Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_004110                                                              20     299
NP_078932                                                              17    2528
XP_005260137                                                           17    2528
NP_003310                                                              17    3301
NP_597676                                                              17    3301
NP_001243779                                                           17    3301
NP_596869                                                              17    3301
XP_005246888                                                           17    3301
XP_006712788                                                           17    3301
XP_006712787                                                           17    3301
XP_006712786                                                           17    3301
NP_001254479                                                           17    3301
NP_597681                                                              17    3301
NP_001074419                                                           17    4312
NP_001074248                                                           17    4312
NP_203693                                                              17    4312
NP_001166217                                                           17    4312
NP_036519                                                              17    4312
NP_001166216                                                           17    4312
NP_031391                                                              17    4312
NP_116780                                                              17    4312
XP_005256712                                                           17    4312
NP_037490                                                              17    4312
NP_006354                                                              17    4312
NP_116781                                                              17    4312
NP_114095                                                              16    5631
XP_006714119                                                           16    5631
NP_009151                                                              16    7355
XP_005274499                                                           16    7355
XP_005245089                                                           16    7355
XP_006711303                                                           16    7355
XP_005245088                                                           16    7355
NP_056018                                                              16    7355
NP_001013870                                                           15    9605
NP_061926                                                              15    9605
XP_006717964                                                           15    9605
XP_006717963                                                           15    9605
XP_006717962                                                           15    9605
XP_006717961                                                           15    9605
XP_005269972                                                           15    9605
XP_005269971                                                           15    9605
XP_006717960                                                           15    9605
XP_006717959                                                           15    9605
XP_005269970                                                           15    9605
XP_005269969                                                           15    9605
XP_005269968                                                           15    9605
XP_006717931                                                           15    9605
XP_006717930                                                           15    9605
XP_005269915                                                           15    9605
XP_005269914                                                           15    9605
XP_006717929                                                           15    9605
XP_006717928                                                           15    9605
NP_001006940                                                           15    9605
>NP_004110
          Length = 993

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   FMLNIRRKP 9
           F LNIRRKP
Sbjct: 431 FTLNIRRKP 439
>NP_078932
          Length = 622

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   FMLNIRRK 8
           FM+N+RR+
Sbjct: 344 FMINLRRR 351
>XP_005260137
          Length = 539

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   FMLNIRRK 8
           FM+N+RR+
Sbjct: 261 FMINLRRR 268
>NP_003310
          Length = 26926

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1     FMLNIRRKP 9
             F+LN++ KP
Sbjct: 25896 FILNVQSKP 25904
>NP_597676
          Length = 27051

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1     FMLNIRRKP 9
             F+LN++ KP
Sbjct: 26021 FILNVQSKP 26029
>NP_001243779
          Length = 34350

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1     FMLNIRRKP 9
             F+LN++ KP
Sbjct: 33320 FILNVQSKP 33328
>NP_596869
          Length = 33423

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1     FMLNIRRKP 9
             F+LN++ KP
Sbjct: 32393 FILNVQSKP 32401
>XP_005246888
          Length = 22663

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1     FMLNIRRKP 9
             F+LN++ KP
Sbjct: 21633 FILNVQSKP 21641
>XP_006712788
          Length = 24022

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1     FMLNIRRKP 9
             F+LN++ KP
Sbjct: 22992 FILNVQSKP 23000
>XP_006712787
          Length = 33978

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1     FMLNIRRKP 9
             F+LN++ KP
Sbjct: 32948 FILNVQSKP 32956
>XP_006712786
          Length = 35484

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1     FMLNIRRKP 9
             F+LN++ KP
Sbjct: 34454 FILNVQSKP 34462
>NP_001254479
          Length = 35991

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1     FMLNIRRKP 9
             F+LN++ KP
Sbjct: 34961 FILNVQSKP 34969
>NP_597681
          Length = 27118

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1     FMLNIRRKP 9
             F+LN++ KP
Sbjct: 26088 FILNVQSKP 26096
>NP_001074419
          Length = 1044

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   FMLNIRRK 8
           F+LN+RR+
Sbjct: 797 FLLNLRRQ 804
>NP_001074248
          Length = 1063

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   FMLNIRRK 8
           F+LN+RR+
Sbjct: 816 FLLNLRRQ 823
>NP_203693
          Length = 1028

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   FMLNIRRK 8
           F+LN+RR+
Sbjct: 781 FLLNLRRQ 788
>NP_001166217
          Length = 749

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   FMLNIRRKP 9
           FM ++RR P
Sbjct: 564 FMFHLRRSP 572
>NP_036519
          Length = 663

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   NIRRKP 9
           N+RRKP
Sbjct: 648 NVRRKP 653
>NP_001166216
          Length = 767

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   FMLNIRRKP 9
           FM ++RR P
Sbjct: 582 FMFHLRRSP 590
>NP_031391
          Length = 665

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   NIRRKP 9
           N+RRKP
Sbjct: 650 NVRRKP 655
>NP_116780
          Length = 767

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   FMLNIRRKP 9
           FM ++RR P
Sbjct: 582 FMFHLRRSP 590
>XP_005256712
          Length = 1039

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   FMLNIRRK 8
           F+LN+RR+
Sbjct: 792 FLLNLRRQ 799
>NP_037490
          Length = 663

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   NIRRKP 9
           N+RRKP
Sbjct: 648 NVRRKP 653
>NP_006354
          Length = 767

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   FMLNIRRKP 9
           FM ++RR P
Sbjct: 582 FMFHLRRSP 590
>NP_116781
          Length = 767

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   FMLNIRRKP 9
           FM ++RR P
Sbjct: 582 FMFHLRRSP 590
>NP_114095
          Length = 1142

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   NIRRKP 9
           N+RRKP
Sbjct: 400 NLRRKP 405
>XP_006714119
          Length = 1142

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   NIRRKP 9
           N+RRKP
Sbjct: 400 NLRRKP 405
>NP_009151
          Length = 317

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   FMLNIRRKP 9
           ++LN++ KP
Sbjct: 300 YVLNVQAKP 308
>XP_005274499
          Length = 317

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   FMLNIRRKP 9
           ++LN++ KP
Sbjct: 300 YVLNVQAKP 308
>XP_005245089
          Length = 934

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   MLNIRRKP 9
           M+N+ +KP
Sbjct: 820 MMNLEKKP 827
>XP_006711303
          Length = 960

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   MLNIRRKP 9
           M+N+ +KP
Sbjct: 846 MMNLEKKP 853
>XP_005245088
          Length = 1435

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   MLNIRRKP 9
           M+N+ +KP
Sbjct: 820 MMNLEKKP 827
>NP_056018
          Length = 1461

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   MLNIRRKP 9
           M+N+ +KP
Sbjct: 846 MMNLEKKP 853
>NP_001013870
          Length = 799

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   MLNIRRKP 9
           +LN+ RKP
Sbjct: 528 LLNLIRKP 535
>NP_061926
          Length = 804

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   MLNIRRKP 9
           +LN+ RKP
Sbjct: 533 LLNLIRKP 540
>XP_006717964
          Length = 781

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   MLNIRRKP 9
           +LN+ RKP
Sbjct: 510 LLNLIRKP 517
>XP_006717963
          Length = 749

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   MLNIRRKP 9
           +LN+ RKP
Sbjct: 549 LLNLIRKP 556
>XP_006717962
          Length = 791

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   MLNIRRKP 9
           +LN+ RKP
Sbjct: 510 LLNLIRKP 517
>XP_006717961
          Length = 799

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   MLNIRRKP 9
           +LN+ RKP
Sbjct: 528 LLNLIRKP 535
>XP_005269972
          Length = 803

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   MLNIRRKP 9
           +LN+ RKP
Sbjct: 532 LLNLIRKP 539
>XP_005269971
          Length = 807

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   MLNIRRKP 9
           +LN+ RKP
Sbjct: 526 LLNLIRKP 533
>XP_006717960
          Length = 809

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   MLNIRRKP 9
           +LN+ RKP
Sbjct: 528 LLNLIRKP 535
>XP_006717959
          Length = 809

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   MLNIRRKP 9
           +LN+ RKP
Sbjct: 528 LLNLIRKP 535
>XP_005269970
          Length = 814

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   MLNIRRKP 9
           +LN+ RKP
Sbjct: 533 LLNLIRKP 540
>XP_005269969
          Length = 820

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   MLNIRRKP 9
           +LN+ RKP
Sbjct: 549 LLNLIRKP 556
>XP_005269968
          Length = 830

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   MLNIRRKP 9
           +LN+ RKP
Sbjct: 549 LLNLIRKP 556
>XP_006717931
          Length = 255

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   LNIRRKP 9
           LNI+R P
Sbjct: 172 LNIKRNP 178
>XP_006717930
          Length = 261

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   LNIRRKP 9
           LNI+R P
Sbjct: 172 LNIKRNP 178
>XP_005269915
          Length = 265

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   LNIRRKP 9
           LNI+R P
Sbjct: 172 LNIKRNP 178
>XP_005269914
          Length = 265

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   LNIRRKP 9
           LNI+R P
Sbjct: 172 LNIKRNP 178
>XP_006717929
          Length = 265

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   LNIRRKP 9
           LNI+R P
Sbjct: 172 LNIKRNP 178
>XP_006717928
          Length = 265

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   LNIRRKP 9
           LNI+R P
Sbjct: 172 LNIKRNP 178
>NP_001006940
          Length = 261

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   LNIRRKP 9
           LNI+R P
Sbjct: 172 LNIKRNP 178
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.343    0.154    0.476 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 535,684
Number of extensions: 809
Number of successful extensions: 53
Number of sequences better than 10000.0: 53
Number of HSP's gapped: 53
Number of HSP's successfully gapped: 53
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.6 bits)
S2: 28 (15.4 bits)

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