Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_004351                                                              21     229
NP_078858                                                              18    1482
NP_001278232                                                           18    1482
NP_001278214                                                           18    1482
NP_005236                                                              17    2528
XP_006714202                                                           17    2528
XP_005262892                                                           17    2528
XP_005262891                                                           17    2528
NP_443132                                                              17    3301
NP_937757                                                              17    3301
NP_937756                                                              17    3301
NP_000205                                                              17    4312
NP_005520                                                              17    4312
XP_006710661                                                           17    4312
XP_005245920                                                           17    4312
XP_006710660                                                           17    4312
XP_006710659                                                           17    4312
XP_006710658                                                           17    4312
XP_006710657                                                           17    4312
NP_694545                                                              16    5631
XP_005255894                                                           16    5631
XP_006721232                                                           16    5631
XP_005255893                                                           16    5631
NP_722579                                                              16    5631
NP_001074295                                                           16    7355
NP_064593                                                              16    7355
NP_001399                                                              16    7355
XP_005272427                                                           16    7355
XP_005272426                                                           16    7355
XP_006710468                                                           16    7355
XP_005270637                                                           16    7355
NP_071800                                                              16    7355
NP_001001563                                                           16    7355
NP_000375                                                              15    9605
NP_689777                                                              15    9605
NP_060360                                                              15    9605
NP_055782                                                              15    9605
NP_001438                                                              15    9605
XP_006725604                                                           15    9605
XP_006725603                                                           15    9605
XP_006725602                                                           15    9605
XP_006725601                                                           15    9605
XP_006725600                                                           15    9605
XP_005254293                                                           15    9605
XP_005254289                                                           15    9605
XP_005254292                                                           15    9605
XP_005254291                                                           15    9605
XP_005254290                                                           15    9605
XP_005250858                                                           15    9605
XP_005250857                                                           15    9605
XP_006714824                                                           15    9605
NP_660156                                                              15    9605
NP_061822                                                              15    9605
>NP_004351
          Length = 882

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   FPAYTLVVQ 9
           FP YTLVVQ
Sbjct: 338 FPTYTLVVQ 346
>NP_078858
          Length = 4981

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    PAYTLVVQ 9
            PAY+LV+Q
Sbjct: 1279 PAYSLVIQ 1286
>NP_001278232
          Length = 4983

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    PAYTLVVQ 9
            PAY+LV+Q
Sbjct: 1279 PAYSLVIQ 1286
>NP_001278214
          Length = 4982

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    PAYTLVVQ 9
            PAY+LV+Q
Sbjct: 1279 PAYSLVIQ 1286
>NP_005236
          Length = 4588

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    PAYTLVVQ 9
            P YTL++Q
Sbjct: 1731 PIYTLIIQ 1738
>XP_006714202
          Length = 4588

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    PAYTLVVQ 9
            P YTL++Q
Sbjct: 1731 PIYTLIIQ 1738
>XP_005262892
          Length = 4600

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    PAYTLVVQ 9
            P YTL++Q
Sbjct: 1731 PIYTLIIQ 1738
>XP_005262891
          Length = 4600

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    PAYTLVVQ 9
            P YTL++Q
Sbjct: 1731 PIYTLIIQ 1738
>NP_443132
          Length = 3538

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1    FPAYTLV 7
            FP YTL+
Sbjct: 2147 FPGYTLI 2153
>NP_937757
          Length = 3667

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1    FPAYTLV 7
            FP YTL+
Sbjct: 2211 FPGYTLI 2217
>NP_937756
          Length = 3707

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1    FPAYTLV 7
            FP YTL+
Sbjct: 2251 FPGYTLI 2257
>NP_000205
          Length = 1218

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    PAYTLV 7
            PAYTLV
Sbjct: 1174 PAYTLV 1179
>NP_005520
          Length = 4391

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    PAYTLV 7
            PAYTLV
Sbjct: 1800 PAYTLV 1805
>XP_006710661
          Length = 4057

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    PAYTLV 7
            PAYTLV
Sbjct: 1983 PAYTLV 1988
>XP_005245920
          Length = 4392

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    PAYTLV 7
            PAYTLV
Sbjct: 1801 PAYTLV 1806
>XP_006710660
          Length = 4397

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    PAYTLV 7
            PAYTLV
Sbjct: 1800 PAYTLV 1805
>XP_006710659
          Length = 4556

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    PAYTLV 7
            PAYTLV
Sbjct: 1959 PAYTLV 1964
>XP_006710658
          Length = 4563

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    PAYTLV 7
            PAYTLV
Sbjct: 1966 PAYTLV 1971
>XP_006710657
          Length = 4579

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    PAYTLV 7
            PAYTLV
Sbjct: 1982 PAYTLV 1987
>NP_694545
          Length = 514

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   PAYTLVVQ 9
           P YTL+++
Sbjct: 118 PTYTLIIR 125
>XP_005255894
          Length = 451

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1  FPAYTLVVQ 9
          FP Y L +Q
Sbjct: 61 FPGYNLTLQ 69
>XP_006721232
          Length = 528

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1  FPAYTLVVQ 9
          FP Y L +Q
Sbjct: 61 FPGYNLTLQ 69
>XP_005255893
          Length = 528

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1  FPAYTLVVQ 9
          FP Y L +Q
Sbjct: 61 FPGYNLTLQ 69
>NP_722579
          Length = 528

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1  FPAYTLVVQ 9
          FP Y L +Q
Sbjct: 61 FPGYNLTLQ 69
>NP_001074295
          Length = 1406

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   PAYTLV 7
           PAYT+V
Sbjct: 157 PAYTMV 162
>NP_064593
          Length = 592

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   FPAYTLVV 8
           +PAY L V
Sbjct: 551 YPAYALAV 558
>NP_001399
          Length = 2923

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   PAYTLVVQ 9
           P Y LV+Q
Sbjct: 990 PEYVLVIQ 997
>XP_005272427
          Length = 1406

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   PAYTLV 7
           PAYT+V
Sbjct: 157 PAYTMV 162
>XP_005272426
          Length = 1406

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   PAYTLV 7
           PAYT+V
Sbjct: 157 PAYTMV 162
>XP_006710468
          Length = 2916

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   PAYTLVVQ 9
           P Y LV+Q
Sbjct: 990 PEYVLVIQ 997
>XP_005270637
          Length = 2921

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   PAYTLVVQ 9
           P Y LV+Q
Sbjct: 990 PEYVLVIQ 997
>NP_071800
          Length = 555

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   FPAYTLVV 8
           +PAY L V
Sbjct: 514 YPAYALAV 521
>NP_001001563
          Length = 456

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   PAYTLVVQ 9
           P YTLV++
Sbjct: 249 PPYTLVLE 256
>NP_000375
          Length = 4563

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2    PAYTLVV 8
            P+YTL++
Sbjct: 3293 PSYTLIL 3299
>NP_689777
          Length = 3997

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2    PAYTLVVQ 9
            P Y++V+Q
Sbjct: 2780 PEYSIVIQ 2787
>NP_060360
          Length = 4022

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2    PAYTLVVQ 9
            P Y++V+Q
Sbjct: 2805 PEYSIVIQ 2812
>NP_055782
          Length = 1017

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   FPAYTL 6
           FP+YT+
Sbjct: 584 FPSYTI 589
>NP_001438
          Length = 4349

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   AYTLVVQ 9
           +YTL++Q
Sbjct: 114 SYTLIIQ 120
>XP_006725604
          Length = 904

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   FPAYTL 6
           FP+YT+
Sbjct: 584 FPSYTI 589
>XP_006725603
          Length = 1017

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   FPAYTL 6
           FP+YT+
Sbjct: 584 FPSYTI 589
>XP_006725602
          Length = 1017

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   FPAYTL 6
           FP+YT+
Sbjct: 584 FPSYTI 589
>XP_006725601
          Length = 1017

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   FPAYTL 6
           FP+YT+
Sbjct: 584 FPSYTI 589
>XP_006725600
          Length = 1017

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   FPAYTL 6
           FP+YT+
Sbjct: 584 FPSYTI 589
>XP_005254293
          Length = 904

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   FPAYTL 6
           FP+YT+
Sbjct: 584 FPSYTI 589
>XP_005254289
          Length = 1017

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   FPAYTL 6
           FP+YT+
Sbjct: 584 FPSYTI 589
>XP_005254292
          Length = 1017

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   FPAYTL 6
           FP+YT+
Sbjct: 584 FPSYTI 589
>XP_005254291
          Length = 1017

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   FPAYTL 6
           FP+YT+
Sbjct: 584 FPSYTI 589
>XP_005254290
          Length = 1017

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   FPAYTL 6
           FP+YT+
Sbjct: 584 FPSYTI 589
>XP_005250858
          Length = 4022

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2    PAYTLVVQ 9
            P Y++V+Q
Sbjct: 2805 PEYSIVIQ 2812
>XP_005250857
          Length = 4022

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2    PAYTLVVQ 9
            P Y++V+Q
Sbjct: 2805 PEYSIVIQ 2812
>XP_006714824
          Length = 4349

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   AYTLVVQ 9
           +YTL++Q
Sbjct: 114 SYTLIIQ 120
>NP_660156
          Length = 198

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   PAYTLVVQ 9
           P Y L+VQ
Sbjct: 99  PIYKLIVQ 106
>NP_061822
          Length = 389

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3  AYTLVV 8
          AYTLVV
Sbjct: 70 AYTLVV 75
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.333    0.143    0.436 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 461,745
Number of extensions: 735
Number of successful extensions: 53
Number of sequences better than 10000.0: 53
Number of HSP's gapped: 53
Number of HSP's successfully gapped: 53
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.3 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package