Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_115927                                                              19     665
XP_006715292                                                           19     665
NP_002418                                                              17    3301
NP_002413                                                              17    3301
NP_002416                                                              17    3301
NP_001093869                                                           17    3301
XP_005262709                                                           17    3301
NP_003038                                                              17    4312
NP_071405                                                              17    4312
NP_001106964                                                           16    5631
NP_001106963                                                           16    5631
NP_001106965                                                           16    5631
NP_006631                                                              16    5631
NP_001106968                                                           16    5631
NP_001106967                                                           16    5631
NP_001106966                                                           16    5631
NP_008973                                                              16    5631
NP_001275925                                                           16    5631
NP_001108479                                                           16    5631
NP_001108480                                                           16    5631
NP_001275926                                                           16    5631
NP_919258                                                              16    5631
NP_653206                                                              16    5631
NP_001147930                                                           16    5631
XP_005276585                                                           16    5631
XP_006721707                                                           16    5631
XP_005257019                                                           16    5631
XP_005257018                                                           16    5631
XP_005257017                                                           16    5631
XP_005257016                                                           16    5631
XP_006721706                                                           16    5631
XP_370934                                                              16    5631
XP_006720909                                                           16    5631
XP_005262809                                                           16    5631
XP_006714144                                                           16    5631
XP_005262807                                                           16    5631
XP_005262806                                                           16    5631
XP_001716413                                                           16    5631
NP_001092253                                                           16    5631
NP_000544                                                              16    7355
NP_004786                                                              16    7355
NP_055791                                                              16    7355
NP_689669                                                              16    7355
NP_001166242                                                           16    7355
NP_001166243                                                           16    7355
NP_002896                                                              16    7355
NP_001186700                                                           16    7355
XP_006719958                                                           16    7355
XP_005269704                                                           16    7355
NP_848551                                                              16    7355
NP_001244336                                                           15    9605
NP_000409                                                              15    9605
NP_001018865                                                           15    9605
NP_001018864                                                           15    9605
NP_619639                                                              15    9605
NP_733842                                                              15    9605
NP_112192                                                              15    9605
NP_001244335                                                           15    9605
NP_001240605                                                           15    9605
NP_006090                                                              15    9605
NP_004856                                                              15    9605
NP_631902                                                              15    9605
NP_001276922                                                           15    9605
NP_001120863                                                           15    9605
XP_005255366                                                           15    9605
XP_005255362                                                           15    9605
XP_005247970                                                           15    9605
XP_005247968                                                           15    9605
XP_006712336                                                           15    9605
>NP_115927
          Length = 1321

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   FRVVNVTPV 9
           F VVNVTPV
Sbjct: 338 FGVVNVTPV 346
>XP_006715292
          Length = 759

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   FRVVNVTPV 9
           F VVNVTPV
Sbjct: 325 FGVVNVTPV 333
>NP_002418
          Length = 471

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   FRVVNVTP 8
           +R+VN TP
Sbjct: 120 YRIVNYTP 127
>NP_002413
          Length = 477

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   FRVVNVTP 8
           +R+VN TP
Sbjct: 116 YRIVNYTP 123
>NP_002416
          Length = 476

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   FRVVNVTP 8
           +R+VN TP
Sbjct: 115 YRIVNYTP 122
>NP_001093869
          Length = 1337

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    RVVNVTPV 9
            R+++VTPV
Sbjct: 1203 RIISVTPV 1210
>XP_005262709
          Length = 1337

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    RVVNVTPV 9
            R+++VTPV
Sbjct: 1203 RIISVTPV 1210
>NP_003038
          Length = 815

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   FRVVNVTP 8
           FR+V +TP
Sbjct: 439 FRIVKLTP 446
>NP_071405
          Length = 513

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   FRVVNVTP 8
           +R++N TP
Sbjct: 113 YRIINYTP 120
>NP_001106964
          Length = 422

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RVVNVTPV 9
           +VVN+ PV
Sbjct: 271 KVVNIVPV 278
>NP_001106963
          Length = 586

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RVVNVTPV 9
           +VVN+ PV
Sbjct: 435 KVVNIVPV 442
>NP_001106965
          Length = 579

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RVVNVTPV 9
           +VVN+ PV
Sbjct: 428 KVVNIVPV 435
>NP_006631
          Length = 568

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RVVNVTPV 9
           +VVN+ PV
Sbjct: 417 KVVNIVPV 424
>NP_001106968
          Length = 335

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RVVNVTPV 9
           +VVN+ PV
Sbjct: 184 KVVNIVPV 191
>NP_001106967
          Length = 474

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RVVNVTPV 9
           +VVN+ PV
Sbjct: 323 KVVNIVPV 330
>NP_001106966
          Length = 422

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RVVNVTPV 9
           +VVN+ PV
Sbjct: 271 KVVNIVPV 278
>NP_008973
          Length = 124

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   FRVVNVTP 8
           FRV+ V+P
Sbjct: 102 FRVIQVSP 109
>NP_001275925
          Length = 660

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   VVNVTPV 9
           VVN TPV
Sbjct: 305 VVNTTPV 311
>NP_001108479
          Length = 528

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   VVNVTPV 9
           VVN TPV
Sbjct: 173 VVNTTPV 179
>NP_001108480
          Length = 528

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   VVNVTPV 9
           VVN TPV
Sbjct: 173 VVNTTPV 179
>NP_001275926
          Length = 528

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   VVNVTPV 9
           VVN TPV
Sbjct: 173 VVNTTPV 179
>NP_919258
          Length = 749

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   VVNVTPV 9
           VVN TPV
Sbjct: 394 VVNTTPV 400
>NP_653206
          Length = 358

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   RVVNVTPV 9
           R VNV PV
Sbjct: 185 RTVNVVPV 192
>NP_001147930
          Length = 312

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   RVVNVTPV 9
           R VNV PV
Sbjct: 139 RTVNVVPV 146
>XP_005276585
          Length = 741

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   FRVVNVTP 8
           FRVV+ TP
Sbjct: 691 FRVVDPTP 698
>XP_006721707
          Length = 335

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RVVNVTPV 9
           +VVN+ PV
Sbjct: 184 KVVNIVPV 191
>XP_005257019
          Length = 335

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RVVNVTPV 9
           +VVN+ PV
Sbjct: 184 KVVNIVPV 191
>XP_005257018
          Length = 335

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RVVNVTPV 9
           +VVN+ PV
Sbjct: 184 KVVNIVPV 191
>XP_005257017
          Length = 335

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RVVNVTPV 9
           +VVN+ PV
Sbjct: 184 KVVNIVPV 191
>XP_005257016
          Length = 362

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RVVNVTPV 9
           +VVN+ PV
Sbjct: 211 KVVNIVPV 218
>XP_006721706
          Length = 422

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RVVNVTPV 9
           +VVN+ PV
Sbjct: 271 KVVNIVPV 278
>XP_370934
          Length = 741

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   FRVVNVTP 8
           FRVV+ TP
Sbjct: 691 FRVVDPTP 698
>XP_006720909
          Length = 358

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   RVVNVTPV 9
           R VNV PV
Sbjct: 185 RTVNVVPV 192
>XP_005262809
          Length = 546

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   VVNVTPV 9
           VVN TPV
Sbjct: 191 VVNTTPV 197
>XP_006714144
          Length = 749

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   VVNVTPV 9
           VVN TPV
Sbjct: 394 VVNTTPV 400
>XP_005262807
          Length = 749

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   VVNVTPV 9
           VVN TPV
Sbjct: 394 VVNTTPV 400
>XP_005262806
          Length = 767

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   VVNVTPV 9
           VVN TPV
Sbjct: 412 VVNTTPV 418
>XP_001716413
          Length = 764

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   FRVVNVTP 8
           FRVV+ TP
Sbjct: 714 FRVVDPTP 721
>NP_001092253
          Length = 124

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   FRVVNVTP 8
           FRV+ V+P
Sbjct: 102 FRVIQVSP 109
>NP_000544
          Length = 1432

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   FRVVNVTP 8
           +R+V VTP
Sbjct: 636 YRIVYVTP 643
>NP_004786
          Length = 1012

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   VNVTPV 9
           VN+TPV
Sbjct: 629 VNITPV 634
>NP_055791
          Length = 1871

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    RVVNVTP 8
            RVV VTP
Sbjct: 1236 RVVKVTP 1242
>NP_689669
          Length = 242

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  FRVVNVT 7
          FR+ NVT
Sbjct: 72 FRIANVT 78
>NP_001166242
          Length = 241

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  FRVVNVT 7
          FR+ NVT
Sbjct: 72 FRIANVT 78
>NP_001166243
          Length = 242

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  FRVVNVT 7
          FR+ NVT
Sbjct: 72 FRIANVT 78
>NP_002896
          Length = 318

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RVVNVTPV 9
           RV+N+T V
Sbjct: 157 RVINITSV 164
>NP_001186700
          Length = 318

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RVVNVTPV 9
           RV+N+T V
Sbjct: 157 RVINITSV 164
>XP_006719958
          Length = 705

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   VNVTPV 9
           VN+TPV
Sbjct: 322 VNITPV 327
>XP_005269704
          Length = 1872

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    RVVNVTP 8
            RVV VTP
Sbjct: 1236 RVVKVTP 1242
>NP_848551
          Length = 137

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  FRVVNVTPV 9
          FR+  VTPV
Sbjct: 71 FRIRPVTPV 79
>NP_001244336
          Length = 810

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   FRVVNVT 7
           FR+ NVT
Sbjct: 157 FRIYNVT 163
>NP_000409
          Length = 825

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   FRVVNVT 7
           FR+ NVT
Sbjct: 172 FRIYNVT 178
>NP_001018865
          Length = 465

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/7 (42%), Positives = 7/7 (100%)

Query: 3  VVNVTPV 9
          ++N+TP+
Sbjct: 35 IINITPL 41
>NP_001018864
          Length = 598

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/7 (42%), Positives = 7/7 (100%)

Query: 3  VVNVTPV 9
          ++N+TP+
Sbjct: 35 IINITPL 41
>NP_619639
          Length = 4074

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    RVVNVTPV 9
            R+VNVT +
Sbjct: 1081 RIVNVTVI 1088
>NP_733842
          Length = 3396

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    RVVNVTPV 9
            R+VNVT +
Sbjct: 1081 RIVNVTVI 1088
>NP_112192
          Length = 597

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   VNVTPV 9
           +NVTP+
Sbjct: 115 INVTPI 120
>NP_001244335
          Length = 825

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   FRVVNVT 7
           FR+ NVT
Sbjct: 172 FRIYNVT 178
>NP_001240605
          Length = 186

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   FRVVNVTPV 9
           F+VVNV  V
Sbjct: 100 FKVVNVLAV 108
>NP_006090
          Length = 628

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   RVVNVTPV 9
           R +N+TP+
Sbjct: 240 RPINITPL 247
>NP_004856
          Length = 186

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   FRVVNVTPV 9
           F+VVNV  V
Sbjct: 100 FKVVNVLAV 108
>NP_631902
          Length = 445

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1  FRVVNVTP 8
          + V+NV+P
Sbjct: 78 YEVINVSP 85
>NP_001276922
          Length = 422

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1  FRVVNVTP 8
          + V+NV+P
Sbjct: 78 YEVINVSP 85
>NP_001120863
          Length = 422

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1  FRVVNVTP 8
          + V+NV+P
Sbjct: 78 YEVINVSP 85
>XP_005255366
          Length = 364

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   FRVVNVT 7
           FR+ NVT
Sbjct: 232 FRIYNVT 238
>XP_005255362
          Length = 885

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   FRVVNVT 7
           FR+ NVT
Sbjct: 232 FRIYNVT 238
>XP_005247970
          Length = 378

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/7 (42%), Positives = 7/7 (100%)

Query: 3  VVNVTPV 9
          ++N+TP+
Sbjct: 35 IINITPL 41
>XP_005247968
          Length = 474

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/7 (42%), Positives = 7/7 (100%)

Query: 3  VVNVTPV 9
          ++N+TP+
Sbjct: 35 IINITPL 41
>XP_006712336
          Length = 262

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1  FRVVNVTP 8
          + V+NV+P
Sbjct: 78 YEVINVSP 85
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.335    0.146    0.433 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 459,508
Number of extensions: 808
Number of successful extensions: 69
Number of sequences better than 10000.0: 69
Number of HSP's gapped: 69
Number of HSP's successfully gapped: 69
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.3 bits)
S2: 28 (15.4 bits)

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