Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_008835                                                              21     229
NP_001075109                                                           21     229
NP_001091681                                                           18    1135
NP_001091683                                                           18    1135
NP_001091682                                                           18    1135
NP_000852                                                              18    1135
NP_057331                                                              17    4312
NP_005106                                                              16    5631
NP_059447                                                              16    5631
NP_000821                                                              16    5631
NP_783300                                                              16    5631
NP_996806                                                              16    5631
XP_005261001                                                           16    5631
XP_005261000                                                           16    5631
XP_005260999                                                           16    5631
XP_006724054                                                           16    5631
NP_997244                                                              16    7355
NP_110447                                                              16    7355
NP_001161707                                                           16    7355
XP_006715287                                                           16    7355
XP_006715286                                                           16    7355
NP_060606                                                              15    9605
NP_000113                                                              15    9605
NP_001193775                                                           15    9605
NP_001269109                                                           15    9605
NP_954646                                                              15    9605
NP_620132                                                              15    9605
NP_001166983                                                           15    9605
NP_006237                                                              15    9605
NP_001269111                                                           15    9605
NP_001269110                                                           15    9605
NP_001269108                                                           15    9605
NP_001073949                                                           15    9605
XP_006717381                                                           15    9605
XP_005252359                                                           15    9605
XP_006715063                                                           15    9605
XP_006715062                                                           15    9605
XP_005263675                                                           15    9605
>NP_008835
          Length = 4128

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    FRDYVAVSR 9
            FRDYVAV+R
Sbjct: 4074 FRDYVAVAR 4082
>NP_001075109
          Length = 4097

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    FRDYVAVSR 9
            FRDYVAV+R
Sbjct: 4043 FRDYVAVAR 4051
>NP_001091681
          Length = 487

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   RDYVAVSR 9
           RDYVAV+R
Sbjct: 319 RDYVAVNR 326
>NP_001091683
          Length = 487

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   RDYVAVSR 9
           RDYVAV+R
Sbjct: 319 RDYVAVNR 326
>NP_001091682
          Length = 487

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   RDYVAVSR 9
           RDYVAV+R
Sbjct: 319 RDYVAVNR 326
>NP_000852
          Length = 487

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   RDYVAVSR 9
           RDYVAV+R
Sbjct: 319 RDYVAVNR 326
>NP_057331
          Length = 1241

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   FRDYVA 6
           FRDY+A
Sbjct: 354 FRDYIA 359
>NP_005106
          Length = 893

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   FRDYVAVSR 9
           FRD+  VSR
Sbjct: 235 FRDFRGVSR 243
>NP_059447
          Length = 893

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   FRDYVAVSR 9
           FRD+  VSR
Sbjct: 235 FRDFRGVSR 243
>NP_000821
          Length = 918

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   FRDYVAVSR 9
           + DY A+SR
Sbjct: 151 YPDYAAISR 159
>NP_783300
          Length = 905

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   FRDYVAVSR 9
           + DY A+SR
Sbjct: 151 YPDYAAISR 159
>NP_996806
          Length = 372

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   FRDYVAVSR 9
           FRDY A+ +
Sbjct: 265 FRDYAAMRK 273
>XP_005261001
          Length = 903

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   FRDYVAVSR 9
           + DY A+SR
Sbjct: 151 YPDYAAISR 159
>XP_005261000
          Length = 920

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   FRDYVAVSR 9
           + DY A+SR
Sbjct: 151 YPDYAAISR 159
>XP_005260999
          Length = 934

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   FRDYVAVSR 9
           + DY A+SR
Sbjct: 151 YPDYAAISR 159
>XP_006724054
          Length = 949

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   FRDYVAVSR 9
           + DY A+SR
Sbjct: 151 YPDYAAISR 159
>NP_997244
          Length = 3169

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    DYVAVSR 9
            DYV +SR
Sbjct: 2060 DYVGISR 2066
>NP_110447
          Length = 957

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   DYVAVSR 9
           DY+A+S+
Sbjct: 196 DYIAISK 202
>NP_001161707
          Length = 2139

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    DYVAVSR 9
            DYV +SR
Sbjct: 2063 DYVGISR 2069
>XP_006715287
          Length = 615

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   DYVAVSR 9
           DY+A+S+
Sbjct: 196 DYIAISK 202
>XP_006715286
          Length = 945

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   DYVAVSR 9
           DY+A+S+
Sbjct: 196 DYIAISK 202
>NP_060606
          Length = 3477

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   FRDYVAVSR 9
           F DY  +SR
Sbjct: 896 FLDYAKISR 904
>NP_000113
          Length = 782

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   FRDYVAV 7
           +R+YVA+
Sbjct: 519 YREYVAI 525
>NP_001193775
          Length = 1892

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   FRDYVAVSR 9
           F DY  +SR
Sbjct: 896 FLDYAKISR 904
>NP_001269109
          Length = 462

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3   DYVAVSR 9
           DY+ +SR
Sbjct: 98  DYITISR 104
>NP_954646
          Length = 201

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  FRDYVAVS 8
          FR+Y+A S
Sbjct: 15 FRNYLAAS 22
>NP_620132
          Length = 262

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  FRDYVAVS 8
          FR+Y+A S
Sbjct: 15 FRNYLAAS 22
>NP_001166983
          Length = 210

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  FRDYVAVS 8
          FR+Y+A S
Sbjct: 15 FRNYLAAS 22
>NP_006237
          Length = 467

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3   DYVAVSR 9
           DY+ +SR
Sbjct: 98  DYITISR 104
>NP_001269111
          Length = 391

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3  DYVAVSR 9
          DY+ +SR
Sbjct: 22 DYITISR 28
>NP_001269110
          Length = 391

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3  DYVAVSR 9
          DY+ +SR
Sbjct: 22 DYITISR 28
>NP_001269108
          Length = 467

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3   DYVAVSR 9
           DY+ +SR
Sbjct: 98  DYITISR 104
>NP_001073949
          Length = 495

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   FRDYVA 6
           F+DY+A
Sbjct: 203 FKDYIA 208
>XP_006717381
          Length = 206

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  FRDYVAVS 8
          FR+Y+A S
Sbjct: 36 FRNYLAAS 43
>XP_005252359
          Length = 283

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  FRDYVAVS 8
          FR+Y+A S
Sbjct: 36 FRNYLAAS 43
>XP_006715063
          Length = 248

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   FRDYVA 6
           F+DY+A
Sbjct: 203 FKDYIA 208
>XP_006715062
          Length = 463

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   FRDYVA 6
           F+DY+A
Sbjct: 171 FKDYIA 176
>XP_005263675
          Length = 718

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   FRDYVAV 7
           +R+YVA+
Sbjct: 455 YREYVAI 461
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.339    0.144    0.417 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 441,715
Number of extensions: 437
Number of successful extensions: 38
Number of sequences better than 10000.0: 38
Number of HSP's gapped: 38
Number of HSP's successfully gapped: 38
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.5 bits)
S2: 28 (15.4 bits)

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