Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_443179                                                              20     390
XP_005266703                                                           20     390
NP_006071                                                              17    2528
XP_006715902                                                           17    2528
XP_006715901                                                           17    2528
XP_005250168                                                           17    2528
XP_005250167                                                           17    2528
NP_001166101                                                           17    3301
XP_006723066                                                           17    3301
XP_006723065                                                           17    3301
XP_005258546                                                           17    3301
XP_006723064                                                           17    3301
XP_005258545                                                           17    3301
XP_005258544                                                           17    3301
XP_006723063                                                           17    3301
XP_006723062                                                           17    3301
NP_001153772                                                           17    4312
NP_443071                                                              17    4312
NP_085152                                                              16    5631
NP_066272                                                              16    5631
XP_005244774                                                           16    5631
XP_005244773                                                           16    5631
XP_005244772                                                           16    5631
XP_005244771                                                           16    5631
XP_006710392                                                           16    5631
NP_079023                                                              16    7355
NP_694960                                                              16    7355
NP_001245221                                                           16    7355
NP_036472                                                              16    7355
NP_001129493                                                           16    7355
NP_775114                                                              16    7355
NP_001230178                                                           16    7355
NP_149020                                                              16    7355
NP_001230176                                                           16    7355
NP_001034565                                                           16    7355
NP_001070818                                                           16    7355
NP_001230177                                                           16    7355
XP_006724673                                                           16    7355
XP_005260470                                                           16    7355
XP_006721791                                                           16    7355
NP_689991                                                              15    9605
NP_065805                                                              15    9605
NP_002408                                                              15    9605
NP_001139438                                                           15    9605
NP_705618                                                              15    9605
NP_001094058                                                           15    9605
NP_004289                                                              15    9605
NP_067082                                                              15    9605
NP_001001788                                                           15    9605
NP_001265241                                                           15    9605
XP_006718995                                                           15    9605
XP_005274425                                                           15    9605
XP_006718994                                                           15    9605
XP_006718993                                                           15    9605
XP_005274424                                                           15    9605
XP_005274423                                                           15    9605
XP_006717927                                                           15    9605
XP_005262957                                                           15    9605
XP_005262955                                                           15    9605
XP_005262954                                                           15    9605
XP_005262953                                                           15    9605
XP_005262950                                                           15    9605
XP_005247728                                                           15    9605
XP_006713777                                                           15    9605
NP_061744                                                              15    9605
NP_114478                                                              15    9605
NP_115271                                                              15    9605
NP_203753                                                              15    9605
NP_061749                                                              15    9605
>NP_443179
          Length = 2170

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   FREPLAVSV 9
           FREP+AVSV
Sbjct: 768 FREPVAVSV 776
>XP_005266703
          Length = 1501

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   FREPLAVSV 9
           FREP+AVSV
Sbjct: 99  FREPVAVSV 107
>NP_006071
          Length = 771

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   FREPLAVS 8
           FREP A+S
Sbjct: 483 FREPTAIS 490
>XP_006715902
          Length = 771

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   FREPLAVS 8
           FREP A+S
Sbjct: 483 FREPTAIS 490
>XP_006715901
          Length = 771

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   FREPLAVS 8
           FREP A+S
Sbjct: 483 FREPTAIS 490
>XP_005250168
          Length = 771

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   FREPLAVS 8
           FREP A+S
Sbjct: 483 FREPTAIS 490
>XP_005250167
          Length = 771

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   FREPLAVS 8
           FREP A+S
Sbjct: 483 FREPTAIS 490
>NP_001166101
          Length = 1123

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   EPLAVSV 9
           EPLAVSV
Sbjct: 661 EPLAVSV 667
>XP_006723066
          Length = 818

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   EPLAVSV 9
           EPLAVSV
Sbjct: 328 EPLAVSV 334
>XP_006723065
          Length = 1162

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   EPLAVSV 9
           EPLAVSV
Sbjct: 672 EPLAVSV 678
>XP_005258546
          Length = 1259

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   EPLAVSV 9
           EPLAVSV
Sbjct: 797 EPLAVSV 803
>XP_006723064
          Length = 1270

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   EPLAVSV 9
           EPLAVSV
Sbjct: 808 EPLAVSV 814
>XP_005258545
          Length = 1287

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   EPLAVSV 9
           EPLAVSV
Sbjct: 797 EPLAVSV 803
>XP_005258544
          Length = 1288

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   EPLAVSV 9
           EPLAVSV
Sbjct: 798 EPLAVSV 804
>XP_006723063
          Length = 1297

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   EPLAVSV 9
           EPLAVSV
Sbjct: 807 EPLAVSV 813
>XP_006723062
          Length = 1298

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   EPLAVSV 9
           EPLAVSV
Sbjct: 808 EPLAVSV 814
>NP_001153772
          Length = 643

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   FREPLAV 7
           F+EPLA+
Sbjct: 443 FKEPLAI 449
>NP_443071
          Length = 677

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   FREPLAV 7
           F+EPLA+
Sbjct: 443 FKEPLAI 449
>NP_085152
          Length = 834

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   REPLAVSV 9
           R+PLA++V
Sbjct: 770 RDPLAIAV 777
>NP_066272
          Length = 329

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  FREPLAVS 8
          F +PLA+S
Sbjct: 24 FEQPLAIS 31
>XP_005244774
          Length = 493

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   REPLAVSV 9
           R+PLA++V
Sbjct: 429 RDPLAIAV 436
>XP_005244773
          Length = 792

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   REPLAVSV 9
           R+PLA++V
Sbjct: 728 RDPLAIAV 735
>XP_005244772
          Length = 801

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   REPLAVSV 9
           R+PLA++V
Sbjct: 737 RDPLAIAV 744
>XP_005244771
          Length = 802

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   REPLAVSV 9
           R+PLA++V
Sbjct: 738 RDPLAIAV 745
>XP_006710392
          Length = 834

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   REPLAVSV 9
           R+PLA++V
Sbjct: 770 RDPLAIAV 777
>NP_079023
          Length = 775

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   REPLAV 7
           REPLAV
Sbjct: 265 REPLAV 270
>NP_694960
          Length = 763

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   FREPLAVS 8
           F+EPL+V+
Sbjct: 291 FQEPLSVN 298
>NP_001245221
          Length = 905

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   FREPLAVS 8
           +REPL +S
Sbjct: 141 YREPLCLS 148
>NP_036472
          Length = 921

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   FREPLAVS 8
           +REPL +S
Sbjct: 161 YREPLCLS 168
>NP_001129493
          Length = 901

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   FREPLAVS 8
           +REPL +S
Sbjct: 141 YREPLCLS 148
>NP_775114
          Length = 925

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   FREPLAVS 8
           +REPL +S
Sbjct: 161 YREPLCLS 168
>NP_001230178
          Length = 544

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   FREPLAVSV 9
           FR PLA +V
Sbjct: 352 FRNPLAPAV 360
>NP_149020
          Length = 1395

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   FREPLAV 7
           F+EPLA+
Sbjct: 827 FKEPLAL 833

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   FREPLAV 7
           F+EPLA+
Sbjct: 945 FKEPLAL 951

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    FREPLAV 7
            F+EPLA+
Sbjct: 1027 FKEPLAL 1033
>NP_001230176
          Length = 491

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   FREPLAVSV 9
           FR PLA +V
Sbjct: 299 FRNPLAPAV 307
>NP_001034565
          Length = 390

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   FREPLAVSV 9
           FR PLA +V
Sbjct: 198 FRNPLAPAV 206
>NP_001070818
          Length = 569

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   FREPLAVSV 9
           FR PLA +V
Sbjct: 377 FRNPLAPAV 385
>NP_001230177
          Length = 544

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   FREPLAVSV 9
           FR PLA +V
Sbjct: 352 FRNPLAPAV 360
>XP_006724673
          Length = 1396

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   FREPLAV 7
           F+EPLA+
Sbjct: 827 FKEPLAL 833

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   FREPLAV 7
           F+EPLA+
Sbjct: 945 FKEPLAL 951

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    FREPLAV 7
            F+EPLA+
Sbjct: 1027 FKEPLAL 1033
>XP_005260470
          Length = 924

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   FREPLAVS 8
           +REPL +S
Sbjct: 160 YREPLCLS 167
>XP_006721791
          Length = 1078

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   FREPLAVS 8
           F+EPL+V+
Sbjct: 220 FQEPLSVN 227
>NP_689991
          Length = 518

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   REPLAVSV 9
           +EPL VS+
Sbjct: 104 KEPLIVSI 111
>NP_065805
          Length = 1444

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   EPLAVSV 9
           EP AVSV
Sbjct: 488 EPFAVSV 494
>NP_002408
          Length = 3256

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    EPLAVS 8
            EPLAVS
Sbjct: 2494 EPLAVS 2499
>NP_001139438
          Length = 2896

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    EPLAVS 8
            EPLAVS
Sbjct: 2134 EPLAVS 2139
>NP_705618
          Length = 1391

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   FREPLA 6
           FR+PLA
Sbjct: 375 FRQPLA 380
>NP_001094058
          Length = 1191

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    FREPLAVSV 9
            F +PL VS+
Sbjct: 1140 FSQPLPVSI 1148
>NP_004289
          Length = 1332

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   FREPLA 6
           FR+PLA
Sbjct: 316 FRQPLA 321
>NP_067082
          Length = 771

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   FREPLAVSV 9
           F  P+AVSV
Sbjct: 558 FLAPIAVSV 566
>NP_001001788
          Length = 334

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   FREPLAVSV 9
           + EPL VS+
Sbjct: 325 YSEPLQVSI 333
>NP_001265241
          Length = 1327

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   FREPLA 6
           FR+PLA
Sbjct: 375 FRQPLA 380
>XP_006718995
          Length = 2382

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    REPLAVSV 9
            R+PL VS+
Sbjct: 1654 RDPLRVSI 1661
>XP_005274425
          Length = 2566

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    REPLAVSV 9
            R+PL VS+
Sbjct: 1839 RDPLRVSI 1846
>XP_006718994
          Length = 2567

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    REPLAVSV 9
            R+PL VS+
Sbjct: 1839 RDPLRVSI 1846
>XP_006718993
          Length = 2602

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    REPLAVSV 9
            R+PL VS+
Sbjct: 1874 RDPLRVSI 1881
>XP_005274424
          Length = 2614

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    REPLAVSV 9
            R+PL VS+
Sbjct: 1887 RDPLRVSI 1894
>XP_005274423
          Length = 2615

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    REPLAVSV 9
            R+PL VS+
Sbjct: 1887 RDPLRVSI 1894
>XP_006717927
          Length = 2406

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    EPLAVS 8
            EPLAVS
Sbjct: 1644 EPLAVS 1649
>XP_005262957
          Length = 229

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   REPLAVSV 9
           +EPL VS+
Sbjct: 104 KEPLIVSI 111
>XP_005262955
          Length = 336

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   REPLAVSV 9
           +EPL VS+
Sbjct: 104 KEPLIVSI 111
>XP_005262954
          Length = 451

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   REPLAVSV 9
           +EPL VS+
Sbjct: 104 KEPLIVSI 111
>XP_005262953
          Length = 469

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   REPLAVSV 9
           +EPL VS+
Sbjct: 104 KEPLIVSI 111
>XP_005262950
          Length = 518

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   REPLAVSV 9
           +EPL VS+
Sbjct: 104 KEPLIVSI 111
>XP_005247728
          Length = 1413

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   EPLAVSV 9
           EP AVSV
Sbjct: 457 EPFAVSV 463
>XP_006713777
          Length = 1424

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   EPLAVSV 9
           EP AVSV
Sbjct: 468 EPFAVSV 474
>NP_061744
          Length = 932

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   EPLAVSV 9
           EPL VSV
Sbjct: 789 EPLCVSV 795
>NP_114478
          Length = 828

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   EPLAVSV 9
           EPL VSV
Sbjct: 789 EPLCVSV 795
>NP_115271
          Length = 820

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   EPLAVS 8
           EPLAVS
Sbjct: 497 EPLAVS 502
>NP_203753
          Length = 2601

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    REPLAVSV 9
            R+PL VS+
Sbjct: 1874 RDPLRVSI 1881
>NP_061749
          Length = 930

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   EPLAVS 8
           EPLAVS
Sbjct: 497 EPLAVS 502
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.328    0.140    0.387 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 631,425
Number of extensions: 789
Number of successful extensions: 73
Number of sequences better than 10000.0: 69
Number of HSP's gapped: 73
Number of HSP's successfully gapped: 73
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.1 bits)
S2: 28 (15.4 bits)

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