Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_733751                                                              19     665
XP_006716142                                                           19     665
XP_005250088                                                           19     665
XP_006716141                                                           19     665
XP_005250085                                                           19     665
XP_006716140                                                           19     665
XP_005250084                                                           19     665
XP_005250083                                                           19     665
XP_005250082                                                           19     665
NP_060626                                                              16    7355
NP_056193                                                              16    7355
NP_002045                                                              16    7355
NP_060287                                                              16    7355
NP_003615                                                              16    7355
NP_015561                                                              16    7355
NP_001036040                                                           16    7355
NP_689775                                                              16    7355
NP_015559                                                              16    7355
NP_036345                                                              16    7355
NP_078928                                                              16    7355
XP_006722992                                                           16    7355
XP_006722991                                                           16    7355
XP_005259721                                                           16    7355
XP_005273475                                                           16    7355
XP_006716359                                                           16    7355
XP_006716358                                                           16    7355
XP_006716357                                                           16    7355
XP_006713677                                                           16    7355
NP_942015                                                              15    9605
NP_059111                                                              15    9605
NP_001244123                                                           15    9605
NP_694992                                                              15    9605
NP_002636                                                              15    9605
NP_004410                                                              15    9605
XP_005260653                                                           15    9605
XP_005260652                                                           15    9605
XP_005260651                                                           15    9605
XP_005260650                                                           15    9605
XP_005260649                                                           15    9605
XP_005260648                                                           15    9605
XP_005260647                                                           15    9605
XP_005260646                                                           15    9605
XP_005260644                                                           15    9605
XP_005253037                                                           15    9605
XP_005253036                                                           15    9605
XP_005253035                                                           15    9605
XP_005253034                                                           15    9605
NP_003648                                                              15    9605
>NP_733751
          Length = 4911

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   TADISSNK 9
           TADISSNK
Sbjct: 926 TADISSNK 933
>XP_006716142
          Length = 4927

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   TADISSNK 9
           TADISSNK
Sbjct: 927 TADISSNK 934
>XP_005250088
          Length = 4928

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   TADISSNK 9
           TADISSNK
Sbjct: 927 TADISSNK 934
>XP_006716141
          Length = 4959

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   TADISSNK 9
           TADISSNK
Sbjct: 927 TADISSNK 934
>XP_005250085
          Length = 4979

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   TADISSNK 9
           TADISSNK
Sbjct: 927 TADISSNK 934
>XP_006716140
          Length = 4982

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   TADISSNK 9
           TADISSNK
Sbjct: 927 TADISSNK 934
>XP_005250084
          Length = 4982

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   TADISSNK 9
           TADISSNK
Sbjct: 927 TADISSNK 934
>XP_005250083
          Length = 4982

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   TADISSNK 9
           TADISSNK
Sbjct: 926 TADISSNK 933
>XP_005250082
          Length = 4983

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   TADISSNK 9
           TADISSNK
Sbjct: 927 TADISSNK 934
>NP_060626
          Length = 4363

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    TADISSNK 9
            TA+ISS+K
Sbjct: 3097 TAEISSSK 3104
>NP_056193
          Length = 4388

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    TADISSNK 9
            TA+ISS+K
Sbjct: 3122 TAEISSSK 3129
>NP_002045
          Length = 180

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   FTADISS 7
           FT+D+SS
Sbjct: 103 FTSDVSS 109
>NP_060287
          Length = 234

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TADISSNK 9
           T DISS+K
Sbjct: 216 TVDISSHK 223
>NP_003615
          Length = 562

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TADISSNK 9
           +AD SSNK
Sbjct: 308 SADASSNK 315
>NP_015561
          Length = 567

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TADISSNK 9
           +AD SSNK
Sbjct: 313 SADASSNK 320
>NP_001036040
          Length = 717

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  ADISSNK 9
          AD+S+NK
Sbjct: 51 ADVSNNK 57
>NP_689775
          Length = 1023

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   FTADISSN 8
           FTA++SS+
Sbjct: 295 FTAEVSSD 302
>NP_015559
          Length = 499

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TADISSNK 9
           +AD SSNK
Sbjct: 245 SADASSNK 252
>NP_036345
          Length = 493

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   TADISSN 8
           T DISSN
Sbjct: 258 TGDISSN 264
>NP_078928
          Length = 2015

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   DISSNK 9
           DISSNK
Sbjct: 335 DISSNK 340
>XP_006722992
          Length = 286

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  TADISSNK 9
          +AD SSNK
Sbjct: 32 SADASSNK 39
>XP_006722991
          Length = 286

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  TADISSNK 9
          +AD SSNK
Sbjct: 32 SADASSNK 39
>XP_005259721
          Length = 494

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TADISSNK 9
           +AD SSNK
Sbjct: 240 SADASSNK 247
>XP_005273475
          Length = 635

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   FTADISSN 8
           FTA++SS+
Sbjct: 295 FTAEVSSD 302
>XP_006716359
          Length = 1028

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   FTADISSN 8
           FTA++SS+
Sbjct: 300 FTAEVSSD 307
>XP_006716358
          Length = 1028

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   FTADISSN 8
           FTA++SS+
Sbjct: 300 FTAEVSSD 307
>XP_006716357
          Length = 1028

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   FTADISSN 8
           FTA++SS+
Sbjct: 300 FTAEVSSD 307
>XP_006713677
          Length = 717

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  ADISSNK 9
          AD+S+NK
Sbjct: 51 ADVSNNK 57
>NP_942015
          Length = 504

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   TADISSNK 9
           T D+SSN+
Sbjct: 187 TLDLSSNR 194
>NP_059111
          Length = 587

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  FTADISSNK 9
          FT D+S +K
Sbjct: 79 FTGDMSESK 87
>NP_001244123
          Length = 555

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  FTADISSNK 9
          FT D+S +K
Sbjct: 47 FTGDMSESK 55
>NP_694992
          Length = 239

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  TADISSNK 9
          T D+S+NK
Sbjct: 42 TIDLSNNK 49
>NP_002636
          Length = 1686

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   FTADISS 7
           FT D+SS
Sbjct: 439 FTCDVSS 445
>NP_004410
          Length = 384

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   TADISSN 8
           TADISS+
Sbjct: 235 TADISSH 241
>XP_005260653
          Length = 506

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   DISSNK 9
           D+SSNK
Sbjct: 122 DVSSNK 127
>XP_005260652
          Length = 537

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   DISSNK 9
           D+SSNK
Sbjct: 122 DVSSNK 127
>XP_005260651
          Length = 551

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   DISSNK 9
           D+SSNK
Sbjct: 122 DVSSNK 127
>XP_005260650
          Length = 570

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   DISSNK 9
           D+SSNK
Sbjct: 122 DVSSNK 127
>XP_005260649
          Length = 590

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  DISSNK 9
          D+SSNK
Sbjct: 83 DVSSNK 88
>XP_005260648
          Length = 593

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   DISSNK 9
           D+SSNK
Sbjct: 122 DVSSNK 127
>XP_005260647
          Length = 607

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   DISSNK 9
           D+SSNK
Sbjct: 122 DVSSNK 127
>XP_005260646
          Length = 615

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   DISSNK 9
           D+SSNK
Sbjct: 122 DVSSNK 127
>XP_005260644
          Length = 629

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   DISSNK 9
           D+SSNK
Sbjct: 122 DVSSNK 127
>XP_005253037
          Length = 1306

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  FTADISS 7
          FT D+SS
Sbjct: 59 FTCDVSS 65
>XP_005253036
          Length = 1686

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   FTADISS 7
           FT D+SS
Sbjct: 439 FTCDVSS 445
>XP_005253035
          Length = 1686

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   FTADISS 7
           FT D+SS
Sbjct: 439 FTCDVSS 445
>XP_005253034
          Length = 1686

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   FTADISS 7
           FT D+SS
Sbjct: 439 FTCDVSS 445
>NP_003648
          Length = 584

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   DISSNK 9
           D+SSNK
Sbjct: 122 DVSSNK 127
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.306    0.116    0.294 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 383,849
Number of extensions: 701
Number of successful extensions: 48
Number of sequences better than 10000.0: 48
Number of HSP's gapped: 48
Number of HSP's successfully gapped: 48
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.5 bits)
S2: 28 (15.4 bits)

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