291032
          Length = 260

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   TLVQRSN 8
           TL+QRSN
Sbjct: 103 TLIQRSN 109
>NP_001229453
          Length = 260

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   TLVQRSN 8
           TL+QRSN
Sbjct: 103 TLIQRSN 109
>NP_001229454
          Length = 260

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   TLVQRSN 8
           TL+QRSN
Sbjct: 103 TLIQRSN 109
>NP_001804
          Length = 2701

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    FTLVQRSNE 9
            F+L+Q  NE
Sbjct: 1046 FSLIQEKNE 1054
>NP_001273663
          Length = 2580

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    FTLVQRSNE 9
            F+L+Q  NE
Sbjct: 1021 FSLIQEKNE 1029
>NP_001127945
          Length = 1113

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LVQRSNE 9
           L+QR+NE
Sbjct: 383 LIQRTNE 389
>NP_003809
          Length = 445

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   FTLVQR 6
           FTLVQR
Sbjct: 150 FTLVQR 155
>NP_001265113
          Length = 1144

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LVQRSNE 9
           L+QR+NE
Sbjct: 414 LIQRTNE 420
>NP_055430
          Length = 1217

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LVQRSNE 9
           L+QR+NE
Sbjct: 487 LIQRTNE 493
>XP_006723723
          Length = 394

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   FTLVQR 6
           FTLVQR
Sbjct: 150 FTLVQR 155
>XP_005255922
          Length = 1154

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LVQRSNE 9
           L+QR+NE
Sbjct: 424 LIQRTNE 430
>XP_006721236
          Length = 1214

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LVQRSNE 9
           L+QR+NE
Sbjct: 484 LIQRTNE 490
>XP_006721235
          Length = 1214

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LVQRSNE 9
           L+QR+NE
Sbjct: 484 LIQRTNE 490
>XP_005255921
          Length = 1227

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LVQRSNE 9
           L+QR+NE
Sbjct: 497 LIQRTNE 503
>XP_005255920
          Length = 1229

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LVQRSNE 9
           L+QR+NE
Sbjct: 499 LIQRTNE 505
>XP_005255919
          Length = 1860

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    LVQRSNE 9
            L+QR+NE
Sbjct: 1292 LIQRTNE 1298
>XP_005255918
          Length = 1949

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    LVQRSNE 9
            L+QR+NE
Sbjct: 1219 LIQRTNE 1225
>XP_005255917
          Length = 1984

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    LVQRSNE 9
            L+QR+NE
Sbjct: 1292 LIQRTNE 1298
>XP_005255916
          Length = 2022

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    LVQRSNE 9
            L+QR+NE
Sbjct: 1292 LIQRTNE 1298
>NP_060626
          Length = 4363

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    FTLVQRSNE 9
            FT V+RS +
Sbjct: 1272 FTFVERSKQ 1280
>NP_056193
          Length = 4388

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    FTLVQRSNE 9
            FT V+RS +
Sbjct: 1272 FTFVERSKQ 1280
>NP_001822
          Length = 449

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2  TLVQRSNE 9
          TL++++NE
Sbjct: 58 TLIEKTNE 65
>NP_001157569
          Length = 2409

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    FTLVQRSNE 9
            F+L++ SNE
Sbjct: 2073 FSLLETSNE 2081
>NP_004376
          Length = 3396

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    FTLVQRSNE 9
            F+L++ SNE
Sbjct: 3060 FSLLETSNE 3068
>XP_006716347
          Length = 501

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   TLVQRSNE 9
           TL++++NE
Sbjct: 110 TLIEKTNE 117
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.318    0.127    0.324 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 338,095
Number of extensions: 540
Number of successful extensions: 29
Number of sequences better than 10000.0: 29
Number of HSP's gapped: 29
Number of HSP's successfully gapped: 29
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.8 bits)
S2: 28 (15.4 bits)

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