Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001245210                                                           20     509
NP_000242                                                              20     509
XP_005264389                                                           20     509
NP_008848                                                              17    4312
NP_002948                                                              17    4312
NP_001243500                                                           17    4312
NP_001243499                                                           17    4312
NP_620417                                                              17    4312
NP_001171582                                                           17    4312
NP_001171583                                                           17    4312
NP_068811                                                              17    4312
NP_001257330                                                           17    4312
XP_006726073                                                           17    4312
XP_005275495                                                           17    4312
XP_006725980                                                           17    4312
XP_005275333                                                           17    4312
XP_006725888                                                           17    4312
XP_005275206                                                           17    4312
XP_006725771                                                           17    4312
XP_005275064                                                           17    4312
XP_006725557                                                           17    4312
XP_005272911                                                           17    4312
XP_006720485                                                           17    4312
XP_006720484                                                           17    4312
XP_006720483                                                           17    4312
XP_006717295                                                           17    4312
XP_005263466                                                           17    4312
XP_006715225                                                           17    4312
XP_005249335                                                           17    4312
NP_055845                                                              16    5631
NP_075463                                                              16    5631
XP_006719812                                                           16    5631
XP_005248150                                                           16    5631
XP_005248148                                                           16    5631
XP_005248147                                                           16    5631
XP_005248145                                                           16    5631
XP_005248144                                                           16    5631
XP_005248143                                                           16    5631
XP_005248142                                                           16    5631
XP_005248141                                                           16    5631
XP_005248140                                                           16    5631
XP_005248139                                                           16    5631
NP_008853                                                              16    7355
NP_001075145                                                           16    7355
NP_001075146                                                           16    7355
NP_001265557                                                           16    7355
NP_001265555                                                           16    7355
NP_001265554                                                           16    7355
NP_001265556                                                           16    7355
NP_057736                                                              16    7355
XP_006712742                                                           16    7355
NP_001028755                                                           15    9605
NP_055793                                                              15    9605
NP_001032248                                                           15    9605
NP_660333                                                              15    9605
NP_808219                                                              15    9605
NP_056346                                                              15    9605
NP_001273506                                                           15    9605
XP_005274529                                                           15    9605
XP_005274528                                                           15    9605
XP_005274527                                                           15    9605
XP_005273954                                                           15    9605
XP_006718558                                                           15    9605
XP_005273953                                                           15    9605
XP_005273952                                                           15    9605
XP_005273950                                                           15    9605
XP_005248194                                                           15    9605
NP_057339                                                              15    9605
NP_006009                                                              15    9605
NP_115943                                                              15    9605
NP_690862                                                              15    9605
>NP_001245210
          Length = 868

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   TFMAEMLE 9
           TFMAEMLE
Sbjct: 658 TFMAEMLE 665
>NP_000242
          Length = 934

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   TFMAEMLE 9
           TFMAEMLE
Sbjct: 724 TFMAEMLE 731
>XP_005264389
          Length = 921

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   TFMAEMLE 9
           TFMAEMLE
Sbjct: 724 TFMAEMLE 731
>NP_008848
          Length = 463

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TFMAEMLE 9
           TF+ EMLE
Sbjct: 450 TFLMEMLE 457
>NP_002948
          Length = 462

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TFMAEMLE 9
           TF+ EMLE
Sbjct: 449 TFLMEMLE 456
>NP_001243500
          Length = 340

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TFMAEMLE 9
           TF+ EMLE
Sbjct: 327 TFLMEMLE 334
>NP_001243499
          Length = 340

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TFMAEMLE 9
           TF+ EMLE
Sbjct: 327 TFLMEMLE 334
>NP_620417
          Length = 235

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   FTFMAEML 8
           FTFMA+++
Sbjct: 110 FTFMAQLV 117
>NP_001171582
          Length = 235

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   FTFMAEML 8
           FTFMA+++
Sbjct: 110 FTFMAQLV 117
>NP_001171583
          Length = 235

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   FTFMAEML 8
           FTFMA+++
Sbjct: 110 FTFMAQLV 117
>NP_068811
          Length = 533

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TFMAEMLE 9
           TF+ EMLE
Sbjct: 520 TFLMEMLE 527
>NP_001257330
          Length = 537

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TFMAEMLE 9
           TF+ EMLE
Sbjct: 524 TFLMEMLE 531
>XP_006726073
          Length = 414

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TFMAEMLE 9
           TF+ EMLE
Sbjct: 401 TFLMEMLE 408
>XP_005275495
          Length = 441

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TFMAEMLE 9
           TF+ EMLE
Sbjct: 428 TFLMEMLE 435
>XP_006725980
          Length = 414

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TFMAEMLE 9
           TF+ EMLE
Sbjct: 401 TFLMEMLE 408
>XP_005275333
          Length = 441

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TFMAEMLE 9
           TF+ EMLE
Sbjct: 428 TFLMEMLE 435
>XP_006725888
          Length = 414

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TFMAEMLE 9
           TF+ EMLE
Sbjct: 401 TFLMEMLE 408
>XP_005275206
          Length = 441

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TFMAEMLE 9
           TF+ EMLE
Sbjct: 428 TFLMEMLE 435
>XP_006725771
          Length = 414

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TFMAEMLE 9
           TF+ EMLE
Sbjct: 401 TFLMEMLE 408
>XP_005275064
          Length = 441

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TFMAEMLE 9
           TF+ EMLE
Sbjct: 428 TFLMEMLE 435
>XP_006725557
          Length = 414

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TFMAEMLE 9
           TF+ EMLE
Sbjct: 401 TFLMEMLE 408
>XP_005272911
          Length = 441

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TFMAEMLE 9
           TF+ EMLE
Sbjct: 428 TFLMEMLE 435
>XP_006720485
          Length = 164

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  FTFMAEML 8
          FTFMA+++
Sbjct: 39 FTFMAQLV 46
>XP_006720484
          Length = 235

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   FTFMAEML 8
           FTFMA+++
Sbjct: 110 FTFMAQLV 117
>XP_006720483
          Length = 253

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   FTFMAEML 8
           FTFMA+++
Sbjct: 128 FTFMAQLV 135
>XP_006717295
          Length = 365

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TFMAEMLE 9
           TF+ EMLE
Sbjct: 352 TFLMEMLE 359
>XP_005263466
          Length = 435

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TFMAEMLE 9
           TF+ EMLE
Sbjct: 422 TFLMEMLE 429
>XP_006715225
          Length = 414

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TFMAEMLE 9
           TF+ EMLE
Sbjct: 401 TFLMEMLE 408
>XP_005249335
          Length = 441

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TFMAEMLE 9
           TF+ EMLE
Sbjct: 428 TFLMEMLE 435
>NP_055845
          Length = 3013

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    TFMAEMLE 9
            T++AE+LE
Sbjct: 2184 TYLAELLE 2191
>NP_075463
          Length = 3013

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    TFMAEMLE 9
            T++AE+LE
Sbjct: 2225 TYLAELLE 2232
>XP_006719812
          Length = 3019

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    TFMAEMLE 9
            T++AE+LE
Sbjct: 2222 TYLAELLE 2229
>XP_005248150
          Length = 2044

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    TFMAEMLE 9
            T++AE+LE
Sbjct: 1215 TYLAELLE 1222
>XP_005248148
          Length = 3028

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    TFMAEMLE 9
            T++AE+LE
Sbjct: 2199 TYLAELLE 2206
>XP_005248147
          Length = 3028

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    TFMAEMLE 9
            T++AE+LE
Sbjct: 2199 TYLAELLE 2206
>XP_005248145
          Length = 3079

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    TFMAEMLE 9
            T++AE+LE
Sbjct: 2250 TYLAELLE 2257
>XP_005248144
          Length = 3099

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    TFMAEMLE 9
            T++AE+LE
Sbjct: 2276 TYLAELLE 2283
>XP_005248143
          Length = 3105

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    TFMAEMLE 9
            T++AE+LE
Sbjct: 2276 TYLAELLE 2283
>XP_005248142
          Length = 3114

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    TFMAEMLE 9
            T++AE+LE
Sbjct: 2291 TYLAELLE 2298
>XP_005248141
          Length = 3119

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    TFMAEMLE 9
            T++AE+LE
Sbjct: 2290 TYLAELLE 2297
>XP_005248140
          Length = 3119

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    TFMAEMLE 9
            T++AE+LE
Sbjct: 2290 TYLAELLE 2297
>XP_005248139
          Length = 3120

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    TFMAEMLE 9
            T++AE+LE
Sbjct: 2291 TYLAELLE 2298
>NP_008853
          Length = 2000

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    FMAEMLE 9
            F+AEM+E
Sbjct: 1605 FLAEMIE 1611
>NP_001075145
          Length = 1951

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    FMAEMLE 9
            F+AEM+E
Sbjct: 1556 FLAEMIE 1562
>NP_001075146
          Length = 1951

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    FMAEMLE 9
            F+AEM+E
Sbjct: 1556 FLAEMIE 1562
>NP_001265557
          Length = 687

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   FTFMAEML 8
           +T+M EML
Sbjct: 155 YTYMEEML 162
>NP_001265555
          Length = 564

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  FTFMAEML 8
          +T+M EML
Sbjct: 32 YTYMEEML 39
>NP_001265554
          Length = 836

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   FTFMAEML 8
           +T+M EML
Sbjct: 304 YTYMEEML 311
>NP_001265556
          Length = 564

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  FTFMAEML 8
          +T+M EML
Sbjct: 32 YTYMEEML 39
>NP_057736
          Length = 848

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   FTFMAEML 8
           +T+M EML
Sbjct: 316 YTYMEEML 323
>XP_006712742
          Length = 2000

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    FMAEMLE 9
            F+AEM+E
Sbjct: 1605 FLAEMIE 1611
>NP_001028755
          Length = 439

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   FTFMAE 6
           FTFM+E
Sbjct: 393 FTFMSE 398
>NP_055793
          Length = 1222

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   FTFMAE 6
           FTF+AE
Sbjct: 967 FTFLAE 972
>NP_001032248
          Length = 448

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   FTFMAE 6
           FTFM+E
Sbjct: 402 FTFMSE 407
>NP_660333
          Length = 1321

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   FMAEMLE 9
           F+AEM+E
Sbjct: 462 FVAEMIE 468
>NP_808219
          Length = 363

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   FTFMAEMLE 9
           FT+M  ML+
Sbjct: 282 FTYMNSMLD 290
>NP_056346
          Length = 1963

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    FMAEMLE 9
            F+AE+LE
Sbjct: 1282 FLAELLE 1288
>NP_001273506
          Length = 2353

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    FMAEMLE 9
            F+AE+LE
Sbjct: 1282 FLAELLE 1288
>XP_005274529
          Length = 379

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   FTFMAE 6
           FTFM+E
Sbjct: 333 FTFMSE 338
>XP_005274528
          Length = 379

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   FTFMAE 6
           FTFM+E
Sbjct: 333 FTFMSE 338
>XP_005274527
          Length = 451

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   FTFMAE 6
           FTFM+E
Sbjct: 405 FTFMSE 410
>XP_005273954
          Length = 1676

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    FMAEMLE 9
            F+AE+LE
Sbjct: 1282 FLAELLE 1288
>XP_006718558
          Length = 1841

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   FMAEMLE 9
           F+AE+LE
Sbjct: 769 FLAELLE 775
>XP_005273953
          Length = 2171

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    FMAEMLE 9
            F+AE+LE
Sbjct: 1099 FLAELLE 1105
>XP_005273952
          Length = 2245

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    FMAEMLE 9
            F+AE+LE
Sbjct: 1173 FLAELLE 1179
>XP_005273950
          Length = 2354

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    FMAEMLE 9
            F+AE+LE
Sbjct: 1282 FLAELLE 1288
>XP_005248194
          Length = 833

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   FMAEMLE 9
           F+AEM+E
Sbjct: 462 FVAEMIE 468
>NP_057339
          Length = 413

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   FMAEMLE 9
           FMAEM++
Sbjct: 250 FMAEMVD 256
>NP_006009
          Length = 387

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   FTFMAEMLE 9
           FT+M  ML+
Sbjct: 282 FTYMNSMLD 290
>NP_115943
          Length = 346

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   FTFMAEMLE 9
           FT+M  ML+
Sbjct: 266 FTYMNSMLD 274
>NP_690862
          Length = 166

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   TFMAEMLE 9
           +FM E+LE
Sbjct: 151 SFMTELLE 158
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.341    0.140    0.382 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 367,080
Number of extensions: 447
Number of successful extensions: 71
Number of sequences better than 10000.0: 71
Number of HSP's gapped: 71
Number of HSP's successfully gapped: 71
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.6 bits)
S2: 28 (15.4 bits)

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