Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000537                                                              20     299
NP_001263689                                                           20     299
NP_001119584                                                           20     299
NP_001119590                                                           20     299
NP_001263690                                                           20     299
NP_001119587                                                           20     299
NP_001263626                                                           20     299
NP_114480                                                              16    5631
NP_114481                                                              16    5631
NP_061737                                                              16    5631
XP_005252109                                                           16    5631
NP_056261                                                              16    7355
NP_536859                                                              16    7355
XP_005250923                                                           16    7355
XP_005272300                                                           16    7355
XP_006713913                                                           16    7355
XP_006711822                                                           16    7355
XP_006711821                                                           16    7355
NP_055194                                                              16    7355
NP_001269356                                                           15    9605
NP_001269355                                                           15    9605
NP_002640                                                              15    9605
NP_689969                                                              15    9605
NP_001272368                                                           15    9605
NP_031361                                                              15    9605
NP_005638                                                              15    9605
NP_001035100                                                           15    9605
NP_001561                                                              15    9605
NP_001399                                                              15    9605
XP_005260183                                                           15    9605
XP_006720934                                                           15    9605
XP_006716090                                                           15    9605
XP_005250500                                                           15    9605
XP_006714526                                                           15    9605
XP_005265687                                                           15    9605
XP_006710468                                                           15    9605
XP_005270637                                                           15    9605
NP_001132938                                                           15    9605
NP_149014                                                              15    9605
>NP_000537
          Length = 393

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   FTLRIRGRE 9
           FTL+IRGRE
Sbjct: 328 FTLQIRGRE 336
>NP_001263689
          Length = 354

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   FTLRIRGRE 9
           FTL+IRGRE
Sbjct: 289 FTLQIRGRE 297
>NP_001119584
          Length = 393

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   FTLRIRGRE 9
           FTL+IRGRE
Sbjct: 328 FTLQIRGRE 336
>NP_001119590
          Length = 354

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   FTLRIRGRE 9
           FTL+IRGRE
Sbjct: 289 FTLQIRGRE 297
>NP_001263690
          Length = 354

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   FTLRIRGRE 9
           FTL+IRGRE
Sbjct: 289 FTLQIRGRE 297
>NP_001119587
          Length = 261

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   FTLRIRGRE 9
           FTL+IRGRE
Sbjct: 196 FTLQIRGRE 204
>NP_001263626
          Length = 234

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   FTLRIRGRE 9
           FTL+IRGRE
Sbjct: 169 FTLQIRGRE 177
>NP_114480
          Length = 837

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   FTLRIRGR 8
           F+L++RGR
Sbjct: 179 FSLQLRGR 186
>NP_114481
          Length = 750

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   FTLRIRGR 8
           F+L++RGR
Sbjct: 179 FSLQLRGR 186
>NP_061737
          Length = 935

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   FTLRIRGR 8
           F+L++RGR
Sbjct: 179 FSLQLRGR 186
>XP_005252109
          Length = 448

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  FTLRIRGRE 9
          +TLR +GRE
Sbjct: 29 WTLRKKGRE 37
>NP_056261
          Length = 2275

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    RIRGRE 9
            R+RGRE
Sbjct: 1946 RVRGRE 1951
>NP_536859
          Length = 624

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   TLRIRGR 8
           TLR RGR
Sbjct: 616 TLRTRGR 622
>XP_005250923
          Length = 500

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LRIRGRE 9
           LR++GRE
Sbjct: 480 LRLKGRE 486
>XP_005272300
          Length = 395

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  FTLRIRGRE 9
          +TLR  GRE
Sbjct: 2  WTLRATGRE 10
>XP_006713913
          Length = 449

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  FTLRIRGRE 9
          +TLR  GRE
Sbjct: 2  WTLRATGRE 10
>XP_006711822
          Length = 2266

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    RIRGRE 9
            R+RGRE
Sbjct: 1937 RVRGRE 1942
>XP_006711821
          Length = 2301

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    RIRGRE 9
            R+RGRE
Sbjct: 1972 RVRGRE 1977
>NP_055194
          Length = 500

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LRIRGRE 9
           LR++GRE
Sbjct: 480 LRLKGRE 486
>NP_001269356
          Length = 1102

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   FTLRIRGRE 9
           F LR+ GR+
Sbjct: 270 FVLRVCGRD 278
>NP_001269355
          Length = 1102

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   FTLRIRGRE 9
           F LR+ GR+
Sbjct: 270 FVLRVCGRD 278
>NP_002640
          Length = 1102

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   FTLRIRGRE 9
           F LR+ GR+
Sbjct: 270 FVLRVCGRD 278
>NP_689969
          Length = 1708

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  LRIRGR 8
          LR+RGR
Sbjct: 13 LRVRGR 18
>NP_001272368
          Length = 1732

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  LRIRGR 8
          LR+RGR
Sbjct: 13 LRVRGR 18
>NP_031361
          Length = 1755

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    TLRIRGR 8
            TLR+RG+
Sbjct: 1736 TLRLRGQ 1742
>NP_005638
          Length = 577

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  RIRGRE 9
          R+RGRE
Sbjct: 30 RLRGRE 35
>NP_001035100
          Length = 235

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  FTLRIR 6
          FTLR+R
Sbjct: 45 FTLRVR 50
>NP_001561
          Length = 625

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RIRGRE 9
           R+RGRE
Sbjct: 502 RLRGRE 507
>NP_001399
          Length = 2923

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   FTLRIRGRE 9
           +TLR+R ++
Sbjct: 470 YTLRVRAQD 478
>XP_005260183
          Length = 668

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  RIRGRE 9
          R+RGRE
Sbjct: 12 RLRGRE 17
>XP_006720934
          Length = 296

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  FTLRIR 6
          FTLR+R
Sbjct: 29 FTLRVR 34
>XP_006716090
          Length = 878

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   FTLRIRGRE 9
           F LR+ GR+
Sbjct: 270 FVLRVCGRD 278
>XP_005250500
          Length = 1102

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   FTLRIRGRE 9
           F LR+ GR+
Sbjct: 270 FVLRVCGRD 278
>XP_006714526
          Length = 1670

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  LRIRGR 8
          LR+RGR
Sbjct: 13 LRVRGR 18
>XP_005265687
          Length = 1758

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    TLRIRGR 8
            TLR+RG+
Sbjct: 1739 TLRLRGQ 1745
>XP_006710468
          Length = 2916

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   FTLRIRGRE 9
           +TLR+R ++
Sbjct: 470 YTLRVRAQD 478
>XP_005270637
          Length = 2921

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   FTLRIRGRE 9
           +TLR+R ++
Sbjct: 470 YTLRVRAQD 478
>NP_001132938
          Length = 577

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  RIRGRE 9
          R+RGRE
Sbjct: 30 RLRGRE 35
>NP_149014
          Length = 735

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  RIRGRE 9
          R+RGRE
Sbjct: 12 RLRGRE 17
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.341    0.157    0.454 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 463,889
Number of extensions: 830
Number of successful extensions: 39
Number of sequences better than 10000.0: 39
Number of HSP's gapped: 39
Number of HSP's successfully gapped: 39
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.4 bits)
S2: 28 (15.4 bits)

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