Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000236                                                              20     299
NP_001120972                                                           20     299
XP_006716054                                                           20     299
XP_006716053                                                           20     299
XP_006716052                                                           20     299
XP_006716051                                                           20     299
NP_001129490                                                           17    4312
NP_001278092                                                           17    4312
NP_000111                                                              17    4312
NP_001167560                                                           16    5631
NP_114423                                                              16    5631
NP_001167561                                                           16    5631
XP_005260914                                                           16    5631
XP_005260913                                                           16    5631
NP_071365                                                              16    7355
XP_005260285                                                           16    7355
XP_006723916                                                           16    7355
NP_001074304                                                           16    7355
NP_001005281                                                           15    9605
>NP_000236
          Length = 1390

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   FNMSLIISN 9
           FNMS+IISN
Sbjct: 634 FNMSIIISN 642
>NP_001120972
          Length = 1408

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   FNMSLIISN 9
           FNMS+IISN
Sbjct: 634 FNMSIIISN 642
>XP_006716054
          Length = 960

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   FNMSLIISN 9
           FNMS+IISN
Sbjct: 204 FNMSIIISN 212
>XP_006716053
          Length = 960

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   FNMSLIISN 9
           FNMS+IISN
Sbjct: 204 FNMSIIISN 212
>XP_006716052
          Length = 1409

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   FNMSLIISN 9
           FNMS+IISN
Sbjct: 653 FNMSIIISN 661
>XP_006716051
          Length = 1427

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   FNMSLIISN 9
           FNMS+IISN
Sbjct: 653 FNMSIIISN 661
>NP_001129490
          Length = 455

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   NMSLIISN 9
           NM+L++SN
Sbjct: 249 NMALVLSN 256
>NP_001278092
          Length = 455

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   NMSLIISN 9
           NM+L++SN
Sbjct: 249 NMALVLSN 256
>NP_000111
          Length = 455

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   NMSLIISN 9
           NM+L++SN
Sbjct: 249 NMALVLSN 256
>NP_001167560
          Length = 875

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   FNMSLIIS 8
           FN+SL++S
Sbjct: 461 FNLSLVMS 468
>NP_114423
          Length = 891

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   FNMSLIIS 8
           FN+SL++S
Sbjct: 477 FNLSLVMS 484
>NP_001167561
          Length = 918

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   FNMSLIIS 8
           FN+SL++S
Sbjct: 504 FNLSLVMS 511
>XP_005260914
          Length = 856

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   FNMSLIIS 8
           FN+SL++S
Sbjct: 442 FNLSLVMS 449
>XP_005260913
          Length = 998

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   FNMSLIIS 8
           FN+SL++S
Sbjct: 584 FNLSLVMS 591
>NP_071365
          Length = 436

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   FNMSLIISN 9
           FN+  IISN
Sbjct: 404 FNLVAIISN 412
>XP_005260285
          Length = 430

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   FNMSLIISN 9
           FN+  IISN
Sbjct: 398 FNLVAIISN 406
>XP_006723916
          Length = 456

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   FNMSLIISN 9
           FN+  IISN
Sbjct: 424 FNLVAIISN 432
>NP_001074304
          Length = 389

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   FNMSLIISN 9
           FN  L++SN
Sbjct: 373 FNTCLLVSN 381
>NP_001005281
          Length = 311

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   FNMSLIIS 8
           FNM+ IIS
Sbjct: 266 FNMNKIIS 273
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.330    0.137    0.353 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 264,054
Number of extensions: 364
Number of successful extensions: 19
Number of sequences better than 10000.0: 19
Number of HSP's gapped: 19
Number of HSP's successfully gapped: 19
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.2 bits)
S2: 28 (15.4 bits)

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